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Volumn 7, Issue 4, 2008, Pages 253-259

Tuning immune suppression in systemic autoimmunity with self-derived peptides

Author keywords

Autoimmunity; CD8+ T cells; Lupus; Regulatory T cells; Self derived peptides; TGF signaling; Tolerance

Indexed keywords

ALTERED PROTEIN LIGAND; AMYLOID BETA PROTEIN; ANTIGEN; COMPLEMENTARY DETEMING REGION 1; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; EDRATIDE; GAMMA INTERFERON; IMMUNOLOGIC AGENT; INTERLEUKIN 2 RECEPTOR ALPHA; MULTIPLE ANTIGENIC PROTEIN; NUCLEOSOMAL HISTONE PROTEIN; NUCLEOSOMAL PROTEIN; PEPTIDE NUCLEIC ACID; PLACEBO; PROTEIN CONSENSUS; SELF ANTIGEN DERIVED PEPTIDE; SMD PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; CD28 ANTIGEN; IMMUNOSUPPRESSIVE AGENT; PEPTIDE;

EID: 58249084120     PISSN: 18715281     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152808786848423     Document Type: Review
Times cited : (11)

References (76)
  • 2
    • 0242403301 scopus 로고    scopus 로고
    • Quantification of regulatory T cells in patients with systemic lupus erythematosus
    • Crispin, J.C.; Martinez, A.; Alcocer-Varela, J. Quantification of regulatory T cells in patients with systemic lupus erythematosus. J. Autoimmun., 2003, 21, 273-6.
    • (2003) J. Autoimmun , vol.21 , pp. 273-276
    • Crispin, J.C.1    Martinez, A.2    Alcocer-Varela, J.3
  • 3
    • 1342267617 scopus 로고    scopus 로고
    • Decreased CD4+CD25+ T cells in peripheral blood of patients with systemic lupus erythematosus
    • Liu, M.F.; Wang, C.R.; Fung, L.L.; Wu, C.R. Decreased CD4+CD25+ T cells in peripheral blood of patients with systemic lupus erythematosus. Scand. J. Immunol., 2004, 59, 198-202.
    • (2004) Scand. J. Immunol , vol.59 , pp. 198-202
    • Liu, M.F.1    Wang, C.R.2    Fung, L.L.3    Wu, C.R.4
  • 5
    • 33846900430 scopus 로고    scopus 로고
    • Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus
    • Valencia, X.; Yarboro, C.; Illei, G.; Lipsky, P.E. Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J. Immunol., 2007, 178, 2579-88.
    • (2007) J. Immunol , vol.178 , pp. 2579-2588
    • Valencia, X.1    Yarboro, C.2    Illei, G.3    Lipsky, P.E.4
  • 6
    • 33746214867 scopus 로고    scopus 로고
    • Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells
    • Scalapino, K.J.; Tang, Q.; Bluestone, J.A.; Bonyhadi, M.L.; Daikh, D.I. Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells. J. Immunol., 2006, 177, 1451-9.
    • (2006) J. Immunol , vol.177 , pp. 1451-1459
    • Scalapino, K.J.1    Tang, Q.2    Bluestone, J.A.3    Bonyhadi, M.L.4    Daikh, D.I.5
  • 7
    • 0035985790 scopus 로고    scopus 로고
    • The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases
    • Horwitz, D.A.; Gray, J.D.; Zheng, S.G. The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases. Arthritis Res., 2002, 4, 241-6.
    • (2002) Arthritis Res , vol.4 , pp. 241-246
    • Horwitz, D.A.1    Gray, J.D.2    Zheng, S.G.3
  • 8
    • 4344634278 scopus 로고    scopus 로고
    • Ig-reactive CD4+CD25+ T cells from tolerized (New Zealand Black x New Zealand White)F1 mice suppress in vitro production of antibodies to DNA
    • La Cava, A.; Ebling, F.M.; Hahn, B.H. Ig-reactive CD4+CD25+ T cells from tolerized (New Zealand Black x New Zealand White)F1 mice suppress in vitro production of antibodies to DNA. J. Immunol., 2004, 173, 3542-8.
    • (2004) J. Immunol , vol.173 , pp. 3542-3548
    • La Cava, A.1    Ebling, F.M.2    Hahn, B.H.3
  • 9
    • 1242340401 scopus 로고    scopus 로고
    • Regulatory T cells generated ex vivo as an approach for the therapy of autoimmune disease
    • Horwitz, D.A.; Zheng, S.G.; Gray, J.D.; Wang, J.H.; Ohtsuka, K.; Yamagiwa, S. Regulatory T cells generated ex vivo as an approach for the therapy of autoimmune disease. Semin. Immunol., 2004, 16, 135-43.
    • (2004) Semin. Immunol , vol.16 , pp. 135-143
    • Horwitz, D.A.1    Zheng, S.G.2    Gray, J.D.3    Wang, J.H.4    Ohtsuka, K.5    Yamagiwa, S.6
  • 10
    • 43249122144 scopus 로고    scopus 로고
    • Quantitative and qualitative normal regulatory T cells are not capable of inducing suppression in SLE patients due to T-cell resistance
    • Vargas-Rojas, M.I.; Crispin, J.C.; Richaud-Patin, Y.; Alcocer-Varela, J. Quantitative and qualitative normal regulatory T cells are not capable of inducing suppression in SLE patients due to T-cell resistance. Lupus, 2008, 17, 289-94.
    • (2008) Lupus , vol.17 , pp. 289-294
    • Vargas-Rojas, M.I.1    Crispin, J.C.2    Richaud-Patin, Y.3    Alcocer-Varela, J.4
  • 11
    • 46849087978 scopus 로고    scopus 로고
    • Clinical significance of increased CD4+CD25-Foxp3+ T cells in patients with new-onset systemic lupus erythematosus
    • Zhang, B.; Zhang, X.; Tang, F.L.; Zhu, L.P.; Liu, Y.; Lipsky, P.E. Clinical significance of increased CD4+CD25-Foxp3+ T cells in patients with new-onset systemic lupus erythematosus. Ann. Rheum. Dis., 2008, 67, 1037-40.
    • (2008) Ann. Rheum. Dis , vol.67 , pp. 1037-1040
    • Zhang, B.1    Zhang, X.2    Tang, F.L.3    Zhu, L.P.4    Liu, Y.5    Lipsky, P.E.6
  • 12
    • 47249145164 scopus 로고    scopus 로고
    • Reduced CD4+,CD25- T cell sensitivity to the suppressive function of CD4+,CD25high,CD127 -/low regulatory T cells in patients with active systemic lupus erythematosus
    • Venigalla, R.K.; Tretter, T.; Krienke, S.; Max, R.; Eckstein, V.; Blank, N.; Fiehn, C.; Ho, A.D.; Lorenz, H.M. Reduced CD4+,CD25- T cell sensitivity to the suppressive function of CD4+,CD25high,CD127 -/low regulatory T cells in patients with active systemic lupus erythematosus. Arthritis Rheum., 2008, 58, 2120-30.
    • (2008) Arthritis Rheum , vol.58 , pp. 2120-2130
    • Venigalla, R.K.1    Tretter, T.2    Krienke, S.3    Max, R.4    Eckstein, V.5    Blank, N.6    Fiehn, C.7    Ho, A.D.8    Lorenz, H.M.9
  • 13
    • 0033562983 scopus 로고    scopus 로고
    • Antigen-specific therapy of murine lupus nephritis using nucleosomal peptides: Tolerance spreading impairs pathogenic function of autoimmune T and B cells
    • Kaliyaperumal, A.; Michaels, M.A.; Datta, S.K. Antigen-specific therapy of murine lupus nephritis using nucleosomal peptides: tolerance spreading impairs pathogenic function of autoimmune T and B cells. J. Immunol., 1999, 162, 5775-83.
    • (1999) J. Immunol , vol.162 , pp. 5775-5783
    • Kaliyaperumal, A.1    Michaels, M.A.2    Datta, S.K.3
  • 15
    • 0028849856 scopus 로고
    • Immune tolerance to autoantibody-derived peptides delays development of autoimmunity in murine lupus
    • Singh, R.R.; Ebling, F.M.; Sercarz, E.E.; Hahn, B.H. Immune tolerance to autoantibody-derived peptides delays development of autoimmunity in murine lupus. J. Clin. Invest., 1995, 96, 2990-6.
    • (1995) J. Clin. Invest , vol.96 , pp. 2990-2996
    • Singh, R.R.1    Ebling, F.M.2    Sercarz, E.E.3    Hahn, B.H.4
  • 16
    • 0032533901 scopus 로고    scopus 로고
    • Evidence for multiple mechanisms of polyclonal T cell activation in murine lupus
    • Singh, R.R.; Hahn, B.H.; Tsao, B.P.; Ebling, F.M. Evidence for multiple mechanisms of polyclonal T cell activation in murine lupus. J. Clin. Invest., 1998, 102, 1841-9.
    • (1998) J. Clin. Invest , vol.102 , pp. 1841-1849
    • Singh, R.R.1    Hahn, B.H.2    Tsao, B.P.3    Ebling, F.M.4
  • 17
    • 0037120006 scopus 로고    scopus 로고
    • Vaccination with minigenes encoding V(H)- derived major histocompatibility complex class I-binding epitopes activates cytotoxic T cells that ablate autoantibody-producing B cells and inhibit lupus
    • Fan, G.C.; Singh, R.R. Vaccination with minigenes encoding V(H)- derived major histocompatibility complex class I-binding epitopes activates cytotoxic T cells that ablate autoantibody-producing B cells and inhibit lupus. J. Exp. Med., 2002, 196, 731-41.
    • (2002) J. Exp. Med , vol.196 , pp. 731-741
    • Fan, G.C.1    Singh, R.R.2
  • 18
    • 3142667575 scopus 로고    scopus 로고
    • Activation and tolerance in CD4(+) T cells reactive to an immunoglobulin variable region
    • Snyder, C.M.; Aviszus, K.; Heiser, R.A.; Tonkin, D.R.; Guth, A.M.; Wysocki, L.J. Activation and tolerance in CD4(+) T cells reactive to an immunoglobulin variable region. J. Exp. Med., 2004, 200, 1-11.
    • (2004) J. Exp. Med , vol.200 , pp. 1-11
    • Snyder, C.M.1    Aviszus, K.2    Heiser, R.A.3    Tonkin, D.R.4    Guth, A.M.5    Wysocki, L.J.6
  • 19
    • 0035970048 scopus 로고    scopus 로고
    • The mechanism by which a peptide based on complementarity-determining region-1 of a pathogenic anti-DNA auto-Ab ameliorates experimental systemic lupus erythematosus
    • Eilat, E.; Dayan, M.; Zinger, H.; Mozes, E. The mechanism by which a peptide based on complementarity-determining region-1 of a pathogenic anti-DNA auto-Ab ameliorates experimental systemic lupus erythematosus. Proc. Natl. Acad. Sci. USA, 2001, 98, 1148-53.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 1148-1153
    • Eilat, E.1    Dayan, M.2    Zinger, H.3    Mozes, E.4
  • 20
    • 33645980321 scopus 로고    scopus 로고
    • Amelioration of murine lupus by a peptide, based on the complementarity determining region-1 of an autoantibody as compared to dexamethasone: Different effects on cytokines and apoptosis
    • Sharabi, A.; Haviv, A.; Zinger, H.; Dayan, M.; Mozes, E. Amelioration of murine lupus by a peptide, based on the complementarity determining region-1 of an autoantibody as compared to dexamethasone: different effects on cytokines and apoptosis. Clin. Immunol., 2006, 119, 146-55.
    • (2006) Clin. Immunol , vol.119 , pp. 146-155
    • Sharabi, A.1    Haviv, A.2    Zinger, H.3    Dayan, M.4    Mozes, E.5
  • 21
    • 34247485287 scopus 로고    scopus 로고
    • Clinical amelioration of murine lupus by a peptide based on the complementarity determining region-1 of an autoantibody and by cyclophosphamide: Similarities and differences in the mechanisms of action
    • Sharabi, A.; Azulai, H.; Sthoeger, Z.M.; Mozes, E. Clinical amelioration of murine lupus by a peptide based on the complementarity determining region-1 of an autoantibody and by cyclophosphamide: similarities and differences in the mechanisms of action. Immunology, 2007, 121, 248-57.
    • (2007) Immunology , vol.121 , pp. 248-257
    • Sharabi, A.1    Azulai, H.2    Sthoeger, Z.M.3    Mozes, E.4
  • 22
    • 28244494166 scopus 로고    scopus 로고
    • Tolerogenic treatment of lupus mice with consensus peptide induces Foxp3-expressing, apoptosis-resistant, TGFbeta-secreting CD8+ T cell suppressors
    • Hahn, B.H.; Singh, R.P.; La Cava, A.; Ebling, F.M. Tolerogenic treatment of lupus mice with consensus peptide induces Foxp3-expressing, apoptosis-resistant, TGFbeta-secreting CD8+ T cell suppressors. J. Immunol., 2005, 175, 7728-37.
    • (2005) J. Immunol , vol.175 , pp. 7728-7737
    • Hahn, B.H.1    Singh, R.P.2    La Cava, A.3    Ebling, F.M.4
  • 23
    • 34250222393 scopus 로고    scopus 로고
    • CD8+ T cell-mediated suppression of autoimmunity in a murine lupus model of peptide-induced immune tolerance depends on Foxp3 expression
    • Singh, R.P.; La Cava, A.; Wong, M.; Ebling, F.; Hahn, B.H. CD8+ T cell-mediated suppression of autoimmunity in a murine lupus model of peptide-induced immune tolerance depends on Foxp3 expression. J. Immunol., 2007, 178, 7649-57.
    • (2007) J. Immunol , vol.178 , pp. 7649-7657
    • Singh, R.P.1    La Cava, A.2    Wong, M.3    Ebling, F.4    Hahn, B.H.5
  • 24
    • 42149151044 scopus 로고    scopus 로고
    • pConsensus peptide induces tolerogenic CD8+ T cells in lupus-prone (NZB x NZW)F1 mice by differentially regulating Foxp3 and PD1 molecules
    • Singh, R.P.; La Cava, A.; Hahn, B.H. pConsensus peptide induces tolerogenic CD8+ T cells in lupus-prone (NZB x NZW)F1 mice by differentially regulating Foxp3 and PD1 molecules. J. Immunol., 2008, 180, 2069-80.
    • (2008) J. Immunol , vol.180 , pp. 2069-2080
    • Singh, R.P.1    La Cava, A.2    Hahn, B.H.3
  • 25
    • 0034792915 scopus 로고    scopus 로고
    • Lessons in lupus: The mighty mouse
    • Hahn, B.H. Lessons in lupus: the mighty mouse. Lupus, 2001, 10, 589-93.
    • (2001) Lupus , vol.10 , pp. 589-593
    • Hahn, B.H.1
  • 26
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi, S.; Sakaguchi, N.; Asano, M.; Itoh, M.; Toda, M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol., 1995, 155, 1151-64.
    • (1995) J. Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 27
    • 0034716925 scopus 로고    scopus 로고
    • Sakaguchi, S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell, 2000, 101, 455-8.
    • Sakaguchi, S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell, 2000, 101, 455-8.
  • 28
    • 0034084162 scopus 로고    scopus 로고
    • Shevach, E.M. Regulatory T cells in autoimmmunity*. Annu. Rev. Immunol., 2000, 18, 423-49.
    • Shevach, E.M. Regulatory T cells in autoimmmunity*. Annu. Rev. Immunol., 2000, 18, 423-49.
  • 31
    • 4644236340 scopus 로고    scopus 로고
    • Differences between CD8+ T cells in lupus-prone (NZB x NZW) F1 mice and healthy (BALB/c x NZW) F1 mice may influence autoimmunity in the lupus model
    • Karpouzas, G.A.; La Cava, A.; Ebling, F.M.; Singh, R.R.; Hahn, B.H. Differences between CD8+ T cells in lupus-prone (NZB x NZW) F1 mice and healthy (BALB/c x NZW) F1 mice may influence autoimmunity in the lupus model. Eur. J. Immunol., 2004, 34, 2489-99.
    • (2004) Eur. J. Immunol , vol.34 , pp. 2489-2499
    • Karpouzas, G.A.1    La Cava, A.2    Ebling, F.M.3    Singh, R.R.4    Hahn, B.H.5
  • 32
    • 0035092481 scopus 로고    scopus 로고
    • Treatment with a consensus peptide based on amino acid sequences in autoantibodies prevents T cell activation by autoantigens and delays disease onset in murine lupus
    • Hahn, B.H.; Singh, R.R.; Wong, W.K.; Tsao, B.P.; Bulpitt, K.; Ebling, F.M. Treatment with a consensus peptide based on amino acid sequences in autoantibodies prevents T cell activation by autoantigens and delays disease onset in murine lupus. Arthritis Rheum., 2001, 44, 432-41.
    • (2001) Arthritis Rheum , vol.44 , pp. 432-441
    • Hahn, B.H.1    Singh, R.R.2    Wong, W.K.3    Tsao, B.P.4    Bulpitt, K.5    Ebling, F.M.6
  • 34
    • 14844346513 scopus 로고    scopus 로고
    • Very low-dose tolerance with nucleosomal peptides controls lupus and induces potent regulatory T cell subsets
    • Kang, H.K.; Michaels, M.A.; Berner, B.R.; Datta, S.K. Very low-dose tolerance with nucleosomal peptides controls lupus and induces potent regulatory T cell subsets. J. Immunol., 2005, 174, 3247-55.
    • (2005) J. Immunol , vol.174 , pp. 3247-3255
    • Kang, H.K.1    Michaels, M.A.2    Berner, B.R.3    Datta, S.K.4
  • 35
    • 34250162775 scopus 로고    scopus 로고
    • Low-dose peptide tolerance therapy of lupus generates plasmacytoid dendritic cells that cause expansion of autoantigen-specific regulatory T cells and contraction of inflammatory th17 cells
    • Kang, H.K.; Liu, M.; Datta, S.K. Low-dose peptide tolerance therapy of lupus generates plasmacytoid dendritic cells that cause expansion of autoantigen-specific regulatory T cells and contraction of inflammatory th17 cells. J. Immunol., 2007, 178, 7849-58.
    • (2007) J. Immunol , vol.178 , pp. 7849-7858
    • Kang, H.K.1    Liu, M.2    Datta, S.K.3
  • 36
    • 29344448889 scopus 로고    scopus 로고
    • Amelioration of SLE-like manifestations in (NZBxNZW)F1 mice following treatment with a peptide based on the complementarity determining region 1 of an autoantibody is associated with a down-regulation of apoptosis and of the proapoptotic factor JNK kinase
    • Rapoport, M.J.; Sharabi, A.; Aharoni, D.; Bloch, O.; Zinger, H.; Dayan, M.; Mozes, E. Amelioration of SLE-like manifestations in (NZBxNZW)F1 mice following treatment with a peptide based on the complementarity determining region 1 of an autoantibody is associated with a down-regulation of apoptosis and of the proapoptotic factor JNK kinase. Clin. Immunol., 2005, 117, 262-70.
    • (2005) Clin. Immunol , vol.117 , pp. 262-270
    • Rapoport, M.J.1    Sharabi, A.2    Aharoni, D.3    Bloch, O.4    Zinger, H.5    Dayan, M.6    Mozes, E.7
  • 37
    • 28244431801 scopus 로고    scopus 로고
    • The inhibition of autoreactive T cell functions by a peptide based on the CDR1 of an anti-DNA autoantibody is via TGF-beta-mediated suppression of LFA-1 and CD44 expression and function
    • Sela, U.; Mauermann, N.; Hershkoviz, R.; Zinger, H.; Dayan, M.; Cahalon, L.; Liu, J.P.; Mozes, E.; Lider, O. The inhibition of autoreactive T cell functions by a peptide based on the CDR1 of an anti-DNA autoantibody is via TGF-beta-mediated suppression of LFA-1 and CD44 expression and function. J. Immunol., 2005, 175, 7255-63.
    • (2005) J. Immunol , vol.175 , pp. 7255-7263
    • Sela, U.1    Mauermann, N.2    Hershkoviz, R.3    Zinger, H.4    Dayan, M.5    Cahalon, L.6    Liu, J.P.7    Mozes, E.8    Lider, O.9
  • 38
    • 0035689690 scopus 로고    scopus 로고
    • Nasal vaccination with beta-amyloid peptide for the treatment of Alzheimer's disease
    • Lemere, C.A.; Maron, R.; Selkoe, D.J.; Weiner, H.L. Nasal vaccination with beta-amyloid peptide for the treatment of Alzheimer's disease. DNA Cell Biol., 2001, 20, 705-11.
    • (2001) DNA Cell Biol , vol.20 , pp. 705-711
    • Lemere, C.A.1    Maron, R.2    Selkoe, D.J.3    Weiner, H.L.4
  • 41
    • 70350034236 scopus 로고    scopus 로고
    • Hahn, B.H.: Anderson, M.: Lee, E.: La Cava, A. Anti-DNA Ig peptides promotes regulatory T cell activity in SLE patients. Arthritis Rheumatism, 2008, In press.
    • Hahn, B.H.: Anderson, M.: Lee, E.: La Cava, A. Anti-DNA Ig peptides promotes regulatory T cell activity in SLE patients. Arthritis Rheumatism, 2008, In press.
  • 43
    • 0035801335 scopus 로고    scopus 로고
    • Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta
    • Nakamura, K.; Kitani, A.; Strober, W. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J. Exp. Med., 2001, 194, 629-44.
    • (2001) J. Exp. Med , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 44
    • 0035191130 scopus 로고    scopus 로고
    • An integrative model of regulation centered on recognition of TCR peptide/MHC complexes
    • Kumar, V.; Sercarz, E. An integrative model of regulation centered on recognition of TCR peptide/MHC complexes. Immunol. Rev., 2001, 182, 113-21.
    • (2001) Immunol. Rev , vol.182 , pp. 113-121
    • Kumar, V.1    Sercarz, E.2
  • 45
    • 36849010574 scopus 로고    scopus 로고
    • The role of CD8+CD28 regulatory cells in suppressing myasthenia gravis-associated responses by a dual altered peptide ligand
    • Ben-David, H.; Sharabi, A.; Dayan, M.; Sela, M.; Mozes, E. The role of CD8+CD28 regulatory cells in suppressing myasthenia gravis-associated responses by a dual altered peptide ligand. Proc. Natl. Acad. Sci. USA, 2007, 104, 17459-64.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 17459-17464
    • Ben-David, H.1    Sharabi, A.2    Dayan, M.3    Sela, M.4    Mozes, E.5
  • 46
    • 1242267910 scopus 로고    scopus 로고
    • CD4+ and CD8+ regulatory T cells generated ex vivo with IL-2 and TGF-beta suppress a stimulatory graft-versus-host disease with a lupus-like syndrome
    • Zheng, S.G.; Wang, J.H.; Koss, M.N.; Quismorio, F.Jr.; Gray, J.D.; Horwitz, D.A. CD4+ and CD8+ regulatory T cells generated ex vivo with IL-2 and TGF-beta suppress a stimulatory graft-versus-host disease with a lupus-like syndrome. J. Immunol., 2004, 172, 1531-9.
    • (2004) J. Immunol , vol.172 , pp. 1531-1539
    • Zheng, S.G.1    Wang, J.H.2    Koss, M.N.3    Quismorio Jr, F.4    Gray, J.D.5    Horwitz, D.A.6
  • 49
    • 0347361653 scopus 로고    scopus 로고
    • The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4+ CD25+ and CD8+ regulatory T cell subsets
    • Horwitz, D.A.; Zheng, S.G.; Gray, J.D. The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4+ CD25+ and CD8+ regulatory T cell subsets. J. Leukoc. Biol., 2003, 74, 471-8.
    • (2003) J. Leukoc. Biol , vol.74 , pp. 471-478
    • Horwitz, D.A.1    Zheng, S.G.2    Gray, J.D.3
  • 50
    • 38449119975 scopus 로고    scopus 로고
    • The role of apoptosis in the ameliorating effects of a CDR1-based peptide on lupus manifestations in a mouse model
    • Sharabi, A.; Luger, D.; Ben-David, H.; Dayan, M.; Zinger, H.; Mozes, E. The role of apoptosis in the ameliorating effects of a CDR1-based peptide on lupus manifestations in a mouse model. J. Immunol., 2007, 179, 4979-87.
    • (2007) J. Immunol , vol.179 , pp. 4979-4987
    • Sharabi, A.1    Luger, D.2    Ben-David, H.3    Dayan, M.4    Zinger, H.5    Mozes, E.6
  • 54
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • Shi, Y.; Massague, J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell, 2003, 113, 685-700.
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 56
    • 34249678653 scopus 로고    scopus 로고
    • TGFbeta signalling in control of Tcell-mediated self-reactivity
    • Rubtsov, Y.P.; Rudensky, A.Y. TGFbeta signalling in control of Tcell-mediated self-reactivity. Nat. Rev. Immunol., 2007, 7, 443-53.
    • (2007) Nat. Rev. Immunol , vol.7 , pp. 443-453
    • Rubtsov, Y.P.1    Rudensky, A.Y.2
  • 57
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • Derynck, R.; Zhang, Y.E. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature, 2003, 425, 577-84.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 58
    • 34247590285 scopus 로고    scopus 로고
    • TGF-beta 1 inhibition of IFN-gamma-induced signaling and Th1 gene expression in CD4+ T cells is Smad3 independent but MAP kinase dependent
    • Park, I.K.; Letterio, J.J.; Gorham, J.D. TGF-beta 1 inhibition of IFN-gamma-induced signaling and Th1 gene expression in CD4+ T cells is Smad3 independent but MAP kinase dependent. Mol. Immunol., 2007, 44, 3283-90.
    • (2007) Mol. Immunol , vol.44 , pp. 3283-3290
    • Park, I.K.1    Letterio, J.J.2    Gorham, J.D.3
  • 59
    • 0037099745 scopus 로고    scopus 로고
    • TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses
    • Yu, L.; Hebert, M.C.; Zhang, Y.E. TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses. EMBO J., 2002, 21, 3749-59.
    • (2002) EMBO J , vol.21 , pp. 3749-3759
    • Yu, L.1    Hebert, M.C.2    Zhang, Y.E.3
  • 60
    • 0037423374 scopus 로고    scopus 로고
    • Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses
    • Itoh, S.; Thorikay, M.; Kowanetz, M.; Moustakas, A.; Itoh, F.; Heldin, C.H.; ten Dijke, P. Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses. J. Biol. Chem., 2003, 278, 3751-61.
    • (2003) J. Biol. Chem , vol.278 , pp. 3751-3761
    • Itoh, S.1    Thorikay, M.2    Kowanetz, M.3    Moustakas, A.4    Itoh, F.5    Heldin, C.H.6    ten Dijke, P.7
  • 61
    • 0037867066 scopus 로고    scopus 로고
    • Transforming growth factor beta blocks Tec kinase phosphorylation, Ca2+ influx, and NFATc translocation causing inhibition of T cell differentiation
    • Chen, C.H.; Seguin-Devaux, C.; Burke, N.A.; Oriss, T.B.; Watkins, S.C.; Clipstone, N.; Ray, A. Transforming growth factor beta blocks Tec kinase phosphorylation, Ca2+ influx, and NFATc translocation causing inhibition of T cell differentiation. J. Exp. Med., 2003, 197, 1689-99.
    • (2003) J. Exp. Med , vol.197 , pp. 1689-1699
    • Chen, C.H.1    Seguin-Devaux, C.2    Burke, N.A.3    Oriss, T.B.4    Watkins, S.C.5    Clipstone, N.6    Ray, A.7
  • 62
    • 0842326032 scopus 로고    scopus 로고
    • Latent membrane protein 2A inhibits transforming growth factor-beta 1-induced apoptosis through the phosphatidylinositol 3-kinase/Akt pathway
    • Fukuda, M.; Longnecker, R. Latent membrane protein 2A inhibits transforming growth factor-beta 1-induced apoptosis through the phosphatidylinositol 3-kinase/Akt pathway. J. Virol., 2004, 78, 1697-705.
    • (2004) J. Virol , vol.78 , pp. 1697-1705
    • Fukuda, M.1    Longnecker, R.2
  • 63
    • 31144464767 scopus 로고    scopus 로고
    • Cutting edge: Deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo
    • Wohlfert, E.A.; Gorelik, L.; Mittler, R.; Flavell, R.A.; Clark, R.B. Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo. J. Immunol., 2006, 176, 1316-20.
    • (2006) J. Immunol , vol.176 , pp. 1316-1320
    • Wohlfert, E.A.1    Gorelik, L.2    Mittler, R.3    Flavell, R.A.4    Clark, R.B.5
  • 64
    • 33846923124 scopus 로고    scopus 로고
    • IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells
    • Zheng, S.G.; Wang, J.; Wang, P.; Gray, J.D.; Horwitz, D.A. IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J. Immunol., 2007, 178, 2018-27.
    • (2007) J. Immunol , vol.178 , pp. 2018-2027
    • Zheng, S.G.1    Wang, J.2    Wang, P.3    Gray, J.D.4    Horwitz, D.A.5
  • 65
    • 33947644716 scopus 로고    scopus 로고
    • IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells
    • Davidson, T.S.; DiPaolo, R.J.; Andersson, J.; Shevach, E.M. Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells. J. Immunol., 2007, 178, 4022-6.
    • (2007) J. Immunol , vol.178 , pp. 4022-4026
    • Davidson, T.S.1    DiPaolo, R.J.2    Andersson, J.3    Shevach4    Cutting Edge, E.M.5
  • 66
    • 0029933309 scopus 로고    scopus 로고
    • Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology
    • Sloan-Lancaster, J.; Allen, P.M. Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu. Rev. Immunol., 1996, 14, 1-27.
    • (1996) Annu. Rev. Immunol , vol.14 , pp. 1-27
    • Sloan-Lancaster, J.1    Allen, P.M.2
  • 68
    • 0035253574 scopus 로고    scopus 로고
    • Diamond, B.T cell studies in a peptide-induced model of systemic lupus erythematosus
    • Khalil, M.; Inaba, K.; Steinman, R.; Ravetch, J.; Diamond, B.T cell studies in a peptide-induced model of systemic lupus erythematosus. J. Immunol., 2001, 166, 1667-74.
    • (2001) J. Immunol , vol.166 , pp. 1667-1674
    • Khalil, M.1    Inaba, K.2    Steinman, R.3    Ravetch, J.4
  • 69
    • 42549152019 scopus 로고    scopus 로고
    • Signalling defects and cellular interactions (2)
    • Datta, S.K.; Mauri, C. Signalling defects and cellular interactions (2). Lupus, 2008, 17, 247-50.
    • (2008) Lupus , vol.17 , pp. 247-250
    • Datta, S.K.1    Mauri, C.2
  • 70
    • 40049108936 scopus 로고    scopus 로고
    • Hom, G.; Graham, R.R.; Modrek, B.; Taylor, K.E.; Ortmann, W.; Garnier, S.; Lee, A.T.; Chung, S.A.; Ferreira, R.C.; Pant, P.V.; Ballinger, D.G.; Kosoy, R.; Demirci, F.Y.; Kamboh, M.I.; Kao, A.H.; Tian, C.; Gunnarsson, I.; Bengtsson, A.A.; Rantapaa-Dahlqvist, S.; Petri, M.; Manzi, S.; Seldin, M.F.; Ronnblom, L.; Syvanen, A.C.; Criswell, L.A.; Gregersen, P.K.; Behrens, T.W. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N. Engl. J. Med., 2008, 358, 900-9.
    • Hom, G.; Graham, R.R.; Modrek, B.; Taylor, K.E.; Ortmann, W.; Garnier, S.; Lee, A.T.; Chung, S.A.; Ferreira, R.C.; Pant, P.V.; Ballinger, D.G.; Kosoy, R.; Demirci, F.Y.; Kamboh, M.I.; Kao, A.H.; Tian, C.; Gunnarsson, I.; Bengtsson, A.A.; Rantapaa-Dahlqvist, S.; Petri, M.; Manzi, S.; Seldin, M.F.; Ronnblom, L.; Syvanen, A.C.; Criswell, L.A.; Gregersen, P.K.; Behrens, T.W. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N. Engl. J. Med., 2008, 358, 900-9.
  • 72
    • 0028939618 scopus 로고
    • The pathogenic human monoclonal anti-DNA that induces experimental systemic lupus erythematosus in mice is encoded by a VH4 gene segment
    • Waisman, A.; Shoenfeld, Y.; Blank, M.; Ruiz, P.J.; Mozes, E. The pathogenic human monoclonal anti-DNA that induces experimental systemic lupus erythematosus in mice is encoded by a VH4 gene segment. Int. Immunol., 1995, 7, 689-96.
    • (1995) Int. Immunol , vol.7 , pp. 689-696
    • Waisman, A.1    Shoenfeld, Y.2    Blank, M.3    Ruiz, P.J.4    Mozes, E.5
  • 73
    • 21644484449 scopus 로고    scopus 로고
    • A peptide based on the complementarity determining region 1 of a human monoclonal autoantibody ameliorates spontaneous and induced lupus manifestations in correlation with cytokine immunomodulation
    • Luger, D.; Dayan, M.; Zinger, H.; Liu, J.P.; Mozes, E. A peptide based on the complementarity determining region 1 of a human monoclonal autoantibody ameliorates spontaneous and induced lupus manifestations in correlation with cytokine immunomodulation. J. Clin. Immunol., 2004, 24, 579-90.
    • (2004) J. Clin. Immunol , vol.24 , pp. 579-590
    • Luger, D.1    Dayan, M.2    Zinger, H.3    Liu, J.P.4    Mozes, E.5
  • 74
    • 34547408930 scopus 로고    scopus 로고
    • Altered gene expression in mice with lupus treated with edratide, a peptide that ameliorates the disease manifestations
    • Elmann, A.; Sharabi, A.; Dayan, M.; Zinger, H.; Ophir, R.; Mozes, E. Altered gene expression in mice with lupus treated with edratide, a peptide that ameliorates the disease manifestations. Arthritis Rheum., 2007, 56, 2371-81.
    • (2007) Arthritis Rheum , vol.56 , pp. 2371-2381
    • Elmann, A.1    Sharabi, A.2    Dayan, M.3    Zinger, H.4    Ophir, R.5    Mozes, E.6
  • 75
    • 27144519105 scopus 로고    scopus 로고
    • Selective modulation of CD4+ T cells from lupus patients by a promiscuous, protective peptide analog
    • Monneaux, F.; Hoebeke, J.; Sordet, C.; Nonn, C.; Briand, J.P.; Maillere, B.; Sibillia, J.; Muller, S. Selective modulation of CD4+ T cells from lupus patients by a promiscuous, protective peptide analog. J. Immunol., 2005, 175, 5839-47.
    • (2005) J. Immunol , vol.175 , pp. 5839-5847
    • Monneaux, F.1    Hoebeke, J.2    Sordet, C.3    Nonn, C.4    Briand, J.P.5    Maillere, B.6    Sibillia, J.7    Muller, S.8
  • 76
    • 4043149909 scopus 로고    scopus 로고
    • Peptides from antibodies to DNA elicit cytokine release from peripheral blood mononuclear cells of patients with systemic lupus erythematosus: Relation of cytokine pattern to disease duration
    • Kalsi, J.K.; Grossman, J.; Kim, J.; Sieling, P.; Gjertson, D.W.; Reed, E.F.; Ebling, F.M.; Linker-Israeli, M.; Hahn, B.H. Peptides from antibodies to DNA elicit cytokine release from peripheral blood mononuclear cells of patients with systemic lupus erythematosus: relation of cytokine pattern to disease duration. Lupus, 2004, 13, 490-500.
    • (2004) Lupus , vol.13 , pp. 490-500
    • Kalsi, J.K.1    Grossman, J.2    Kim, J.3    Sieling, P.4    Gjertson, D.W.5    Reed, E.F.6    Ebling, F.M.7    Linker-Israeli, M.8    Hahn, B.H.9


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