Characterization of functional thrombin receptors in human pancreatic tumor cells (MIA PACA-2)

Pancreas

Volumn 16, Issue 2, 1998, Pages 189-194

  Rudroff, Claudia ^a   Schafberg, Heiko ^a   Nowak, Götz ^a   Weinel, Rolf ^a   Scheele, Johannes ^a   Kaufmann, Roland ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

MIA PaCa 2; Pancreatic tumor cells; Thrombin receptor activating peptide, TRAP 6; Thrombin receptors

Indexed keywords

CALCIUM; DNA; MONOCLONAL ANTIBODY; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; RADIOLIGAND; RECEPTOR ANTIBODY; THROMBIN; THROMBIN RECEPTOR; THROMBIN RECEPTOR ACTIVATING PEPTIDE; TRITIUM;

ARTICLE; CALCIUM MOBILIZATION; CONTROLLED STUDY; DNA SYNTHESIS; HUMAN; HUMAN CELL; PANCREAS TUMOR; PRIORITY JOURNAL; PROTEIN TRANSPORT; RECEPTOR AFFINITY; RECEPTOR BINDING; TUMOR CELL LINE;

EID: 0031930315     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-199803000-00013     Document Type: Article

References (23)

1. Vu TKH, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991;64:1057-68.
2. Nanevicz T, Ishii M, Wang L, et al. Mechanism of thrombin receptor agonist specifity. Chimeric receptors and complementary mutations identify an agonist recognition site. J Biol Chem 1995; 270:21619-25.
3. Berndt M, Philipps D. Platelet membrane proteins: composition and receptor function. In: J. Gordon J, ed. Platelets in biology and pathology. Amsterdam: Elsevier/North Holland, 198:43-7.
4. Glenn K, Carney D, Fenton J, Cunningham D. Thrombin active-site regions required for fibroblast receptor binding and initiation of cell division. J Biol Chem 1980;255:6609-16.
5. Bar-Shavit R, Mudd M, Wilner G, Mann K, Fenton JW II. Monocyte chemotaxis: stimulation by specific exosite region in thrombin. Science 1983;220:728-31.
6. Zacharski LR. Small cell carcinoma of the lung: interaction with the blood coagulation mechanism and treatment with anticoagulants. Onkologie 1987;10:264-70.
7. Chahinian AP. A randomized trial of anticoagulation with warfarin and of alternating chemotherapy in extensive small-cell lung cancer by the cancer and leukemia group B. J Clin Oncol 1989;7:993-1002.
8. Nierodzik ML, Kajumo LR, Karpatkin S. Effect of thrombin treatment of tumor cells on adhesion of tumor cells to platelets in vitro and tumor metastasis in vivo. Cancer Res 1992;52:3267-72.
9. Wojtukiewicz MZ, Tang DG, Ben-Josef E, Nenaud C, Walz DA, Honn KV. Solid tumor cells express functional "tethered ligand" thrombin receptor. Cancer Res 1995;55:698-704.
10. Leung HY, Gullick WJ, Lemoine NR. Expression and functional activity of fibroblast growth factors and their receptors in human pancreatic cancer. Int J Cancer 1994;59:667-75.
11. Liu CD, Slice LW, Balasubramaniam A, et al. Y2 receptors decrease human pancreatic cancer growth and intracellular cyclic adenosine monophosphate levels. Surgery 1992;118:229-36.
12. Swift IR, Smith JP. Cholecystokinin analog, JMV-180, stimulates growth of human pancreatic cancer. Dig Dis Sci 1994;39:1007-13.
13. Yamada M, Ohata H, Momose K, Yamada M, Richelson E. Pharmacological characterization of SR 48692 sensitive neurotensin receptor in human pancreatic cancer cells, MIA PaCa-2. Res Commun Mol Pathol Pharmacol 1995;90:37-47.
14. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951;193: 265-75.
15. Munson PJ, Rodbard D. LIGAND: a versatile computerized approach for characterization of ligand-binding systems. Anal Biochem 1980;107:220-39.
16. Tsien RY. Fluorescence probes of cell signaling. Annu Rev Neurosci 1989;12:227-53.
17. Krüger H, Schröder W, Buchner K, Hucho F. Protein kinase C inhibition by calmodulin and its fragments. J Protein Chem 1990; 9:467-73.
18. Alexander DR, Cantrell DA. Kinases and phosphatases in T-cell activation. Immunol Today 1989;10:200-5.
19. Huang KP. The mechanism of protein kinase C activation. Trends Neurosci 1989;12:425-32.
20. Norton KJ, Scarborough RM, Kutok JL, Escobedo M-A, Nannizzi L, Coller BS. Immunologic analysis of the cloned thrombin receptor activation mechanism: evidence supporting receptor cleavage, release of the N-terminal peptide, and the secretion of the tethered ligand into a protected environment. Blood 1993;82:2125-36.
21. Harmon JT, Jamieson GA. The glycocalicin portion of platelet glycoprotein Ib express both high and moderate affinity receptor sites for thrombin. J Biol Chem 1986;261:3184-8.
22. Esmon NL, Owen WG, Esmon CT. Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C. J Biol Chem 1982;257:859-64.
23. Baker JB, Low DA, Simmer RL, Cunningham DD. Protease nexin: a cellular component that links thrombin and plasminogen activator and mediates their binding to cells. Cell 1980;21:37-45.