Deciphering the pathways of germ cell apoptosis in the testis

Journal of Steroid Biochemistry and Molecular Biology

Volumn 85, Issue 2-5, 2003, Pages 175-182

  Sinha Hikim, Amiya P ^a   Lue, Yanhe ^a   Diaz Romero, Maruja ^a   Yen, Pauline H ^a   Wang, Christina ^a   Swerdloff, Ronald S ^a  

^a HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Bax; Caspases; Cytochrome c; Mitochondria; Testis

Indexed keywords

CASPASE 9; CYTOCHROME C; FAS ANTIGEN; FAS LIGAND; PROTEIN BAX;

ANIMAL CELL; APOPTOSIS; CELL DEATH; CELL FRACTIONATION; CELL LYSATE; CELL SPECIFICITY; CONFERENCE PAPER; CONTROLLED STUDY; CYTOSOL; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; GERM CELL; MITOCHONDRION; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PROTEIN DEGRADATION; RAT; SCROTUM; SIGNAL TRANSDUCTION; TEMPERATURE DEPENDENCE; TESTIS; WESTERN BLOTTING;

EID: 0041386552     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(03)00193-6     Document Type: Conference Paper

References (32)

1. L.D. Russell, R.A. Ettlin, A.P. Sinha Hikim, E.D. Clegg, Histological and Histopathological Evaluation of the Testis, Cache River Press, Clearwater, FL, 1990, pp. 1-275.
2. R.M. Sharpe, Regulation of spermatogenesis, in: E. Knobil, J.D. Neil (Eds.), The Physiology of Reproduction, Raven Press, New York, 1994, pp. 1363-1434.
3. Sinha Hikim A.P., Wang C., Leung A., Swerdloff R.S. Involvement of apoptosis in the induction of germ cell degeneration in adult rats after gonadotropin-releasing hormone antagonist treatment. Endocrinology. 136:1995;2770-2775.
4. Sinha Hikim A.P., Rajavashisth T.B., Sinha Hikim I., Lue Y., Bonavera J.J., Leung A., Wang C., Swerdloff R.S. Significance of apoptosis in the temporal and stage-specific loss of germ cells in the adult rat after gonadotropin deprivation. Biol. Reprod. 57:1997;1193-1201.
5. Blanco-Rodriguez J., Martinenz-Garcia C. Apoptosis precedes detachment of germ cells from the seminiferous epithelium after hormone suppression by short-term oestradiol treatment of rats. Int. J. Androl. 21:1998;109-115.
6. Lue Y., Sinha Hikim A.P., Wang C., Im M., Leung A., Swerdloff R.S. Testicular heat exposure enhances the suppression of spermatogenesis by testosterone in rats: the "two-hit" approach to male contraceptive development. Endocrinology. 141:2000;1414-1424.
7. Lue Y., Sinha Hikim A.P., Swerdloff R.S., Im P., Taing K.S., Bui T., Leung A., Wang C. Single exposure to heat induces stage-specific germ cell apoptosis in rats: role of intratesticular testosterone (T) on stage-specificity. Endocrinology. 140:1999;1709-1717.
8. Lee J., Richburg J.H., Shipp E.B., Meistrich M.L., Boekelheide K. The Fas system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in Sertoli cell versus germ cell injury of the testis. Endocrinology. 140:1999;852-858.
9. Cai L., Hales B.F., Robaire B B. Induction of apoptosis in the germ cells of adult male rats after exposure to cyclophosphamide. Biol. Reprod. 56:1997;1490-1497.
10. Sinha Hikim A.P., Wang C., Lue Y., Johnson L., Wang X.H., Swerdloff R.S. Spontaneous germ cell apoptosis in humans: evidence for ethnic differences in the susceptibility of germ cells to programmed cell death. J. Clin. Endocr. Metab. 83:1998;152-156.
11. Dunkel L., Taskinen S., Hovatta O., Tilly J.L., Wikstrom S. Germ cell apoptosis after treatment of cryptorchidism with human chorionic gonadotropin is associated with impaired reproductive function in the adult. J. Clin. Invest. 100:1997;2341-2346.
12. Hadziselimovic F., Geneto R., Emmons L.R. Increased apoptosis in the contralateral testis in patients with testicular torsion. Lancet. 350:1997;118.
13. Lin W.W., Lamb D.J., Wheeler T.M., Lipshultz L.I., Kim E.D. In situ end-labeling of human testicular tissue demonstrates increased apoptosis in conditions of abnormal spermatogenesis. Fertil. Steril. 68:1997;1065-1069.
14. Lin W.W., Lamb D.J., Wheeler T.M., Abrams J., Lipshultz L.I., Kim E.D. Apoptotic frequency is increased in spermatogenic maturation arrest and hypospermatogenic states. J. Urol. 158:1997;1791-1793.
15. Adams J.M., Cory S. The bcl-2 protein family: arbiters of cell survival. Science. 281:1998;1322-1326.
16. Ashkenazi A., Dixit V.M. Death receptors: signaling and modulation. Science. 281:1998;1305-1308.
17. Green D.R. Apoptotic pathways: paper wraps stone blunts scissors. Cell. 102:2000;1-4.
18. Hengartner M.O. The biochemistry of apoptosis. Nature. 407:2000;770-776.
19. Reed J.C. Mechanisms of apoptosis. Am. J. Pathol. 157:2000;1415-1430.
20. Nakagawa T., Zhu H., Morishima N., Li E., Xu J., Yankner B.A., Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β Nature. 403:2000;98-103.
21. World Health Organization Task Force on methods for the regulation of male fertility, Contraceptive efficacy of testosterone-induced azoospermia in normal men. Lancet 336 (1990) 955-959.
22. Yamamoto C.M., Sinha Hikim A.P., Huynh P.N., Shapiro B., Lue Y., Salameh W.A., Wang C., Swerdloff R.S. Redistribution of Bax is an early step in an apoptotic pathway leading to germ cell death in rats, triggered by mild testicular hyperthermia. Biol. Reprod. 63:2000;1683-1690.
23. A.P. Sinha Hikim, Y. Lue, C.M. Yamamoto, Y. Vera, S. Rodriguez, P.H. Yen, K. Soeng, C. Wang, R.S. Swerdloff, Key apoptotic pathways for heat-induced programmed germ cell death in the testis, Endocrinology, in press.
24. Wang X. The extending role of mitochondria in apoptosis. Genes Dev. 15:2001;2922-2933.
25. Li K., Li Y., Shelton J.M., Richardson J.A., Spencer E., Chen Z.J., Wang X., Sanders Williams R. Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis. Cell. 101:2000;389-399.
26. Yoshida H., Kong Y.-Y., Yoshida R., Elia A.J., Hakem A., Hakem R., Penninger J.M., Mak T.W. Apaf-1 is required for mitochondrial pathways of apoptosis and brain development. Cell. 94:1998;739-750.
27. Kuida K., Haydar T.F., Kuan C.-Y., Gu Y., Taya C., Karasuyama H., Su M.S.S., Rakic P., Flavell R.A. Reduced apoptosis and cytochrome-mediated caspase activation in mice lacking caspase 9. Cell. 94:1998;325-337.
28. Hakem R., Hakem A., Duncan G.S., Hengerson J.T., Woo M., Soengas M.S., Elia A., de la Pompa J.L., Kagi D., Khoo W., Potter J., Yoshida R., Kaufman S.A., Lowe S.W., Penninger J.M., Mak T.W. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell. 94:1998;339-352.
29. Wei M.C., Zong W.-X., Cheng E.H.-Y., Lindsten T., Panoutsakopoulou V., Ross A.J., Roth K.A., MacGregor G.R., Thompson C.B., Korsmeyer S.J. Proapoptotic Bax and Bak: a requisite gateway to mitochondrial dysfunction and death. Science. 292:2001;727-730.
30. Nagata S., Golstein P. The Fas death factor. Science. 267:1995;1449-1455.
31. Richberg J.H., Nanez A., Williams L.R., Embree M.E., Boekelheide K. Sensitivity of testicular germ cells to toxicant-induced apoptosis in gld mice that express a nonfunctional form of Fas-ligand. Endocrinology. 141:2000;787-793.
32. Putcha G.V., Harris C.A., Moulder K.L., Easton R.M., Thompson C.B., Johnson E.M. Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons for the analysis of mutant mice. J. Cell. Biol. 157:2002;441-453.