Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes

EMBO Journal

Volumn 16, Issue 22, 1997, Pages 6615-6625

  Patel, Amanda J ^a   Lazdunski, Michel ^a   Honoré, Eric ^a  

^a CNRS   (France)

Author keywords

Dex fenfluramine; Hypoxia; Oxygen sensitivity pulmonary hypertension; Vasoconstriction

Indexed keywords

ADENOSINE TRIPHOSPHATE; DEXFENFLURAMINE; POTASSIUM CHANNEL; PROTEIN SUBUNIT; TETRYLAMMONIUM;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE EXPRESSION; HYPOXIA; MEMBRANE STEADY POTENTIAL; METABOLIC REGULATION; MOLECULAR CLONING; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 0030859539     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.22.6615     Document Type: Article

References (46)

1. Areher, S.L. (1996) Diversity of phenotype and function of vascular smooth muscle cells. J. Lab. Clin. Med., 127, 524-529.
2. 2 sensor in rat pulmonary vasculature. Circ Res., 73, 1100-1112.
3. Archer, S.L., Huang, J.M., Reeve, H.L., Hampl, V., Tolarova, S., Michelakis, E. and Weir, E.K. (1996) Differential distribution of electrophysiologically distinct myocytcs in conduit and resistance arteries determines their response to nitric oxide and hypoxia. Circ. Res., 78, 431-442.
4. Barnes, P.J. and Liu, S.F. (1995) Regulation of pulmonary vascular tone. Pharmacol. Rev., 47, 87-131.
5. Baumann, A., Grupe, A., Ackermann, A. and Pongs, O. (1988) Structure of the voltage-dependent potassium channel is highly conserved from Drosophila to vertebrate central nervous systems. EMBO J., 7, 2457-2463.
6. Beckh, S. and Pongs, O. (1990) Members of the RCK potassium channel family are differentially expressed in the rat nervous system. EMBO J., 9, 777-782.
7. Bennie, R.E., Packer, C.S., Powell, D.R., Jin.N. and Rhoades, R.A. (1991) Biphasic contractile response of pulmonary artery to hypoxia. Am. J. Physiol., 261, L156-L163.
8. i in pulmonary arterial smooth muscle cells. Am. J. Physiol., 269, U203-L208.
9. Cornfield, D.N., Stevens, T., McMurtry, I.F., Abman, S.H. and Rodman, D.M. (1994) Acute hypoxia causes membrane depolarization and calcium influx in fetal pulmonary artery smooth muscle cells. Am. J. Physiol., 266, L469-L475.
10. + channel mRNAs from different subfamilies. J. Neurosci., 12, 538-548.
11. + channels to reactive oxygen species. Proc. Natl Acad. Sci. USA. 92, 11796-11800.
12. Evans, A.M., Clapp, L.H. and Gurney, A.M. (1994) Augmentation by intraccllular ATP of the delayed rectifier current independently of the glibenclamide-sensitive K-current in rabbit arterial myocytes. Br. J. Pharmacol., 111, 972-974.
13. + current that is active at resting potential in rabbit pulmonary artery smooth muscle cells. J. Physiol., 496, 407-420.
14. Frech, G.C. VanDongen, A.M., Schuster, G., Brown, A.M. and Joho, R.H. (1989) A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning. Nature. 340, 642-645.
15. 2+ concentration in rat pulmonary artery myocytes. Am. J. Physiol., 271, L450-L458.
16. + channel current arc generated by different levels of a single mRNA. EMBO J., 11, 2465-2471.
17. Hugnot, J.P., Salinas, M., Lesage, K. Guillemare, E., de Weille, J., Heurteaux, C., Mattei, M.G. and Lazdunski, M. (1996) Kv8.l. a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels. EMBO J., 15, 3322-3331.
18. Jin, N., Packer, C.S. and Rhoades, R.A. (1992) Pulmonary arterial hypoxic contraction: signal transduction. Am. J. Physiol., 263, L73-L78.
19. Koztowski, R.Z. (1995) Ion channels, oxygen sensation and signal transduction in pulmonary arterial smooth muscle. Cardiovasc. Res., 30, 318-325.
20. Lopez-Bameo, J. (1994) Oxygen-sensitive ion channels: how ubiquitous are they? Trends Neurosci., 17, 133-135.
21. Lopez-Barneo, J. (1996) Oxygen-sensing by ion channels and the regulation of cellular functions. Trends Neurosci., 19, 435-440.
22. Lopez-Bameo, J., Ortega-Saenz, P., Molina, A., Franco-Obregon, A., Urena, J. and Castellano, A. (1997) Oxygen sensing by ion channels. Kidney Int., 51, 454-461.
23. 2-sensing potassium current. Br. J. Pharmacol., 120, 1461-1470.
24. Pongs, O. (1992) Molecular biology of voltage-dependent potassium channels. Physiol. Rev., 72, S69-S88.
25. Post, J.M., Hume, J.R., Archer, S.L. and Weir, E.K. (1992) Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction. Am. J. Physiol., 262, C882-C890.
26. + channels in canine pulmonary artery. Novel mechanism for hypoxia-induced membrane depolarization. Circ. Res., 77, 131-139.
27. Post, M.A., Kirsch, G.E. and Brown, A.M. (1996) Kv2.1 and electrically silent Kv6.l potassium channel subunits combine and express a novel current. FEBS Lett., 399, 177-182.
28. + channels. Trends Pharmacol. Sci., 10, 431-134.
29. Rounds, S. and McMurtry, I.F. (1981) Inhibitors of oxidative ATP production cause transient vasoconstriction and block subsequent presser responses in rat lungs. Circ. Res., 48, 393-400.
30. Ruppersberg, J.P., Stocker, M., Pongs, O., Heinemann.S.H.. Frank, R. and Koenen, M. (1991) Regulation of fast inactivation of cloned mammalian IK(A) channels by cystcine oxidation. Nature. 352, 711-714.
31. + channel activity by the Kv8.1 subunit. J. Biol. Chem., 272, 8774-8780.
32. + channels. J. Biol. Chem.. 272, 24371-24379.
33. + channels expressed in transfected mammalian cells. J. Biol. Chem., 269, 23204-23211.
34. + current in rat pulmonary artery muscle cells. Am. J. Physiol., 266, H365-H370.
35. Stuhmer, W., Ruppersberg, J.P., Schroter, K.H., Sakmann, B., Stocker, M., Giese, K.P., Perschke, A., Baumann, A. and Pongs, O. (1989) Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. EMBO J., 8, 3235-3244.
36. + channel may function as an oxygen sensor complex in airway chemoreceptors and small cell lung carcinoma cell lines. Proc. Natl Acad. Sci. USA. 93, 13182-13187.
37. Weir, E.K. and Archer, S.L. (1995) The mechanism of acute hypoxic pulmonary vasoconstriction: the tale of two channels. FASEB J., 9, 183-189.
38. Weir, E.K., Recve, H.L., Huang, J.M., Michelakis, E., Nelson, D.P., Hampl, V. and Archer, S.L. (1996) Anorexic agents aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in rat pulmonary vascular smooth muscle and cause pulmonary vasoconstriction. Circulation. 94, 2216-2220.
39. Youngson, C., Nurse, C. Yeger, H. and Cutz, E. (1993) Oxygen sensing in airway chemoreceptors. Nature. 365, 153-155.
40. i in pulmonary arterial myocytes. Circ. Res., 77, 370-378.
41. Yuan, X.J., Goldman, W.F., Tod, M.L., Rubin, L.J. and Blaustein, M.P. (1993a) Hypoxia reduces potassium currents in cultured rat pulmonary but not mesemeric arterial myocytes. Am. J. Physiol., 264, L116-L123.
42. Yuan, X.J., Goldman, W.F., Tod, M.L., Rubin, L.J. and Blaustein, M.P. (1993b) Ionic currents in rat pulmonary and mesemeric arterial myocytes in primary culture and subculture. Am. J. Physiol., 264, L107-L115.
43. 2+ conductances in pulmonary artery cells. Am. J. Physiol., 267, L52-L63.
44. + channels in rat pulmonary artery smooth muscle cells. Exp. Physiol., 80, 803-813.
45. + currents in pulmonary arterial myocytes. Am. J. Physiol., 268, C259-C270.
46. Yuan, X.J., Sugiyama, T., Goldman, W.F., Rubin, L.J. and Blaustein, M.P. (1996) A mitochondrial uncoupler increases KCa currents but decreases KV currents in pulmonary artery myocytes. Am. J. Physiol., 270, C321-C331.