Angiogenesis Induced in Vivo by Hepatocyte Growth Factor Is Mediated by Platelet-Activating Factor Synthesis from Macrophages

Journal of Immunology

Volumn 158, Issue 3, 1997, Pages 1302-1309

  Camussi, Giovanni ^a   Montrucchio, Giuseppe ^b   Lupia, Enrico ^b   Soldi, Raffaella ^b   Comoglio, Paolo M ^b   Bussolino, Federico ^b  

^a UNIVERSITY OF PAVIA   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AZEPINE DERIVATIVE; BEPAFANT; CELL SURFACE RECEPTOR; COLLAGEN; FIBRINOGEN RECEPTOR; G PROTEIN COUPLED RECEPTOR; LAMININ; MATRIGEL; PHOSPHOTYROSINE; PROTEIN TYROSINE KINASE; PROTEOGLYCAN; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; THROMBOCYTE ACTIVATING FACTOR; THROMBOCYTE ACTIVATING FACTOR RECEPTOR; TRIAZOLE DERIVATIVE;

ANGIOGENESIS; ANIMAL; ARTICLE; C57BL MOUSE; CATTLE; CELL CULTURE; CELL MOTION; DRUG ANTAGONISM; DRUG COMBINATION; HUMAN; METABOLISM; MOUSE; NEUTROPHIL CHEMOTAXIS; PERITONEUM MACROPHAGE; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; AZEPINES; CATTLE; CELL MOVEMENT; CELLS, CULTURED; CHEMOTAXIS, LEUKOCYTE; COLLAGEN; DRUG COMBINATIONS; HEPATOCYTE GROWTH FACTOR; HUMANS; LAMININ; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHOTYROSINE; PLATELET ACTIVATING FACTOR; PLATELET MEMBRANE GLYCOPROTEINS; PROTEOGLYCANS; PROTO-ONCOGENE PROTEINS C-MET; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TRIAZOLES;

EID: 0031065163     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Nakamura, T., K. Nawa, and A. Ichihara. 1984. Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats. Biochem. Biophys. Res. Commun. 122:1450.
2. Michalopoulus, G. K., K. A. Houck, M. L. Dolan, and N. C. Luetteke. 1984. Control of hepatocyte replication by two serum factors. Cancer Res. 44:4414.
3. Gherardi, E., and M. Stoker. 1991. Hepatocyte growth factor-scatter factor: mitogen, motogen and met. Cancer Cells 3:227.
4. Comoglio, P. M. 1993. Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells. In Hepatocyte Growth Factor-Scatter Factor (HGF-SF) and the c-Met Receptor. I. D. Goldberg and E. M. Rosen, eds. Birkauser-Verlag, Basel, Switzerland, p. 131.
5. Godha, E., H. Tsubouchi, H. Nakayama, S. Hirono, O. Sakiyama, K. Takahashi, H. Miyazaki, S. Hashimoto, and Y. Daikuhara. 1988. Purification and partial characterization of hepatocyte growth factor from plasma of a patient with hepatic failure. J. Clin. Invest. 81:414.
6. Russel, W. E., J. A. McGowan, and N. R. L. Bucher. 1984. Partial characterization of a hepatocyte growth factor from rat platelet. J. Cell. Physiol. 119:183.
7. Naldini, L., K. M. Weidner, E. Vigna, G. Gaudino, A. Bardelli, C. Ponzetto, R. P. Narsimhan, G. Hartman, R. Zarnegar, G. K. Michalopoulos, W. Birchmeier, and P. M. Comoglio. 1991. Scatter factor and hepatocytes growth factor are indistinguishable ligands for the MET receptor. EMBO J. 10:2867.
8. Weidner, K. M., N. Arakaki, G. Hartmann, J. Vandekerckhove, S. Wengart, H. Rieder, C. Fonotsch, H. Tsobouchi, T. Hishida, Y. Daikuhara, and W. Birchemeier. 1991. Evidence for the identity of human scatter factor and human hepatocyte growth factor. Proc. Natl. Acad. Sci. USA 88:7001.
9. Nakamura, T., T. Nishizawa, M. Hagiya, T. Seki, M. Shimonishi, A. Sugimura, K. Tashiro, and S. Shimizu. 1989. Molecular cloning and expression of human hepatocyte growth factor. Nature 342:440.
10. Park, M., M. Dean, C. S. Cooper, M. Schmidt, S. J. O'Brian, D. G. Blair, and G. F. Van de Woude. 1986. Mechanism of met oncogene activation. Cell 45:895.
11. Giordano, S., C. Ponzetto, M. F. Di Renzo, C. S. Cooper, and P. M. Comoglio. 1989. Tyrosine kinase receptor indistinguishable from the c-met protein. Nature 339:155.
12. Rosen, E. M., S. Jaken, W. Carley, P. M. Luckett, E. Setter, M. Bhargava, and I. D. Goldberg. 1991. Regulation of motility in bovine brain endothelial cells. J. Cell Physiol. 146:325.
13. Bussolino, F., M. F. Di Renzo, M. Ziehe, E. Bocchietto, M. Olivero, L. Naldini, G. Gaudino, L. Tamagnone, A. Coffer, and P. M. Comoglio. 1992. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J. Cell Biol. 119:629.
14. Grant, D. S., H. K. Kleinman, I. D. Goldberg, M. M. Bhargava, B. J. Nickoloff, J. L. Kinsella, P. Polverini, and E. M. Rosen. 1993. Scatter factor induces blood vessel formation in vivo. Proc. Natl. Acad. Sci. USA. 90:1937.
15. Sato, Y., K. Okamura, A. Morimoto, R. Hamanaka, K. Hamaguchi, T. Shimada, M. K. Ono, M. Kohno, T. Sakata, and M. Kuwano. 1993. Indispensable role of tissue-type plasminogen activator in growth factor-dependent tube formation of human microvascular endothelial cells in vitro. Exp. Cell Res. 204(2):223.
16. F. Silvagno, A. Follenzi, M. Arese, M. Prat, E. Giraudo, G. Gaudino, G. Camussi, P. M. Comoglio, and F. Bussolino. 1995. In vivo activation of Met tyrosine kinase by heterodimeric HGF molecule promotes angiogenesis. Arterioscler. Thromb. Vasc. Biol. 15:1857.
17. Folkman, J., and Y. Shing. 1992. Angiogenesis. J. Biol. Chem. 267:10931.
18. Mantovani, A., B. Bottazzi, F. Colotta, S. Sozzani, and L. Ruco. 1992. The origin and function of tumor-associated macrophages. Immunol. Today. 13:265.
19. Montrucchio, G., E. Lupia, E. Battaglia, G. Passerini, F. Bussolino, G. Emanuelli, and G. Camussi. 1994. Tumor-necrosis factor α-induced angiogenesis depends on in situ platelet activating factor biosynthesis. J. Exp. Med. 180:377.
20. Camussi, G., G. Montrucchio, E. Lupia, A. DeMartino, L. Perona, M. Arese, A., Vercellone, A. Toniolo, and F. Bussolino. 1995. Platelet-activating factor directly stimulates in vitro migration of endothelial cells and promotes in vivo angiogenesis by a heparin-dependent mechanism. J. Immunol. 154:6492.
21. Bussolino, F., M. Arese, G. Montrucchio, L. Barra, L. Primo, R. Benelli, F. Sanavio, M. Aglietta, D. Ghigo, M. Rola-Pleszczynski, A. Bosia, A. Albini, and O. Camussi. 1995. Platelet activating factor produced in vitro by Kaposi's sarcoma cells induces and sustains in vivo angiogenesis. J. Clin. Invest. 96:940.
22. Prescott, S. M., G. A. Zimmerman, and T. M. McIntyre. 1990. Platelet-activating factor. J. Biol. Chem. 268:17381.
23. McManus, L. M., D. S. Woodard, S. I. Deavers, and R. N. Pinckard. 1993. PAF molecular heterogeneity: pathobiological implications. Lab. Invest. 69:639.
24. Honda, Z., M. Nakamura, I. Miki, M. Minami, T. Watanabe, Y. Seyama, H. Okado, H., Toh, K. Ito, T. Myamoto, and T. Shimizu. 1991. Cloning by functional expression of platelet activating factor receptor from guinea pig lung. Nature 349:342.
25. Passaniti A., R. M. Taylor, R. Pili, Y. Guo, P. V. Long, J. A. Haney, R. R. Pauly, D. S. Grant, and G. R. Martin. 1992. A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor. Lab. Invest. 67:519.
26. Heuer, H. O., J. Casals-Stenzel, G. Muacevic, and K. H. Weber. 1990. Pharmacologic activity of bepafant (WEB 2170), a new and selective hetrazepinoic antagonist of platelet-activating factor. J. Pharmacol. Exp. Ther. 255:962.
27. Prat, M., T. Crepaldi, L. Gandino, S. Giordano, P. Longati, and P. M. Comoglio. 1991. C-terminal truncated forms of Met, the hepatocyte growth factor receptor. Mol. Cell. Biol. 11:5954.
28. Camussi G., F. Bussolino, G. Salvidio, and C. Baglioni. 1987. Tumor necrosis factor/cachectin stimulates peritoneal macrophages, polymorphonuclear neutrophils, and vascular endothelial cells to synthesize and release platelet-activating factor. J. Exp. Med. 166:1390.
29. Bocchietto, E., A. Guglielmetti, F. Silvagno, G. Taraboletti, G. P. Pescarmona, A. Mantovani, and F. Bussolino. 1993. Proliferative and migratory responses of murine microvascular endothelial cells to granulocyte-colony-stimulating factor. J. Cell. Physiol. 155:89.
30. Bussolino, F., M. De Rossi, A. Sica, F. Colotta, J. M. Wang, E. Bocchietto, I. Martin Padura, A. Bosia, E. Dejana, and A. Mantovani. 1991. Murine endothelioma cell lines transformed by polyoma middle T oncogene as target for and producers of cytokines. J. Immunol. 147:2122.
31. Montrucchio G., E. Lupia, A. De Martino, L. Silvestro, S. Rizea-Savu, G. Cacace, P. G. De Filippi, G. Emanuelli, and G. Camussi. 1996. Plasmin promotes an endothelium-dependent adhesion of neutrophils. Involvement of platelet-activating factor and P-selectin. Circulation 93:2152.
32. Quinn MT, S. Parthasarathy, and D., Steinberg. 1985. Endothelial cell-derived chemotactic activity for mouse peritoneal macrophages and the effects of modified forms of low density lipoprotein. Proc. Natl. Acad. Sci. USA 82:5949.
33. Dejana, E., L. R. Languino, N. Polentarutti, and C. Balconi, J. J. Ryckewaert, M. J. Larrieu, A. Mantovani, and G. Marguerie. 1985. Interaction between fibrinogen and cultured endothelial cells. Induction of migration and specific binding. J. Clin. Invest. 75:11.
34. Kueng, K., E. Silfer, and V. Eppenberger. 1989. Quantification of cell cultured on 96-well plates. Anal. Biochem. 182:16.
35. Taub, M., Y. Wang, T. M. Szczesny, and H. K. Kleinman. 1990. Epidermal growth factor or transforming growth factor alpha is required for kidney tubulogenesis in matrigel cultures in serum-free medium. Proc. Natl. Acad. Sci. USA 87:4002.
36. Vukicevic, S., H. K. Kleinman, F. P. Luyten, A. B. Roberts, N. S. Roche, and A. H. Reddi. 1992. Identification of multiple active growth factors in basement membrane matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components. Exp. Cell Res. 202:1.
37. Santos, O. F. P., and S. K. Nigam. 1993. HGF-induced tubulogenesis and branching of epithelial cells is modulated by extracellular matrix and TGF-β. Dev. Biol. 160:293.
38. Nachlas M. M. and A. M. Seligman. 1949. Histochemical demonstration of esterase. J. Natl. Cancer Inst. 9:41535.
39. Kibbey M. C., D. S. Grant, and H. K. Klieinman. 1992. Role of the SIKVAV site of laminin in promotion of angiogenesis and tumor growth: an in vivo matrigel model. J. Natl. Cancer Inst. 84:1633.
40. Kimball E. S. and M. C. Fisher. 1994. Absence of significant effects by levamisole on circulating neutrophil levels in normal mice treated with 5-FU. Immunopharmacology 27:137.
41. Camussi G., M. Aglietta, F. Malavasi, C. Tetta, W. Piacibello, F. Sanavio, and F. Bussolino. 1983. The release of platelet-activating factor from human endothelial cells in culture. J. Immunol. 131:2397.
42. Silvestro L., R., Da Col, E. Scappaticci, D. Libertucci, L. Biancone, and G. Camussi. 1993. Development of an HPLC-MS technique, with an ionspray interface, for the determination of PAF and lyso-PAF in biological samples. J. Chromatogr. 647:261.
43. Bussolino F., F. Gremo, C. Tetta, G. P. Pescarmona, and G. Camussi. 1986. Production of platelet-activating factor by chick retina. J. Biol. Chem. 261:16502.
44. Azizkhan, R. G., J. Clifford Azizkhan, B. R. Zetter, and J. Folkman. 1980. Mast cell heparin stimulates migration of capillary endothelial cells in vitro. J. Exp. Med. 152:931.
45. Shukla S. D. 1992. Platelet activating factor receptor and signal transduction mechanism. FASEB J. 6:2296.
46. Bussolino, F. and G. Camussi. 1995. Platelet-activating factor produced by endothelial cells: a molecule with autocrine and paracrine properties. Eur. J. Biochem. 229:327.
47. Leonard E. J., and A. Skeel. 1976. A serum protein that stimulates macrophage movement, chemotaxis and spreading. Exp. Cell. Res. 102:434.
48. Skeel A., and E. J. Leonard. 1994. Action and target cell specificity of human macrophage-stimulating protein (MSP). J. Immunol. 152:4618.
49. Frater-Schroder M., W. Risau, R. Hallaman, P. Gautschi and P. Bohlen. 1987. Tumor-necrosis factor type α, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo. Proc. Natl. Acad. Sci. USA 84:5277.
50. Leibovich S. J., P. J. Polverini, H. M. Shepard, D. M. Wiseman, V. Shively and N. Nuseir. 1987. Macrophage-induced angiogenesis is mediated by tumor necrosis factor-α. Nature 239:630.
51. Pandey A. H. Shao, R. M. Marks, P. J. Polverini, and V. M. Dixit. 1995. Role of B61, the ligand for Eck receptor tyrosine kinase, in TNF-α-induced angiogenesis. Science 268:567.
52. Sarma V., F. W. Wolf, R. M. Marks, T. B. Shows, and V. M. Dixit. 1992. Cloning of a novel tumor necrosis-α-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro. J Immunol. 148:3302.
53. Leibovich S. J., P. J. Polverini, H. M. Shepard, D. M. Wiseman, V. Shively, and N. Nuseir. 1987. Macrophage-induced angiogenesis is mediated by tumor necrosis factor-α. Nature 329:630.
54. Koch A. E., P. J. Polverini, S. L. Kunkel, L. A. Harlow, L. A. Di Pietro, V. M. Elner, S. G. Einer, and R. M. Strieter. 1992. Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 258:1798.
55. Koch A. E., L. A. Harlow, G. K. Haines, E. P. Amento, E. N. Unemori, W. L. Wong, R. M. Pope, and N. Ferrara. 1994. Vascular endothelial growth factor: a cytokine modulating endothelial function in rheumatoid arthritis. J. Immunol. 152:4149.
56. Lupia E., G. Montrucchio, E. Battaglia, V. Modena, and G. Camussi. 1996. Role of tumor necrosis factor-α and platelet activating factor in neoangiogenesis induced by synovial fluids of patients with rheumatoid arthritis. Eur. J. Immunol. 26:1690.