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Volumn 37, Issue 1, 2009, Pages 78-95

Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; FLUOROPYRIMIDINE; FLUOROURACIL; MESSENGER RNA; MUTANT PROTEIN; OXALIPLATIN; PROTEIN P53; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR SP1; URACIL;

EID: 58549097306     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkn910     Document Type: Article
Times cited : (47)

References (63)
  • 1
    • 0023967987 scopus 로고
    • Lethality of a dut (deoxyuridine triphosphatase) mutation in Escherichia coli
    • el-Hajj,H.H., Zhang,H. and Weiss,B. (1988) Lethality of a dut (deoxyuridine triphosphatase) mutation in Escherichia coli. J. Bacteriol., 170, 1069-1075.
    • (1988) J. Bacteriol , vol.170 , pp. 1069-1075
    • el-Hajj, H.H.1    Zhang, H.2    Weiss, B.3
  • 2
    • 0027426749 scopus 로고
    • dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiae
    • Gadsden,M.H., McIntosh,E.M., Game,J.C., Wilson,P.J. and Haynes,R.H. (1993) dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiae. EMBO J., 12, 4425-4431.
    • (1993) EMBO J , vol.12 , pp. 4425-4431
    • Gadsden, M.H.1    McIntosh, E.M.2    Game, J.C.3    Wilson, P.J.4    Haynes, R.H.5
  • 3
    • 0038387494 scopus 로고    scopus 로고
    • 5-fluorouracil: Mechanisms of action and clinical strategies
    • Longley,D.B., Harkin,D.P. and Johnston,P.G. (2003) 5-fluorouracil: mechanisms of action and clinical strategies. Nat. Rev Cancer, 3, 330-338.
    • (2003) Nat. Rev Cancer , vol.3 , pp. 330-338
    • Longley, D.B.1    Harkin, D.P.2    Johnston, P.G.3
  • 4
    • 0025832444 scopus 로고
    • Mechanism of cell death following thymidylate synthase inhibition: 2′-deoxyuridine-5′-triphosphate accumulation, DNA damage, and growth inhibition following exposure to CB3717 and dipyridamole
    • Curtin,N.J, Harris,A.L. and Aherne,G.W. (1991) Mechanism of cell death following thymidylate synthase inhibition: 2′-deoxyuridine-5′-triphosphate accumulation, DNA damage, and growth inhibition following exposure to CB3717 and dipyridamole. Cancer Res. 51, 2346-2352.
    • (1991) Cancer Res , vol.51 , pp. 2346-2352
    • Curtin, N.J.1    Harris, A.L.2    Aherne, G.W.3
  • 5
    • 0035800492 scopus 로고    scopus 로고
    • The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition
    • Webley,S.D., Welsh,S.J., Jackman,A.L. and Aherne,G.W. (2001) The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition. Br. J. Cancer, 85, 446-452.
    • (2001) Br. J. Cancer , vol.85 , pp. 446-452
    • Webley, S.D.1    Welsh, S.J.2    Jackman, A.L.3    Aherne, G.W.4
  • 6
    • 0036731991 scopus 로고    scopus 로고
    • dUTPase and uracil-DNA glycosylase are central modulators of antifolate toxicity in Saccharomyces cerevisiae
    • Tinkelenberg,B.A., Hansbury,M.J. and Ladner,R.D. (2002) dUTPase and uracil-DNA glycosylase are central modulators of antifolate toxicity in Saccharomyces cerevisiae. Cancer Res., 62, 4909-4915.
    • (2002) Cancer Res , vol.62 , pp. 4909-4915
    • Tinkelenberg, B.A.1    Hansbury, M.J.2    Ladner, R.D.3
  • 8
    • 0028223117 scopus 로고
    • Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of Escherichia coli deoxyuridinetriphosphatase
    • Canman,C.E., Radany,E.H., Parsels,L.A., Davis,M.A., Lawrence,T.S. and Maybaum,J. (1994) Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of Escherichia coli deoxyuridinetriphosphatase. Cancer Res., 54 2296-2298.
    • (1994) Cancer Res , vol.54 , pp. 2296-2298
    • Canman, C.E.1    Radany, E.H.2    Parsels, L.A.3    Davis, M.A.4    Lawrence, T.S.5    Maybaum, J.6
  • 9
    • 4944241573 scopus 로고    scopus 로고
    • Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition
    • Kochler,S.E. and Ladner,R.D. (2004) Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition. Mol. Pharmacol., 66, 620-626.
    • (2004) Mol. Pharmacol , vol.66 , pp. 620-626
    • Kochler, S.E.1    Ladner, R.D.2
  • 10
    • 0034234872 scopus 로고    scopus 로고
    • dUTP nucleotidohydrolase isoform expression in normal and neoplastic tissues: Association with survival and response to 5-fluorouracil in colorectal cancer
    • Ladner,R.D., Lynch,F.J., Groshen,S., Xiong,Y.P., Sherrod,A., Caradonna,S.J., Stochlmacher,J. and Lenz,H.J. (2000) dUTP nucleotidohydrolase isoform expression in normal and neoplastic tissues: association with survival and response to 5-fluorouracil in colorectal cancer. Cancer Res., 60, 3493-3503.
    • (2000) Cancer Res , vol.60 , pp. 3493-3503
    • Ladner, R.D.1    Lynch, F.J.2    Groshen, S.3    Xiong, Y.P.4    Sherrod, A.5    Caradonna, S.J.6    Stochlmacher, J.7    Lenz, H.J.8
  • 12
    • 0030587564 scopus 로고    scopus 로고
    • Human dUTP pyrophosphatase: Uracil recognition by a beta hairpin and active sites formed by three separate subunits
    • Mol,C.D., Harris,J.M., McIntosh,E.M. and Tainer,J.A. (1996) Human dUTP pyrophosphatase: Uracil recognition by a beta hairpin and active sites formed by three separate subunits. Structure, 4, 1077-1092.
    • (1996) Structure , vol.4 , pp. 1077-1092
    • Mol, C.D.1    Harris, J.M.2    McIntosh, E.M.3    Tainer, J.A.4
  • 13
    • 36349007726 scopus 로고    scopus 로고
    • Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme
    • Toth,J., Varga,B., Kovacs,M., Malnasi-Csizmadia,A. and Vertessy,B.G. (2007) Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme. J. Biol. Chem., 282, 33572-33582.
    • (2007) J. Biol. Chem , vol.282 , pp. 33572-33582
    • Toth, J.1    Varga, B.2    Kovacs, M.3    Malnasi-Csizmadia, A.4    Vertessy, B.G.5
  • 15
    • 0030791450 scopus 로고    scopus 로고
    • The human dUTPase gene encodes both nuclear and mitochondrial isoforms. Differential expression of the isoforms and characterization of a cDNA encoding the mitochondrial species
    • Ladner,R.D. and Caradonna,S.J. (1997) The human dUTPase gene encodes both nuclear and mitochondrial isoforms. Differential expression of the isoforms and characterization of a cDNA encoding the mitochondrial species. J. Biol. Chem., 272, 19072-19080.
    • (1997) J. Biol. Chem , vol.272 , pp. 19072-19080
    • Ladner, R.D.1    Caradonna, S.J.2
  • 16
    • 0033811850 scopus 로고    scopus 로고
    • Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331
    • Webley,S.D., Hardcastle,A., Ladner,R.D., Jackman,A.L. and Aherne,G.W. (2000) Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331. Br. J. Cancer, 83, 792-799.
    • (2000) Br. J. Cancer , vol.83 , pp. 792-799
    • Webley, S.D.1    Hardcastle, A.2    Ladner, R.D.3    Jackman, A.L.4    Aherne, G.W.5
  • 18
    • 0037080483 scopus 로고    scopus 로고
    • E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints
    • Ren,B., Cam,H., Takahashi,Y., Volkert,T., Terragni,J., Young,R.A. and Dynlacht,B.D. (2002) E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev., 16, 245-256.
    • (2002) Genes Dev , vol.16 , pp. 245-256
    • Ren, B.1    Cam, H.2    Takahashi, Y.3    Volkert, T.4    Terragni, J.5    Young, R.A.6    Dynlacht, B.D.7
  • 19
    • 39149103752 scopus 로고    scopus 로고
    • Kajimoto,S., Horic,M., Manabe,H., Masuda,Y., Shibayama-Imazu,T., Nakajo,S., Gong,X.F., Obama.T., Itabe,H. and Nakaya,K. (2007) A tyrosine kinase inhibitor, beta-hydroxyisovalerylshikonin, induced apoptosis in human lung cancer DMS114 cells through reduction of dUTP nucleotidohydrolase activity. Biochim. Biophys. Acta., 1782, 41-50.
    • Kajimoto,S., Horic,M., Manabe,H., Masuda,Y., Shibayama-Imazu,T., Nakajo,S., Gong,X.F., Obama.T., Itabe,H. and Nakaya,K. (2007) A tyrosine kinase inhibitor, beta-hydroxyisovalerylshikonin, induced apoptosis in human lung cancer DMS114 cells through reduction of dUTP nucleotidohydrolase activity. Biochim. Biophys. Acta., 1782, 41-50.
  • 20
    • 33646240050 scopus 로고    scopus 로고
    • Functional proteomics of resveratrol-induced colon cancer cell apoptosis: Caspase-6-mediated cleavage of lamin A is a major signaling loop
    • Lee,S.C., Chan,J., Clement,M.V. and Pervaiz,S. (2006) Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop. Proteomics, 6, 2386-2394.
    • (2006) Proteomics , vol.6 , pp. 2386-2394
    • Lee, S.C.1    Chan, J.2    Clement, M.V.3    Pervaiz, S.4
  • 21
    • 33746437215 scopus 로고    scopus 로고
    • Transcriptional profiting of MCF7 breast cancer cells in response to 5-fluorouracil: Relationship with cell cycle changes and apoptosis, and identification of novel targets of p53
    • Hernandez-Vargas,H., Ballestar,E., Carmona-Saez,P., von Kobbe,C., Banon-Rodriguez,I., Esteller,M., Moreno-Bueno,G. and Palacios,J. (2006) Transcriptional profiting of MCF7 breast cancer cells in response to 5-fluorouracil: Relationship with cell cycle changes and apoptosis, and identification of novel targets of p53. Int. J. Cancer, 119, 1164-1175.
    • (2006) Int. J. Cancer , vol.119 , pp. 1164-1175
    • Hernandez-Vargas, H.1    Ballestar, E.2    Carmona-Saez, P.3    von Kobbe, C.4    Banon-Rodriguez, I.5    Esteller, M.6    Moreno-Bueno, G.7    Palacios, J.8
  • 24
    • 0037063173 scopus 로고    scopus 로고
    • Novel gain of function activity of p53 mutants: Activation of the dUTPase gene expression leading to resistance to 5-fluorouracil
    • Pugacheva,E.N., Ivanov,A.V., Kravchenko, J.E., Kopnin, B.P., Levine,A.J. and Chumakov,P.M. (2002) Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil. Oncogene, 21, 4595-4600.
    • (2002) Oncogene , vol.21 , pp. 4595-4600
    • Pugacheva, E.N.1    Ivanov, A.V.2    Kravchenko, J.E.3    Kopnin, B.P.4    Levine, A.J.5    Chumakov, P.M.6
  • 25
    • 0037530083 scopus 로고    scopus 로고
    • Identification of sequence determinants of human nuclear dUTPase isoform localization
    • Tinkelenberg,B.A., Fazzone,W., Lynch,F.J. and Ladner,R.D. (2003) Identification of sequence determinants of human nuclear dUTPase isoform localization. Exp. Cell Res., 287, 39-46.
    • (2003) Exp. Cell Res , vol.287 , pp. 39-46
    • Tinkelenberg, B.A.1    Fazzone, W.2    Lynch, F.J.3    Ladner, R.D.4
  • 26
    • 0029912969 scopus 로고    scopus 로고
    • Characterization of distinct nuclear and mitochondrial forms of human deoxyuridine triphosphate nucleotidohydrolase
    • Ladner,R.D., McNulty,D.E., Carr,S.A., Roberts,G.D. and Caradonna,S.J. (1996a) Characterization of distinct nuclear and mitochondrial forms of human deoxyuridine triphosphate nucleotidohydrolase. J. Biol. Chem. 271, 7745-7751.
    • (1996) J. Biol. Chem , vol.271 , pp. 7745-7751
    • Ladner, R.D.1    McNulty, D.E.2    Carr, S.A.3    Roberts, G.D.4    Caradonna, S.J.5
  • 27
    • 0024402491 scopus 로고
    • Enzymatic assay for deoxyribonucleoside triphosphates using synthetic oligonucleotides as template primers
    • Sherman,P.A. and Fyfe,J.A. (1989) Enzymatic assay for deoxyribonucleoside triphosphates using synthetic oligonucleotides as template primers. Anal. Biochem., 180, 222-226.
    • (1989) Anal. Biochem , vol.180 , pp. 222-226
    • Sherman, P.A.1    Fyfe, J.A.2
  • 28
    • 0030804554 scopus 로고    scopus 로고
    • Measurement of deoxyuridine triphosphate and thymidine triphosphate in the extracts of thymidylate synthase-inhibited cells using a modified DNA polymerase assay
    • Horowitz,R.W., Zhang,H., Schwartz,E.L., Ladner,R.D. and Wadler,S. (1997) Measurement of deoxyuridine triphosphate and thymidine triphosphate in the extracts of thymidylate synthase-inhibited cells using a modified DNA polymerase assay. Biochem. Pharmacol., 54, 635-638.
    • (1997) Biochem. Pharmacol , vol.54 , pp. 635-638
    • Horowitz, R.W.1    Zhang, H.2    Schwartz, E.L.3    Ladner, R.D.4    Wadler, S.5
  • 29
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak,K.J. and Schmittgen,T.D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods, 25, 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 30
    • 0037567591 scopus 로고    scopus 로고
    • A novel single nucleotide polymorphism within the 5′ tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity
    • Mandola,M.V., Stoehlmacher,J., Muller-Weeks,S., Cesarone,G., Yu,M.C., Lenz,H.J. and Ladner,R.D. (2003) A novel single nucleotide polymorphism within the 5′ tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity. Cancer Res., 63, 2898-2904.
    • (2003) Cancer Res , vol.63 , pp. 2898-2904
    • Mandola, M.V.1    Stoehlmacher, J.2    Muller-Weeks, S.3    Cesarone, G.4    Yu, M.C.5    Lenz, H.J.6    Ladner, R.D.7
  • 31
    • 0030931381 scopus 로고    scopus 로고
    • Distinct roles for Sp1 and E2F sites in the growth/cell cycle regulation of the DHFR promoter
    • Jensen,D.E., Black,A.R., Swick,A.G. and Azizkhan,J.C. (1997) Distinct roles for Sp1 and E2F sites in the growth/cell cycle regulation of the DHFR promoter. J. Cell. Biochem., 67, 24-31.
    • (1997) J. Cell. Biochem , vol.67 , pp. 24-31
    • Jensen, D.E.1    Black, A.R.2    Swick, A.G.3    Azizkhan, J.C.4
  • 32
    • 0029981560 scopus 로고    scopus 로고
    • Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction
    • Lin,S.Y., Black,A.R., Kostic,D., Pajovic,S., Hoover,C.N. and Azizkhan,J.C. (1996) Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction. Mol. Cell. Biol., 16 1668-1675.
    • (1996) Mol. Cell. Biol , vol.16 , pp. 1668-1675
    • Lin, S.Y.1    Black, A.R.2    Kostic, D.3    Pajovic, S.4    Hoover, C.N.5    Azizkhan, J.C.6
  • 33
    • 27544439766 scopus 로고    scopus 로고
    • Sp transcription factor family and its role in cancer
    • Safe,S. and Abdelrahim,M. (2005) Sp transcription factor family and its role in cancer. Eur. J. Cancer, 41, 2438-2448.
    • (2005) Eur. J. Cancer , vol.41 , pp. 2438-2448
    • Safe, S.1    Abdelrahim, M.2
  • 34
    • 11244325724 scopus 로고    scopus 로고
    • Inhibition of p53-mediated transcriptional responses by mithramycin A
    • Koutsodontis,G. and Kardassis,D. (2004) Inhibition of p53-mediated transcriptional responses by mithramycin A. Oncogene, 23, 9190-9200.
    • (2004) Oncogene , vol.23 , pp. 9190-9200
    • Koutsodontis, G.1    Kardassis, D.2
  • 35
    • 0033552595 scopus 로고    scopus 로고
    • Regulation of p53 in response to DNA damage
    • Lakin,N.D. and Jackson,S.P. (1999) Regulation of p53 in response to DNA damage. Oncogene, 18, 7644-7655.
    • (1999) Oncogene , vol.18 , pp. 7644-7655
    • Lakin, N.D.1    Jackson, S.P.2
  • 36
    • 33847244929 scopus 로고    scopus 로고
    • Drug resistance, predictive markers and pharmacogenomics in colorectal cancer
    • Longley,D.B., Allen,W.L. and Johnston,P.G. (2006) Drug resistance, predictive markers and pharmacogenomics in colorectal cancer. Biochim. Biophys. Acta, 1766, 184-196.
    • (2006) Biochim. Biophys. Acta , vol.1766 , pp. 184-196
    • Longley, D.B.1    Allen, W.L.2    Johnston, P.G.3
  • 37
    • 0037531121 scopus 로고    scopus 로고
    • Superiority of oxaliplatin and fluorouracil- leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil-leucovorin: Interim results of a phase III. trial
    • Rothenberg,M.L., Oza,A.M., Bigelow,R.H., Berlin,J.D., Marshall,J.L., Ramanathan,R.K., Hart,L.L., Gupta,S., Garay,C.A., Burger,B.G. et al. (2003) Superiority of oxaliplatin and fluorouracil- leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil-leucovorin: Interim results of a phase III. trial. J. Clin. Oncol., 21, 2059-2069.
    • (2003) J. Clin. Oncol , vol.21 , pp. 2059-2069
    • Rothenberg, M.L.1    Oza, A.M.2    Bigelow, R.H.3    Berlin, J.D.4    Marshall, J.L.5    Ramanathan, R.K.6    Hart, L.L.7    Gupta, S.8    Garay, C.A.9    Burger, B.G.10
  • 38
    • 1842735419 scopus 로고    scopus 로고
    • Proteolytic degradation of the nuclear isoform of uracil-DNA-glycosylase occurs during the S phase of the cell cycle
    • Fischer,J.A., Muller-Weeks,S. and Caradonna,S. (2004) Proteolytic degradation of the nuclear isoform of uracil-DNA-glycosylase occurs during the S phase of the cell cycle. DNA Repair, 3, 505-513.
    • (2004) DNA Repair , vol.3 , pp. 505-513
    • Fischer, J.A.1    Muller-Weeks, S.2    Caradonna, S.3
  • 39
    • 33749014429 scopus 로고    scopus 로고
    • Fluorodeoxyuridine Modulates Cellular Expression of the DNA Base Excision Repair Enzyme Uracil-DNA Glycosylase
    • Fischer,J.A., Muller-Weeks,S. and Caradonna,S.J. (2006) Fluorodeoxyuridine Modulates Cellular Expression of the DNA Base Excision Repair Enzyme Uracil-DNA Glycosylase. Cancer Res., 66 8829-8837.
    • (2006) Cancer Res , vol.66 , pp. 8829-8837
    • Fischer, J.A.1    Muller-Weeks, S.2    Caradonna, S.J.3
  • 40
    • 0041857759 scopus 로고    scopus 로고
    • p21/CDKN1A mediates negative regulation of transcription by p53
    • Lohr,K., Moritz,C., Contente,A. and Dobbclstein,M. (2003) p21/CDKN1A mediates negative regulation of transcription by p53. J. Biol. Chem. 278, 32507-32516.
    • (2003) J. Biol. Chem , vol.278 , pp. 32507-32516
    • Lohr, K.1    Moritz, C.2    Contente, A.3    Dobbclstein, M.4
  • 42
    • 0348223971 scopus 로고    scopus 로고
    • Transcription factor Sp1 expression is a significant predictor of survival in human gastric cancer
    • Wang,L., Wei,D., Huang,S., Peng,Z., Le,X., Wu,T.T., Yao,J., Ajani,J. and Xie,K. (2003) Transcription factor Sp1 expression is a significant predictor of survival in human gastric cancer. Clin. Cancer Res., 9, 6371-6380.
    • (2003) Clin. Cancer Res , vol.9 , pp. 6371-6380
    • Wang, L.1    Wei, D.2    Huang, S.3    Peng, Z.4    Le, X.5    Wu, T.T.6    Yao, J.7    Ajani, J.8    Xie, K.9
  • 43
    • 3042570272 scopus 로고    scopus 로고
    • Association between expression of transcription factor Spl and increased vascular endothelial growth factor expression, advanced stage, and poor survival in patients with resected gastric cancer
    • Yao,J.C., Wang,L., Wei,D., Gong,W., Hassan,M., Wu,T.T., Mansfield,P., Ajani,J. and Xie,K. (2004) Association between expression of transcription factor Spl and increased vascular endothelial growth factor expression, advanced stage, and poor survival in patients with resected gastric cancer. Clin. Cancer Res., 10, 4109-4117.
    • (2004) Clin. Cancer Res , vol.10 , pp. 4109-4117
    • Yao, J.C.1    Wang, L.2    Wei, D.3    Gong, W.4    Hassan, M.5    Wu, T.T.6    Mansfield, P.7    Ajani, J.8    Xie, K.9
  • 44
    • 0034192487 scopus 로고    scopus 로고
    • Levels of E2F-1 expression are higher in lung metastasis of colon cancer as compared with hepatic metastasis and correlate with levels of thymidylate synthase
    • Banerjee,D., Gorlick,R., Liefshitz,A., Danenberg,K., Danenberg,P.C., Danenberg,P.V., Klimstra,D., Jhanwar,S., Cordon-Cardo,C., Fong,Y. et al. (2000) Levels of E2F-1 expression are higher in lung metastasis of colon cancer as compared with hepatic metastasis and correlate with levels of thymidylate synthase. Cancer Res., 60, 2365-2367.
    • (2000) Cancer Res , vol.60 , pp. 2365-2367
    • Banerjee, D.1    Gorlick, R.2    Liefshitz, A.3    Danenberg, K.4    Danenberg, P.C.5    Danenberg, P.V.6    Klimstra, D.7    Jhanwar, S.8    Cordon-Cardo, C.9    Fong, Y.10
  • 45
    • 0036677062 scopus 로고    scopus 로고
    • Role of retinoblastoma protein and E2F-1 transcription factor in the acquisition of 5-fluorouracil resistance by colon cancer cells
    • Obama,K., Kanai,M., Kawai,Y., Fukushima,M. and Takabayashi,A. (2002) Role of retinoblastoma protein and E2F-1 transcription factor in the acquisition of 5-fluorouracil resistance by colon cancer cells. Int. J. Oncol., 21, 309-314.
    • (2002) Int. J. Oncol , vol.21 , pp. 309-314
    • Obama, K.1    Kanai, M.2    Kawai, Y.3    Fukushima, M.4    Takabayashi, A.5
  • 47
    • 85047699837 scopus 로고    scopus 로고
    • E2Fs up-regulate expression of genes involved in DNA replication. DNA repair and mitosis
    • Polager,S., Kalma,Y., Berkovich,E. and Ginsberg,D. (2002) E2Fs up-regulate expression of genes involved in DNA replication. DNA repair and mitosis. Oncogene, 21, 437-446.
    • (2002) Oncogene , vol.21 , pp. 437-446
    • Polager, S.1    Kalma, Y.2    Berkovich, E.3    Ginsberg, D.4
  • 48
    • 33847069272 scopus 로고    scopus 로고
    • TSP50 encodes a testis-specific protease and is negatively regulated by p53
    • Xu,H., Shan,J., Jurukovski,V., Yuan,L., Li,J. and Tian,K. (2007) TSP50 encodes a testis-specific protease and is negatively regulated by p53. Cancer Res., 67, 1239-1245.
    • (2007) Cancer Res , vol.67 , pp. 1239-1245
    • Xu, H.1    Shan, J.2    Jurukovski, V.3    Yuan, L.4    Li, J.5    Tian, K.6
  • 49
    • 38049113224 scopus 로고    scopus 로고
    • The action of Pdcd4 may be cell type specific: Evidence that reduction of dUTPasc levels might contribute to its tumor suppressor activity in Bon-1 cells
    • Lankat-Buttgereit,B., Lenschen,B., Schmidt,H. and Goke,R. (2008) The action of Pdcd4 may be cell type specific: Evidence that reduction of dUTPasc levels might contribute to its tumor suppressor activity in Bon-1 cells. Apoptosis, 13, 157-164.
    • (2008) Apoptosis , vol.13 , pp. 157-164
    • Lankat-Buttgereit, B.1    Lenschen, B.2    Schmidt, H.3    Goke, R.4
  • 50
    • 0035176182 scopus 로고    scopus 로고
    • Characterization of a thymidylate synthase (TS)-inducible cell line: A model system for studying sensitivity to TS- and non-TS-targeted chemotherapies
    • Longley,D.B., Ferguson,P.R., Boyer,J., Latif,T., Lynch,M., Maxwell,P., Harkin,D.P. and Johnston,P.G. (2001) Characterization of a thymidylate synthase (TS)-inducible cell line: A model system for studying sensitivity to TS- and non-TS-targeted chemotherapies. Clin. Cancer Res., 7, 3533-3539.
    • (2001) Clin. Cancer Res , vol.7 , pp. 3533-3539
    • Longley, D.B.1    Ferguson, P.R.2    Boyer, J.3    Latif, T.4    Lynch, M.5    Maxwell, P.6    Harkin, D.P.7    Johnston, P.G.8
  • 51
    • 0031864830 scopus 로고    scopus 로고
    • Oxaliplatin: Mechanism of action and antineoplastic activity
    • Raymond,E., Faivre,S., Waynarowski,J.M. and Chaney,S.G. (1998) Oxaliplatin: Mechanism of action and antineoplastic activity. Semin. Oncol., 25, 4-12.
    • (1998) Semin. Oncol , vol.25 , pp. 4-12
    • Raymond, E.1    Faivre, S.2    Waynarowski, J.M.3    Chaney, S.G.4
  • 52
    • 1642327569 scopus 로고    scopus 로고
    • Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil, oxaliplatin, and irinotecan
    • Boyer,J., McLean,E.G., Aroori,S., Wilson,P., McCulla,A., Carey,P.D., Longley,D.B. and Johnston,P.G. (2004) Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil, oxaliplatin, and irinotecan. Clin. Cancer Res., 10, 2158-2167.
    • (2004) Clin. Cancer Res , vol.10 , pp. 2158-2167
    • Boyer, J.1    McLean, E.G.2    Aroori, S.3    Wilson, P.4    McCulla, A.5    Carey, P.D.6    Longley, D.B.7    Johnston, P.G.8
  • 53
    • 34547118327 scopus 로고    scopus 로고
    • Regulation of p53 expression in response to 5-fluorouracil in human cancer RKO cells
    • Ju,J., Schmitz,J.C., Song,B., Kudo,K. and Chu,E. (2007) Regulation of p53 expression in response to 5-fluorouracil in human cancer RKO cells. Clin. Cancer Res., 13, 4245-4251.
    • (2007) Clin. Cancer Res , vol.13 , pp. 4245-4251
    • Ju, J.1    Schmitz, J.C.2    Song, B.3    Kudo, K.4    Chu, E.5
  • 56
    • 44649094568 scopus 로고    scopus 로고
    • p53-dependent repression of the human MCL-1 gene encoding an anti-apoptotic member of the BCL-2 family: The role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoter
    • Pietrzak,M. and Puzianowska-Kuznicka,M. (2008) p53-dependent repression of the human MCL-1 gene encoding an anti-apoptotic member of the BCL-2 family: The role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoter. Biol. Chem., 389, 383-393.
    • (2008) Biol. Chem , vol.389 , pp. 383-393
    • Pietrzak, M.1    Puzianowska-Kuznicka, M.2
  • 57
    • 33746819118 scopus 로고    scopus 로고
    • Dhar,S.K., Xu,Y., Chen,Y. and St Clair,D.K. (2006) Specificity protein 1-dependent p53-mediated suppression of human manganese superoxide dismutase gene expression. J Brol. Chem., 281, 21698-21709.
    • Dhar,S.K., Xu,Y., Chen,Y. and St Clair,D.K. (2006) Specificity protein 1-dependent p53-mediated suppression of human manganese superoxide dismutase gene expression. J Brol. Chem., 281, 21698-21709.
  • 58
    • 41149097172 scopus 로고    scopus 로고
    • Regulation of the human AP-endonuclease (APE1,Ref-1) expression by the tumor suppressor p53 in response to DNA damage
    • Zaky,A., Busso,C. Izumi,T., Chattopadhyay,R., Bassiouny,A., Mitra,S. and Bhakat,K.K. (2008) Regulation of the human AP-endonuclease (APE1,Ref-1) expression by the tumor suppressor p53 in response to DNA damage. Nucleic Acids Res., 5, 1555-1566.
    • (2008) Nucleic Acids Res , vol.5 , pp. 1555-1566
    • Zaky, A.1    Busso, C.2    Izumi, T.3    Chattopadhyay, R.4    Bassiouny, A.5    Mitra, S.6    Bhakat, K.K.7
  • 59
    • 0035264636 scopus 로고    scopus 로고
    • Spl-p53 heterocomplex mediates activation of HTLV-I long terminal repeat by 12-O-tetradecanoyl- phorbol-13-acetate that is antagonized by protein kinase C
    • Torgeman,A., Mor-Vaknin,N., Zelin,E., Ben-Aroya,Z., Lochelt,M., Flugel,R.M. and Aboud,M. (2001) Spl-p53 heterocomplex mediates activation of HTLV-I long terminal repeat by 12-O-tetradecanoyl- phorbol-13-acetate that is antagonized by protein kinase C. Virology 281, 10-20.
    • (2001) Virology , vol.281 , pp. 10-20
    • Torgeman, A.1    Mor-Vaknin, N.2    Zelin, E.3    Ben-Aroya, Z.4    Lochelt, M.5    Flugel, R.M.6    Aboud, M.7
  • 60
    • 0033215387 scopus 로고    scopus 로고
    • Transcriptional repression by wild-type p53 utilizes historic dwacetylases, mediated by interaction with mSin3a
    • Murphy,M., Ahn,J., Walker,K.K., Hoffman,W.H., Evans,R.M., Levine,A.J. and George,D.L. (1999) Transcriptional repression by wild-type p53 utilizes historic dwacetylases, mediated by interaction with mSin3a. Genes Dev., 13, 2490-2501.
    • (1999) Genes Dev , vol.13 , pp. 2490-2501
    • Murphy, M.1    Ahn, J.2    Walker, K.K.3    Hoffman, W.H.4    Evans, R.M.5    Levine, A.J.6    George, D.L.7
  • 61
    • 0036988907 scopus 로고    scopus 로고
    • Can capecitabine replace 5-FU leucovorin in combination with oxaliplatin for the treatment of advanced colorectal cancer?
    • Twelves,C. (2002) Can capecitabine replace 5-FU leucovorin in combination with oxaliplatin for the treatment of advanced colorectal cancer? Oncology, 16, 23-26.
    • (2002) Oncology , vol.16 , pp. 23-26
    • Twelves, C.1
  • 62
    • 1942485339 scopus 로고    scopus 로고
    • Down-regulation of thymidylate synthase expression and its steady-state mRNA by oxaliplatin in colon cancer cells
    • Yeh,K.H., Cheng,A.L., Wan,J.P., Lin,C.S. and Liu,C.C. (2004) Down-regulation of thymidylate synthase expression and its steady-state mRNA by oxaliplatin in colon cancer cells. Anticancer Drugs, 15 371-376.
    • (2004) Anticancer Drugs , vol.15 , pp. 371-376
    • Yeh, K.H.1    Cheng, A.L.2    Wan, J.P.3    Lin, C.S.4    Liu, C.C.5
  • 63
    • 0036189997 scopus 로고    scopus 로고
    • Boisdron-Celle,M., Craipeau,C., Brienza,S. Delva,R., Guerin-Meyer,V., Cvitkovic.E. and Gamelin.E. (2002) Influence of oxaliplatin on 5-fluorouracil plasma clearance and clinical consequences. Cancer Chemother. Pharmacol., 49, 235-243.
    • Boisdron-Celle,M., Craipeau,C., Brienza,S. Delva,R., Guerin-Meyer,V., Cvitkovic.E. and Gamelin.E. (2002) Influence of oxaliplatin on 5-fluorouracil plasma clearance and clinical consequences. Cancer Chemother. Pharmacol., 49, 235-243.


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