AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology

Journal of Cellular Physiology

Volumn 212, Issue 3, 2007, Pages 655-665

  Near, Richard I ^a   Zhang, Yujun ^a   Makkinje, Anthony ^a   Vanden Borre, Pierre ^a   Lerner, Adam ^a,b  

^a BOSTON MEDICAL CENTER   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIESTROGEN; CRK ASSOCIATED SUBSTRATE PROTEIN; CYCLIN D1; ESTROGEN RECEPTOR ALPHA; FIBRONECTIN; FULVESTRANT; PROTEIN BCAR3; PROTEIN CDC42; PROTEIN KINASE B; PROTEIN NSP1; PROTEIN NSP3; PROTEIN SH2; RAC PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER RESISTANCE; CELL ADHESION; CELL INTERACTION; CELL STRAIN MCF 7; CELL STRUCTURE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTINEOPLASTIC AGENTS, HORMONAL; BREAST NEOPLASMS; CADHERINS; CDC42 GTP-BINDING PROTEIN; CELL ADHESION; CELL LINE, TUMOR; CELL SHAPE; CRK-ASSOCIATED SUBSTRATE PROTEIN; CYCLINS; DRUG RESISTANCE, NEOPLASM; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR MODULATORS; FEMALE; FIBRONECTINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERCELLULAR JUNCTIONS; MESODERM; PHENOTYPE; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-AKT; RAC GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 34547932906     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21059     Document Type: Article

References (36)

1. Albanese C, Johnson J, Watanabe G, Eklund N, Vu D, Arnold A, Pestell RG. 1995. Transforming p21 Ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J Biol Chem 270:23589-23597.
2. Altucci L, Addeo R, Cicatiello L, Dauvois S, Parker M, Truss M, Beato M, Sica V, Bresciani F, Weisz A. 1996. 17β-estradiol induces cyclin D1 gene transcription, p36D1-p34Cdk4 complex activation and 105Rb phosphorylation during mitogenic stimulation of G1-arrested human breast cancer cells. Oncogene 12:2315-2324.
3. Avizienyte E, Frame MC. 2005. Src and FAK signalling controls adhesion fate and the epithelial-to-meserrchymal transition. Curr Opin Cell Biol 17:542-547.
4. Avizienyte E, Wyke AW, Jones RJ, McLean GW, Westhoff MA, Brunton VG, Frame MC. 2002. Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling. Nat Cell Biol 4:632-638.
5. Bill HM, Knudsen B, Moores SL, Muthuswamy SK, Rao VR, Brugge JS, Miranti CK. 2004. Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells. Mol Cell Biol 24:8586-8599.
6. Brinkman A, van der Flier S, Kok EM, Dorssers LCJ. 2000. BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells. J Natl Cancer Inst 92:112-120.
7. Cai D, Clayton LK, Smolyar A, Lerner A. 1999. AND-34, a novel p 130Cas-binding thymic stromal cell protein regulated by adhesion and inflammatory cytokines. J Immunol 163:2104-2112.
8. Cai D, Felekkis K, Near R, Iyer A, O'Neill GM, Seventer JM, Golemis EA, Lerner A. 2003a. The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42. J Immunol 170:969-978.
9. Cai D, Iyer A, Felekkis K, Near R, Luo Z, Chernoff J, Albanese C, Pestell RG, Lerner A. 2003b. AND-34/BCAR3, a GDP exchange factor whose over-expression confers antiestrogen resistance, activates Rac1, Pak1 and the cyclin D1 promoter. Cancer Res 63:6802-6808.
10. Clarke R, Liu MC, Bouker KB, Gu Z, Lee RY, Zhu Y, Skaar TC, Gomez B, O'Brien K, Wang Y, Hilakivi-Clarke LA. 2003. Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling. Oncogene 22:7316-7339.
11. Dail M, Kalo MS, Seddon JA, Cote JF, Vuori K, Pasquale EB. 2004. SHEP1 function in cell migration is impaired by a single amino acid mutation that disrupts association with the scaffolding protein Cas but not with Ras GTPases. J Biol Chem
12. Dodelet VC, Pazzagli C, Zisch AH, Hauser CA, Pasquale EB. 1999. A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A. J Biol Chem 274:31941-31946.
13. Dorssers LC, van Agthoven T, Dekker A, van Agthoven TL, Kok EM. 1993. Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of bear-1, a common integration site. Mol Endocrinol 7:870-878.
14. Dorssers LC, van Agthoven T, Brinkman A, Veldscholte J, Smid M, Dechering KJ. 2005. Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or the epidermal growth factor receptor signalling pathway. Breast Cancer Res 7:R82-R92.
15. Felekkis KN, Narsimhan RP, Near R, Castro AF, Zheng Y, Quilliam LA, Lerner A. 2005. AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner. Mol Cancer Res 3:32-41.
16. Cas regulates the activity of AND-34, a novel Ral, Rap1 and R-Ras guanine nucleotide exchange factor. J Biol Chem 275:30118-30123.
17. Hu M, Carles-Kinch KL, Zelinski DP, Kinch MS. 2004. EphA2 induction of fibronectin creates a permissive microenvironment for malignant cells. Mol Cancer Res 2:533-540.
18. Kang Y, Massague J. 2004. Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 118:277-279.
19. Kuwada SK, Li X. 2000. Integrin alpha5/beta1 mediates fibronectin-dependent epithelial cell proliferation through epidermal growth factor receptor activation. Mol Biol Cell 11:2485-2496.
20. Lacroix M, Leclercq G. 2004. Relevance of breast cancer cell lines as models for breast tumours: an update. Breast Cancer Res Treat 83:249-289.
21. Law SF, Zhang Y-Z, Klein-Szanto AJP, Golemis EA. 1998. Cell-cycle-regulated processing of Hef1 to multiple protein forms differentially targeted to multiple subcellular compartments. Mol Cell Biol 18:3540-3551.
22. Lu Y, Brush J, Stewart TA. 1999a. NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway. J Biol Chem 274:10047-10052.
23. Lu Y, Brush J, Stewart TA. 1999b. NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-jun N-terminal kinase/stress-activated protein kinase signaling pathway. J Biol Chem 274:10047-10052.
24. Lu M, Miller KD, Gokmen-Polar Y, Jeng MH, Kinch MS. 2003. EphA2 overexpression decreases estrogen dependence and tamoxifen sensitivity. Cancer Res 63:3425-3429.
25. Matsuo M, Sakurai H, Ueno Y, Ohtani O, Saiki I. 2006. Activation of MEK/ERK and PI3K/Akt pathways by fibronectin requires integrin alphav-mediated ADAM activity in hepatocellular carcinoma: a novel functional target for gefitinib. Cancer Sci 97:155-162.
26. McClelland RA, Barrow D, Madden TA, Dutkowski CM, Pamment J, Knowlden JM, Gee JMW, Nicholson RI. 2001. Enhanced epidermal growth factor receptor signaling in MCF7 breast cancer cells after long term culture in the presence of the pure antiestrogen ICI 182,780 (Faslodex). Endocrinology 142:2776-2788.
27. Meijer D, van Agthoven T, Bosma PT, Nooter K, Dorssers LC. 2006. Functional screen for genes responsible for tamoxifen resistance in human breast cancer cells. Mol Cancer Res 4:379-386.
28. Moro L, Venturino M, Bozzo C, Silengo L, Altruda F, Beguinot L, Tarone G, Defilippi P. 1998. Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival. EMBO J 17:6622-6632.
29. O'Neill GM, Golemis EA. 2001. Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics. Mol Cell Biol 21:5094-5108.
30. Sakakibara A, Hattori S. 2000. CHAT, a Cas/HEF1-associated adapter protein that integrates multiple signaling pathways. J Biol Chem 275:6404-6410.
31. Sakakibara A, Ohba Y, Kurokawa K, Matsuda M, Hattori S. 2002. Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation. J Cell Sci 115:4915-4924.
32. Sakakibara A, Hattori S, Nakamura S, Katagiri T. 2003. A novel hematopoietic adaptor protein, Chat-H, positively regulates T cell receptor-mediated interleukin-2 production by Jurkat cells. J Biol Chem 278:6012-6017.
33. Van Agthoven T, Van Agthoven TLA, Portengen H, Foekens JA, Dorssers CJ. 1992. Ectopic expression of epidermal growth factor receptors induces hormone independence in ZR-75-1 human breast cancer cells. Cancer Res 52:5082-5088.
34. van Agthoven T, van Agthoven T, Dekker A, Spek P, Vreede L, Dorssers L. 1998. Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. EMBO J 17:2799-2808.
35. van der Flier S, Brinkman A, Look MP, Kok EM, Meijer-van Gelder ME, Klijn JG, Dorssers LC, Foekens JA. 2000. Bcar1/p130Cas protein and primary breast cancer: prognosis and response to tamoxifen treatment. J Natl Cancer Inst 92:120-127.
36. Yu Y, Feig LA. 2002. Involvement of R-Ras and Ral GTPases in estrogen-independent proliferation of breast cancer cells. Oncogene 21:7557-7568.