Soy phytoestrogens are neuroprotective against stroke-like injury in vitro

Neuroscience

Volumn 158, Issue 2, 2009, Pages 602-609

  Schreihofer, D A ^a   Redmond, L ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; DAIDZEIN; ESTROGEN RECEPTOR; FODRIN; GENISTEIN; GLUTAMIC ACID; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHYTOESTROGEN; THAPSIGARGIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; CELL PROTECTION; CONTROLLED STUDY; EMBRYO; HIPPOCAMPUS; HYPOTHALAMUS; IMMUNOCYTOCHEMISTRY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOYBEAN; STROKE;

ANIMALS; ANOXIA; APOPTOSIS; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GLUCOSE; GLUTAMIC ACID; L-LACTATE DEHYDROGENASE; NEUROPROTECTIVE AGENTS; PHYTOESTROGENS; RATS; RATS, LONG-EVANS; RECEPTORS, ESTROGEN; RNA, MESSENGER; SOYBEANS; SPECTRIN; THAPSIGARGIN;

EID: 58249086371     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2008.10.003     Document Type: Article

References (57)

1. Aguado-Llera D., Arilla-Ferreiro E., Chowen J.A., Argente J., Puebla-Jimenez L., Frago L.M., and Barrios V. 17 beta-Estradiol protects depletion of rat temporal cortex somatostatinergic system by beta-amyloid. Neurobiol Aging 28 (2007) 1396-1409
2. Alonso de Lecinana M., and Egido J.A. Estrogens as neuroprotectants against ischemic stroke. Cerebrovasc Dis 21 Suppl 2 (2006) 48-53
3. Amantea D., Russo R., Bagetta G., and Corasaniti M.T. From clinical evidence to molecular mechanisms underlying neuroprotection afforded by estrogens. Pharmacol Res 52 (2005) 119-132
4. Bake S., and Sohrabji F. 17 beta-Estradiol differentially regulates blood-brain barrier permeability in young and aging female rats. Endocrinology 145 (2004) 5471-5475
5. Bramlett H.M., and Dietrich W.D. Neuropathological protection after traumatic brain injury in intact female rats versus males or ovariectomized females. J Neurotrauma 18 (2001) 891-900
6. Brass L.M. Hormone replacement therapy and stroke: clinical trials review. Stroke 35 (2004) 2644-2647
7. Burguete M.C., Torregrosa G., Perez-Asensio F.J., Castello-Ruiz M., Salom J.B., Gil J.V., and Alborch E. Dietary phytoestrogens improve stroke outcome after transient focal cerebral ischemia in rats. Eur J Neurosci 23 (2006) 703-710
8. Callier S., Morissette M., Grandbois M., Pelaprat D., and Di Paolo T. Neuroprotective properties of 17 beta-estradiol, progesterone, and raloxifene in MPTP C57Bl/6 mice. Synapse 41 (2001) 131-138
9. Carswell H.V., Macrae I.M., Gallagher L., Harrop E., and Horsburgh K.J. Neuroprotection by a selective estrogen receptor {beta} agonist in a mouse model of global ischemia. Am J Physiol Heart Circ Physiol 287 (2004) H1501-H1504
10. Chen S., Nilsen J., and Brinton R.D. Dose and temporal pattern of estrogen exposure determines neuroprotective outcome in hippocampal neurons: therapeutic implications. Endocrinology 147 (2006) 5303-5313
11. Cimarosti H., Siqueira I.R., Zamin L.L., Nassif M., Balk R., Frozza R., Dalmaz C., Netto C.A., and Salbego C. Neuroprotection and protein damage prevention by estradiol replacement in rat hippocampal slices exposed to oxygen-glucose deprivation. Neurochem Res 30 (2005) 583-589
12. D'Astous M., Mendez P., Morissette M., Garcia-Segura L.M., and Di Paolo T. Implication of the phosphatidylinositol-3 kinase/protein kinase B signaling pathway in the neuroprotective effect of estradiol in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice. Mol Pharmacol 69 (2006) 1492-1498
13. Dubal D.B., Zhu H., Yu J., Rau S.W., Shughrue P.J., Merchenthaler I., Kindy M.S., and Wise P.M. Estrogen receptor α, not β, is a critical link in estradiol-mediated protection against brain injury. Proc Natl Acad Sci U S A 98 (2000) 1952-1957
14. Fitzpatrick J.L., Mize A.L., Wade C.B., Harris J.A., Shapiro R.A., and Dorsa D.M. Estrogen-mediated neuroprotection against beta-amyloid toxicity requires expression of estrogen receptor alpha or beta and activation of the MAPK pathway. J Neurochem 82 (2002) 674-682
15. Gibson C.L., Gray L.J., Murphy S.P., and Bath P.M. Estrogens and experimental ischemic stroke: a systematic review. J Cereb Blood Flow Metab 26 (2006) 1103-1113
16. Gollapudi L., and Oblinger M.M. Stable transfection of PC12 cells with estrogen receptor (ERα): protective effects of estrogen on cell survival after serum deprivation. J Neurosci Res 56 (1999) 99-108
17. Harms C., Lautenschlager M., Bergk A., Katchanov J., Freyer D., Kapinya K., Herwig U., Megow D., Dirnagl U., Weber J.R., and Hortnagl H. Differential mechanisms of neuroprotection by 17 beta-estradiol in apoptotic versus necrotic neurodegeneration. J Neurosci 21 (2001) 2600-2609
18. Heyer A., Hasselblatt M., von Ahsen N., Hafner H., Siren A.L., and Ehrenreich H. In vitro gender differences in neuronal survival on hypoxia and in 17 beta-estradiol-mediated neuroprotection. J Cereb Blood Flow Metab 25 (2005) 427-430
19. Honda K., Sawada H., Kihara T., Urushitani M., Nakamizo T., Akaike A., and Shimohama S. Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons. J Neurosci Res 60 (2000) 321-327
20. Honda K., Shimohama S., Sawada H., Kihara T., Nakamizo T., Shibasaki H., and Akaike A. Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons. J Neurosci Res 64 (2001) 466-475
21. Hurn P.D., and Brass L.M. Estrogen and stroke: a balanced analysis. Stroke 34 (2003) 338-341
22. Jones P.A., May G.R., McLuckie J.A., Iwashita A., and Sharkey J. Apoptosis is not an invariable component of in vitro models of cortical cerebral ischaemia. Cell Res 14 (2004) 241-250
23. Jover T., Tanaka H., Calderone A., Oguro K., Bennett M.V., Etgen A.M., and Zukin R.S. Estrogen protects against global ischemia-induced neuronal death and prevents activation of apoptotic signaling cascades in the hippocampal CA1. J Neurosci 22 (2002) 2115-2124
24. Kajta M., Domin H., Grynkiewicz G., and Lason W. Genistein inhibits glutamate-induced apoptotic processes in primary neuronal cell cultures: an involvement of aryl hydrocarbon receptor and estrogen receptor/glycogen synthase kinase-3beta intracellular signaling pathway. Neuroscience 145 (2007) 592-604
25. Krause D.N., Duckles S.P., and Pelligrino D.A. Influence of sex steroid hormones on cerebrovascular function. J Appl Physiol 101 (2006) 1252-1261
26. Linford N.J., and Dorsa D.M. 17 beta-Estradiol and the phytoestrogen genistein attenuate neuronal apoptosis induced by the endoplasmic reticulum calcium-ATPase inhibitor thapsigargin. Steroids 67 (2002) 1029-1040
27. Linford N.J., Yang Y., Cook D.G., and Dorsa D.M. Neuronal apoptosis resulting from high doses of the isoflavone genistein: role for calcium and p42/44 mitogen-activated protein kinase. J Pharmacol Exp Ther 299 (2001) 67-75
28. Mahesh V.B., Dhandapani K.M., and Brann D.W. Role of astrocytes in reproduction and neuroprotection. Mol Cell Endocrinol 246 (2006) 1-9
29. McCullough L.D., and Hurn P.D. Estrogen and ischemic neuroprotection: an integrated view. Trends Endocrinol Metab 14 (2003) 228-235
30. Mendelowitsch A., Ritz M.F., Ros J., Langemann H., and Gratzl O. 17 beta-Estradiol reduces cortical lesion size in the glutamate excitotoxicity model by enhancing extracellular lactate: a new neuroprotective pathway. Brain Res 901 (2001) 230-236
31. Mize A.L., Shapiro R.A., and Dorsa D.M. Estrogen receptor-mediated neuroprotection from oxidative stress requires activation of the mitogen-activated protein kinase pathway. Endocrinology 144 (2003) 306-312
32. Morissette M., Jourdain S., Al Sweidi S., Menniti F.S., Ramirez A.D., and Di Paolo T. Role of estrogen receptors in neuroprotection by estradiol against MPTP toxicity. Neuropharmacology 52 (2007) 1509-1520
33. Nilsen J., and Brinton R.D. Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate. Endocrinology 143 (2002) 205-212
34. Noshita N., Lewen A., Sugawara T., and Chan P.H. Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice. J Cereb Blood Flow Metab 21 (2001) 1442-1450
35. O'Donnell M.E., Lam T.I., Tran L.Q., Foroutan S., and Anderson S.E. Estradiol reduces activity of the blood-brain barrier Na-K-Cl cotransporter and decreases edema formation in permanent middle cerebral artery occlusion. J Cereb Blood Flow Metab 26 (2006) 1234-1249
36. Pelligrino D.A., Santizo R., Baughman V.L., and Wang Q. Cerebral vasodilating capacity during forebrain ischemia: effects of chronic estrogen depletion and repletion and the role of neuronal nitric oxide synthase. Neuroreport 9 (1998) 3285-3291
37. Prokai L., and Simpkins J.W. Structure-nongenomic neuroprotection relationship of estrogens and estrogen-derived compounds. Pharmacol Ther 114 (2007) 1-12
38. Quesada A., Lee B.Y., and Micevych P.E. PI3 kinase/Akt activation mediates estrogen and IGF-1 nigral DA neuronal neuroprotection against a unilateral rat model of Parkinson's disease. Dev Neurobiol 68 (2008) 632-644
39. Redmond L., Kashani A.H., and Ghosh A. Calcium regulation of dendritic growth via CaM Kinase IV and CREB-mediated transcription. Neuron 34 (2002) 999-1010
40. Sampei K., Goto S., Alkayed N.J., Crain B.J., Korach K.S., Traystman R.J., Demas G.E., Nelson R.J., and Hurn P.D. Stroke in estrogen receptor-alpha-deficient mice. Stroke 31 (2000) 738-743 discussion 744
41. Sarkar F.H., and Li Y. Mechanisms of cancer chemoprevention by soy isoflavone genistein. Cancer Metastasis Rev 21 (2002) 265-280
42. Sawada H., Ibi M., Kihara T., Urushitani M., Honda K., Nakanishi M., Akaike A., and Shimohama S. Mechanisms of antiapoptotic effects of estrogens in nigral dopaminergic neurons. FASEB J 14 (2000) 1202-1214
43. Schreihofer D.A. Transcriptional regulation by phytoestrogens in neuronal cell lines. Mol Cell Endocrinol 231 (2005) 13-22
44. Schreihofer D.A., Do K.D., and Schreihofer A.M. High-soy diet decreases infarct size after permanent middle cerebral artery occlusion in female rats. Am J Physiol Regul Integr Comp Physiol 289 (2005) R103-R108
45. Setchell K.D. Soy isoflavones-benefits and risks from nature's selective estrogen receptor modulators (SERMs). J Am Coll Nutr 20 (2001) 354S-362S discussion 381S-383S
46. Singer C.A., Figueroa-Masot X.A., Batchelor R.H., and Dorsa D.M. The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons. J Neurosci 19 (1999) 2455-2463
47. Sribnick E.A., Ray S.K., Nowak M.W., Li L., and Banik N.L. 17 beta-Estradiol attenuates glutamate-induced apoptosis and preserves electrophysiologic function in primary cortical neurons. J Neurosci Res 76 (2004) 688-696
48. Suzuki S., Brown C.M., Dela Cruz C.D., Yang E., Bridwell D.A., and Wise P.M. Timing of estrogen therapy after ovariectomy dictates the efficacy of its neuroprotective and antiinflammatory actions. Proc Natl Acad Sci U S A 104 (2007) 6013-6018
49. Trieu V.N., and Uckun F.M. Genistein is neuroprotective in murine models of familial amyotrophic lateral sclerosis and stroke. Biochem Biophys Res Commun 258 (1999) 685-688
50. Wang R., Zhang Q.G., Han D., Xu J., Lu Q., and Zhang G.Y. Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats. J Neurochem 99 (2006) 1543-1554
51. Wassertheil-Smoller S., Hendrix S.L., Limacher M., Heiss G., Kooperberg C., Baird A., Kotchen T., Curb J.D., Black H., Rossouw J.E., Aragaki A., Safford M., Stein E., Laowattana S., and Mysiw W.J. Effect of estrogen plus progestin on stroke in postmenopausal women: the Women's Health Initiative: a randomized trial. JAMA 289 (2003) 2673-2684
52. Wathen C.N. Alternatives to hormone replacement therapy: a multi-method study of women's experiences. Complement Ther Med 14 (2006) 185-192
53. Wilson M.E., Dubal D.B., and Wise P.M. Estradiol protects against injury-induced cell death in cortical explant cultures: a role for estrogen receptors. Brain Res 873 (2000) 235-242
54. Wilson M.E., Liu Y., and Wise P.M. Estradiol enhances Akt activation in cortical explant cultures following neuronal injury. Brain Res Mol Brain Res 102 (2002) 48-54
55. Yu X., Rajala R.V., McGinnis J.F., Li F., Anderson R.E., Yan X., Li S., Elias R.V., Knapp R.R., Zhou X., and Cao W. Involvement of insulin/phosphoinositide 3-kinase/Akt signal pathway in 17 beta-estradiol-mediated neuroprotection. J Biol Chem 279 (2004) 13086-13094
56. Zeng H., Chen Q., and Zhao B. Genistein ameliorates beta-amyloid peptide (25-35)-induced hippocampal neuronal apoptosis. Free Radic Biol Med 36 (2004) 180-188
57. Zhao L., Chen Q., and Diaz Brinton R. Neuroprotective and neurotrophic efficacy of phytoestrogens in cultured hippocampal neurons. Exp Biol Med (Maywood) 227 (2002) 509-519