Hypoxia, energy state and pulmonary vasomotor tone

Respiratory Physiology and Neurobiology

Volumn 132, Issue 1, 2002, Pages 55-67

  Leach, Richard M ^a   Hill, Heidi S ^a   Snetkov, Vladimir A ^a   Ward, Jeremy P T ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Hypoxia, pulmonary vasculature; Pulmonary circulation, hypoxic vasoconstriction; Smooth muscle, pulmonary blood vessels, energy state, mitochondria, glycolysis, oxidative phosphorylation

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENYLATE CYCLASE; CALCIUM ION; CREATINE PHOSPHATE; GLUCOSE; OXYGEN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

AEROBIC METABOLISM; ANAEROBIC METABOLISM; ARTERY DILATATION; BLOOD VESSEL TONE; CALCIUM CELL LEVEL; CELL ENERGY; CELL METABOLISM; GLYCOLYSIS; HUMAN; HYPOXIA; HYPOXIC LUNG VASOCONSTRICTION; LUNG BLOOD VESSEL; LUNG VASOCONSTRICTION; MITOCHONDRION; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; RESPIRATORY CHAIN; REVIEW; SMOOTH MUSCLE RELAXATION; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ANIMALS; ANOXIA; ENERGY METABOLISM; MUSCLE TONUS; MUSCLE, SMOOTH, VASCULAR; PULMONARY CIRCULATION;

EID: 0037158627     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1569-9048(02)00049-6     Document Type: Article

References (54)

1. Effect of hypoxia on force, intracellular pH and Ca2+ concentration in rat cerebral and mesenteric arteries
2. A redox-based O2 sensor in rat pulmonary vasculature
3. Cross-bridge cycling in smooth muscle; A short review
4. Insulin regulation of vascular smooth muscle glucose transport in insulin-sensitive and resistant rats
5. Energy state and vasomotor tone in hypoxic pig lungs
6. Stimulation of glucose transport in skeletal muscle by hypoxia
7. Cellular oxygen sensing by mitochondria: Old questions, new insight
8. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1a during hypoxia
9. The creatine kinase system in smooth muscle
10. Rate-limiting energy-dependent steps controlling oxidative metabolism-contraction coupling in rabbit aorta
11. Mitochondria are a source of reactive oxygen species during reductive stress in rat hepatocytes
12. Influence of cellular energy metabolism on contractions of porcine carotid artery smooth muscle
13. Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion
14. Mitochondrial oxygen affinity, respiratory flux control and excess capacity of cytochrome c oxidase
15. Tension responses of sheep aorta to simultaneous decreases in phosphocreatine, inorganic phosphate and ATP
16. Time-resolved measurements of phosphate release by cycling cross-bridges in portal vein smooth muscle
17. Unifying theory of hypoxia tolerance; Molecular/metabolic defense and rescue mechanisms for surviving oxygen lack
18. Effects of hypoxia on energy state and pH in resting pulmonary and femoral arterial smooth muscles
19. Energy state, pH, and vasomotor tone during hypoxia in precontracted pulmonary and femoral arteries
20. Divergent roles of glycolysis and the mitochondrial electron transport chain in hypoxic pulmonary vasoconstriction of the rat: Identity of the hypoxic sensor
21. Hypoxic constriction of porcine distal pulmonary arteries: Endothelium and endothelin dependence
22. The effects of MgADP on cross-bridge kinetics: A laser flash photolysis study of guinea-pig smooth muscle
23. Time course of pulmonary vasoconstriction with repeated hypoxia and glucose depletion
24. Mechanisms of hypoxic vasodilatation of isolated rat mesenteric arteries: A comparison with metabolic inhibition
25. Functional compartmentalization of oxidative and glycolytic metabolism in vascular smooth muscle
26. Smooth muscle energetics
27. Metabolic features of isolated rat lung cells. I. Factors controlling glucose utilization
28. Hypoxic vasoconstriction and intracellular Ca2+ in pulmonary arteries: Evidence for PKC-independent Ca2+ sensitization
29. Inhibition of sustained hypoxic vasoconstriction by Y-27632 in isolated intrapulmonary arteries and perfused lung of the rat
30. Hypoxia induces the release of a pulmonary-selective, Ca2+-sensitising, vasoconstrictor from the perfused rat lung
31. Inhibitors of oxidative ATP production cause transient vasoconstriction and block subsequent pressor responses in rat lungs
32. Phosphocreatine and oxidative metabolism-contraction coupling in rabbit aorta
33. Lack of contribution of mitochondrial electron transport to acute O2 sensing in model airway chemoreceptors
34. Hypoxia inducible factor 1: Master regulator of O2 homeostasis
35. Effect of hypoxia on isometric force, intracellular Ca2+, pH, and energetics in porcine coronary artery
36. Pharmacomechanical coupling: The role of calcium, G-proteins, kinases and phosphatases
37. Inhibition of glycolysis potentiates hypoxic vasoconstriction in rat lungs
38. Effects of changes in pH and CO2 on pulmonary arterial wall tension are not endothelium dependent
39. Hypoxia and smooth muscle function: Key regulatory events during metabolic stress
40. Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria
41. Mechanisms of hypoxic pulmonary vasoconstriction: Can anyone be right?
42. The role of the endothelium in hypoxic pulmonary vasoconstriction
43. Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing
44. The mechanism of acute hypoxic pulmonary vasoconstriction: The tale of two channels
45. Effects of substrate and hypoxia on smooth muscle metabolism and contraction
46. Effects of glucose on hypoxic vasoconstriction in isolated ferret lungs
47. Effects of insulin, glucose analogues, and pyruvate on vascular responses to anoxia in isolated ferret lungs
48. ATP-dependent K+ channels modulate vasoconstrictor responses to severe hypoxia in isolated ferret lungs
49. ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase act as a redox sensor: A primary role for cADPR in hypoxic pulmonary vasoconstriction
50. Regulation of glucose transport by hypoxia
51. The vein utilizes different sources of energy than the artery during pulmonary hypoxic vasoconstriction