Pathways involved in testicular germ cell apoptosis induced by H 2O2in vitro

FEBS Journal

Volumn 276, Issue 3, 2009, Pages 870-881

  Maheshwari, Ankur ^a   Misro, Man M ^a   Aggarwal, Archana ^a   Sharma, Rajnesh K ^b   Nandan, Deoki ^a  

^a NATIONAL INSTITUTE OF HEALTH AND FAMILY WELFARE   (India)

^b KURUKSHETRA UNIVERSITY   (India)

Author keywords

Apoptosis; Germ cell; H2O2; Pathways; Testis

Indexed keywords

CASPASE 8; CASPASE 9; CATALASE; FAS ANTIGEN; FAS LIGAND; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BAD; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE DISMUTASE; SYNAPTOPHYSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GERM CELL; IN VITRO STUDY; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; TESTIS; UPREGULATION;

ANIMALS; APOPTOSIS; CELLS, CULTURED; GENE EXPRESSION REGULATION; GERM CELLS; HYDROGEN PEROXIDE; MALE; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TESTIS;

EID: 58449133203     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2008.06831.x     Document Type: Article

References (46)

1. Kerr JB (1992) Spontaneous degeneration of germ cells in normal rat testis: assessment of cell types and frequency during the spermatogenic cycle. J Reprod Fertil 95, 825 830.
2. Tapanainen JS, Tilly JL, Vihko KK Hsueh AJW (1993) Hormonal control of apoptotic cell death in the testis: gonadotropins and androgens as testicular cell survival factors. Mol Endocrinol 7, 643 650.
3. Peltola V, Huhtaniemi I Ahutopa M (1992) Antioxidant enzyme activity in the maturing rat testis. J Androl 13, 450 455.
4. Aitken RJ, Gordon E, Harkiss D, Twigg JP, Milne P, Jennings Z Irvine DS (1998) Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa. Biol Reprod 59, 1037 1046.
5. Hampton MB Orrenius S (1997) Dual regulation of caspase activity by hydrogen peroxide:implications for apoptosis. FEBS Lett 414, 552 556.
6. Genestra M (2007) Oxyl radicals, redox-sensitive signalling cascades and antioxidants. Cell Signal 19, 1807 1919.
7. Sinha-Hikim AP, Lue Y, Diaz-Romero M, Yen PH, Wang C Swerdloff RS (2003) Deciphering the pathways of germ cell apoptosis in the testis. J Steroid Biochem Mol Biol 85, 175 182.
8. Nagata S Golstein P (1995) The Fas death factor. Science 267, 1449 1456.
9. Cory S Adams JM (2002) The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2, 647 656.
10. Hengartner MO (2000) The biochemistry of apoptosis. Nature 407, 770 776.
11. 2 at physiological concentrations modulates leydig cell function inducing oxidative stress and apoptosis. Apoptosis 11, 39 46.
12. 2 levels and induces germ cell apoptosis in the rat testis. Apoptosis 12 (7 1173 1182.
13. Gechev TS Hille J (2005) Hydrogen peroxide as a signal controlling plant programmed cell death. J Cell Biol 168, 17 20.
14. Kim DK, Cho ES Um HD (2000) Caspase dependent and independent events in apoptosis induced by hydrogen peroxide. Exp Cell Res 257, 82 88.
15. Dumont A, Hehner SP, Hofmann TG, Ueffing M, Droge W Schmitz ML (1999) Hydrogen peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-kB. Oncogene 18, 747 757.
16. 2 treatment. Eur J Cell Biol 80, 222 229.
17. Chaki SP, Ghosh D Misro MM (2003) Simultaneous increase in germ cell apoptosis and oxidative stress under acute unilateral testicular ischemia in rats. Intl J Androl 26, 319 328.
18. Chaki SP, Misro MM, Ghosh D, Gautam DK Srinivas M (2005) Apoptosis and cell removal in the cryptorchid rat testis. Apoptosis 10, 395 406.
19. Eid NAS, Shibata M-A, Ito Y, Kusakabe K, Hammad H Otsuki Y (2002) Involvement of Fas system and active caspases in apoptotic signaling in testicular germ cells of ethanol-treated rats. Int J Androl 25, 159 167.
20. Huang W, Dobberfuhl A, Filippopoulos T, Ingelsson M, Fileta JB, Poulin AR Grosskreutz CL (2005) Transcriptional up regulation and activation of initiating caspases in experimental glaucoma. Am J Pathol 167, 673 681.
21. Chausiaux OE, Abel MH, Baxter FO, Khaled WT, Ellis PJ, Charlton HM Affara NA (2008) Hypogonadal mouse, a model to study the effect of the endogenous lack of gonadotropins on apoptosis. Biol Reprod 78, 77 90.
22. Woolveridge I, de Boer-brouwer M, Taylor MF, Teerds KJ, Wu FCW Morris ID (1999) Apoptosis in the rat spermatogenetic epithelium following androgen withdrawal: changes in apoptosis related genes. Biol Reprod 60, 461 470.
23. Rodriguez I, Ody C, Araki K, Garcia I Vassalli P (1997) An early and massive wave of germinal cell apoptosis is required for the development of functional spermatogenesis. EMBO J 16, 2262 2270.
24. Yan W, Suominen J, Samson M, Jegou B Toppari J (2000) Involvement of Bcl-2 family proteins in germ cell apoptosis during testicular development in the rat and pro-survival effect of stem cell factor on germ cells in vitro. Mol Cell Endocrinol 165, 115 129.
25. Richburg JH (2000) The relevance of spontaneous- and chemically-induced alterations in testicular germ cell apoptosis to toxicology. Toxicol Lett 112, 113, 79 86.
26. Jang JH Surh YJ (2004) Bcl-2 protects against Aβ25-35-induced oxidative PC12 cell death by potentiation of antioxidant capacity. Biochem Biophys Res Commun 320, 880 886.
27. Hockenbery DM, Oltvai ZN, Yin XM, Milliman CL Korsmeyer SJ (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75, 241 251.
28. Carmody RJ Cotter TG (2001) Signalling apoptosis: a radical approach. Red Report 6, 77 90.
29. Chandrasekaran Y Richburg JH (2005) The p53 protein influences the sensitivity of testicular germ cells to mono-(2-ethylhexyl) phthalate-induced apoptosis by increasing the membrane levels of Fas and DR5 and decreasing the intracellular amount of c-FLIP. Biol Reprod 72, 206 213.
30. Delfino F Walker WH (1999) Hormonal regulation of the NF-κB signaling pathway. Mol Cell Endocrinol 157, 1 9.
31. Pentikainen V, Suomalainen L, Erkkila K, Martelin E, Parvinen M, Pentikainen MO Dunkel L (2002) Nuclear factor-kappa B activation in human testicular apoptosis. Am J Pathol 160, 205 218.
32. Rasoulpour RJ Boekelheide K (2007) NF-kappaB activation elicited by ionizing radiation is proapoptotic in testis. Biol Reprod 76, 279 285.
33. Shen H-M Liu Z-G (2006) JNK signalling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species. Free Rad Biol Med 40, 928 939.
34. Kim D-S, Jeon S-E, Jeong Y-M, Kim S-Y, Kwon S-B Park K-C (2006) Hydrogen peroxide is a mediator of indole-3-acetic acid/horshradish peroxidase-induced apoptosis. FEBS Lett 580, 1439 1446.
35. Lee MW, Park SC, Yang YG, Yim SO, Chae HS, Bach JH, Lee HJ, Kim KY, Lee WB Kim SS (2002) The involvement of reactive oxygen species (ROS) and p38 mitogen activated protein (MAP) kinase in TRAIL/Apo2L-induced apoptosis. FEBS Lett 512, 313 318.
36. Park MT, Choi JA, Kim MJ, Um H-D, Bae S, Kang C-M, Cho C-K, Kang S, Chung HY Lee Y-S (2003) Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells. J Biol Chem 278, 50624 50634.
37. Vera Y, Erkkila K, Wang C, Nunez C, Kyttanen S, Lue Y, Dunkel L, Swerdloff RS Sinha-Hikim AP (2006) Involvement of p38 mitogen-activated protein kinase and inducible nitric oxide synthase in apoptotic signaling of murine and human male germ cells after hormone deprivation. Mol Endocrinol 20, 1597 1609.
38. Ikeda M, Kodama H, Fukuda J, Shimizu Y, Murata M, Kumagai J Tanaka T (1999) Role of radical oxygen species in rat testicular germ cell apoptosis induced by heat stress. Biol Reprod 61, 393 399.
39. Ohkawa H, Ohishi N Yagi K (1979) Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction. Anal Biochem 95, 351 358.
40. Das K, Samantha L Chainy GBN (2000) A modified spectrophotometric assay of superoxide dismutase using nitrite formation of superoxide radicals. Indian J Biochem Biophy 237, 201 204.
41. Aebi H (1984) Catalse in vitro. Meth Enzymol 105, 121 126.
42. Habig WH, Pabst MJ Jakoby WB (1974) Glutathione-s-transferase. J Biol Chem 249, 7130 7139.
43. Lievre V, Becuwe P, Bianchi A, Bossenmeyer-Pourie C, Koziel V, Franck P, Nicolas MB, Dauca M, Vert P Daval JL (2001) Intracellular generation of free radicals and modifications of detoxifying enzymes in cultured neurons from the developing rat forebrain in response to transient hypoxia. Neuroscience 105, 287 297.
44. Tolba RH, Schildberg FA, Schnurr C, Glatzel U, Decker D Minor T (2006) Reduced liver apoptosis after venous systemic oxygen persufflation in non-heart-beating donors. J Invest Surg 19, 219 227.
45. Lee J, Richburg JH, Younkin SC Boekelheide K (1997) The Fas system is a key regulator of germ cell apoptosis in the testis. Endocrinology 138, 2081 2088.
46. Ohsako S, Kubota K, Kurosawa S, Takeda K, Qing W, Ishimura R Tohyama C (2003) Alterations of gene expression in adult male rat testis and pituitary shortly after subacute administration of the antiandrogen flutamide. J Reprod Dev 49, 275 290.