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Volumn 28, Issue 5, 2008, Pages 400-420

Pharmacology of heparins and direct anticoagulants;Pharmakologie der heparine und der direkten antikoagulanzien

Author keywords

Argatroban; Bivalirduin; Dabigatran etexilate; Direct factor Xa inhibitors; Direct thrombin inhibitors; Fondaparinux; Glycosaminoglycans; Idraparinux; Lepirudin; Low molecular weight heparins; Rivaroxaban; SR123781A; Ximelagatran

Indexed keywords

2 [4 [(1 ACETIMIDOYL 3 PYRROLIDINYL)OXY]PHENYL] 3 (7 AMIDINO 2 NAPHTHYL)PROPIONIC ACID; ANTICOAGULANT AGENT; ANTISTASIN; ANTITHROMBIN; ANTIVITAMIN K; APIXABAN; ARGATROBAN; BLOOD CLOTTING FACTOR 10A; CERTOPARIN; DABIGATRAN; DABIGATRAN ETEXILATE; DALTEPARIN; DANAPAROID; DESULFATOHIRUDIN; ENOXAPARIN; FLAXIPARIN; FONDAPARINUX; GLYCOSAMINOGLYCAN POLYSULFATE; HEPARIN; HIRULOG; IDRAPARINUX; LEPIRUDIN; LOW MOLECULAR WEIGHT HEPARIN; MONOEMBOLEX; NADROPARIN; OLIGOSACCHARIDE; OTAMIXABAN; PHENPROCOUMON; PROTEIN; REVIPARIN; RIVAROXABAN; SR 123781A; SSR 126517E; TINZAPARIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; WARFARIN; XIMELAGATRAN;

EID: 58149471441     PISSN: 07209355     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1617187     Document Type: Review
Times cited : (28)

References (160)
  • 1
    • 0027502387 scopus 로고
    • Heparin/low molecular weight heparin and tissue factor pathway inhibitor
    • Abildgaard U. Heparin/low molecular weight heparin and tissue factor pathway inhibitor. Haemostasis 1993; 23 Suppl 1: 103-106.
    • (1993) Haemostasis , vol.23 , Issue.SUPPL. 1 , pp. 103-106
    • Abildgaard, U.1
  • 2
    • 0035023991 scopus 로고    scopus 로고
    • Plasma levels of total and free tissue factor pathway inhibitor (TFPI) as individual pharmacological parameters of various heparins
    • Alban S, Gastpar R. Plasma levels of total and free tissue factor pathway inhibitor (TFPI) as individual pharmacological parameters of various heparins. Thromb Haemost 2001; 85: 824-829.
    • (2001) Thromb Haemost , vol.85 , pp. 824-829
    • Alban, S.1    Gastpar, R.2
  • 3
    • 85131230758 scopus 로고    scopus 로고
    • Role of sulfated polysaccharides in the pathogenesis of heparin-induced thrombocytopenia
    • Warkentin T, Greinacher A eds, 4th edition. New York: Marcel Dekker
    • th edition. New York: Marcel Dekker 2007; 67-116.
    • (2007) Heparin-induced thrombocytopenia , pp. 67-116
    • Alban, S.1    Greinacher, A.2
  • 4
    • 58149465121 scopus 로고    scopus 로고
    • Alban S, Scriba GKE. Kommentar zur Monographie Danaparoid sodium PhEur 5.5, 2090. In: Arzneibuch-Kommentar. Band 5, Monographien D bis H. Stuttgart, Eschborn, Wissenschaftliche Verlagsgesellschaft, Govi-Verlag 2007; 26. Lieferung (PhEur 5.5).
    • Alban S, Scriba GKE. Kommentar zur Monographie "Danaparoid sodium" PhEur 5.5, 2090. In: Arzneibuch-Kommentar. Band 5, Monographien D bis H. Stuttgart, Eschborn, Wissenschaftliche Verlagsgesellschaft, Govi-Verlag 2007; 26. Lieferung (PhEur 5.5).
  • 5
    • 14844321969 scopus 로고    scopus 로고
    • From heparins to factor Xa inhibitors and beyond
    • Alban S. From heparins to factor Xa inhibitors and beyond. Eur J Clin Invest 2005; 35 Suppl I: 12-20.
    • (2005) Eur J Clin Invest , vol.35 , Issue.SUPPL. I , pp. 12-20
    • Alban, S.1
  • 6
    • 34547173906 scopus 로고    scopus 로고
    • Kapitel 20. Kohlenhydrate III: Aminoglykane und Glykosaminoglykane
    • eds, Pharmakognosie, Phytopharmazie. Heidelberg: Springer
    • Alban S. Kapitel 20. Kohlenhydrate III: Aminoglykane und Glykosaminoglykane. In: Hänsel R, Sticher O. (eds). Pharmakognosie - Phytopharmazie. Heidelberg: Springer 2006; 655-704.
    • (2006) Hänsel R, Sticher O , pp. 655-704
    • Alban, S.1
  • 7
    • 3042785874 scopus 로고    scopus 로고
    • Paradigm change in anticoagulation. Natural substances that are selective factor Xa inhibitors
    • Alban S. Paradigm change in anticoagulation. Natural substances that are selective factor Xa inhibitors. Pharm Unserer Zeit 2004; 33: 190-194.
    • (2004) Pharm Unserer Zeit , vol.33 , pp. 190-194
    • Alban, S.1
  • 8
    • 14844285422 scopus 로고    scopus 로고
    • The 'precautionary principle' as a guide for future drug development
    • Alban S. The 'precautionary principle' as a guide for future drug development. Eur J Clin Invest 2005; 35 Suppl I: 33-44.
    • (2005) Eur J Clin Invest , vol.35 , Issue.SUPPL. I , pp. 33-44
    • Alban, S.1
  • 9
    • 33644848865 scopus 로고    scopus 로고
    • Fixed dosage of low-molecular-weight heparins causes large individual variation in coagulability, only partly correlated to body weight
    • Al Dieri R, Alban S, Beguin S et al. Fixed dosage of low-molecular-weight heparins causes large individual variation in coagulability, only partly correlated to body weight. Thromb Haemost 2006; 4: 83-89.
    • (2006) Thromb Haemost , vol.4 , pp. 83-89
    • Al Dieri, R.1    Alban, S.2    Beguin, S.3
  • 10
    • 0028236050 scopus 로고
    • Adjusted versus fixed doses of the low-molecular-weight heparin fragmin in the treatment of deep vein thrombosis. Fragmin-Study Group
    • Alhenc-Gelas M, Jestin-Le Guernic C, Vitoux JF et al. Adjusted versus fixed doses of the low-molecular-weight heparin fragmin in the treatment of deep vein thrombosis. Fragmin-Study Group. Thromb Haemost 1994; 71: 698-702.
    • (1994) Thromb Haemost , vol.71 , pp. 698-702
    • Alhenc-Gelas, M.1    Jestin-Le Guernic, C.2    Vitoux, J.F.3
  • 11
    • 0030980765 scopus 로고    scopus 로고
    • Absence of cross-reactivity of SR90107A/ORG 31540 pentasaccharide with antibodies to heparin-PF4 complexes developed in heparin-induced thrombocytopenia
    • Amiral J, Lormeau JC, Marfaing-Koka A et al. Absence of cross-reactivity of SR90107A/ORG 31540 pentasaccharide with antibodies to heparin-PF4 complexes developed in heparin-induced thrombocytopenia. Blood Coagul Fibrinolysis 1997; 8: 114-117.
    • (1997) Blood Coagul Fibrinolysis , vol.8 , pp. 114-117
    • Amiral, J.1    Lormeau, J.C.2    Marfaing-Koka, A.3
  • 13
    • 0021268420 scopus 로고
    • Low-affinity heparin potentiates the action of high-affinity heparin oligosaccharides
    • Barrowcliffe TW, Merton RE, Havercroft SJ et al. Low-affinity heparin potentiates the action of high-affinity heparin oligosaccharides. Thromb Res 1984; 34: 125-133.
    • (1984) Thromb Res , vol.34 , pp. 125-133
    • Barrowcliffe, T.W.1    Merton, R.E.2    Havercroft, S.J.3
  • 14
    • 23844519605 scopus 로고    scopus 로고
    • Transitioning from argatroban to warfarin in heparin-induced thrombocytopenia: An analysis of outcomes in patients with elevated international normalized ratio (INR)
    • Bartholomew JR, Hursting MJ. Transitioning from argatroban to warfarin in heparin-induced thrombocytopenia: an analysis of outcomes in patients with elevated international normalized ratio (INR). J Thromb Thrombolysis 2005; 19: 183-188.
    • (2005) J Thromb Thrombolysis , vol.19 , pp. 183-188
    • Bartholomew, J.R.1    Hursting, M.J.2
  • 15
    • 0034573085 scopus 로고    scopus 로고
    • The mechanism of action of thrombin inhibitors
    • Bates SM, Weitz JI. The mechanism of action of thrombin inhibitors. J Invasive Cardiol 2000; 12 (Suppl F): 27F-32F.
    • (2000) J Invasive Cardiol , vol.12 , Issue.SUPPL. F
    • Bates, S.M.1    Weitz, J.I.2
  • 16
    • 33744779960 scopus 로고    scopus 로고
    • The status of new anticoagulants
    • Bates SM, Weitz JI. The status of new anticoagulants. Br J Haematol 2006; 134: 3-19.
    • (2006) Br J Haematol , vol.134 , pp. 3-19
    • Bates, S.M.1    Weitz, J.I.2
  • 17
    • 0036080277 scopus 로고    scopus 로고
    • Fondaparinux, a synthetic pentasaccharide: The first in a new class of antithrombotic agents - the selective factor Xa inhibitors
    • Bauer KA, Hawkins DW, Peters PC et al. Fondaparinux, a synthetic pentasaccharide: the first in a new class of antithrombotic agents - the selective factor Xa inhibitors. Cardiovasc Drug Rev 2002; 20: 37-52.
    • (2002) Cardiovasc Drug Rev , vol.20 , pp. 37-52
    • Bauer, K.A.1    Hawkins, D.W.2    Peters, P.C.3
  • 18
    • 34249339959 scopus 로고    scopus 로고
    • Hematology Am Soc Hematol Educ Program
    • Bauer KA. New anticoagulants. Hematology Am Soc Hematol Educ Program 2006: 450-456.
    • (2006) New anticoagulants , pp. 450-456
    • Bauer, K.A.1
  • 19
    • 32544453399 scopus 로고    scopus 로고
    • New anticoagulants: Anti IIa vs anti Xa - is one better?
    • Bauer KA. New anticoagulants: anti IIa vs anti Xa - is one better? J Thromb Thrombolysis 2006; 21 (1): 67-72.
    • (2006) J Thromb Thrombolysis , vol.21 , Issue.1 , pp. 67-72
    • Bauer, K.A.1
  • 20
    • 33947328223 scopus 로고    scopus 로고
    • Perioperative bridging with fondaparinux in a woman with antithrombin deficiency
    • Bauersachs R, Alban S. Perioperative bridging with fondaparinux in a woman with antithrombin deficiency. Thromb Haemost 2007; 97: 498-499.
    • (2007) Thromb Haemost , vol.97 , pp. 498-499
    • Bauersachs, R.1    Alban, S.2
  • 21
    • 0343484317 scopus 로고    scopus 로고
    • Conjectures and refutations on the mode of action of heparins. The limited importance of anti-factor Xa activity as a pharmaceutical mechanism and a yardstick for therapy
    • Beguin S, Welzel D, Al Dieri R et al. Conjectures and refutations on the mode of action of heparins. The limited importance of anti-factor Xa activity as a pharmaceutical mechanism and a yardstick for therapy. Haemostasis 1999; 29: 170-178.
    • (1999) Haemostasis , vol.29 , pp. 170-178
    • Beguin, S.1    Welzel, D.2    Al Dieri, R.3
  • 22
    • 0027959329 scopus 로고
    • Effects of the synthetic thrombin inhibitor argatroban on fibrin- or clot-incorporated thrombin: Comparison with heparin and recombinant hirudin
    • Berry CN, Girardot C, Lecoffre C et al. Effects of the synthetic thrombin inhibitor argatroban on fibrin- or clot-incorporated thrombin: comparison with heparin and recombinant hirudin. Thromb Haemost 1994; 72: 381-386.
    • (1994) Thromb Haemost , vol.72 , pp. 381-386
    • Berry, C.N.1    Girardot, C.2    Lecoffre, C.3
  • 23
    • 34547092177 scopus 로고    scopus 로고
    • Variability of heparins and heterogeneity of low molecular weight heparins
    • Bianchini P, Liverani L, Spelta F et al. Variability of heparins and heterogeneity of low molecular weight heparins. Semin Thromb Hemost 2007; 33: 496-502.
    • (2007) Semin Thromb Hemost , vol.33 , pp. 496-502
    • Bianchini, P.1    Liverani, L.2    Spelta, F.3
  • 24
    • 33947322997 scopus 로고    scopus 로고
    • Prevention and treatment of experimental thrombosis in rabbits with rivaroxaban (BAY 597939) - an oral, direct factor Xa inhibitor
    • Biemond BJ, Perzborn E, Friederich PW et al. Prevention and treatment of experimental thrombosis in rabbits with rivaroxaban (BAY 597939) - an oral, direct factor Xa inhibitor. Thromb Haemost 2007; 97: 471-477.
    • (2007) Thromb Haemost , vol.97 , pp. 471-477
    • Biemond, B.J.1    Perzborn, E.2    Friederich, P.W.3
  • 25
    • 0037069334 scopus 로고    scopus 로고
    • Ability of recombinant factor VIIa to reverse the anticoagulant effect of the pentasaccharide fondaparinux in healthy volunteers
    • Bijsterveld NR, Moons AH, Boekholdt SM et al. Ability of recombinant factor VIIa to reverse the anticoagulant effect of the pentasaccharide fondaparinux in healthy volunteers. Circulation 2002; 106: 2550-2554.
    • (2002) Circulation , vol.106 , pp. 2550-2554
    • Bijsterveld, N.R.1    Moons, A.H.2    Boekholdt, S.M.3
  • 26
    • 0001973353 scopus 로고
    • Molecular mechanisms of the accelerating effect of heparin on the reactions between antithrombin and clotting proteinases
    • Lane DA, Lindahl U eds, Boca Raton, Fl: CRC Press
    • Björk I, Olson ST, Shore JD. Molecular mechanisms of the accelerating effect of heparin on the reactions between antithrombin and clotting proteinases. In: Lane DA, Lindahl U (eds). Heparin, chemical and biological properties, clinical applications. Boca Raton, Fl: CRC Press 1989; 229-256.
    • (1989) Heparin, chemical and biological properties, clinical applications , pp. 229-256
    • Björk, I.1    Olson, S.T.2    Shore, J.D.3
  • 27
    • 38749131205 scopus 로고    scopus 로고
    • The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans
    • Blech S, Ebner T, Ludwig-Schwellinger E et al. The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans. Drug Metab Dispos 2008; 36: 386-399.
    • (2008) Drug Metab Dispos , vol.36 , pp. 386-399
    • Blech, S.1    Ebner, T.2    Ludwig-Schwellinger, E.3
  • 28
    • 40149110688 scopus 로고    scopus 로고
    • Emerging anticoagulants and heparin-induced thrombocytopenia: Indirect and direct factor Xa inhibitors and oral thrombin inhibitors
    • Warkentin T, Greinacher A eds, 4th edition. New York: Marcel Dekker
    • th edition. New York: Marcel Dekker 2007; 441-486.
    • (2007) Heparin-induced thrombocytopenia , pp. 441-486
    • Bradner, J.E.1    Eikelboom, J.W.2
  • 29
    • 2142812859 scopus 로고    scopus 로고
    • Factor Xa is highly protected from antithrombin-fondaparinux and antithrombin-enoxaparin when incorporated into the prothrombinase complex
    • Brufatto N, Ward A, Nesheim ME. Factor Xa is highly protected from antithrombin-fondaparinux and antithrombin-enoxaparin when incorporated into the prothrombinase complex. J Thromb Haemost 2003; 1: 1258-1264.
    • (2003) J Thromb Haemost , vol.1 , pp. 1258-1264
    • Brufatto, N.1    Ward, A.2    Nesheim, M.E.3
  • 30
    • 34250706406 scopus 로고    scopus 로고
    • Cancer and thrombosis: From molecular mechanisms to clinical presentations
    • Buller HR, van Doormaal FF, van Sluis GL et al. Cancer and thrombosis: from molecular mechanisms to clinical presentations. J Thromb Haemost 2007; Suppl 1: 246-254.
    • (2007) J Thromb Haemost , Issue.SUPPL. 1 , pp. 246-254
    • Buller, H.R.1    van Doormaal, F.F.2    van Sluis, G.L.3
  • 31
    • 0033086427 scopus 로고    scopus 로고
    • Cardiovascular drug highlight: Hirudin
    • Cheng-Lai A. Cardiovascular drug highlight: hirudin. Heart Dis 1999; 1: 41-49.
    • (1999) Heart Dis , vol.1 , pp. 41-49
    • Cheng-Lai, A.1
  • 32
    • 0021061174 scopus 로고
    • Structure-activity relationship in heparin: A synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity
    • Choay J, Petitou M, Lormeau JC et al. Structure-activity relationship in heparin: a synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity. Biochem Biophys Res Commun 1983; 116: 492-499.
    • (1983) Biochem Biophys Res Commun , vol.116 , pp. 492-499
    • Choay, J.1    Petitou, M.2    Lormeau, J.C.3
  • 33
    • 33947132649 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: An autoimmune disorder regulated through dynamic autoantigen assembly/disassembly
    • Cines DB, Rauova L, Arepally G et al. Heparin-induced thrombocytopenia: an autoimmune disorder regulated through dynamic autoantigen assembly/disassembly. J Clin Apheresis 2007; 22: 31-36.
    • (2007) J Clin Apheresis , vol.22 , pp. 31-36
    • Cines, D.B.1    Rauova, L.2    Arepally, G.3
  • 34
    • 0028933964 scopus 로고
    • Comparison of the pharmacokinetic profiles of three low molecular mass heparins - dalteparin, enoxaparin and nadroparin - administered subcutaneously in healthy volunteers (doses for prevention of thromboembolism)
    • Collignon F, Frydman A, Caplain H et al. Comparison of the pharmacokinetic profiles of three low molecular mass heparins - dalteparin, enoxaparin and nadroparin - administered subcutaneously in healthy volunteers (doses for prevention of thromboembolism). Thromb Haemost 1995; 73: 630-640.
    • (1995) Thromb Haemost , vol.73 , pp. 630-640
    • Collignon, F.1    Frydman, A.2    Caplain, H.3
  • 35
    • 0036159892 scopus 로고    scopus 로고
    • Mechanisms responsible for the failure of protamine to inactivate low-molecular-weight heparin
    • Crowther MA, Berry LR, Monagle PT et al. Mechanisms responsible for the failure of protamine to inactivate low-molecular-weight heparin. Br J Haematol 2000; 116: 178-186.
    • (2000) Br J Haematol , vol.116 , pp. 178-186
    • Crowther, M.A.1    Berry, L.R.2    Monagle, P.T.3
  • 36
    • 0242585716 scopus 로고    scopus 로고
    • Blood coagulation
    • Dahlbäck B. Blood coagulation. Lancet. 2000; 355: 1627-1632.
    • (2000) Lancet , vol.355 , pp. 1627-1632
    • Dahlbäck, B.1
  • 37
    • 40149106332 scopus 로고
    • Catabolism of low-dose in man
    • Dawa J, Pepper DS. Catabolism of low-dose in man. Thromb Res 1986; 43: 1-6.
    • (1986) Thromb Res , vol.43 , pp. 1-6
    • Dawa, J.1    Pepper, D.S.2
  • 38
    • 12444301735 scopus 로고    scopus 로고
    • Comparative study of the pharmacokinetic profiles of two LMWHs - bemiparin (3500 IU, anti-Xa) and tinzaparin (4500 IU, anti-Xa) - administered subcutaneously to healthy male volunteers
    • Depasse F, Gonzalez de Suso MJ, Lagoutte I et al. Comparative study of the pharmacokinetic profiles of two LMWHs - bemiparin (3500 IU, anti-Xa) and tinzaparin (4500 IU, anti-Xa) - administered subcutaneously to healthy male volunteers. Thromb Res 2003; 109: 109-117.
    • (2003) Thromb Res , vol.109 , pp. 109-117
    • Depasse, F.1    Gonzalez de Suso, M.J.2    Lagoutte, I.3
  • 40
    • 0024445042 scopus 로고
    • Antistasin, a leech-derived inhibitor of factor Xa. Kinetic analysis of enzyme inhibition and identification of the reactive site
    • Dunwiddie C, Thornberry NA, Bull HG et al. Antistasin, a leech-derived inhibitor of factor Xa. Kinetic analysis of enzyme inhibition and identification of the reactive site. J Biol Chem 1989; 264: 16694-16699.
    • (1989) J Biol Chem , vol.264 , pp. 16694-16699
    • Dunwiddie, C.1    Thornberry, N.A.2    Bull, H.G.3
  • 41
    • 34548010265 scopus 로고    scopus 로고
    • Off-pump coronary artery bypass with bivalirudin for patients with heparin-induced thrombocytopenia or antiplatelet factor four/heparin antibodies
    • Dyke CM, Aldea G, Koster A et al. Off-pump coronary artery bypass with bivalirudin for patients with heparin-induced thrombocytopenia or antiplatelet factor four/heparin antibodies. Ann Thorac Surg 2007; 84: 836-839.
    • (2007) Ann Thorac Surg , vol.84 , pp. 836-839
    • Dyke, C.M.1    Aldea, G.2    Koster, A.3
  • 42
    • 0027199974 scopus 로고
    • Importance of factor Xa in determining the procoagulant activity of whole-blood clots
    • Eisenberg PR, Siegel JE, Abendschein DR et al. Importance of factor Xa in determining the procoagulant activity of whole-blood clots. J Clin Invest 1993; 91: 1877-1883.
    • (1993) J Clin Invest , vol.91 , pp. 1877-1883
    • Eisenberg, P.R.1    Siegel, J.E.2    Abendschein, D.R.3
  • 43
    • 58149461966 scopus 로고    scopus 로고
    • EMEA. European Public Assessment Report for Angiox. H-C-562-N-12.13.07. 2007. http://www.emea.europa.eu/humandocs/Humans/EPAR/angiox/angiox.htm. Accessed: 13.05.2008.
    • EMEA. European Public Assessment Report for Angiox. H-C-562-N-12.13.07. 2007. http://www.emea.europa.eu/humandocs/Humans/EPAR/angiox/angiox.htm. Accessed: 13.05.2008.
  • 44
    • 58149460838 scopus 로고    scopus 로고
    • EMEA. European Public Assessment Report for Refludan. H-C-122-IA-31. 15.10.2007. http://www.emea.europa.eu/humandocs/Humans/EPAR/refludan/refludan. htm. Accessed: 13.05.2008.
    • EMEA. European Public Assessment Report for Refludan. H-C-122-IA-31. 15.10.2007. http://www.emea.europa.eu/humandocs/Humans/EPAR/refludan/refludan. htm. Accessed: 13.05.2008.
  • 45
    • 58149464041 scopus 로고    scopus 로고
    • FDA, CDER. Label information for Angiomax, NDA 20-873/S-011. 30.11.2005. http://www.fda.gov/cder/foi/label/2005/020873s011lbl.pdf. Accessed: 13.05.2008.
    • FDA, CDER. Label information for Angiomax, NDA 20-873/S-011. 30.11.2005. http://www.fda.gov/cder/foi/label/2005/020873s011lbl.pdf. Accessed: 13.05.2008.
  • 46
    • 58149456398 scopus 로고    scopus 로고
    • FDA, CDER. Label information for Argatroban, 20-883/S-004. 04.03.2002. http://www.fda.gov/cder/foi/label/2002/20883s4lbl.pdf. Accessed: 13.05.2008.
    • FDA, CDER. Label information for Argatroban, 20-883/S-004. 04.03.2002. http://www.fda.gov/cder/foi/label/2002/20883s4lbl.pdf. Accessed: 13.05.2008.
  • 47
    • 58149460843 scopus 로고    scopus 로고
    • FDA, CDER. Label information for Refludan, 20-807/S-015. 11.07.2006. http://www.fda.gov/cder/foi/label/2006/020807s011lbl.pdf. Accessed: 13.05.2008.
    • FDA, CDER. Label information for Refludan, 20-807/S-015. 11.07.2006. http://www.fda.gov/cder/foi/label/2006/020807s011lbl.pdf. Accessed: 13.05.2008.
  • 48
    • 0029921343 scopus 로고    scopus 로고
    • Low-molecular-weight heparins: An overview of their pharmacodynamics, pharmacokinetics and metabolism in humans
    • Frydman A. Low-molecular-weight heparins: an overview of their pharmacodynamics, pharmacokinetics and metabolism in humans. Haemostasis 1996; 26 Suppl 2: 24-38.
    • (1996) Haemostasis , vol.26 , Issue.SUPPL. 2 , pp. 24-38
    • Frydman, A.1
  • 49
    • 0037270545 scopus 로고    scopus 로고
    • Monitoring low molecular weight heparins
    • Garon JE. Monitoring low molecular weight heparins. Clin Leadersh Manag Rev 2003; 17: 47-50.
    • (2003) Clin Leadersh Manag Rev , vol.17 , pp. 47-50
    • Garon, J.E.1
  • 50
    • 34147147085 scopus 로고    scopus 로고
    • In vitro inhibition of thrombin generation, after tissue factor pathway activation, by the oral, direct factor Xa inhibitor rivaroxaban
    • Gerotziafas GT, Elalamy I, Depasse F et al. In vitro inhibition of thrombin generation, after tissue factor pathway activation, by the oral, direct factor Xa inhibitor rivaroxaban. J Thromb Haemost 2007; 5: 886-888.
    • (2007) J Thromb Haemost , vol.5 , pp. 886-888
    • Gerotziafas, G.T.1    Elalamy, I.2    Depasse, F.3
  • 51
    • 33646038234 scopus 로고    scopus 로고
    • A systematic review of NSAIDs withdrawn from the market due to hepatotoxicity: Lessons learned from the bromfenac experience
    • Goldkind L, Laine L. A systematic review of NSAIDs withdrawn from the market due to hepatotoxicity: lessons learned from the bromfenac experience. Pharmacoepidemiol Drug Saf 2006; 15: 213-220.
    • (2006) Pharmacoepidemiol Drug Saf , vol.15 , pp. 213-220
    • Goldkind, L.1    Laine, L.2
  • 52
    • 35448932027 scopus 로고    scopus 로고
    • Effects of the oral, direct factor xa inhibitor rivaroxaban on platelet-induced thrombin generation and prothrombinase activity
    • Graff J, von Hentig N, Misselwitz F et al. Effects of the oral, direct factor xa inhibitor rivaroxaban on platelet-induced thrombin generation and prothrombinase activity. J Clin Pharmacol 2007; 47: 1398-1407.
    • (2007) J Clin Pharmacol , vol.47 , pp. 1398-1407
    • Graff, J.1    von Hentig, N.2    Misselwitz, F.3
  • 53
    • 0028117252 scopus 로고
    • Low affinity heparin is an antithrombotic agent
    • Gray E, Cesmeli S, Lormeau JC et al. Low affinity heparin is an antithrombotic agent. Thromb Haemost 1994; 71: 203-207.
    • (1994) Thromb Haemost , vol.71 , pp. 203-207
    • Gray, E.1    Cesmeli, S.2    Lormeau, J.C.3
  • 54
    • 0029086769 scopus 로고
    • Characterization of the structural requirements for a carbohydrate based anticoagulant with a reduced risk of inducing the immunological type of heparin-associated thrombocvtopenia
    • Greinacher A, Alban S, Dummel V et al. Characterization of the structural requirements for a carbohydrate based anticoagulant with a reduced risk of inducing the immunological type of heparin-associated thrombocvtopenia. Thromb Haemost 1995; 74: 886-892.
    • (1995) Thromb Haemost , vol.74 , pp. 886-892
    • Greinacher, A.1    Alban, S.2    Dummel, V.3
  • 55
    • 44549083477 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: A stoichiometry-based model to explain the different immunogenicities of unfractionated heparin, low-molecular-weight heparin, and fondaparinux
    • Greinacher A, Alban S, Orner-Adam MA et al. Heparin-induced thrombocytopenia: A stoichiometry-based model to explain the different immunogenicities of unfractionated heparin, low-molecular-weight heparin, and fondaparinux. Thromb Res 2008; 122: 211-220.
    • (2008) Thromb Res , vol.122 , pp. 211-220
    • Greinacher, A.1    Alban, S.2    Orner-Adam, M.A.3
  • 56
    • 33749059398 scopus 로고    scopus 로고
    • Close approximation of two platelet factor 4 tetramers by charge neutralization forms the antigens recognized by HIT antibodies
    • Greinacher A, Gopinadhan M, Gunther JU et al. Close approximation of two platelet factor 4 tetramers by charge neutralization forms the antigens recognized by HIT antibodies. Arterioscler Thromb Vasc Biol 2006; 26: 2386-2389.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 2386-2389
    • Greinacher, A.1    Gopinadhan, M.2    Gunther, J.U.3
  • 57
    • 33845269804 scopus 로고    scopus 로고
    • Effect of renal function on argatroban therapy in heparin-induced thrombocytopenia
    • Guzzi LM, McCollum DA, Hursting MJ. Effect of renal function on argatroban therapy in heparin-induced thrombocytopenia. J Thromb Thrombolysis 2006; 22: 169-176.
    • (2006) J Thromb Thrombolysis , vol.22 , pp. 169-176
    • Guzzi, L.M.1    McCollum, D.A.2    Hursting, M.J.3
  • 58
    • 0026741587 scopus 로고
    • Study of low molecular weight heparin effect on the relation between anticoagulant activity and antithrombin III affinity
    • Hamano S, Nishiyama M, Kikuchi S et al. Study of low molecular weight heparin effect on the relation between anticoagulant activity and antithrombin III affinity. Thromb Res 1992; 66: 299-307.
    • (1992) Thromb Res , vol.66 , pp. 299-307
    • Hamano, S.1    Nishiyama, M.2    Kikuchi, S.3
  • 59
    • 0028269097 scopus 로고
    • DX-9065a, a new synthetic, potent anticoagulant and selective inhibitor for factor Xa
    • Hara T, Yokoyama A, Ishihara H et al. DX-9065a, a new synthetic, potent anticoagulant and selective inhibitor for factor Xa. Thromb Haemost 1994; 71: 314-319.
    • (1994) Thromb Haemost , vol.71 , pp. 314-319
    • Hara, T.1    Yokoyama, A.2    Ishihara, H.3
  • 60
    • 3042626812 scopus 로고    scopus 로고
    • Transition from argatroban to oral anticoagulation with phenprocoumon or acenocoumarol: Effects on prothrombin time, activated partial thromboplastin time, and Ecarin Clotting Time
    • Harder S, Graff J, Klinkhardt U et al. Transition from argatroban to oral anticoagulation with phenprocoumon or acenocoumarol: effects on prothrombin time, activated partial thromboplastin time, and Ecarin Clotting Time. Thromb Haemost 2004; 91: 1137-1145.
    • (2004) Thromb Haemost , vol.91 , pp. 1137-1145
    • Harder, S.1    Graff, J.2    Klinkhardt, U.3
  • 61
    • 0037171819 scopus 로고    scopus 로고
    • Structure-based design of novel potent nonpeptide thrombin inhibitors
    • Hauel NH, Nar H, Priepke H et al. Structure-based design of novel potent nonpeptide thrombin inhibitors. J Med Chem 2002; 45: 1757-1766.
    • (2002) J Med Chem , vol.45 , pp. 1757-1766
    • Hauel, N.H.1    Nar, H.2    Priepke, H.3
  • 62
    • 0025214647 scopus 로고
    • Comparison of the anticoagulant and antithrombotic effects of synthetic thrombin and factor Xa inhibitors
    • Hauptmann J, Kaiser B, Nowak G et al. Comparison of the anticoagulant and antithrombotic effects of synthetic thrombin and factor Xa inhibitors. Thromb Haemost 1990; 63: 220-223.
    • (1990) Thromb Haemost , vol.63 , pp. 220-223
    • Hauptmann, J.1    Kaiser, B.2    Nowak, G.3
  • 63
    • 0030772346 scopus 로고    scopus 로고
    • Comparative effects of two direct and indirect factor Xa inhibitors on free and clot-bound prothrombinase
    • Hérault JP, Bernat A, Pflieger AM et al. Comparative effects of two direct and indirect factor Xa inhibitors on free and clot-bound prothrombinase. J Pharmacol Exp Ther 1997; 283: 16-22.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 16-22
    • Hérault, J.P.1    Bernat, A.2    Pflieger, A.M.3
  • 64
    • 0036281553 scopus 로고    scopus 로고
    • Pharmacokinetics of new synthetic heparin mimetics
    • Herault JP, Bernat A, Roye F et al. Pharmacokinetics of new synthetic heparin mimetics. Thromb Haemost 2002; 87: 985-989.
    • (2002) Thromb Haemost , vol.87 , pp. 985-989
    • Herault, J.P.1    Bernat, A.2    Roye, F.3
  • 67
    • 33947422061 scopus 로고    scopus 로고
    • High affinity interaction between a synthetic, highly negatively charged pentasaccharide and alpha- or beta-antithrombin is predominantly due to nonionic interactions
    • Hjelm R, Schedin-Weiss S. High affinity interaction between a synthetic, highly negatively charged pentasaccharide and alpha- or beta-antithrombin is predominantly due to nonionic interactions. Biochemistry 2007; 46: 3378-3384.
    • (2007) Biochemistry , vol.46 , pp. 3378-3384
    • Hjelm, R.1    Schedin-Weiss, S.2
  • 68
  • 69
    • 58149464044 scopus 로고    scopus 로고
    • Accessed: 13.05.2008
    • http://climcaltrials.gov/ct2/results?intr=%22SR123781A%22. Accessed: 13.05.2008.
  • 70
    • 22544466120 scopus 로고    scopus 로고
    • Transitioning from argatroban to warfarin therapy in patients with heparin-induced thrombocytopenia
    • Hursting MJ, Lewis BE, Macfarlane DE. Transitioning from argatroban to warfarin therapy in patients with heparin-induced thrombocytopenia. Clin Appl Thromb Hemost 2005; 11: 79-87.
    • (2005) Clin Appl Thromb Hemost , vol.11 , pp. 79-87
    • Hursting, M.J.1    Lewis, B.E.2    Macfarlane, D.E.3
  • 71
    • 34548335207 scopus 로고    scopus 로고
    • Dabigatran etexilate, a thrombin inhibitor for the prevention of venous thromboembolism and stroke
    • Ieko M. Dabigatran etexilate, a thrombin inhibitor for the prevention of venous thromboembolism and stroke. Curr Opin Investig Drugs 2007; 8: 758-768.
    • (2007) Curr Opin Investig Drugs , vol.8 , pp. 758-768
    • Ieko, M.1
  • 72
    • 34347220458 scopus 로고    scopus 로고
    • Heparin enhances osteoclastic bone resorption by inhibiting osteoprotegerin activity
    • Irie A, Takami M, Kubo H et al. Heparin enhances osteoclastic bone resorption by inhibiting osteoprotegerin activity. Bone 2007; 41: 165-174.
    • (2007) Bone , vol.41 , pp. 165-174
    • Irie, A.1    Takami, M.2    Kubo, H.3
  • 73
    • 0029030280 scopus 로고
    • Antithrombin III affinity dependence on the anticoagulant, antiprotease, and tissue factor pathway inhibitor actions of heparins.Semin
    • Jeske W, Lormeau JC, Callas D et al. Antithrombin III affinity dependence on the anticoagulant, antiprotease, and tissue factor pathway inhibitor actions of heparins.Semin Thromb Hemost 1995; 21: 193-200.
    • (1995) Thromb Hemost , vol.21 , pp. 193-200
    • Jeske, W.1    Lormeau, J.C.2    Callas, D.3
  • 74
    • 14344256853 scopus 로고    scopus 로고
    • Platelets and the new comprehension of haemostasis
    • Jurk K, Kehrel BE. Platelets and the new comprehension of haemostasis. Hamostaseologie 2005; 25: 39-49.
    • (2005) Hamostaseologie , vol.25 , pp. 39-49
    • Jurk, K.1    Kehrel, B.E.2
  • 75
    • 34247494229 scopus 로고    scopus 로고
    • Kakar P, Watson T, Lip GY. Rivaroxaban. Drugs Today (Barc) 2007; 43: 129-136.
    • Kakar P, Watson T, Lip GY. Rivaroxaban. Drugs Today (Barc) 2007; 43: 129-136.
  • 76
    • 46049106502 scopus 로고    scopus 로고
    • RECORD2 Investigators. Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: A double-blind, randomised controlled trial
    • Kakkar AK, Brenner B, Dahl OE et al; RECORD2 Investigators. Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a double-blind, randomised controlled trial. Lancet 2008; 372: 31-39.
    • (2008) Lancet , vol.372 , pp. 31-39
    • Kakkar, A.K.1    Brenner, B.2    Dahl, O.E.3
  • 77
    • 40249096193 scopus 로고    scopus 로고
    • Prediction of drug-induced liver injury in humans by using in vitro methods: The case of ximelagatran
    • Kenne K, Skanberg I, Glinghammar B et al. Prediction of drug-induced liver injury in humans by using in vitro methods: the case of ximelagatran. Toxicol In Vitro 2008; 22: 730-746.
    • (2008) Toxicol In Vitro , vol.22 , pp. 730-746
    • Kenne, K.1    Skanberg, I.2    Glinghammar, B.3
  • 78
    • 0021327417 scopus 로고    scopus 로고
    • Kikumoto R, Tamao Y, Tezuka T et al. Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl) sulfonyl]-1-arginyl)]-2-piperidinecarboxylic acid. Biochemistry 1984; 23: 85-90.
    • Kikumoto R, Tamao Y, Tezuka T et al. Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl) sulfonyl]-1-arginyl)]-2-piperidinecarboxylic acid. Biochemistry 1984; 23: 85-90.
  • 79
    • 33645468255 scopus 로고    scopus 로고
    • Emerging anticoagulants: Mechanism of action and future potential
    • Klement P, Rak J. Emerging anticoagulants: mechanism of action and future potential. Vnitr Lek 2006; 52 Suppl 1: 119-122.
    • (2006) Vnitr Lek , vol.52 , Issue.SUPPL. 1 , pp. 119-122
    • Klement, P.1    Rak, J.2
  • 80
    • 0141527584 scopus 로고    scopus 로고
    • Short- and long-acting synthetic pentasaccharides
    • Koopman MM, Buller HR. Short- and long-acting synthetic pentasaccharides. J Intern Med 2003; 254: 335-342.
    • (2003) J Intern Med , vol.254 , pp. 335-342
    • Koopman, M.M.1    Buller, H.R.2
  • 81
    • 33846519559 scopus 로고    scopus 로고
    • Bivalirudin during cardiopulmonary bypass in patients with previous or acute heparin-induced thrombocytopenia and heparin antibodies: Results of the CHOOSE-ON trial
    • Koster A, Dyke CM, Aldea G et al. Bivalirudin during cardiopulmonary bypass in patients with previous or acute heparin-induced thrombocytopenia and heparin antibodies: results of the CHOOSE-ON trial. Ann Thorac Surg 2007; 83: 572-577.
    • (2007) Ann Thorac Surg , vol.83 , pp. 572-577
    • Koster, A.1    Dyke, C.M.2    Aldea, G.3
  • 82
    • 33947205635 scopus 로고    scopus 로고
    • Rivaroxaban (BAY 59-7939) - an oral, direct Factor Xa inhibitor - has no clinically relevant interaction with naproxen
    • Kubitza D, Becka M, Mueck W et al. Rivaroxaban (BAY 59-7939) - an oral, direct Factor Xa inhibitor - has no clinically relevant interaction with naproxen. Br J Clin Pharmacol 2007; 63: 469-476.
    • (2007) Br J Clin Pharmacol , vol.63 , pp. 469-476
    • Kubitza, D.1    Becka, M.2    Mueck, W.3
  • 83
    • 33747068794 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacodynamics, and pharmacokinetics of rivaroxaban - an oral, direct factor Xa inhibitor - are not affected by aspirin
    • Kubitza D, Becka M, Mueck W et al. Safety, tolerability, pharmacodynamics, and pharmacokinetics of rivaroxaban - an oral, direct factor Xa inhibitor - are not affected by aspirin. J Clin Pharmacol 2006; 46: 981-990.
    • (2006) J Clin Pharmacol , vol.46 , pp. 981-990
    • Kubitza, D.1    Becka, M.2    Mueck, W.3
  • 84
    • 25844525489 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor
    • Kubitza D, Becka M, Voith B et al. Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor. Clin Pharmacol Ther 2005; 78: 412-421.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 412-421
    • Kubitza, D.1    Becka, M.2    Voith, B.3
  • 85
    • 33846448135 scopus 로고    scopus 로고
    • Body weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (BAY 59-7939) in healthy subjects
    • Kubitza D, Becka M, Zuehlsdorf M et al. Body weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (BAY 59-7939) in healthy subjects. J Clin Pharmacol 2007; 47: 218-226.
    • (2007) J Clin Pharmacol , vol.47 , pp. 218-226
    • Kubitza, D.1    Becka, M.2    Zuehlsdorf, M.3
  • 86
    • 33645779998 scopus 로고    scopus 로고
    • Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct factor Xa inhibitor, in healthy subjects
    • Kubitza D, Becka M, Zuehlsdorf M et al. Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct factor Xa inhibitor, in healthy subjects. J Clin Pharmacol 2006; 46: 549-558.
    • (2006) J Clin Pharmacol , vol.46 , pp. 549-558
    • Kubitza, D.1    Becka, M.2    Zuehlsdorf, M.3
  • 87
    • 0026101905 scopus 로고
    • Pharmakokinetics and biotransformation of technetium 99m labelled standard heparin and a low molecular weight heparin (enoxaparin) after intravenous injection innormal volunteers
    • Laforest MD, Linhart CN, Guiraud-Vitaux F et al. Pharmakokinetics and biotransformation of technetium 99m labelled standard heparin and a low molecular weight heparin (enoxaparin) after intravenous injection innormal volunteers. Br J Haematol 1991; 77: 201-208.
    • (1991) Br J Haematol , vol.77 , pp. 201-208
    • Laforest, M.D.1    Linhart, C.N.2    Guiraud-Vitaux, F.3
  • 88
    • 45949103416 scopus 로고    scopus 로고
    • RECORD3 Investigators. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty
    • Lassen MR, Ageno W, Borris LC et al; RECORD3 Investigators. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. N Engl J Med 2008; 358: 2776-2786.
    • (2008) N Engl J Med , vol.358 , pp. 2776-2786
    • Lassen, M.R.1    Ageno, W.2    Borris, L.C.3
  • 89
    • 34547106820 scopus 로고    scopus 로고
    • Preclinical and clinical characteristics of rivaroxaban: A novel, oral, direct factor Xa inhibitor
    • Laux V, Perzbora E, Kubitza D et al. Preclinical and clinical characteristics of rivaroxaban: a novel, oral, direct factor Xa inhibitor. Semin Thromb Hemost 2007; 33: 515-523.
    • (2007) Semin Thromb Hemost , vol.33 , pp. 515-523
    • Laux, V.1    Perzbora, E.2    Kubitza, D.3
  • 91
    • 0027399508 scopus 로고
    • Factor Xa inhibition: Correlation between the plasma levels of anti-Xa activity and occurrence of thrombosis and haemorrhage
    • Leizorovicz A, Bara L, Samama MM et al. Factor Xa inhibition: correlation between the plasma levels of anti-Xa activity and occurrence of thrombosis and haemorrhage. Haemostasis 1993; 23 Suppl 1: 89-98.
    • (1993) Haemostasis , vol.23 , Issue.SUPPL. 1 , pp. 89-98
    • Leizorovicz, A.1    Bara, L.2    Samama, M.M.3
  • 92
    • 4644293243 scopus 로고    scopus 로고
    • Levine MN, Raskob G, Beyth RJ et al. Hemorrhagic complications of anticoagulant treatment: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004; 126: 287S-310S.
    • Levine MN, Raskob G, Beyth RJ et al. Hemorrhagic complications of anticoagulant treatment: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004; 126: 287S-310S.
  • 93
    • 33646492822 scopus 로고    scopus 로고
    • Argatroban therapy in heparin-induced thrombocytopenia with hepatic dysfunction
    • Levine RL, Hursting MJ, McCollum D. Argatroban therapy in heparin-induced thrombocytopenia with hepatic dysfunction. Chest 2006; 129: 1167-1175.
    • (2006) Chest , vol.129 , pp. 1167-1175
    • Levine, R.L.1    Hursting, M.J.2    McCollum, D.3
  • 94
    • 33750023407 scopus 로고    scopus 로고
    • Effects of the direct thrombin inhibitor dabigatran on ex vivo coagulation time in orthopaedic surgery patients: A population model analysis
    • Liesenfeld KH, Schäfer HG, Trocóniz IF et al. Effects of the direct thrombin inhibitor dabigatran on ex vivo coagulation time in orthopaedic surgery patients: a population model analysis. Br J Clin Pharmacol 2006; 62: 527-537.
    • (2006) Br J Clin Pharmacol , vol.62 , pp. 527-537
    • Liesenfeld, K.H.1    Schäfer, H.G.2    Trocóniz, I.F.3
  • 95
    • 33646449376 scopus 로고    scopus 로고
    • Meta-analysis: Low-molecular-weight heparin and bleeding in patients with severe renal insufficiency
    • Lim W, Dentali F, Eikelboom JW et al. Meta-analysis: low-molecular-weight heparin and bleeding in patients with severe renal insufficiency. Ann Intern Med 2006; 144: 673-684.
    • (2006) Ann Intern Med , vol.144 , pp. 673-684
    • Lim, W.1    Dentali, F.2    Eikelboom, J.W.3
  • 97
    • 0029563321 scopus 로고
    • The effect of the synthetic pentasaccharide SR 90107/ORG 31540 on thrombin generation ex vivo is uniquely due to ATIII-mediated neutralization of factor Xa
    • Lormeau JC, Herault JP. The effect of the synthetic pentasaccharide SR 90107/ORG 31540 on thrombin generation ex vivo is uniquely due to ATIII-mediated neutralization of factor Xa. Thromb Haemost 1995; 74: 1474-1477.
    • (1995) Thromb Haemost , vol.74 , pp. 1474-1477
    • Lormeau, J.C.1    Herault, J.P.2
  • 98
    • 33645542177 scopus 로고    scopus 로고
    • The ability of different forms of heparins to suppress P-selectin function in vitro correlates to their inhibitory capacity on bloodborne metastasis in vivo
    • Ludwig RJ, Alban S, Bistrian R et al. The ability of different forms of heparins to suppress P-selectin function in vitro correlates to their inhibitory capacity on bloodborne metastasis in vivo. Thromb Haemost 2006; 95: 535-540.
    • (2006) Thromb Haemost , vol.95 , pp. 535-540
    • Ludwig, R.J.1    Alban, S.2    Bistrian, R.3
  • 99
    • 33748647001 scopus 로고    scopus 로고
    • Structural requirements of heparin and related molecules to exert a multitude of anti-inflammatory activities
    • Ludwig RJ, Alban S, Boehncke WH. Structural requirements of heparin and related molecules to exert a multitude of anti-inflammatory activities. Mini Rev Med Chem 2006; 6: 1009-1023.
    • (2006) Mini Rev Med Chem , vol.6 , pp. 1009-1023
    • Ludwig, R.J.1    Alban, S.2    Boehncke, W.H.3
  • 100
    • 34247095231 scopus 로고    scopus 로고
    • Tinzaparin and enoxaparin given at prophylactic dose for eight days in medical elderly patients with impaired renal function: A comparative pharmacokinetic study
    • Mahé I, Aghassarian M, Drouet L et al. Tinzaparin and enoxaparin given at prophylactic dose for eight days in medical elderly patients with impaired renal function: a comparative pharmacokinetic study. Thromb Haemost 2007; 97: 581-586.
    • (2007) Thromb Haemost , vol.97 , pp. 581-586
    • Mahé, I.1    Aghassarian, M.2    Drouet, L.3
  • 101
    • 0022456678 scopus 로고
    • Partial reversal of low molecular weight heparin (PK 10169) anti-Xa activity by protamine sulfate: In vitro and in vivo study during cardiac surgery with extracorporeal circulation
    • Massonnet-Castel S, Pelissier E, Bara L et al. Partial reversal of low molecular weight heparin (PK 10169) anti-Xa activity by protamine sulfate: in vitro and in vivo study during cardiac surgery with extracorporeal circulation. Haemostasis 1986; 16: 139-146.
    • (1986) Haemostasis , vol.16 , pp. 139-146
    • Massonnet-Castel, S.1    Pelissier, E.2    Bara, L.3
  • 102
    • 33748744792 scopus 로고    scopus 로고
    • Safety and efficacy of argatroban in patients with heparin-induced thrombocytopenia
    • Matthai WH Jr. Safety and efficacy of argatroban in patients with heparin-induced thrombocytopenia. Curr Hematol Rep 2006; 5: 95-99.
    • (2006) Curr Hematol Rep , vol.5 , pp. 95-99
    • Matthai Jr., W.H.1
  • 103
    • 0021345419 scopus 로고
    • High and low affinity heparin compared with unfractionated heparin as antithrombotic drugs
    • Merton RE, Thomas DP, Havercroft SJ et al. High and low affinity heparin compared with unfractionated heparin as antithrombotic drugs. Thromb Haemost 1984; 51: 254-256.
    • (1984) Thromb Haemost , vol.51 , pp. 254-256
    • Merton, R.E.1    Thomas, D.P.2    Havercroft, S.J.3
  • 105
    • 34250166525 scopus 로고    scopus 로고
    • Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban-an oral, direct factor xa inhibitor - in healthy subjects
    • Mueck W, Becka M, Kubitza D et al. Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban-an oral, direct factor xa inhibitor - in healthy subjects. Int J Clin Pharmacol Ther 2007; 45: 335-344.
    • (2007) Int J Clin Pharmacol Ther , vol.45 , pp. 335-344
    • Mueck, W.1    Becka, M.2    Kubitza, D.3
  • 106
    • 42949123582 scopus 로고    scopus 로고
    • Population pharmacokinetics and pharmacodynamics of rivaroxaban - an oral, direct factor Xa inhibitor - in patients undergoing major orthopaedic surgery
    • Mueck W, Eriksson BI, Bauer KA et al. Population pharmacokinetics and pharmacodynamics of rivaroxaban - an oral, direct factor Xa inhibitor - in patients undergoing major orthopaedic surgery. Clin Pharmacokinet 2008; 47: 203-216.
    • (2008) Clin Pharmacokinet , vol.47 , pp. 203-216
    • Mueck, W.1    Eriksson, B.I.2    Bauer, K.A.3
  • 107
    • 0036628436 scopus 로고    scopus 로고
    • BIBR-1048 Boehringer Ingelheim
    • Mungall D. BIBR-1048 Boehringer Ingelheim. Curr Opin Investig Drugs 2002; 3: 905-907.
    • (2002) Curr Opin Investig Drugs , vol.3 , pp. 905-907
    • Mungall, D.1
  • 108
    • 58149457504 scopus 로고    scopus 로고
    • N.N. Danaparoid sodium. European Pharmacopoeia 5.5 2006; No. 07/2006:2090.
    • N.N. Danaparoid sodium. European Pharmacopoeia 5.5 2006; No. 07/2006:2090.
  • 109
    • 58149464043 scopus 로고    scopus 로고
    • N.N. Low molecular weight heparins. European Pharmacopoeia 5.0 2004; No. 2318
    • N.N. Low molecular weight heparins. European Pharmacopoeia 5.0 2004; No. 2318
  • 110
    • 0028265990 scopus 로고
    • Dibasic (amidinoaryl)propanoic acid derivatives as novel blood coagulation factor Xa inhibitors
    • Nagahara T, Yokoyama Y, Inamura K et al. Dibasic (amidinoaryl)propanoic acid derivatives as novel blood coagulation factor Xa inhibitors. J Med Chem 1994; 37: 1200-1207.
    • (1994) J Med Chem , vol.37 , pp. 1200-1207
    • Nagahara, T.1    Yokoyama, Y.2    Inamura, K.3
  • 111
    • 0030733012 scopus 로고    scopus 로고
    • Hazards of heparin: Allergy, heparin-induced thrombocytopenia and osteoporosis
    • Nelson-Piercy C. Hazards of heparin: allergy, heparin-induced thrombocytopenia and osteoporosis. Baillieres Clin Obstet Gynaecol 199; 11: 489-509.
    • Baillieres Clin Obstet Gynaecol , vol.199 , Issue.11 , pp. 489-509
    • Nelson-Piercy, C.1
  • 112
    • 0025996472 scopus 로고
    • Identification of risk factors for bleeding during treatment of acute venous thromboembolism with heparin or low molecular weight heparin
    • Nieuwenhuis HK, Albada J, Banga JD et al. Identification of risk factors for bleeding during treatment of acute venous thromboembolism with heparin or low molecular weight heparin. Blood 1991; 78: 2337-2343.
    • (1991) Blood , vol.78 , pp. 2337-2343
    • Nieuwenhuis, H.K.1    Albada, J.2    Banga, J.D.3
  • 113
    • 33644830185 scopus 로고    scopus 로고
    • Low-molecular-weight heparins and angiogenesis
    • Norrby K. Low-molecular-weight heparins and angiogenesis. APMIS 2006; 114: 79-102.
    • (2006) APMIS , vol.114 , pp. 79-102
    • Norrby, K.1
  • 114
    • 1842305308 scopus 로고
    • Antithrombotic mechanisms of heparin and related compounds
    • Lane DA, Lindahl U eds, Boca Raton, Fl: CRC Press
    • Ofosu FA. Antithrombotic mechanisms of heparin and related compounds. In: Lane DA, Lindahl U (eds). Heparin, chemical and biological properties, clinical applications. Boca Raton, Fl: CRC Press 1989; 433-454.
    • (1989) Heparin, chemical and biological properties, clinical applications , pp. 433-454
    • Ofosu, F.A.1
  • 115
    • 0019891328 scopus 로고
    • Potent inhibition of thrombin by the newly synthesized arginine derivative No. 805. The importance of stereostructure of its hydrophobic carboxamide portion
    • Okamoto S, Hijikata A, Kikumoto R et al. Potent inhibition of thrombin by the newly synthesized arginine derivative No. 805. The importance of stereostructure of its hydrophobic carboxamide portion. Biochem Biophys Res Commun 1981; 101: 440-446.
    • (1981) Biochem Biophys Res Commun , vol.101 , pp. 440-446
    • Okamoto, S.1    Hijikata, A.2    Kikumoto, R.3
  • 116
    • 0026690347 scopus 로고
    • Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement
    • Olson ST, Björk I, Sheffer R et al. Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement. J Biol Chem 1992; 267: 12528-12538.
    • (1992) J Biol Chem , vol.267 , pp. 12528-12538
    • Olson, S.T.1    Björk, I.2    Sheffer, R.3
  • 117
    • 34249804158 scopus 로고    scopus 로고
    • Fondaparinux as a treatment option for heparin-induced thrombocytopenia
    • Papadopoulos S, Flynn JD, Lewis DA. Fondaparinux as a treatment option for heparin-induced thrombocytopenia. Pharmacotherapy 2007; 27: 921-926.
    • (2007) Pharmacotherapy , vol.27 , pp. 921-926
    • Papadopoulos, S.1    Flynn, J.D.2    Lewis, D.A.3
  • 118
    • 35349006989 scopus 로고    scopus 로고
    • A novel, oral, direct factor Xa inhibitor in clinical development for the prevention and treatment of thromboembolic disorders
    • Perzborn E, Kubitza D, Misselwitz F. Rivaroxaban. A novel, oral, direct factor Xa inhibitor in clinical development for the prevention and treatment of thromboembolic disorders. Hamostaseologie 2007; 27: 282-289.
    • (2007) Hamostaseologie , vol.27 , pp. 282-289
    • Perzborn, E.1    Kubitza, D.2    Misselwitz, F.3    Rivaroxaban4
  • 119
    • 22844442726 scopus 로고    scopus 로고
    • In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939 - an oral, direct Factor Xa inhibitor
    • Perzbom E, Strassburger J, Wilmen A et al. In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939 - an oral, direct Factor Xa inhibitor. J Thromb Haemost 2005; 3: 514-521.
    • (2005) J Thromb Haemost , vol.3 , pp. 514-521
    • Perzbom, E.1    Strassburger, J.2    Wilmen, A.3
  • 120
    • 0033583465 scopus 로고    scopus 로고
    • Synthetic oligosaccharides having various functional domains: Potent and potentially safe heparin mimetics
    • Petitou M, Driguez PA, Duchaussoy P et al. Synthetic oligosaccharides having various functional domains: potent and potentially safe heparin mimetics. Bioorg Med Chem Lett 1999; 9: 1161-1166.
    • (1999) Bioorg Med Chem Lett , vol.9 , pp. 1161-1166
    • Petitou, M.1    Driguez, P.A.2    Duchaussoy, P.3
  • 121
    • 0033583519 scopus 로고    scopus 로고
    • New synthetic heparin mimetics able to inhibit thrombin and factor Xa
    • Petitou M, Duchaussoy P, Driguez PA et al. New synthetic heparin mimetics able to inhibit thrombin and factor Xa. Bioorg Med Chem Lett 1999; 9: 1155-1160.
    • (1999) Bioorg Med Chem Lett , vol.9 , pp. 1155-1160
    • Petitou, M.1    Duchaussoy, P.2    Driguez, P.A.3
  • 122
    • 0030969911 scopus 로고    scopus 로고
    • Synthesis and pharmacological properties of a close analogue of an antithrombotic pentasaccharide (SR 90107A/ORG 31540)
    • Petitou M, Duchaussoy P, Jaurand G et al. Synthesis and pharmacological properties of a close analogue of an antithrombotic pentasaccharide (SR 90107A/ORG 31540). J Med Chem 1997; 40: 1600-1607.
    • (1997) J Med Chem , vol.40 , pp. 1600-1607
    • Petitou, M.1    Duchaussoy, P.2    Jaurand, G.3
  • 123
    • 0344938369 scopus 로고    scopus 로고
    • Synthesis of thrombin-inhibiting heparin mimetics without side effects
    • Petitou M, Herault JP, Bernat A et al. Synthesis of thrombin-inhibiting heparin mimetics without side effects. Nature 1999; 398: 417-422.
    • (1999) Nature , vol.398 , pp. 417-422
    • Petitou, M.1    Herault, J.P.2    Bernat, A.3
  • 124
    • 29244470272 scopus 로고    scopus 로고
    • Development of antibodies specific to polyanion-modified platelet factor 4 during treatment with fondaparinux
    • Pouplard C, Couvret C, Regina S et al. Development of antibodies specific to polyanion-modified platelet factor 4 during treatment with fondaparinux. J Thromb Haemost 2005; 3: 2813-2815.
    • (2005) J Thromb Haemost , vol.3 , pp. 2813-2815
    • Pouplard, C.1    Couvret, C.2    Regina, S.3
  • 125
    • 11144238284 scopus 로고    scopus 로고
    • Ultra-large complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia
    • Rauova L, Poncz M, McKenzie SE et al. Ultra-large complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia. Blood 2005; 105: 131-138.
    • (2005) Blood , vol.105 , pp. 131-138
    • Rauova, L.1    Poncz, M.2    McKenzie, S.E.3
  • 126
    • 0035871772 scopus 로고    scopus 로고
    • Prothrombin protects factor Xa in the prothrombinase complex from inhibition by the heparin-antithrombin complex
    • Rezaie AR. Prothrombin protects factor Xa in the prothrombinase complex from inhibition by the heparin-antithrombin complex. Blood 2001; 97: 2308-2313.
    • (2001) Blood , vol.97 , pp. 2308-2313
    • Rezaie, A.R.1
  • 127
    • 24944536065 scopus 로고    scopus 로고
    • Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3-[4-{3-oxomorpholin-4-yl) phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): An oral, direct factor Xa inhibitor
    • Roehrig S, Straub A, Pohlmann J et al. Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3-[4-{3-oxomorpholin-4-yl) phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor. J Med Chem 2005; 48: 5900-5908.
    • (2005) J Med Chem , vol.48 , pp. 5900-5908
    • Roehrig, S.1    Straub, A.2    Pohlmann, J.3
  • 129
    • 58149465124 scopus 로고    scopus 로고
    • Sanofi-Aventis. Idraparinux shows encouraging results in van Gogh clinical trials program. Press release 10.12.2006
    • Sanofi-Aventis. Idraparinux shows encouraging results in van Gogh clinical trials program. Press release 10.12.2006.
  • 130
    • 33845480738 scopus 로고    scopus 로고
    • Direct thrombin inhibitors - a survey of recent developments
    • Schwienhorst A. Direct thrombin inhibitors - a survey of recent developments. Cell Mol Life Sci 2006; 63: 2773-2791.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 2773-2791
    • Schwienhorst, A.1
  • 131
    • 30344472717 scopus 로고    scopus 로고
    • Argatroban, a direct thrombin inhibitor for heparin-induced thrombocytopaenia: Present and future perspectives
    • Serebruany MV, Malinin AI, Serebruany VL. Argatroban, a direct thrombin inhibitor for heparin-induced thrombocytopaenia: present and future perspectives. Expert Opin Pharmacother 2006; 7: 81-89.
    • (2006) Expert Opin Pharmacother , vol.7 , pp. 81-89
    • Serebruany, M.V.1    Malinin, A.I.2    Serebruany, V.L.3
  • 132
    • 34249075408 scopus 로고    scopus 로고
    • Kinetic analysis of heparin and glucan sulfates binding to P-selectin and its impact on the general understanding of selectin inhibition
    • Simonis D, Fritzsche J, Alban S et al. Kinetic analysis of heparin and glucan sulfates binding to P-selectin and its impact on the general understanding of selectin inhibition. Biochemistry 2007; 46: 6156-6164.
    • (2007) Biochemistry , vol.46 , pp. 6156-6164
    • Simonis, D.1    Fritzsche, J.2    Alban, S.3
  • 133
    • 0026558347 scopus 로고
    • Conjunctive enhancement of enzymatic thrombolysis and prevention of thrombotic reocclusion with the selective factor Xa inhibitor, tick anticoagulant peptide. Comparison to hirudin and heparin in a canine model of acute coronary artery thrombosis
    • Sitko GR, Ramjit DR, Stabilito I et al. Conjunctive enhancement of enzymatic thrombolysis and prevention of thrombotic reocclusion with the selective factor Xa inhibitor, tick anticoagulant peptide. Comparison to hirudin and heparin in a canine model of acute coronary artery thrombosis. Circulation 1992; 85: 805-815.
    • (1992) Circulation , vol.85 , pp. 805-815
    • Sitko, G.R.1    Ramjit, D.R.2    Stabilito, I.3
  • 134
    • 33750599861 scopus 로고    scopus 로고
    • Effect of fondaparinux on coagulation assays: Results of College of American Pathologists proficiency testing
    • Smogorzewska A, Brandt JT, Chandler WL et al. Effect of fondaparinux on coagulation assays: results of College of American Pathologists proficiency testing. Arch Pathol Lab Med 2006; 130: 1605-1611.
    • (2006) Arch Pathol Lab Med , vol.130 , pp. 1605-1611
    • Smogorzewska, A.1    Brandt, J.T.2    Chandler, W.L.3
  • 135
    • 0035109328 scopus 로고    scopus 로고
    • The complex effects of heparins on cancer progression and metastasis in experimental studies
    • Smorenburg SM, Van Noorden CJ. The complex effects of heparins on cancer progression and metastasis in experimental studies. Pharmacol Rev 2001; 53: 93-105.
    • (2001) Pharmacol Rev , vol.53 , pp. 93-105
    • Smorenburg, S.M.1    Van Noorden, C.J.2
  • 136
    • 17644400166 scopus 로고    scopus 로고
    • Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement
    • Stangier J, Eriksson BI, Dahl OE et al. Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement. J Clin Pharmacol 2005; 45: 555-563.
    • (2005) J Clin Pharmacol , vol.45 , pp. 555-563
    • Stangier, J.1    Eriksson, B.I.2    Dahl, O.E.3
  • 137
    • 34548031359 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
    • Stangier J, Rathgen K, Stähle H et al. The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br J Clin Pharmacol 2007; 64: 292-303.
    • (2007) Br J Clin Pharmacol , vol.64 , pp. 292-303
    • Stangier, J.1    Rathgen, K.2    Stähle, H.3
  • 138
    • 3042739277 scopus 로고    scopus 로고
    • From fibrinogen and hirudin to synthetic anticoagulants. Rational design of thrombin inhibitors
    • Steinmetzer T, Stürzebecher J. From fibrinogen and hirudin to synthetic anticoagulants. Rational design of thrombin inhibitors. Pharm Unserer Zeit 2004; 33: 196-205.
    • (2004) Pharm Unserer Zeit , vol.33 , pp. 196-205
    • Steinmetzer, T.1    Stürzebecher, J.2
  • 139
    • 4444257019 scopus 로고    scopus 로고
    • Progress in the development of synthetic thrombin inhibitors as new orally active anticoagulants
    • Steinmetzer T, Stürzebecher J. Progress in the development of synthetic thrombin inhibitors as new orally active anticoagulants. Curr Med Chem 2004; 11: 2297-2321.
    • (2004) Curr Med Chem , vol.11 , pp. 2297-2321
    • Steinmetzer, T.1    Stürzebecher, J.2
  • 140
    • 11144227722 scopus 로고    scopus 로고
    • Effect of lepirudin on the international normalized ratio
    • Stephens JL, Koerber JM, Mattson JC et al. Effect of lepirudin on the international normalized ratio. Ann Pharmacother 2005; 39: 28-31.
    • (2005) Ann Pharmacother , vol.39 , pp. 28-31
    • Stephens, J.L.1    Koerber, J.M.2    Mattson, J.C.3
  • 141
    • 26444566779 scopus 로고    scopus 로고
    • Differential metastasis inhibition by clinically relevant levels of heparins - correlation with selectin inhibition, not antithrombotic activity
    • Stevenson JL, Choi SH, Varki A. Differential metastasis inhibition by clinically relevant levels of heparins - correlation with selectin inhibition, not antithrombotic activity. Clin Cancer Res 2005; 11: 7003-7011.
    • (2005) Clin Cancer Res , vol.11 , pp. 7003-7011
    • Stevenson, J.L.1    Choi, S.H.2    Varki, A.3
  • 142
    • 0026595286 scopus 로고
    • Hirudins: Antithrombin anticoagulants
    • Stringer KA, Lindenfeld J. Hirudins: antithrombin anticoagulants. Ann Pharmacother 1992; 26: 1535-1540.
    • (1992) Ann Pharmacother , vol.26 , pp. 1535-1540
    • Stringer, K.A.1    Lindenfeld, J.2
  • 143
    • 0034049121 scopus 로고    scopus 로고
    • The pharmacokinetics and pharmacodynamics of argatroban: Effects of age, gender, and hepatic or renal dysfunction
    • Swan SK, Hursting MJ. The pharmacokinetics and pharmacodynamics of argatroban: effects of age, gender, and hepatic or renal dysfunction. Pharmacotherapy 2000; 20: 318-329.
    • (2000) Pharmacotherapy , vol.20 , pp. 318-329
    • Swan, S.K.1    Hursting, M.J.2
  • 144
    • 0033937140 scopus 로고    scopus 로고
    • Comparison of anticoagulant effects and safety of argatroban and heparin in healthy subjects
    • Swan SK, St Peter JV, Lambrecht LJ et al. Comparison of anticoagulant effects and safety of argatroban and heparin in healthy subjects. Pharmacotherapy 2000; 20: 756-770.
    • (2000) Pharmacotherapy , vol.20 , pp. 756-770
    • Swan, S.K.1    St Peter, J.V.2    Lambrecht, L.J.3
  • 145
    • 60249089726 scopus 로고    scopus 로고
    • Comparison of rivaroxaban - an oral, direct factor Xa inhibitor - and subcutaneous enoxaparin for thromboprophylaxis after total knee replacement (RECORD4: A phase 3 study)
    • May 29-June 1, Nice, France. Abstract F85
    • Turpie A, Bauer K, Davidson B et al. Comparison of rivaroxaban - an oral, direct factor Xa inhibitor - and subcutaneous enoxaparin for thromboprophylaxis after total knee replacement (RECORD4: a phase 3 study). European Federation of National Associations of Orthopaedics and Traumatology (EFFORT) 2008 Annual Meeting; May 29-June 1, 2008; Nice, France. Abstract F85.
    • (2008) European Federation of National Associations of Orthopaedics and Traumatology (EFFORT) 2008 Annual Meeting
    • Turpie, A.1    Bauer, K.2    Davidson, B.3
  • 146
    • 0023189460 scopus 로고
    • Isolation and characterization of antistasin. An inhibitor of metastasis and coagulation
    • Tuszynski GP, Gasic TB, Gasic GJ. Isolation and characterization of antistasin. An inhibitor of metastasis and coagulation. J Biol Chem 1987; 262: 9718-9723.
    • (1987) J Biol Chem , vol.262 , pp. 9718-9723
    • Tuszynski, G.P.1    Gasic, T.B.2    Gasic, G.J.3
  • 147
    • 0026520008 scopus 로고
    • Synergism between full length TFPI and heparin: Evidence for TFPI as an important factor for the antithrombotic activity of heparin [letter]
    • Valentin S, Ostergaard P, Kristensen H et al. Synergism between full length TFPI and heparin: evidence for TFPI as an important factor for the antithrombotic activity of heparin [letter]. Blood Coagul Fibrinolysis 1992; 3: 221-222.
    • (1992) Blood Coagul Fibrinolysis , vol.3 , pp. 221-222
    • Valentin, S.1    Ostergaard, P.2    Kristensen, H.3
  • 148
    • 34548768174 scopus 로고    scopus 로고
    • van Gogh Investigators. Buller HR, Cohen AT et al. Idraparinux versus standard therapy for venous thromboembolic disease. N Engl J Med 2007; 357: 1094-1104.
    • van Gogh Investigators. Buller HR, Cohen AT et al. Idraparinux versus standard therapy for venous thromboembolic disease. N Engl J Med 2007; 357: 1094-1104.
  • 149
    • 34548712332 scopus 로고    scopus 로고
    • Extended prophylaxis of venous thromboembolism with idraparinux
    • van Gogh Investigators
    • van Gogh Investigators, Buller HR, Cohen AT et al. Extended prophylaxis of venous thromboembolism with idraparinux. N Engl J Med 2007; 357: 1105-1112.
    • (2007) N Engl J Med , vol.357 , pp. 1105-1112
    • Buller, H.R.1    Cohen, A.T.2
  • 150
    • 0025891319 scopus 로고
    • Comparison of the in vivo anticoagulant properties of standard heparin and the highly selective factor Xa inhibitors antistasin and tick anticoagulant peptide (TAP) in a rabbit model of venous thrombosis
    • Vlasuk GP, Ramjit D, Fujita T et al. Comparison of the in vivo anticoagulant properties of standard heparin and the highly selective factor Xa inhibitors antistasin and tick anticoagulant peptide (TAP) in a rabbit model of venous thrombosis. Thromb Haemost 1991; 65: 257-262.
    • (1991) Thromb Haemost , vol.65 , pp. 257-262
    • Vlasuk, G.P.1    Ramjit, D.2    Fujita, T.3
  • 151
    • 28444494385 scopus 로고    scopus 로고
    • Anti-platelet factor 4/heparin antibodies in orthopedic surgery patients receiving antithrombotic prophylaxis with fondaparinux or enoxaparin
    • Warkentin TE, Cook RJ, Marder VJ et al. Anti-platelet factor 4/heparin antibodies in orthopedic surgery patients receiving antithrombotic prophylaxis with fondaparinux or enoxaparin. Blood 2005; 106: 3791-3796.
    • (2005) Blood , vol.106 , pp. 3791-3796
    • Warkentin, T.E.1    Cook, R.J.2    Marder, V.J.3
  • 152
    • 34250749333 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia associated with fondaparinux
    • Warkentin TE, Maurer BT, Aster RH. Heparin-induced thrombocytopenia associated with fondaparinux. N Engl J Med 2007; 356: 2653-2655.
    • (2007) N Engl J Med , vol.356 , pp. 2653-2655
    • Warkentin, T.E.1    Maurer, B.T.2    Aster, R.H.3
  • 153
    • 0025375504 scopus 로고
    • Tick anticoagulant peptide (TAP) is a novel inhibitor of blood coagulation factor Xa
    • Waxman L, Smith DE, Arcuri KE et al. Tick anticoagulant peptide (TAP) is a novel inhibitor of blood coagulation factor Xa. Science 1990; 248: 593-596.
    • (1990) Science , vol.248 , pp. 593-596
    • Waxman, L.1    Smith, D.E.2    Arcuri, K.E.3
  • 154
    • 0031936090 scopus 로고    scopus 로고
    • Thrombin binds to soluble fibrin degradation products where it is protected frominhibition by heparinantithrombin but susceptible to inactivation by antithrombinindependent inhibitors
    • Weitz J, Leslie B, Hudoba M. Thrombin binds to soluble fibrin degradation products where it is protected frominhibition by heparinantithrombin but susceptible to inactivation by antithrombinindependent inhibitors. Circulation 1998; 97: 544-552.
    • (1998) Circulation , vol.97 , pp. 544-552
    • Weitz, J.1    Leslie, B.2    Hudoba, M.3
  • 155
    • 0036588770 scopus 로고    scopus 로고
    • Direct thrombin inhibitors
    • Weitz JI, Crowther M. Direct thrombin inhibitors. Thromb Res 2002; 106: V275-284.
    • (2002) Thromb Res , vol.106
    • Weitz, J.I.1    Crowther, M.2
  • 156
    • 0038344806 scopus 로고    scopus 로고
    • A novel approach to thrombin inhibition
    • Weitz JI. A novel approach to thrombin inhibition. Thromb Res 2003; 109 Suppl 1: S17-22.
    • (2003) Thromb Res , vol.109 , Issue.SUPPL. 1
    • Weitz, J.I.1
  • 157
    • 34250030035 scopus 로고    scopus 로고
    • Antithrombotic and anticoagulant effects of the direct thrombin inhibitor dabigatran, and its oral prodrug, dabigatran etexilate, in a rabbit model of venous thrombosis
    • Wienen W, Stassen JM, Priepke H et al. Antithrombotic and anticoagulant effects of the direct thrombin inhibitor dabigatran, and its oral prodrug, dabigatran etexilate, in a rabbit model of venous thrombosis. J Thromb Haemost 2007; 5: 1237-1242.
    • (2007) J Thromb Haemost , vol.5 , pp. 1237-1242
    • Wienen, W.1    Stassen, J.M.2    Priepke, H.3
  • 158
    • 34547924093 scopus 로고    scopus 로고
    • Effects of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate, on thrombus formation and bleeding time in rats
    • Wienen W, Stassen JM, Priepke H et al. Effects of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate, on thrombus formation and bleeding time in rats. Thromb Haemost 2007; 98: 333-338.
    • (2007) Thromb Haemost , vol.98 , pp. 333-338
    • Wienen, W.1    Stassen, J.M.2    Priepke, H.3
  • 159
    • 34447522035 scopus 로고    scopus 로고
    • In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate
    • Wienen W, Stassen JM, Priepke H et al. In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate. Thromb Haemost 2007; 98: 155-162.
    • (2007) Thromb Haemost , vol.98 , pp. 155-162
    • Wienen, W.1    Stassen, J.M.2    Priepke, H.3
  • 160
    • 0034671656 scopus 로고    scopus 로고
    • Heparinase I acts on a synthetic heparin pentasaccharide corresponding to the antithrombin III binding site
    • Yu G, LeBrun L, Gunay NS et al. Heparinase I acts on a synthetic heparin pentasaccharide corresponding to the antithrombin III binding site. Thromb Res 2000; 100: 549-556.
    • (2000) Thromb Res , vol.100 , pp. 549-556
    • Yu, G.1    LeBrun, L.2    Gunay, N.S.3


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