Neuronal apoptosis resulting from high doses of the isoflavone genistein: Role for calcium and p42/44 mitogen-activated protein kinase

Journal of Pharmacology and Experimental Therapeutics

Volumn 299, Issue 1, 2001, Pages 67-75

  Linford, Nancy J ^a,b   Yang, Yaxiong ^a   Cook, David G ^a   Dorsa, Daniel M ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CALCIUM; CASPASE; DAIDZEIN; DANTROLENE; ESTER DERIVATIVE; ESTROGEN RECEPTOR; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; FULVESTRANT; GENISTEIN; ISOFLAVONE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; PROTEIN BCL X; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CELL; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL DEATH; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DRUG EXPOSURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ESTROGEN ACTIVITY; MITOSIS INHIBITION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTICARCINOGENIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CALCIUM; CASPASES; CEREBRAL CORTEX; DNA FRAGMENTATION; GENES, BCL-2; GENISTEIN; INDICATORS AND REAGENTS; L-LACTATE DEHYDROGENASE; MICROSCOPY, PHASE-CONTRAST; MITOGEN-ACTIVATED PROTEIN KINASE 1; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN;

EID: 0034813095     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. The Bcl-2 protein family: Arbiters of cell survival
2. Ganistein, a specific inhibitor of tyrosine-specific protein kinases
3. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
4. Ganistein-induced cell cycle arrest and apoptosis in a head and neck squamous cell carcinoma cell line
5. Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase
6. Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination
7. Mass spectrometric determination of Genistein tissue distribution in diet-exposed Sprague-Dawley rats
8. Serine/threonine protein kinases and apoptosis
9. Growth inhibition of human breast cancer cells by herbs and phytoestrogens
10. Genistein in the control of breast cancer cell growth: Insights into the mechanism of actian in vitro
11. Genistein, a dietary-derived inhibitor of in vitro angiogenesis
12. The activation state of p38 mitogen-activated protein kinase determines the efficiency of ATP competition for pyridinylimidazole inhibitor binding
13. Troglitazone and rosiglitazone induce apoptosis of vascular smooth muscle cells through an extracellular signal-regulated kinase-independent pathway
14. Identification of DNA topoisomerase-II activity in terminally differentiated mammalian organs and in non-growing cultured cells
15. The tyrosine kinase inhibitor genistein directly inhibits GABAA receptors
16. UV irradiation induces downregulation of bcl-2 expression in vitro and in vivo
17. New agents for cancer chemoprevention
18. Pivotal role of mitochondrial calcium uptake in neural cell apoptosis and necrosis
19. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta
20. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
21. Induction of apoptosis and inhibition of c-erbB-2 in MDA-MB-435 cells by genistein
22. Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II
23. Phytoestrogen interaction with estrogen receptors in human breast cancer cells
24. Genistein arrests cell cycle progression at G2-M
25. FK506 markedly enhances apoptosis of antigen-stimulated peripheral T cells by down-regulation of Bcl-xL
26. Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: Evidence for cell cycle-independent toxicity
27. Etoposide induces programmed death in neurons cultured from the fetal rat central nervous system
28. Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3
29. Tyrosine kinase inhibitors reduce bcl-2 expression and induce apoptosis in androgen-dependent cells
30. Direct block of voltage-sensitive sodium channels by genistein, a tyrosine kinase inhibitor
31. Biological properties of genistein. A review of in vitro and in vivo data
32. Estrogen protects primary cortical neurons from glutamate toxicity
33. A role for JNK/SAPK in proliferation, but not apoptosis, of IL-3-dependent cells
34. Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures
35. Requirement for ERK activation in cisplatin-induced apoptosis
36. Pharmacokinetics of soybean isoflavones in plasma, urine and feces of men after ingestion of 60 g baked soybean powder (kinako)
37. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
38. Carbachol blocks beta-amyloid fragment 31-35 induced apoptosis in cultured cortical neurons
39. Genistein induces apoptosis of RPE-J cells by opening mitochondrial PTP
40. BCL-2 inhibits death of central neural cells induced by multiple agents