Induction of autoantibody production is limited in nonautoimmune mice

Journal of Immunology

Volumn 169, Issue 1, 2002, Pages 587-594

  Singh, Ram Raj ^a   Ebling, Fanny M ^a   Albuquerque, D Alves ^a   Saxena, Vijay ^a   Kumar, Vipin ^a   Giannini, Edward H ^a   Marion, Tony N ^a   Finkelman, Fred D ^a   Hahn, Bevra H ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CREATININE; DNA ANTIBODY; DOUBLE STRANDED DNA; IMMUNOGLOBULIN G ANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCLONAL ANTIBODY; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOLOGICAL TOLERANCE; MOUSE; NEPHRITIS; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; UREA NITROGEN BLOOD LEVEL;

EID: 0036644567     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.1.587     Document Type: Article

References (43)

1. Dermato-polymyositis: A recent outbreak
2. Antibodies to DNA
3. Comparison of pathogenic and nonpathogenic murine antibodies to DNA: Antigen binding and structural characteristics
4. T-cell determinants from autoantibodies to DNA can upregulate autoimmunity in murine lupus
5. Nucleosomal peptide epitopes for nephritis-inducing helper T cells of murine lupus
6. Potential use of peptides and vaccination to treat systemic lupus erythematosus
7. Autoreactive T cells in murine lupus: Origins and roles in autoantibody production
8. Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice
9. Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death
10. Regulation of anti-double stranded DNA B cells in nonautoimmune mice: Localization to the T-B interface of the splenic follicle
11. Anatomy of autoantibody production: Dominant localization of antibody-producing cells to T cell zones in Fas-deficient mice
12. MRL-lpr/lpr mice exhibit a defect in maintaining developmental arrest and follicular exclusion of anti-double-stranded DNA B cells
13. Functional consequences of the developmental arrest and follicular exclusion of anti-double-stranded DNA B cells
14. 1 mouse model of systemic lupus erythematosus
15. Evidence for multiple mechanisms of polyclonal T cell activation in murine lupus
16. 1 murine SLE model
17. Detection of native and denatured DNA antibody forming cells by the enzyme-linked immunospot assay
18. Comparison of the frequencies of arginines in heavy chain CDR3 of antibodies expressed in the primary B-cell repertoires of autoimmune-prone and normal mice
19. Neonatal peptide exposure can prime T cells, and upon subsequent immunization induce their immune deviation: Implications for antibody vs. T cell-mediated autoimmunity
20. Immune tolerance to autoantibody-derived peptides delays development of autoimmunity in murine lupus
21. 1 mice
22. MHC class II-restricted presentation of intracellular antigen
23. Reciprocal T-B determinant spreading develops spontaneously in murine lupus: Implications for pathogenesis
24. Somatic origin of T-cell epitopes within antibody variable regions: Significance to monoclonal therapy and genesis of systemic autoimmune diseases
25. Characterization and role in experimental systemic lupus erythematosus of T cell lines specific to peptides based on CDR-1 and CDR-3 of a pathogenic anti-DNA monoclonal antibody
26. Immunoglobulin-specific T-B cell interaction. 11. T cell clones recognize the processed form of B cells' own surface immunoglobulin in the context of the major histocompatibility complex class II molecule
27. A receptor presentation hypothesis for T cell help that recruits autoreactive B cells
28. Human T cell responses to autoantibody variable region peptides
29. 1 mice
30. 1 mice by treatment with CDRI and CDR3-based peptides of pathogenic autoantibody
31. Modulation of the disease activity in murine systemic lupus erythematosus by cytokine gene delivery
32. Decreased production of TGF-beta by lymphocytes from patients with systemic lupus erythematosus
33. Activated self-MHC-reactive T cells have the cytokine phenotype of Th3/T regulatory cell 1 T cells
34. + antimyelin basic protein rat T lymphocytes inhibit disease induction
35. Regulatory T cells in autoimmunity
36. + T and NK cells
37. + T cells
38. - thymocytes
39. Regulatory T cells specific for the same framework 3 region of the Vβ8.2 chain are involved in the control of collagen II-induced arthritis and experimental autoimmune encephalomyelitis
40. + T cell lines
41. Resistance to herpes stromal keratitis conferred by an IgG2a-derived peptide
42. + T cells that prevent spontaneous autoimmune encephalomyelitis
43. Peripheral autoantigen induces regulatory T cells that prevent autoimmunity