Emerging roles of PAR-1 and PAFR in melanoma metastasis

Cancer Microenvironment

Volumn 1, Issue 1, 2008, Pages 103-111

  Melnikova, Vladislava O ^a   Villares, Gabriel J ^a   Bar Eli, Menashe ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Melanoma; Metastasis; PAR 1; Platelet activating factor; Platelets; Thrombin receptor; Tumor microenvironment

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 1; ARACHIDONIC ACID; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GELATINASE A; GLYCEROPHOSPHOLIPID; INTEGRIN; INTERLEUKIN 8; MATRIX METALLOPROTEINASE 14; PLATELET DERIVED GROWTH FACTOR; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN; THROMBOCYTE ACTIVATING FACTOR; THROMBOCYTE ACTIVATING FACTOR RECEPTOR; VASCULOTROPIN;

ANGIOGENESIS; BLOOD CLOTTING; CANCER GROWTH; CELL ADHESION; ENDOTHELIUM CELL; HUMAN; MELANOMA; METASTASIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVIEW; THROMBOCYTE ACTIVATION; TUMOR GROWTH;

EID: 58649117121     PISSN: 18752292     EISSN: 18752284     Source Type: Journal    
DOI: 10.1007/s12307-008-0002-7     Document Type: Review

References (102)

1. IJ Fidler 2003 The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited Nat Rev Cancer 3 6 453 458
2. F Balkwill A Mantovani 2001 Inflammation and cancer: back to Virchow Lancet 357 9255 539 545
3. LM Coussens Z Werb 2002 Inflammation and cancer Nature 420 6917 860 867
4. A Mantovani 2005 Cancer: inflammation by remote control Nature 435 7043 752 753
5. E Pikarsky 2004 NF-kappa B functions as a tumour promoter in inflammation-associated cancer Nature 431 7007 461 466
6. KS Smalley M Lioni M Herlyn 2005 Targeting the stromal fibroblasts: a novel approach to melanoma therapy Expert Rev Anticancer Ther 5 6 1069 1078
7. Denardo DG, Johansson M, Coussens LM (2007) Immune cells as mediators of solid tumor metastasis. Cancer Metastasis Rev DOI 10.1007/s10555-007-9100-0
8. TD Tlsty LM Coussens 2006 Tumor stroma and regulation of cancer development Annu Rev Pathol 1 119 150
9. NK Haass M Herlyn 2005 Normal human melanocyte homeostasis as a paradigm for understanding melanoma J Investig Dermatol Symp Proc 10 2 153 163
10. JT Lee M Herlyn 2006 Microenvironmental influences in melanoma progression J Cell Biochem 101 4 862 872
11. LM Postovit 2006 Influence of the microenvironment on melanoma cell fate determination and phenotype Cancer Res 66 16 7833 7836
12. T Schwarz TA Luger 1989 Effect of UV irradiation on epidermal cell cytokine production J Photochem Photobiol B 4 1 1 13
13. GK Marathe 2005 Ultraviolet B radiation generates platelet-activating factor-like phospholipids underlying cutaneous damage J Biol Chem 280 42 35448 35457
14. Y Pei 1998 Activation of the epidermal platelet-activating factor receptor results in cytokine and cyclooxygenase-2 biosynthesis J Immunol 161 4 1954 1961
15. JP Walterscheid SE llrich DX Nghiem 2002 Platelet-activating factor, a molecular sensor for cellular damage, activates systemic immune suppression J Exp Med 195 2 171 179
16. SE Ullrich 2005 Mechanisms underlying UV-induced immune suppression Mutat Res 571 1-2 185 205
17. MY Hsu F Meier M Herlyn 2002 Melanoma development and progression: a conspiracy between tumor and host Differentiation 70 9-10 522 536
18. C Gaggioli 2007 Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells Nat Cell Biol 9 12 1392 1400
19. M De Palma 2005 Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors Cancer Cell 8 3 211 226
20. CE Lewis M De Palma L Naldini 2007 Tie2-expressing monocytes and tumor angiogenesis: regulation by hypoxia and angiopoietin-2 Cancer Res 67 18 8429 8432
21. LM Coussens 2000 MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis Cell 103 3 481 490
22. GJ Gasic TB Gasic CC Stewart 1968 Antimetastatic effects associated with platelet reduction Proc Natl Acad Sci U S A 61 1 46 52
23. ML Nierodzik S Karpatkin 2006 Thrombin induces tumor growth, metastasis, and angiogenesis: evidence for a thrombin-regulated dormant tumor phenotype Cancer Cell 10 5 355 362
24. ML Nierodzik 1998 Protease-activated receptor 1 (PAR-1) is required and rate-limiting for thrombin-enhanced experimental pulmonary metastasis Blood 92 10 3694 3700
25. RA Gupta RN Dubois 2001 Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2 Nat Rev Cancer 1 1 11 21
26. NI Affara LM Coussens 2007 IKK alpha at the crossroads of inflammation and metastasis Cell 129 1 25 26
27. JR Brown RN DuBois 2004 Cyclooxygenase as a target in lung cancer Clin Cancer Res 10 12 Pt 2 4266s 4269s
28. DJ Dauer 2005 Stat3 regulates genes common to both wound healing and cancer Oncogene 24 21 3397 3408
29. SC Robinson LM Coussens 2005 Soluble mediators of inflammation during tumor development Adv Cancer Res 93 159 187
30. O Nyormoi M Bar-Eli 2003 Transcriptional regulation of metastasis-related genes in human melanoma Clin Exp Metastasis 20 3 251 263
31. ME Bromberg 1995 Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation Proc Natl Acad Sci U S A 92 18 8205 8209
32. EG Fischer W Ruf BM Mueller 1995 Tissue factor-initiated thrombin generation activates the signaling thrombin receptor on malignant melanoma cells Cancer Res 55 8 1629 1632
33. W Ruf BM Mueller 2006 Thrombin generation and the pathogenesis of cancer Semin Thromb Hemost 32 Suppl 1 61 68
34. C Tellez M Bar-Eli 2003 Role and regulation of the thrombin receptor (PAR-1) in human melanoma Oncogene 22 20 3130 3137
35. N Kepner A Lipton 1981 A mitogenic factor for transformed fibroblasts from human platelets Cancer Res 41 2 430 432
36. R Mohle 1997 Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets Proc Natl Acad Sci U S A 94 2 663 668
37. JJ Li 2001 Thrombin induces the release of angiopoietin-1 from platelets Thromb Haemost 85 2 204 206
38. A Boucharaba 2004 Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer J Clin Invest 114 12 1714 1725
39. B Nieswandt 1999 Lysis of tumor cells by natural killer cells in mice is impeded by platelets Cancer Res 59 6 1295 1300
40. GC Haralabopoulos 1997 Thrombin promotes endothelial cell alignment in Matrigel in vitro and angiogenesis in vivo Am J Physiol 273 1 Pt 1 C239-C245
41. W Ruf 2007 Tissue factor and PAR signaling in tumor progression Thromb Res 120 Suppl 2 S7 S12
42. KK Hansen M Saifeddine MD Hollenberg 2004 Tethered ligand-derived peptides of proteinase-activated receptor 3 (PAR3) activate PAR1 and PAR2 in Jurkat T cells Immunology 112 2 183 190
43. PJ O'Brien 2001 Protease activated receptors: theme and variations Oncogene 20 13 1570 1581
44. A Boire 2005 PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells Cell 120 3 303 313
45. SC Even-Ram 2001 Tumor cell invasion is promoted by activation of protease activated receptor-1 in cooperation with the alpha v beta 5 integrin J Biol Chem 276 14 10952 10962
46. MZ Wojtukiewicz 1992 Thrombin enhances tumor cell adhesive and metastatic properties via increased alpha IIb beta 3 expression on the cell surface Thromb Res 68 3 233 245
47. DR Senger 1996 Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin Am J Pathol 149 1 293 305
48. ML Nierodzik 1996 Presence of the seven transmembrane thrombin receptor on human tumour cells: effect of activation on tumour adhesion to platelets and tumor tyrosine phosphorylation Br J Haematol 92 2 452 457
49. S Zucker 1995 Thrombin induces the activation of progelatinase A in vascular endothelial cells. Physiologic regulation of angiogenesis J Biol Chem 270 40 23730 23738
50. S Shimizu 2000 Thrombin stimulates the expression of PDGF in lung epithelial cells Am J Physiol Lung Cell Mol Physiol 279 3 L503-L510
51. A Ueno 1996 Thrombin stimulates production of interleukin-8 in human umbilical vein endothelial cells Immunology 88 1 76 81
52. A Cucina 1999 Thrombin induces production of growth factors from aortic smooth muscle cells J Surg Res 82 1 61 66
53. YQ Huang 2001 Thrombin induces increased expression and secretion of VEGF from human FS4 fibroblasts, DU145 prostate cells and CHRF megakaryocytes Thromb Haemost 86 4 1094 1098
54. D Massi 2005 Expression of protease-activated receptors 1 and 2 in melanocytic nevi and malignant melanoma Hum Pathol 36 6 676 685
55. CS Tellez 2007 Quantitative analysis of melanocytic tissue array reveals inverse correlation between activator protein-2alpha and protease-activated receptor-1 expression during melanoma progression J Invest Dermatol 127 2 387 393
56. S Even-Ram 1998 Thrombin receptor overexpression in malignant and physiological invasion processes Nat Med 4 8 909 914
57. V Kaushal 2006 Thrombin receptor expression is upregulated in prostate cancer Prostate 66 3 273 282
58. C Rudroff 1998 Characterization of functional thrombin receptors in human pancreatic tumor cells (MIA PACA-2) Pancreas 16 2 189 194
59. MZ Wojtukiewicz 1995 Solid tumor cells express functional "tethered ligand" thrombin receptor Cancer Res 55 3 698 704
60. C Tellez 2003 Loss of activator protein-2alpha results in overexpression of protease-activated receptor-1 and correlates with the malignant phenotype of human melanoma J Biol Chem 278 47 46632 46642
61. J Benveniste 1979 Semi-synthesis and proposed structure of platelet-activating factor (P.A.F.): PAF-acether an alkyl ether analog of lysophosphatidylcholine C R Seances Acad Sci D 289 14 1037 1040
62. ML Blank 1979 Antihypertensive activity of an alkyl ether analog of phosphatidylcholine Biochem Biophys Res Commun 90 4 1194 1200
63. CA Demopoulos RN Pinckard DJ Hanahan 1979 Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators) J Biol Chem 254 19 9355 9358
64. J Benveniste PM Henson CG Cochrane 1972 Leukocyte-dependent histamine release from rabbit platelets. The role of IgE, basophils, and a platelet-activating factor J Exp Med 136 6 1356 1377
65. GK Marathe 1999 Inflammatory platelet-activating factor-like phospholipids in oxidized low density lipoproteins are fragmented alkyl phosphatidylcholines J Biol Chem 274 40 28395 28404
66. Y Uemura TC Lee F Snyder 1991 A coenzyme A-independent transacylase is linked to the formation of platelet-activating factor (PAF) by generating the lyso-PAF intermediate in the remodeling pathway J Biol Chem 266 13 8268 8272
67. G Montrucchio G Alloatti G Camussi 2000 Role of platelet-activating factor in cardiovascular pathophysiology Physiol Rev 80 4 1669 1699
68. ML Blank 1988 Stimulation of the de novo pathway for the biosynthesis of platelet-activating factor (PAF) via cytidylyltransferase activation in cells with minimal endogenous PAF production J Biol Chem 263 12 5656 5661
69. H Shindou 2007 A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase J Biol Chem 282 9 6532 6539
70. H Bito 1994 Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA Eur J Biochem 221 1 211 218
71. M Nakamura 1991 Molecular cloning and expression of platelet-activating factor receptor from human leukocytes J Biol Chem 266 30 20400 20405
72. RD Ye 1991 Characterization of a human cDNA that encodes a functional receptor for platelet activating factor Biochem Biophys Res Commun 180 1 105 111
73. MF Brizzi 1999 Thrombopoietin stimulates endothelial cell motility and neoangiogenesis by a platelet-activating factor-dependent mechanism Circ Res 84 7 785 796
74. G Camussi 1995 Platelet-activating factor directly stimulates in vitro migration of endothelial cells and promotes in vivo angiogenesis by a heparin-dependent mechanism J Immunol 154 12 6492 6501
75. G Camussi 1997 Angiogenesis induced in vivo by hepatocyte growth factor is mediated by platelet-activating factor synthesis from macrophages J Immunol 158 3 1302 1309
76. G Montrucchio 1994 Tumor necrosis factor alpha-induced angiogenesis depends on in situ platelet-activating factor biosynthesis J Exp Med 180 1 377 382
77. G Montrucchio 1997 Nitric oxide mediates angiogenesis induced in vivo by platelet-activating factor and tumor necrosis factor-alpha Am J Pathol 151 2 557 563
78. G Montrucchio 1998 Potential angiogenic role of platelet-activating factor in human breast cancer Am J Pathol 153 5 1589 1596
79. EG Robert JD Hunt 2001 Lipid messengers as targets for antiangiogenic therapy Curr Pharm Des 7 16 1615 1626
80. F Bussolino 1995 Platelet activating factor produced in vitro by Kaposi's sarcoma cells induces and sustains in vivo angiogenesis J Clin Invest 96 2 940 952
81. B Bussolati 2000 PAF produced by human breast cancer cells promotes migration and proliferation of tumor cells and neo-angiogenesis Am J Pathol 157 5 1713 1725
82. TW Axelrad 2004 Platelet-activating factor (PAF) induces activation of matrix metalloproteinase 2 activity and vascular endothelial cell invasion and migration Faseb J 18 3 568 570
83. DD Deo 2002 Phosphorylation of STAT-3 in response to basic fibroblast growth factor occurs through a mechanism involving platelet-activating factor, JAK-2, and Src in human umbilical vein endothelial cells. Evidence for a dual kinase mechanism J Biol Chem 277 24 21237 21245
84. MG Sirois ER Edelman 1997 VEGF effect on vascular permeability is mediated by synthesis of platelet-activating factor Am J Physiol 272 6 Pt 2 H2746-H2756
85. S Rollin 2004 VEGF-mediated endothelial P-selectin translocation: role of VEGF receptors and endogenous PAF synthesis Blood 103 10 3789 3797
86. R Maliba 2006 Angiopoietins-1 and -2 are both capable of mediating endothelial PAF synthesis: intracellular signalling pathways Cell Signal 18 11 1947 1957
87. SY Im 1996 Augmentation of tumor metastasis by platelet-activating factor Cancer Res 56 11 2662 2665
88. S Sato 1999 Accelerated proliferation of epidermal keratinocytes by the transgenic expression of the platelet-activating factor receptor Arch Dermatol Res 291 11 614 621
89. S Ishii 1997 Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor Embo J 16 1 133 142
90. LA Barber DF Spandau SC Rathman RC Murphy CA Johnson SW Kelley SA Hurwitz JB Travers 1998 Expression of the platelet-activating factor receptor results in enhanced ultraviolet B radiation-induced apoptosis in a human epidermal cell line J Biol Chem 273 30 18891 18897
91. Y Sheng DL Birkle 1995 Release of platelet activating factor (PAF) and eicosanoids in UVC-irradiated corneal stromal cells Curr Eye Res 14 5 341 347
92. A Calignano 1988 Isolation and identification of platelet-activating factor in UV-irradiated guinea pig skin J Pharmacol Methods 19 1 89 91
93. JB Travers 1995 Identification of functional platelet-activating factor receptors on human keratinocytes J Invest Dermatol 105 6 816 823
94. EC De Fabo 2004 Ultraviolet B but not ultraviolet A radiation initiates melanoma Cancer Res 64 18 6372 6376
95. FP Noonan 2001 Neonatal sunburn and melanoma in mice Nature 413 6853 271 272
96. Q Zhang 2005 Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor J Clin Invest 115 10 2855 2861
97. L Biancone 2003 Platelet-activating factor inactivation by local expression of platelet-activating factor acetyl-hydrolase modifies tumor vascularization and growth Clin Cancer Res 9 11 4214 4220
98. A Fallani 2006 Platelet-activating factor (PAF) is the effector of IFN gamma-stimulated invasiveness and motility in a B16 melanoma line Prostaglandins Other Lipid Mediat 81 3-4 171 177
99. HM Ko 2007 Critical role for matrix metalloproteinase-9 in platelet-activating factor-induced experimental tumor metastasis Int J Cancer 120 6 1277 1283
100. G Mannori 2000 Interaction of tumor cells with vascular endothelia: role of platelet-activating factor Clin Exp Metastasis 18 1 89 96
101. VO Melnikova 2006 Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis J Biol Chem 281 5 2911 2922
102. DD Deo NG Bazan JD Hunt 2004 Activation of platelet-activating factor receptor-coupled G alpha q leads to stimulation of Src and focal adhesion kinase via two separate pathways in human umbilical vein endothelial cells J Biol Chem 279 5 3497 3508