Tissue factor and PAR signaling in tumor progression

Thrombosis Research

Volumn 120, Issue SUPPL. 2, 2007, Pages S7-

  Ruf, Wolfram ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Angiogenesis; Cancer; PAR; Tissue factor

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBIN; BLOOD CLOTTING FACTOR 10A INHIBITOR; PROTEINASE ACTIVATED RECEPTOR; THROMBOPLASTIN;

ANGIOGENESIS; ANTICOAGULANT THERAPY; ARTICLE; BLEEDING; CELL COMPARTMENTALIZATION; CELL INTERACTION; HEMOSTASIS; HOST CELL; HUMAN; IMMUNOMODULATION; METASTASIS; MICROENVIRONMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TUMOR CELL; TUMOR GROWTH;

ANIMALS; DISEASE PROGRESSION; HUMANS; MICE; NEOPLASM METASTASIS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; RECEPTORS, PROTEINASE-ACTIVATED; SIGNAL TRANSDUCTION; THROMBOPLASTIN;

EID: 36048981196     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(07)70125-1     Document Type: Article

References (59)

1. Rickles F., Patierno S., and Fernandez P. Tissue factor, thrombin, and cancer. Chest 124 (2003) 58S-68S
2. Clauss M., Gerlach M., Gerlach H., Brett J., Wang F., Familletti P., et al. Vascular permeability factor: A tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration. J Exp Med 172 (1990) 1535-1545
3. Shoji M., Hancock W., Abe K., Micko C., Casper K., Baine R., et al. Activation of coagulation and angiogenesis in cancer. Immunohistochemical localization in situ of clotting proteins and vascular endothelial growth factor in human cancer. Am J Pathol 152 (1998) 399-411
4. Ruf W., and Mueller B. Thrombin generation and the pathogenesis of cancer. Semin Thromb Hemost 32 Suppl 1 (2006) 61-68
5. Schulman S., and Lindmarker P. Incidence of cancer after prophylaxis with warfarin against recurrent venous thromboembolism. Duration of Anticoagulation Trial. N Engl J Med 342 (2000) 1953-1958
6. Coughlin S. Thrombin signalling and protease-activated receptors. Nature 407 (2000) 258-264
7. Rao L., and Pendurthi U. Tissue factor-factor VIIa signaling. Arterioscler Thromb Vasc Biol 25 (2005) 47-56
8. Belting M., Ahamed J., and Ruf W. Signaling of the tissue factor coagulation pathway in angiogenesis and cancer. Arterioscler Thromb Vasc Biol 25 (2005) 1545-1550
9. Ahamed J., Versteeg H., Kerver M., Chen V., Mueller B., Hogg P., et al. Disulfide isomerization switches tissue factor from coagulation to cell signaling. Proc Natl Acad Sci USA 103 (2006) 13932-13937
10. Dorfleutner A., Hintermann E., Tarui T., Takada Y., and Ruf W. Crosstalk of integrin a3b1 and tissue factor in cell migration. Mol Biol Cell 15 (2004) 4416-4425
11. Ahamed J., and Ruf W. Protease-activated receptor 2-dependent phosphorylation of the tissue factor cytoplasmic domain. J Biol Chem 279 (2004) 23038-23044
12. Ott I., Weigand B., Michl R., Seitz I., Sabbari-Erfani N., Neumann F., et al. Tissue factor cytoplasmic domain stimulates migration by activation of the GTPase Rac1 and the mitogen-activated protein kinase p38. Circulation 111 (2005) 349-355
13. Ahamed J., Niessen F., Kurokawa T., Lee Y., Bhattacharjee G., Morrissey J., et al. Regulation of macrophage procoagulant responses by the tissue factor cytoplasmic domain in endotoxemia. Blood 109 (2007) 5251-5259
14. Siegbahn A., Johnell M., Sørensen B., Petersen L., and Heldin C. Regulation of chemotaxis by the cytoplasmic domain of tissue factor. Thromb Haemost 93 1 (2005) 27-34
15. Ruf W., Dorfleutner A., and Riewald M. Specificity of coagulation factor signaling. J Thromb Haemost 1 (2003) 1495-1503
16. Morris D., Ding Y., Ricks T., Gullapalli A., Wolfe B., and Trejo J. Protease-activated receptor-2 is essential for factor VIIa and Xa-induced signaling, migration, and invasion of breast cancer cells. Cancer Res 66 (2006) 307-314
17. Hjortoe G., Petersen L., Albrektsen T., Sorensen B., Norby P., Mandal S., et al. Tissue factor factor VIIa specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated via PAR-2 and results in increased cell migration. Blood 103 (2004) 3029-3037
18. Zoudilova M., Kumar P., Ge L., Wang P., Bokoch G., and DeFea K. beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2. J Biol Chem 282 (2007) 20634-20646
19. Koizume S., Jin M.-S., Miyagi E., Hirahara F., Nakamura Y., Piao J.-H., et al. Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII. Cancer Res 66 (2006) 9453-9460
20. Kamath L., Meydani A., Foss F., and Kuliopulos A. Signaling from protease-activated receptor-1 inhibits migration and invasion of breast cancer cells. Cancer Res 61 (2001) 5933-5940
21. Sorensen B., Rao L., Tornehave D., Gammeltoft S., and Petersen L. Anti-apoptotic effect of coagulation factor VIIa. Blood 102 (2003) 1708-1715
22. Versteeg H., Arnold S., Richel D., and Peppelenbosch M. Coagulation factors VIIa and Xa inhibit apoptosis and anoikis. Oncogene 23 (2004) 410-417
23. Pendurthi U., Allen K., Ezban M., and Rao L. Factor VIIa and thrombin induce the expression of cyr61 and connective tissue growth factor, extracellular matrix signaling proteins that could act as possible downstream mediators in factor VIIa tissue factor-induced signal transduction. J Biol Chem 275 (2000) 14632-14641
24. Camerer E., Gjernes E., Wiiger M., Pringle S., and Prydz H. Binding of factor VIIa to tissue factor on keratinocytes induces gene expression. J Biol Chem 275 (2000) 6580-6585
25. Albrektsen T., Sorensen B., Hjortø G., Fleckner J., Rao L., and Petersen L. Transcriptional program induced by factor VIIa-tissue factor, PAR1 and PAR2 in MDA-MB-231 cells. J Thromb Haemost 5 (2007) 1588-1597
26. Uusitalo-Jarvinen H., Kurokawa T., Mueller B., Andrade-Gordon P., Friedlander M., and Ruf W. Role of protease activated receptor 1 and 2 signaling in hypoxia-induced angiogenesis. Arterioscler Thromb Vasc Biol 27 (2007) 1456-1462
27. Camerer E., Qazi A., Duong D., Cornelissen I., Advincula R., and Coughlin S. Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis. Blood 104 (2004) 397-401
28. Palumbo J., Kombrinck K., Drew A., Grimes T., Kiser J., Degen J., et al. Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells. Blood 96 (2000) 3302-3309
29. Palumbo J., Talmage K., Massari J., La Jeunesse C., Flick M., Kombrinck K., et al. Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and -independent mechanisms. Blood (2007)
30. Mueller B., Reisfeld R., Edgington T., and Ruf W. Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis. Proc Natl Acad Sci USA 89 (1992) 11832-11836
31. Nierodzik M., and Karpatkin S. Thrombin induces tumor growth, metastasis, and angiogenesis: Evidence for a thrombin-regulated dormant tumor phenotype. Cancer Cell 10 (2006) 355-362
32. Mueller B., and Ruf W. Requirement for binding of catalytically active factor VIIa in tissue factor dependent experimental metastasis. J Clin Invest 101 (1998) 1372-1378
33. Bromberg M., Konigsberg W., Madison J., Pawashe A., and Garen A. Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation. Proc Natl Acad Sci USA 92 (1995) 8205-8209
34. Wang H., Fu W., Im J., Zhou Z., Santoro S., Iyer V., et al. Tumor cell alpha3beta1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis. J Cell Biol 164 (2004) 935-941
35. Belting M., Dorrell M., Sandgren S., Aguilar E., Ahamed J., Dorfleutner A., et al. Regulation of angiogenesis by tissue factor cytoplasmic domain signaling. Nature Med 10 (2004) 502-509
36. Griffin C., Srinavasan Y., Zheng Y.-W., Huang W., and Coughlin S. A role for thrombin receptor signaling in endothelial cells during embryonic development. Science 293 (2001) 1666-1670
37. Caunt M., Huang Y., Brooks P., and Karpatkin S. Thrombin induces neoangiogenesis in the chick chorioallantoic membrane. J Thromb Haemost 1 (2003) 2097-2102
38. Haralabopoulos G., Grant D., Kleinman H., and Maragoudakis M. Thrombin promotes endothelial cell alignment in Matrigel in vitro and angiogenesis in vivo. Am J Physiol 273 (1997) C239-C245
39. Zania P., Kritikou S., Flordellis C., Maragoudakis M., and Tsopanoglou N. Blockade of angiogenesis by small molecule antagonists to protease-activated receptor-1 (PAR-1): Association with endothelial cell growth suppression and induction of apoptosis. J Pharmacol Exp Ther (2006)
40. D'Andrea M., Derian C., Santulli R., and Andrade-Gordon P. Differential expression of protease-activated receptors-1 and -2 in stromal fibroblasts of normal, benign, and malignant human tissues. Am J Pathol 158 (2001) 2031-2041
41. Colognato R., Slupsky J., Jendrach M., Burysek L., Syrovets T., and Simmet T. Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells. Blood 102 (2003) 2645-2652
42. Fields R., Schoenecker J., Hart J., Hoffman M., Pizzo S., and Lawson J. Protease-activated receptor-2 signaling triggers dendritic cell development. Am J Pathol 162 (2003) 1817-1822
43. Csernok E., Ai M., Gross W., Wicklein D., Petersen A., Lindner B., et al. Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway. Blood 107 (2006) 4440-4448
44. Kisucka J., Butterfield C., Duda D., Eichenberger S., Saffaripour S., Ware J., et al. Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage. Proc Natl Acad Sci USA 103 (2006) 855-860
45. Zhang Y., Deng Y., Luther T., M̈uller M., Ziegler R., Waldherr R., et al. Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice. J Clin Invest 94 (1994) 1320-1327
46. Kakkar A., Chinswangwatanakul V., Lemoine N., Tebbutt S., and Williamson R. Role of tissue factor expression on tumour cell invasion and growth of experimental pancreatic adenocarcinoma. Br J Surg 86 (1999) 890-894
47. Abe K., Shoji M., Chen J., Bierhaus A., Danave I., Micko C., et al. Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factor. Proc Natl Acad Sci USA 96 (1999) 8663-8668
48. Yu J., May L., Lhotak V., Shahrzad S., Shirasawa S., Weitz J., et al. Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis. Blood 105 (2005) 1734-1741
49. Yin Y., Salah Z., Grisaru-Granovsky S., Cohen I., Cohen Even-Ram S., Maoz M., et al. Human protease-activated receptor 1 expression in malignant epithelia. A role in invasiveness. Arterioscler Thromb Vasc Biol 23 (2003) 940-944
50. Martin C., Mahon G., Klinger M., Kay R., Symons M., Der C., et al. The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways. Oncogene 20 (2001) 1953-1963
51. Yin Y., Katz V., Salah Z., Maoz M., Cohen I., Uziely B., et al. Mammary gland tissue targeted overexpression of human protease-activated receptor 1 reveals a novel link to beta-catenin stabilization. Cancer Res 66 (2006) 5224-5233
52. Gupta G., Nguyen D., Chiang A., Bos P., Kim J., Nadal C., et al. Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature 446 (2007) 765-770
53. Caunt M., Hu L., Tang T., Brooks P., Ibrahim S., and Karpatkin S. Growth-regulated oncogene is pivotal in thrombin-induced angiogenesis. Cancer Res 66 (2006) 4125-4132
54. Miller G., Bauer K., Howarth D., Cooper J., Humphries S., and Rosenberg R. Increased incidence of neoplasia of the digestive tract in men with persistent activation of the coagulant pathway. J Thromb Haemost 2 (2004) 2107-2114
55. Zacharski L., Henderson W., Rickles F., Forman W., Cornell Jr. C., et al. Effect of warfarin anticoagulation on survival in carcinoma of the lung, colon, head and neck, and prostate. Cancer 53 (1984) 2046-2052
56. Klerk C., Smorenburg S., Otten H., Lensing A., Prins M., Piovella F., et al. The effect of low molecular weight heparin on survival in patients with advanced malignancy. J Clin Oncol 23 (2005) 2130-2135
57. Kakkar A., Levine M., Kadziola Z., Lemoine N., Low V., Patel H., et al. Low molecular weight heparin. therapy with dalteparin, and survival in advanced cancer: the fragmin advanced malignancy outcome study (FAMOUS). J Clin Oncol 22 (2004) 1944-1948
58. Lee A., Rickles F., Julian J., Gent M., Baker R., Bowden C., et al. Randomized comparison of low molecular weight heparin and coumarin derivatives on the survival of patients with cancer and venous thromboembolism. J Clin Oncol 23 (2005) 2123-2129
59. Hembrough T., Swartz G., Papathanassiu A., Vlasuk G., Rote W., Green S., et al. Tissue factor/factor VIIa inhibitors block angiogenesis and tumor growth through a nonhemostatic mechanism. Cancer Res 63 (2003) 2997-3000