Expression of deoxyuridine triphosphatase (dUTPase) in colorectal tumours

International Journal of Cancer

Volumn 84, Issue 6, 1999, Pages 614-617

  Fleischmann, Johann ^a   Kremmer, Elisabeth ^b   Müller, Susanna ^a   Sommer, Peter ^c   Kirchner, Thomas ^a   Niedobitek, Gerald ^a   Grässer, Friedrich A ^c  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; FLUOROURACIL; KI 67 ANTIGEN; MONOCLONAL ANTIBODY;

ADULT; AGED; ARTICLE; CANCER GRADING; CELL PROLIFERATION; CLINICAL ARTICLE; COLON ADENOCARCINOMA; COLON ADENOMA; COLORECTAL TUMOR; CONTROLLED STUDY; DRUG RESISTANCE; FEMALE; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; RECTUM ADENOMA; RECTUM CARCINOMA;

ADENOCARCINOMA; ADENOMA; AGED; ANTIBODIES, MONOCLONAL; COLORECTAL NEOPLASMS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; HUMANS; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; POLYPS; PYROPHOSPHATASES; STATISTICS, NONPARAMETRIC; TUMOR MARKERS, BIOLOGICAL;

EID: 0032763166     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19991222)84:6<614::AID-IJC13>3.0.CO;2-P     Document Type: Article

References (11)

1. CANMAN, C.E., LAWRENCE, T.S., SHEWACH, D.S., TANG, H.-Y. and MAYBAUM, J., Resistance to fluorodeoxyxuridine-induced DNA damage and cytotoxicity correlates with an elevation of deoxyuridine triphosphatase activity and failure to accumulate deoxyuridine triphosphate. Cancer Res., 53, 5219-5224 (1993).
2. CANMAN, C.E., RADANY, E.H., PARSELS, L.A., DAVIS, M.A., LAWRENCE, T.S. and MAYBAUM, J., Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumour cells by expression of Escherichia coli deoxyuridinetriphosphatase. Cancer Res., 54, 2296-2298 (1994).
3. GERDES, J., SCHWAB, U., LEMKE, H. and STEIN, H., Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int. J. Cancer, 31, 13-20 (1983).
4. GOULIAN, M., BLEILE, B. and TSENG, B.Y., The effect of methotrexate on levels of dUTP in animal cells. J. biol. Chem., 255, 10630-10637 (1980a).
5. GOULIAN, M., BLEILE, B. and TSENG, B.Y., Methotrexate-induced misincorporation of uracil into DNA. Proc. nat. Acad. Sci. (Wash.). 77, 1956-1960 (1980b).
6. JANSSON, A. and SUN, X.-F., Ki-67 expression in relation to clinicopathological variables and prognosis in colorectal adenocarcinomas. APMIS, 105, 730-734 (1997).
7. JOHNSTON, P.G., O'BRIEN, M.J., DERVAN, P.A. and CARNEY, D.N., Immunohistochemical analysis of cell kinetic parameters in colorectal adenocarcinomas, adenomas and normal mucosa. Hum. Pathol., 20, 696-700 (1989).
8. KREMMER, E., SOMMER, P. and GRÄSSER, F.A., Epstein-Barr-virus-encoded deoxyuridine triphosphate nucleotidyohydrolase (dUTPas): a potential target for drug therapy. Transplant. Proc., 29, 812-814 (1997).
9. MAHAGAOKAR, S., ORENGO, A. and RAO, P.N., The turnover of deoxyuridine triphosphate during the HeLa cell cycle. Exp. Cell Res., 125, 87-94 (1980).
10. MCINTOSH, E.M. and HAYNES, R.H., dUTP prophosphatase as a potential target for chemotherapeutic drug development. Acta biochim. pol., 44, 159-171 (1997).
11. STRAHLER, J.R., ZHU, X.-X., HORA, N., WANG, Y.K., ANDREWS, P.C., ROSEMAN, N.A., NEEL, J.V., TURKA, L. and HANASH, S.M., Maturation stage and proliferation-dependent expression of dUTPase in human T cells. Proc. nat. Acad. Sci. (Wash.), 90, 4991-4995 (1993).