NF-kappaB activation elicited by ionizing radiation is proapoptotic in testis

Biology of Reproduction

Volumn 76, Issue 2, 2007, Pages 279-285

  Rasoulpour, Reza J ^a   Boekelheide, Kim ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

Apoptosis; Ionizing radiation; NF kappaB; Spermatogenesis; Toxicology

Indexed keywords

CASPASE 3; CASPASE 9; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P21;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CELL STRESS; CONTROLLED STUDY; ENZYME ACTIVATION; IN VIVO STUDY; IONIZING RADIATION; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; RADIATION INJURY; REAL TIME POLYMERASE CHAIN REACTION; SPERMATOZOON COUNT; TESTIS;

ANIMALS; APOPTOSIS; CASPASES; DISEASE SUSCEPTIBILITY; ENZYME ACTIVATION; GAMMA RAYS; GENE EXPRESSION PROFILING; I-KAPPA B KINASE; MALE; MICE; MICE, KNOCKOUT; NF-KAPPA B; PHENOTYPE; RADIATION INJURIES; RNA; SPERMATOZOA; TESTIS; TIME FACTORS;

MUS;

EID: 33846888271     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod.106.054924     Document Type: Article

References (35)

1. Holdcraft RW, Braun RE. Hormonal regulation of spermatogenesis. Int J Androl 2004; 27:335-342.
2. Lilienbaum A, Sage J, Memet S, Rassoulzadegan M, Cuzin F, Israel A. NF-kappa B is developmentally regulated during spermatogenesis in mice. Dev Dyn 2000; 219:333-340.
3. Sage J, Martin L, Cuzin F, Rassoulzadegan M. cDNA sequence of the murine synaptonemal complex protein 1 (SCP1). Biochim Biophys Acta 1995; 1263:258-260.
4. Delfino F, Walker WH. Stage-specific nuclear expression of NF-kappaB in mammalian testis. Mol Endocrinol 1998; 12:1696-1707.
5. Pentikainen V, Suomalainen L, Erkkila K, Martelin E, Parvinen M, Pentikainen MO, Dunkel L. Nuclear factor-kappa B activation in human testicular apoptosis. Am J Pathol 2002; 160:205-218.
6. Delfino FJ, Walker WH. NF-kappaB induces cAMP-response element-binding protein gene transcription in Sertoli cells. J Biol Chem 1999; 274:35607-35613.
7. Delfino F, Walker WH. Hormonal regulation of the NF-kappaB signaling pathway. Mol Cell Endocrinol 1999; 157:1-9.
8. Delfino FJ, Boustead JN, Fix C, Walker WH. NF-kappaB and TNF-alpha stimulate androgen receptor expression in Sertoli cells. Mol Cell Endocrinol 2003; 201:1-12.
9. Suominen JS, Wang Y, Kaipia A, Toppari J. Tumor necrosis factor-alpha (TNF-alpha) promotes cell survival during spermatogenesis, and this effect can be blocked by infliximab, a TNF-alpha antagonist. Eur J Endocrinol 2004; 151:629-640.
10. Lysiak JJ, Bang HJ, Nguyen QA, Turner TT. Activation of the nuclear factor kappa B pathway following ischemia-reperfusion of the murine testis. J Androl 2005; 26:129-135.
11. Rasoulpour RJ, Boekelheide K. NF-kappaB is activated in the rat testis following exposure to mono-(2-ethylhexyl) phthalate. Biol Reprod 2005; 72:479-486.
12. Karin M. How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex. Oncogene 1999; 18:6867-6874.
13. Karin M. The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation. J Biol Chem 1999; 274:27339-27342.
14. Li ZW, Chu W, Hu Y, Delhase M, Deerinck T, Ellisman M, Johnson R, Karin M. The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med 1999; 189:1839-1845.
15. Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature 1995; 376:167-170.
16. Li ZW, Omori SA, Labuda T, Karin M, Rickert RC. IKK beta is required for peripheral B cell survival and proliferation. J Immunol 2003; 170: 4630-4637.
17. Rasoulpour RJ, Boekelheide K. The Sycp-1Cre transgenic mouse and male germ cell inhibition of NF-{kappa}B. J Androl 2006; 27:729-733.
18. Li N, Karin M. Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms. Proc Natl Acad Sci U S A 1998; 95:13012-13017.
19. Vidal F, Sage J, Cuzin F, Rassoulzadegan M. Cre expression in primary spermatocytes: a tool for genetic engineering of the germ line. Mol Reprod Dev 1998; 51:274-280.
20. Sage J, Martin L, Meuwissen R, Heyting C, Cuzin F, Rassoulzadegan M. Temporal and spatial control of the Sycp1 gene transcription in the mouse meiosis: regulatory elements active in the male are not sufficient for expression in the female gonad. Mech Dev 1999; 80:29-39.
21. Rassoulzadegan M, Magliano M, Cuzin F. Transvection effects involving DNA methylation during meiosis in the mouse. EMBO J 2002; 21:440-450.
22. Chung SS, Cuzin F, Rassoulzadegan M, Wolgemuth DJ. Primary spermatocyte-specific Cre recombinase activity in transgenic mice. Transgenic Res 2004; 13:289-294.
23. Egan LJ, Eckmann L, Greten FR, Chae S, Li ZW, Myhre GM, Robine S, Karin M, Kagnoff MF. IkappaB-kinase beta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Proc Natl Acad Sci U S A 2004; 101:2452-2457.
24. Rasoulpour RJ, Schoenfeld HA, Gray DA, Boekelheide K. Expression of a K48R mutant ubiquitin protects mouse testis from cryptorchid injury and aging. Am J Pathol 2003; 163:2595-2603.
25. Inan MS, Rasoulpour RJ, Yin L, Hubbard AK, Rosenberg DW, Giardina C. The luminal short-chain fatty acid butyrate modulates NF-kappaB activity in a human colonie epithelial cell line. Gastroenterology 2000; 118:724-734.
26. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001; 29:e45.
27. Embree-Ku M, Venturini D, Boekelheide K. Fas is involved in the p53-dependent apoptotic response to ionizing radiation in mouse testis. Biol Reprod 2002; 66:1456-1461.
28. Sha WC, Liou HC, Tuomanen EI, Baltimore D. Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses. Cell 1995; 80:321-330.
29. Lee SJ, Dimtchev A, Lavin MF, Dritschilo A, Jung M. A novel ionizing radiation-induced signaling pathway that activates the transcription factor NF-kappaB. Oncogene 1998; 17:1821-1826.
30. Piret B, Schoonbroodt S, Piette J. The ATM protein is required for sustained activation of NF-kappaB following DNA damage. Oncogene 1999; 18:2261-2271.
31. Li N, Banin S, Ouyang H, Li GC, Courtois G, Shiloh Y, Karin M, Rotman G. ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaks. J Biol Chem 2001; 276:8898-8903.
32. Peng Y, Gallagher SF, Haines K, Baksh K, Murr MM. Nuclear factor-kappaB mediates Kupffer cell apoptosis through transcriptional activation of Fas/FasL. J Surg Res 2006; 130:58-65.
33. Glasgow JN, Qiu J, Rassin D, Grafe M, Wood T, Perez-Pol JR. Transcriptional regulation of the BCL-X gene by NF-kappaB is an element of hypoxic responses in the rat brain. Neurochem Res 2001; 26:647-659.
34. Lin B, Williams-Skipp C, Tao Y, Schleicher MS, Cano LL, Duke RC, Scheinman RI. NF-kappaB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type. Cell Death Differ 1999; 6:570-582.
35. Suomalainen L, Pentikainen V, Dunkel L. Sphingosine-1-phosphate inhibits nuclear factor kappaB activation and germ cell apoptosis in the human testis independently of its receptors. Am J Pathol 2005; 166:773-781.