메뉴 건너뛰기




Volumn 52, Issue 1, 2009, Pages 31-42

Current progress in epigenetic research for hepatocarcinomagenesis

Author keywords

DNA methylation; Epigenetics; Heaptocellular carcinoma; MicroRNA; Tumor

Indexed keywords

MICRORNA;

EID: 58649091781     PISSN: 10069305     EISSN: 18622798     Source Type: Journal    
DOI: 10.1007/s11427-009-0014-7     Document Type: Review
Times cited : (30)

References (70)
  • 1
    • 0242584454 scopus 로고    scopus 로고
    • Chromosomal instability and tumors promoted by DNA hypomethylation
    • 5618
    • A. Eden F. Gaudet A. Waghmare 2003 Chromosomal instability and tumors promoted by DNA hypomethylation Science 300 5618 455
    • (2003) Science , vol.300 , pp. 455
    • Eden, A.1    Gaudet, F.2    Waghmare, A.3
  • 2
    • 0141648473 scopus 로고    scopus 로고
    • Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis
    • 4
    • S. Lee H. J. Lee J. H. Kim 2003 Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis Am J Pathol 163 4 1371 1378
    • (2003) Am J Pathol , vol.163 , pp. 1371-1378
    • Lee, S.1    Lee, H.J.2    Kim, J.H.3
  • 3
    • 0030791718 scopus 로고    scopus 로고
    • P53 mutations, chronic hepatitis B virus infection, and aflatoxin exposure in hepatocellular carcinoma in Taiwan
    • R. M. Lunn Y. J. Zhang L. Y. Wang 1997 p53 mutations, chronic hepatitis B virus infection, and aflatoxin exposure in hepatocellular carcinoma in Taiwan Cancer Res 57 3471 3477
    • (1997) Cancer Res , vol.57 , pp. 3471-3477
    • Lunn, R.M.1    Zhang, Y.J.2    Wang, L.Y.3
  • 4
    • 0345006147 scopus 로고    scopus 로고
    • Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas
    • A. de La Costa B. Romagnolo P. Billuart 1998 Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas Proc Natl Acad Sci USA 95 8847 8851
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8847-8851
    • De La Costa, A.1    Romagnolo, B.2    Billuart, P.3
  • 5
    • 0037468934 scopus 로고    scopus 로고
    • Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinoma
    • 12
    • U. Schagdarsurengin L. Wilkens D. Steinemann 2003 Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinoma Oncogene 22 12 1866 1871
    • (2003) Oncogene , vol.22 , pp. 1866-1871
    • Schagdarsurengin, U.1    Wilkens, L.2    Steinemann, D.3
  • 6
    • 0032924622 scopus 로고    scopus 로고
    • P16(INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma
    • Y. Matsuda T. Ichida J. Matsuzawa 1999 p16(INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma Gastroenterology 116 394 400
    • (1999) Gastroenterology , vol.116 , pp. 394-400
    • Matsuda, Y.1    Ichida, T.2    Matsuzawa, J.3
  • 7
    • 33244455402 scopus 로고    scopus 로고
    • Downregulation of E-cadherin by hepatitis B virus X antigen in hepatocellullar carcinoma
    • 7
    • J. Liu Z. Lian S. Han 2006 Downregulation of E-cadherin by hepatitis B virus X antigen in hepatocellullar carcinoma Oncogene 25 7 1008 1017
    • (2006) Oncogene , vol.25 , pp. 1008-1017
    • Liu, J.1    Lian, Z.2    Han, S.3
  • 8
    • 3442885926 scopus 로고    scopus 로고
    • Apoptotic speck protein-like, a highly homologous protein to apoptotic speck protein in the pyrin domain, is silenced by DNA methylation and induces apoptosis in human hepatocellular carcinoma
    • T. Kubo J. Yamamoto Y. Shikauchi 2004 Apoptotic speck protein-like, a highly homologous protein to apoptotic speck protein in the pyrin domain, is silenced by DNA methylation and induces apoptosis in human hepatocellular carcinoma Cancer Res 64 5172 5177
    • (2004) Cancer Res , vol.64 , pp. 5172-5177
    • Kubo, T.1    Yamamoto, J.2    Shikauchi, Y.3
  • 9
    • 0344844475 scopus 로고    scopus 로고
    • Genetic and epigenetic alterations of DLC-1 gene in hepatocellular carcinoma
    • C. M. Wong J. M. Lee Y. P. Ching 2003 Genetic and epigenetic alterations of DLC-1 gene in hepatocellular carcinoma Cancer Res 63 7646 7651
    • (2003) Cancer Res , vol.63 , pp. 7646-7651
    • Wong, C.M.1    Lee, J.M.2    Ching, Y.P.3
  • 10
    • 34447095260 scopus 로고    scopus 로고
    • Up-regulation of DLK1 gene could contribute to human hepatocellular carcinoma
    • 5
    • J. Huang X. Zhang M. Zhang 2007 Up-regulation of DLK1 gene could contribute to human hepatocellular carcinoma Carcinogenesis 28 5 1094 1103
    • (2007) Carcinogenesis , vol.28 , pp. 1094-1103
    • Huang, J.1    Zhang, X.2    Zhang, M.3
  • 11
    • 34547770885 scopus 로고    scopus 로고
    • Down-regulation of SFRP1 as a tumor suppressor gene can contribute to human hepatocellular carcinoma
    • J. Huang Y. L. Zhang X. M. Teng 2007 Down-regulation of SFRP1 as a tumor suppressor gene can contribute to human hepatocellular carcinoma BMC Cancer 7 126
    • (2007) BMC Cancer , vol.7 , pp. 126
    • Huang, J.1    Zhang, Y.L.2    Teng, X.M.3
  • 12
    • 33746296615 scopus 로고    scopus 로고
    • Promoter methylation of the secreted frizzled-related protein 1 gene SFRP1 is frequent in hepatocellular carcinoma
    • Y. L. Shih R. Y. Shyu C. B. Hsieh 2006 Promoter methylation of the secreted frizzled-related protein 1 gene SFRP1 is frequent in hepatocellular carcinoma Cancer 107 579 590
    • (2006) Cancer , vol.107 , pp. 579-590
    • Shih, Y.L.1    Shyu, R.Y.2    Hsieh, C.B.3
  • 13
    • 18844482200 scopus 로고    scopus 로고
    • GSTP1 CpG island DNA hypermethylation in hepatocellular carcinomas
    • 4
    • J. C. Tchou X. Lin D. Freije 2000 GSTP1 CpG island DNA hypermethylation in hepatocellular carcinomas Int J Oncol 16 4 663 676
    • (2000) Int J Oncol , vol.16 , pp. 663-676
    • Tchou, J.C.1    Lin, X.2    Freije, D.3
  • 14
    • 35648947815 scopus 로고    scopus 로고
    • Hypermethylation of multiple genes as clonal markers in multicentric hepatocellular carcinoma
    • 9
    • S. Nomoto T. Kinoshita K. Kato 2007 Hypermethylation of multiple genes as clonal markers in multicentric hepatocellular carcinoma Br J Cancer 97 9 1260 1265
    • (2007) Br J Cancer , vol.97 , pp. 1260-1265
    • Nomoto, S.1    Kinoshita, T.2    Kato, K.3
  • 15
    • 0020699979 scopus 로고
    • Hypomethylation distinguishes genes of some human cancers from their normal counterparts
    • A. P. Feinberg B. Vogelstein 1983 Hypomethylation distinguishes genes of some human cancers from their normal counterparts Nature 301 89 92
    • (1983) Nature , vol.301 , pp. 89-92
    • Feinberg, A.P.1    Vogelstein, B.2
  • 16
    • 0028111446 scopus 로고
    • Global DNA hypomethylation increases progressively in cervical dysplasia and carcinoma
    • Y. I. Kim A. Giuliano K. D. Hatch 1994 Global DNA hypomethylation increases progressively in cervical dysplasia and carcinoma Cancer 74 893 899
    • (1994) Cancer , vol.74 , pp. 893-899
    • Kim, Y.I.1    Giuliano, A.2    Hatch, K.D.3
  • 17
    • 0023230209 scopus 로고
    • Hypomethylation of DNA in pathological conditions of the human prostate
    • M. T. Bedford P. D. van Helden 1987 Hypomethylation of DNA in pathological conditions of the human prostate Cancer Res 47 5274 5276
    • (1987) Cancer Res , vol.47 , pp. 5274-5276
    • Bedford, M.T.1    Van Helden, P.D.2
  • 18
    • 0033535612 scopus 로고    scopus 로고
    • A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer
    • G. Strathdee M. J. MacKean M. Illand 1999 A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer Oncogene 18 2335 2341
    • (1999) Oncogene , vol.18 , pp. 2335-2341
    • Strathdee, G.1    MacKean, M.J.2    Illand, M.3
  • 19
    • 0030909356 scopus 로고    scopus 로고
    • Establishment of methylation-sensitive-representational difference analysis and isolation of hypo- and hypermethylated genomic fragments in mouse liver tumors
    • 6
    • T. Ushijima K. Morimura Y. Hosoya 1997 Establishment of methylation-sensitive-representational difference analysis and isolation of hypo- and hypermethylated genomic fragments in mouse liver tumors Proc Natl Acad Sci USA 94 6 2284 2289
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2284-2289
    • Ushijima, T.1    Morimura, K.2    Hosoya, Y.3
  • 20
    • 34848881905 scopus 로고    scopus 로고
    • Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma
    • 9
    • D. F. Calvisi S. Ladu A. Gorden 2007 Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma J Clin Invest 117 9 2713 2722
    • (2007) J Clin Invest , vol.117 , pp. 2713-2722
    • Calvisi, D.F.1    Ladu, S.2    Gorden, A.3
  • 21
    • 0035872493 scopus 로고    scopus 로고
    • Genome-wide hypomethylation in hepatocellular carcinogenesis
    • C. H. Lin S. Y. Hsieh I. S. Sheen 2001 Genome-wide hypomethylation in hepatocellular carcinogenesis Cancer Res 61 4238 4243
    • (2001) Cancer Res , vol.61 , pp. 4238-4243
    • Lin, C.H.1    Hsieh, S.Y.2    Sheen, I.S.3
  • 22
    • 0032480226 scopus 로고    scopus 로고
    • DNA hypomethylation leads to elevated mutation rates
    • 6697
    • R. Z. Chen U. Pettersson C. Beard 1998 DNA hypomethylation leads to elevated mutation rates Nature 395 6697 89 93
    • (1998) Nature , vol.395 , pp. 89-93
    • Chen, R.Z.1    Pettersson, U.2    Beard, C.3
  • 23
    • 0242584449 scopus 로고    scopus 로고
    • Induction of tumors in mice by genomic hypomethylation
    • 5618
    • F. Gaudet J. G. Hodgson A. Edcn 2003 Induction of tumors in mice by genomic hypomethylation Science 300 5618 489 492
    • (2003) Science , vol.300 , pp. 489-492
    • Gaudet, F.1    Hodgson, J.G.2    Edcn, A.3
  • 24
    • 0242584454 scopus 로고    scopus 로고
    • Chromosomal instability tumors promoted by DNA hypomethylation
    • 5618
    • A. Eden F. Gaudet A. waghmare 2003 Chromosomal instability tumors promoted by DNA hypomethylation Science 300 5618 455
    • (2003) Science , vol.300 , pp. 455
    • Eden, A.1    Gaudet, F.2    Waghmare, A.3
  • 25
    • 0034880162 scopus 로고    scopus 로고
    • Hypomethylation of chromosome 1 heterochromatin DNA correlates with q-arm copy gain in human hepatocellular carcinoma
    • 2
    • N. Wong W. C. Lam P. B. Lai 2001 Hypomethylation of chromosome 1 heterochromatin DNA correlates with q-arm copy gain in human hepatocellular carcinoma Am J Pathol 159 2 465 471
    • (2001) Am J Pathol , vol.159 , pp. 465-471
    • Wong, N.1    Lam, W.C.2    Lai, P.B.3
  • 26
    • 26444473234 scopus 로고    scopus 로고
    • Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis
    • 38
    • Y. Yamada L. Jackson-Grusby H. Linhart 2005 Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis Proc Natl Acad Sci USA 102 38 13580 13585
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 13580-13585
    • Yamada, Y.1    Jackson-Grusby, L.2    Linhart, H.3
  • 27
    • 0032987773 scopus 로고    scopus 로고
    • DNA methylation and expression of LINE-1 and HERV-k provirus sequences in urothelial and renal cell carcinomas
    • A. R. Florl R. Löwer B. J. Schmitz-Dräger 1999 DNA methylation and expression of LINE-1 and HERV-k provirus sequences in urothelial and renal cell carcinomas Br J Cancer 80 1312 1321
    • (1999) Br J Cancer , vol.80 , pp. 1312-1321
    • Florl, A.R.1    Löwer, R.2    Schmitz-Dräger, B.J.3
  • 28
    • 0033814412 scopus 로고    scopus 로고
    • Hypomethylation of LINE1 retrotransposon in human hepatocellular carcinomas, but not in surrounding liver cirrhosis
    • 7
    • D. Takai Y. Yagi N. Habib 2000 Hypomethylation of LINE1 retrotransposon in human hepatocellular carcinomas, but not in surrounding liver cirrhosis Jpn J Clin Oncol 30 7 306 309
    • (2000) Jpn J Clin Oncol , vol.30 , pp. 306-309
    • Takai, D.1    Yagi, Y.2    Habib, N.3
  • 29
    • 0023238110 scopus 로고
    • Site-specific hypomethylation of the c-myc oncogene in human hepatocellular carcinoma
    • 7
    • S. Nambu K. Inoue H. Saski 1987 Site-specific hypomethylation of the c-myc oncogene in human hepatocellular carcinoma Jpn J Cancer Res 78 7 695 704
    • (1987) Jpn J Cancer Res , vol.78 , pp. 695-704
    • Nambu, S.1    Inoue, K.2    Saski, H.3
  • 30
    • 0030795755 scopus 로고    scopus 로고
    • Correlation between hypomethylation of c-myc and c-N-ras oncogenes and pathological changes in human hepatocellular carcinoma
    • 3
    • L. Shen D. Qui J. Fang 1997 Correlation between hypomethylation of c-myc and c-N-ras oncogenes and pathological changes in human hepatocellular carcinoma Zhonghua Zhong Liu Za Zhi 19 3 173 176
    • (1997) Zhonghua Zhong Liu Za Zhi , vol.19 , pp. 173-176
    • Shen, L.1    Qui, D.2    Fang, J.3
  • 31
    • 0030900070 scopus 로고    scopus 로고
    • Germ-line mutations of the p16INK4(MTS1) gene occur in a subset of patients with hepatocellular carcinoma
    • 6
    • P. Chaubert R. Gayer A. Zimmermann 1997 Germ-line mutations of the p16INK4(MTS1) gene occur in a subset of patients with hepatocellular carcinoma Hepatology 25 6 1376 1381
    • (1997) Hepatology , vol.25 , pp. 1376-1381
    • Chaubert, P.1    Gayer, R.2    Zimmermann, A.3
  • 32
    • 1842454118 scopus 로고    scopus 로고
    • P16 promoter hypermethylation in human hepatocellular carcinoma with or without hepatitis 29 virus infection
    • 1
    • T. Narimatsu A. Tamori N. Koh 2004 p16 promoter hypermethylation in human hepatocellular carcinoma with or without hepatitis 29 virus infection Intervimlogy 47 1 26 31
    • (2004) Intervimlogy , vol.47 , pp. 26-31
    • Narimatsu, T.1    Tamori, A.2    Koh, N.3
  • 33
    • 0035042611 scopus 로고    scopus 로고
    • SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
    • 1
    • H. Yoshikawa K. Matsubara G. S. Qian 2001 SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity Nat Genet 28 1 29 35
    • (2001) Nat Genet , vol.28 , pp. 29-35
    • Yoshikawa, H.1    Matsubara, K.2    Qian, G.S.3
  • 34
    • 0242610382 scopus 로고    scopus 로고
    • Methylation-mediated silencing of SOCS-1 gene in hepatocellular Carcinoma derived from cirrhosis
    • 14
    • O. Okochi K. Hi M. S.M. Au. Sakai 2003 Methylation-mediated silencing of SOCS-1 gene in hepatocellular Carcinoma derived from cirrhosis Clin Cancer Res 9 14 5295 5298
    • (2003) Clin Cancer Res , vol.9 , pp. 5295-5298
    • Okochi, O.1    Hi, K.2    Au, S.M.3
  • 35
    • 0036789450 scopus 로고    scopus 로고
    • High frequency of promoter hypermethylation of RASSF1A and p16 and its relationship to aflatoxin B1-DNA adduct levels in human hepatocellular carcinoma
    • 2
    • Y. J. Zhang H. Ahsan Y. Chen 2002 High frequency of promoter hypermethylation of RASSF1A and p16 and its relationship to aflatoxin B1-DNA adduct levels in human hepatocellular carcinoma Mol Carcinog 35 2 85 92
    • (2002) Mol Carcinog , vol.35 , pp. 85-92
    • Zhang, Y.J.1    Ahsan, H.2    Chen, Y.3
  • 36
    • 0037468934 scopus 로고    scopus 로고
    • Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinoma
    • 12
    • U. Schagdarsurengin L. Wilkens D. Steinnarm 2003 Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinoma Oncogene 22 12 1866 1871
    • (2003) Oncogene , vol.22 , pp. 1866-1871
    • Schagdarsurengin, U.1    Wilkens, L.2
  • 37
    • 18844482200 scopus 로고    scopus 로고
    • GSTP1 CpG islandDNA hypermethylation in hepatocellular carcinomas
    • 4
    • J. C. Tchou X. Lin D. et al. Freije 2000 GSTP1 CpG islandDNA hypermethylation in hepatocellular carcinomas Int J Oncol 16 4 663 676
    • (2000) Int J Oncol , vol.16 , pp. 663-676
    • Tchou, J.C.1    Lin, X.2
  • 38
    • 0141648473 scopus 로고    scopus 로고
    • Aberrant CpG island hypermethylation along muhistep hepatocarcinog enesis
    • 4
    • S. Lee H. J. Lee J. H. et al. Kim 2003 Aberrant CpG island hypermethylation along muhistep hepatocarcinog enesis Am J Pathol 163 4 1371 1378
    • (2003) Am J Pathol , vol.163 , pp. 1371-1378
    • Lee, S.1    Lee, H.J.2
  • 39
    • 34248664108 scopus 로고    scopus 로고
    • Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma
    • 5
    • C. M. Wong Y. L. Ng J. M. Lee 2007 Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma Hepatology 45 5 1129 1138
    • (2007) Hepatology , vol.45 , pp. 1129-1138
    • Wong, C.M.1    Ng, Y.L.2    Lee, J.M.3
  • 40
    • 0030846298 scopus 로고    scopus 로고
    • Tying it all together: Epigenetics, genetics, cell cycle, and cancer
    • 5334
    • S. B. Baylin 1997 Tying it all together: epigenetics, genetics, cell cycle, and cancer Science 277 5334 1948 1949
    • (1997) Science , vol.277 , pp. 1948-1949
    • Baylin, S.B.1
  • 41
    • 0035872493 scopus 로고    scopus 로고
    • Genome-wide hypomethylation in hepatocellular carcinogenesis
    • 10
    • C. H. Lin S. Y. Hsieh I. S. Sheen 2001 Genome-wide hypomethylation in hepatocellular carcinogenesis Cancer Res 61 10 4238 4243
    • (2001) Cancer Res , vol.61 , pp. 4238-4243
    • Lin, C.H.1    Hsieh, S.Y.2    Sheen, I.S.3
  • 42
    • 8644236540 scopus 로고    scopus 로고
    • Alterations in gene expression associated with the overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, during human hepatocarcinogenesis
    • 11
    • Y. Kanai Y. Saito S. Ushijima 2004 Alterations in gene expression associated with the overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, during human hepatocarcinogenesis J Cancer Res Clin Oncol 130 11 636 644
    • (2004) J Cancer Res Clin Oncol , vol.130 , pp. 636-644
    • Kanai, Y.1    Saito, Y.2    Ushijima, S.3
  • 43
    • 0037162542 scopus 로고    scopus 로고
    • Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis
    • 15
    • Y. Saito Y. Kanai M. Sakamoto 2002 Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis Proc Natl Acad Sci USA 99 15 10060 10065
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 10060-10065
    • Saito, Y.1    Kanai, Y.2    Sakamoto, M.3
  • 44
    • 34548074239 scopus 로고    scopus 로고
    • DNA methyltransferase expression and DNA methylation in human hepatocellular carcinoma and their clinicopathological correlation
    • 1
    • B. K. Oh H. Kim H. J. Park 2007 DNA methyltransferase expression and DNA methylation in human hepatocellular carcinoma and their clinicopathological correlation Int J Mol Med 20 1 65 73
    • (2007) Int J Mol Med , vol.20 , pp. 65-73
    • Oh, B.K.1    Kim, H.2    Park, H.J.3
  • 45
    • 33644642358 scopus 로고    scopus 로고
    • DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma
    • 2
    • H. J. Park E. Yu Y. H. Shim 2006 DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma Cancer Lett 233 2 271 278
    • (2006) Cancer Lett , vol.233 , pp. 271-278
    • Park, H.J.1    Yu, E.2    Shim, Y.H.3
  • 46
    • 39249084744 scopus 로고    scopus 로고
    • Hepatitis C virus core protein downregulates E-cadherin expression via activation of DNA methyltransferase 1 and 3b
    • 2
    • P. Arora E. O. Kim J. K. Jung 2008 Hepatitis C virus core protein downregulates E-cadherin expression via activation of DNA methyltransferase 1 and 3b Cancer Lett 261 2 244 252
    • (2008) Cancer Lett , vol.261 , pp. 244-252
    • Arora, P.1    Kim, E.O.2    Jung, J.K.3
  • 47
    • 34250854122 scopus 로고    scopus 로고
    • Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway
    • 12
    • J. K. Jung P. Arora J. S. Pagano 2007 Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway Cancer Res 67 12 5771 5778
    • (2007) Cancer Res , vol.67 , pp. 5771-5778
    • Jung, J.K.1    Arora, P.2    Pagano, J.S.3
  • 48
    • 34247190634 scopus 로고    scopus 로고
    • Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein
    • 4
    • I. Y. Park Y. H. Chung S. J. Surzycki 2007 Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein Gastroenterology 132 4 1476 1494
    • (2007) Gastroenterology , vol.132 , pp. 1476-1494
    • Park, I.Y.1    Chung, Y.H.2    Surzycki, S.J.3
  • 49
    • 0032893755 scopus 로고    scopus 로고
    • Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients
    • 1
    • I. H. Wong Y. M. Lo J. Zhang 1999 Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients Cancer Res 59 1 71 73
    • (1999) Cancer Res , vol.59 , pp. 71-73
    • Wong, I.H.1    Lo, Y.M.2    Zhang, J.3
  • 50
    • 0037339723 scopus 로고    scopus 로고
    • Quantitative analysis of tumor-derived methylated p16 sequences in plasma, serum, and blood cells of hepatocellular carcinoma patients
    • 3
    • I. H. Wong J. Zhang P. B. et. al. Lai 2003 Quantitative analysis of tumor-derived methylated p16 sequences in plasma, serum, and blood cells of hepatocellular carcinoma patients Clin Cancer Res 9 3 1047 1052
    • (2003) Clin Cancer Res , vol.9 , pp. 1047-1052
    • Wong, I.H.1    Zhang, J.2
  • 51
    • 0034112883 scopus 로고    scopus 로고
    • Tumor-derived epigenetic changes in the plasma and serum of liver cancer patients. Implications for cancer detection and monitoring
    • I. H. Wong P. J. Johnson P. B. et. al. Lai 2000 Tumor-derived epigenetic changes in the plasma and serum of liver cancer patients. Implications for cancer detection and monitoring Ann NY Acad Sci 906 102 105
    • (2000) Ann NY Acad Sci , vol.906 , pp. 102-105
    • Wong, I.H.1    Johnson, P.J.2
  • 52
    • 33646091508 scopus 로고    scopus 로고
    • Detection of aberrant promoter methylation of GSTP1 in the tumor and serum of Chinese human primary hepatocellular carcinoma patients
    • 4
    • J. Wang Y. Qin B. Li 2006 Detection of aberrant promoter methylation of GSTP1 in the tumor and serum of Chinese human primary hepatocellular carcinoma patients Clin Biochem 39 4 344 348
    • (2006) Clin Biochem , vol.39 , pp. 344-348
    • Wang, J.1    Qin, Y.2    Li, B.3
  • 53
    • 34247895661 scopus 로고    scopus 로고
    • Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA
    • 8
    • Y. J. Zhang H. C. Wu J. Shen 2007 Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA Clin Cancer Res 13 8 2378 2384
    • (2007) Clin Cancer Res , vol.13 , pp. 2378-2384
    • Zhang, Y.J.1    Wu, H.C.2    Shen, J.3
  • 54
    • 33645976174 scopus 로고    scopus 로고
    • Ubiquitous activation of Ras and Jak/Stat pathways in human HCC
    • 4
    • D. F. Calvisi S. Ladu A. Gorden 2006 Ubiquitous activation of Ras and Jak/Stat pathways in human HCC Gastroenterology 130 4 1117 1128
    • (2006) Gastroenterology , vol.130 , pp. 1117-1128
    • Calvisi, D.F.1    Ladu, S.2    Gorden, A.3
  • 55
    • 0035893767 scopus 로고    scopus 로고
    • Reversal of GSTPl CpG island hypermethylation and reactivation of GSTP1 expression in human prostate cancer cells by treatment with procainamide
    • 24
    • X. H. Lin K. Asgan M. J. Putzi 2001 Reversal of GSTPl CpG island hypermethylation and reactivation of GSTP1 expression in human prostate cancer cells by treatment with procainamide Cancer Res 61 24 8611 8616
    • (2001) Cancer Res , vol.61 , pp. 8611-8616
    • Lin, X.H.1    Asgan, K.2    Putzi, M.J.3
  • 56
    • 0027751663 scopus 로고
    • The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • R. C. Lee R. L. Feinbaum V. Ambros 1993 The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 Cell 75 843 854
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 57
    • 0034708122 scopus 로고    scopus 로고
    • The 21. nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
    • B. J. Reinhan F. J. Slack M. et. al. Basson 2000 The 21. nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans Nature 403 901 906
    • (2000) Nature , vol.403 , pp. 901-906
    • Reinhan, B.J.1    Slack, F.J.2
  • 58
    • 0035955374 scopus 로고    scopus 로고
    • Identification of novel genes coding for small expressed RNAs
    • M. Lagos-Quintana R. Rauhut W. et. al. Lendeckel 2001 Identification of novel genes coding for small expressed RNAs Science 294 853 858
    • (2001) Science , vol.294 , pp. 853-858
    • Lagos-Quintana, M.1    Rauhut, R.2
  • 59
    • 0041570083 scopus 로고    scopus 로고
    • MicroRNAs: Key participants in gene regulatory networks
    • X. S. Ke C. M. Liu D. P. Liu 2003 MicroRNAs: key participants in gene regulatory networks Curr Opin Chem Biol 7 516 523
    • (2003) Curr Opin Chem Biol , vol.7 , pp. 516-523
    • Ke, X.S.1    Liu, C.M.2    Liu, D.P.3
  • 60
    • 3042767202 scopus 로고    scopus 로고
    • MicroRNAs: Small RNAs with a big role in gene regulation
    • L. He G. J. Hannon 2004 MicroRNAs: small RNAs with a big role in gene regulation Nat Rev Genet 5 522 531
    • (2004) Nat Rev Genet , vol.5 , pp. 522-531
    • He, L.1    Hannon, G.J.2
  • 61
    • 0037694970 scopus 로고    scopus 로고
    • The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism
    • P. Xu S. Y. Vernooy M. Guo 2003 The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism Curr Biol 13 790 795
    • (2003) Curr Biol , vol.13 , pp. 790-795
    • Xu, P.1    Vernooy, S.Y.2    Guo, M.3
  • 62
    • 33646157967 scopus 로고    scopus 로고
    • Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues
    • 17
    • Y. Murakami T. Yasuda K. Saigo 2006 Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues Oncogene 25 17 2537 2545
    • (2006) Oncogene , vol.25 , pp. 2537-2545
    • Murakami, Y.1    Yasuda, T.2    Saigo, K.3
  • 63
    • 37249006781 scopus 로고    scopus 로고
    • Microarray analysis of microRNA expression in hepatocellular carcinoma and non-tumorous tissues without viral hepatitis
    • 1
    • Y. S. Huang Y. Dai X. F. Yu 2008 Microarray analysis of microRNA expression in hepatocellular carcinoma and non-tumorous tissues without viral hepatitis J Gastroenterol Hepatol 23 1 87 94
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 87-94
    • Huang, Y.S.1    Dai, Y.2    Yu, X.F.3
  • 64
    • 40949087185 scopus 로고    scopus 로고
    • Identification of metastasis-related microRNAs in hepatocellular carcinoma
    • 3
    • A. Budhu H. L. Jia M. Forgues 2008 Identification of metastasis-related microRNAs in hepatocellular carcinoma Hepatology 47 3 897 907
    • (2008) Hepatology , vol.47 , pp. 897-907
    • Budhu, A.1    Jia, H.L.2    Forgues, M.3
  • 65
    • 42249089850 scopus 로고    scopus 로고
    • MicroRNA gene expression profile of HCV-associated hepatocellular carcinoma
    • Accepted Article Online
    • Varnholt H, Drebber U, Schulze, F, et al. MicroRNA gene expression profile of HCV-associated hepatocellular carcinoma. Hepatology, 2008 (Accepted Article Online)
    • (2008) Hepatology
    • Varnholt, H.1    Drebber, U.2    Schulze, F.3
  • 66
    • 7744220635 scopus 로고    scopus 로고
    • MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
    • C. M. Shachaf A. M. Kopelman C. Arvanitis 2004 MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer Nature 431 1112 1117
    • (2004) Nature , vol.431 , pp. 1112-1117
    • Shachaf, C.M.1    Kopelman, A.M.2    Arvanitis, C.3
  • 67
    • 20444460289 scopus 로고    scopus 로고
    • MicroRNA expression profiles classify human cancers
    • J. Lu G. Getz E. A. Miska 2005 MicroRNA expression profiles classify human cancers Nature 435 834 838
    • (2005) Nature , vol.435 , pp. 834-838
    • Lu, J.1    Getz, G.2    Miska, E.A.3
  • 68
    • 20444467290 scopus 로고    scopus 로고
    • A microRNA polycistron as a potential human oncogene
    • L. He J. M. Thomson M. T. Hemann 2005 A microRNA polycistron as a potential human oncogene Nature 435 828 833
    • (2005) Nature , vol.435 , pp. 828-833
    • He, L.1    Thomson, J.M.2    Hemann, M.T.3
  • 69
    • 85047694402 scopus 로고    scopus 로고
    • Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
    • Y. Horie A. Suzuki E. Kataoka 2004 Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas J Clin Invest 113 1774 1783
    • (2004) J Clin Invest , vol.113 , pp. 1774-1783
    • Horie, Y.1    Suzuki, A.2    Kataoka, E.3
  • 70
    • 33744521896 scopus 로고    scopus 로고
    • Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines
    • F. Meng R. Henson M. Lang 2006 Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines Gastroenterology 130 2113 2129
    • (2006) Gastroenterology , vol.130 , pp. 2113-2129
    • Meng, F.1    Henson, R.2    Lang, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.