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Volumn 29, Issue 2-3, 1999, Pages 170-178

Conjectures and refutations on the mode of action of heparins: The limited importance of anti-factor Xa activity as a pharmaceutical mechanism and a yardstick for therapy

Author keywords

Factor Xa; Low molecular weight heparins; Thrombin

Indexed keywords

BLOOD CLOTTING FACTOR 10A INHIBITOR; CALCIUM ION; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; THROMBIN ANTITHROMBIN COMPLEX; TISSUE FACTOR PATHWAY INHIBITOR;

EID: 0343484317     PISSN: 03010147     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (48)

References (37)
  • 2
    • 0024563615 scopus 로고
    • The mode of action of low molecular weight heparin preparation (PK10169) and two of its major components on thrombin generation in plasma
    • Béguin S, Mardiguian J, Lindhout T, Hemker HC: The mode of action of low molecular weight heparin preparation (PK10169) and two of its major components on thrombin generation in plasma. Thromb Haemost 1989;61:30-34.
    • (1989) Thromb Haemost , vol.61 , pp. 30-34
    • Béguin, S.1    Mardiguian, J.2    Lindhout, T.3    Hemker, H.C.4
  • 4
    • 0007053316 scopus 로고
    • The mode of action of heparin in plasma
    • Verstraete M, Vermylen J, Lijnen HR, Arnout J (eds): Leuven, University Press
    • Hemker HC: The mode of action of heparin in plasma; in Verstraete M, Vermylen J, Lijnen HR, Arnout J (eds): Thrombosis and Haemostasis. Leuven, University Press, 1987, pp 17-36.
    • (1987) Thrombosis and Haemostasis , pp. 17-36
    • Hemker, H.C.1
  • 5
    • 0023214250 scopus 로고
    • Antithrombotic activity of a synthetic heparin pentasaccharide in a rabbit stasis thrombosis model using different thrombogenic challenges
    • Walenga J, Petitou M, Lormeau JC, Samama M, Farced J, Choay J: Antithrombotic activity of a synthetic heparin pentasaccharide in a rabbit stasis thrombosis model using different thrombogenic challenges Thromb Res 1987;46:187-198.
    • (1987) Thromb Res , vol.46 , pp. 187-198
    • Walenga, J.1    Petitou, M.2    Lormeau, J.C.3    Samama, M.4    Farced, J.5    Choay, J.6
  • 6
    • 0010213440 scopus 로고
    • Structure-activity relationship in heparin. A synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity
    • Choay J, Petitou M, Lormeau JC, Sinay P, Casu B, Gatti G: Structure-activity relationship in heparin. A synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity. Biochem Biophys Res Commun 1985;128:134-140.
    • (1985) Biochem Biophys Res Commun , vol.128 , pp. 134-140
    • Choay, J.1    Petitou, M.2    Lormeau, J.C.3    Sinay, P.4    Casu, B.5    Gatti, G.6
  • 7
    • 0024339952 scopus 로고
    • The action of a synthetic pentasaccharide on thrombin generation in whole plasma
    • Béguin S, Choay J, Hemker HC: The action of a synthetic pentasaccharide on thrombin generation in whole plasma. Thromb Haemost 1989;61:397-401.
    • (1989) Thromb Haemost , vol.61 , pp. 397-401
    • Béguin, S.1    Choay, J.2    Hemker, H.C.3
  • 8
    • 0024582005 scopus 로고
    • The relative antithrombotic effectiveness of heparin, a low molecular weight heparin, and a pentasaccharide fragment in an animal model
    • Thomas DP, Merton RE, Gray E, Barrowcliffe TW: The relative antithrombotic effectiveness of heparin, a low molecular weight heparin, and a pentasaccharide fragment in an animal model. Thromb Haemost 1989;61:204-207.
    • (1989) Thromb Haemost , vol.61 , pp. 204-207
    • Thomas, D.P.1    Merton, R.E.2    Gray, E.3    Barrowcliffe, T.W.4
  • 10
    • 0025918279 scopus 로고
    • Factor IXa inhibition contributes to the heparin effect
    • Béguin S, Dol F, Hemker HC: Factor IXa inhibition contributes to the heparin effect. Thromb Haemost 1991;66:306-309.
    • (1991) Thromb Haemost , vol.66 , pp. 306-309
    • Béguin, S.1    Dol, F.2    Hemker, H.C.3
  • 11
    • 0015217874 scopus 로고
    • Biological properties of the naturally occurring plasma inhibitor to activated factor X
    • Yin ET, Wessler S, Stoll PJ: Biological properties of the naturally occurring plasma inhibitor to activated factor X. J Biol Chem 1971;246: 3703-3711.
    • (1971) J Biol Chem , vol.246 , pp. 3703-3711
    • Yin, E.T.1    Wessler, S.2    Stoll, P.J.3
  • 12
    • 0015217918 scopus 로고
    • Identity of plasma-activated factor X inhibitor with antithrombin III and heparin cofactor
    • Yin ET, Wessler S, Stoll PJ: Identity of plasma-activated factor X inhibitor with antithrombin III and heparin cofactor. J Biol Chem 1971;246: 3712-3719.
    • (1971) J Biol Chem , vol.246 , pp. 3712-3719
    • Yin, E.T.1    Wessler, S.2    Stoll, P.J.3
  • 14
    • 0019904650 scopus 로고
    • Comparison of the in vivo hemorrhagic and antithrombotic effects of a low antithrombin-III affinity heparin fraction
    • Ockelford PA, Carter CJ, Cerskus A, Smith CA, Hirsh J: Comparison of the in vivo hemorrhagic and antithrombotic effects of a low antithrombin-III affinity heparin fraction. Thromb Res 1982;27:679-690.
    • (1982) Thromb Res , vol.27 , pp. 679-690
    • Ockelford, P.A.1    Carter, C.J.2    Cerskus, A.3    Smith, C.A.4    Hirsh, J.5
  • 15
    • 0028307325 scopus 로고
    • Low-affinity material does not contribute to the antithrombotic activity of Orgaran (Org 10172) in human plasma
    • Zammit A, Dawes J: Low-affinity material does not contribute to the antithrombotic activity of Orgaran (Org 10172) in human plasma. Thromb Haemost 1994;71:759-767.
    • (1994) Thromb Haemost , vol.71 , pp. 759-767
    • Zammit, A.1    Dawes, J.2
  • 17
    • 0021344246 scopus 로고
    • Anticoagulant activities of heparin oligosaccharides and their neutralization by platelet factor 4
    • Lane DA, Denton J, Flynn AM, Thunberg L, Lindahl U: Anticoagulant activities of heparin oligosaccharides and their neutralization by platelet factor 4. Biochem J 1984; 218:725-732.
    • (1984) Biochem J , vol.218 , pp. 725-732
    • Lane, D.A.1    Denton, J.2    Flynn, A.M.3    Thunberg, L.4    Lindahl, U.5
  • 18
    • 0018669485 scopus 로고
    • Molecular weight dependence of the anticoagulant properties of heparin: Intravenous and subcutaneous administration of fractionated heparins to man
    • Lane DA, MacGregor IR, VanRoss M, Cella G, Kakkar VV: Molecular weight dependence of the anticoagulant properties of heparin: Intravenous and subcutaneous administration of fractionated heparins to man. Thromb Res 1979;16:651-662.
    • (1979) Thromb Res , vol.16 , pp. 651-662
    • Lane, D.A.1    MacGregor, I.R.2    VanRoss, M.3    Cella, G.4    Kakkar, V.V.5
  • 19
    • 0023244130 scopus 로고
    • The inhibition of thrombin-dependent positive-feedback reactions is critical to the expression of the anticoagulant effect of heparin
    • Ofosu FA, Sie P, Modi GJ, Fernandez F, Buchanan MR, Blajchman MA, Boneu B, Hirsh J: The inhibition of thrombin-dependent positive-feedback reactions is critical to the expression of the anticoagulant effect of heparin. Biochem J 1987; 243:579-588.
    • (1987) Biochem J , vol.243 , pp. 579-588
    • Ofosu, F.A.1    Sie, P.2    Modi, G.J.3    Fernandez, F.4    Buchanan, M.R.5    Blajchman, M.A.6    Boneu, B.7    Hirsh, J.8
  • 20
    • 0024566520 scopus 로고
    • The effect of trace amounts of tissue factor on thrombin generation in platelet rich plasma. Its inhibition by heparin
    • Béguin S, Lindhout T, Hemker HC: The effect of trace amounts of tissue factor on thrombin generation in platelet rich plasma. Its inhibition by heparin. Thromb Haemost 1989; 61:25-29.
    • (1989) Thromb Haemost , vol.61 , pp. 25-29
    • Béguin, S.1    Lindhout, T.2    Hemker, H.C.3
  • 21
    • 0029974813 scopus 로고    scopus 로고
    • Can the haemorrhagic component of heparin be identified? Or an attempt at clean thinking on a dirty drug
    • Hemker HC, Béguin S, Kakkar VV: Can the haemorrhagic component of heparin be identified? Or an attempt at clean thinking on a dirty drug. Haemostasis 1996;26:117-126.
    • (1996) Haemostasis , vol.26 , pp. 117-126
    • Hemker, H.C.1    Béguin, S.2    Kakkar, V.V.3
  • 22
    • 0028346093 scopus 로고
    • Pharmacokinetics and pharmacodynamics of a low molecular weight heparin (enoxaparin) after subcutaneous injection. Comparison with unfractionated heparin. A three way cross over study in human volunteers
    • Bendetowicz AV, Béguin S, Caplain H, Hemker HC: Pharmacokinetics and pharmacodynamics of a low molecular weight heparin (enoxaparin) after subcutaneous injection. Comparison with unfractionated heparin. A three way cross over study in human volunteers. Thromb Haemost 1994;71:305-313.
    • (1994) Thromb Haemost , vol.71 , pp. 305-313
    • Bendetowicz, A.V.1    Béguin, S.2    Caplain, H.3    Hemker, H.C.4
  • 23
    • 0027440451 scopus 로고
    • Standard-and method-independent units for heparin anticoagulant activities
    • Hemker HC, Béguin S: Standard-and method-independent units for heparin anticoagulant activities. Thromb Haemost 1993;70:724-728.
    • (1993) Thromb Haemost , vol.70 , pp. 724-728
    • Hemker, H.C.1    Béguin, S.2
  • 26
    • 0023217697 scopus 로고
    • The disappearance of a low-molecular weight heparin fraction (CY 216) differs from standard heparin in rabbits
    • Boneu B, Buchanan MR, Caranobe C, Gabaig AM, Dupouy D, Sie P, Hirsh J: The disappearance of a low-molecular weight heparin fraction (CY 216) differs from standard heparin in rabbits. Thromb Res 1987; 46:845-853.
    • (1987) Thromb Res , vol.46 , pp. 845-853
    • Boneu, B.1    Buchanan, M.R.2    Caranobe, C.3    Gabaig, A.M.4    Dupouy, D.5    Sie, P.6    Hirsh, J.7
  • 27
    • 0027527403 scopus 로고
    • 2+ ions: Why the anti-Xa activity of LMW heparins is about two times overestimated
    • 2+ ions: Why the anti-Xa activity of LMW heparins is about two times overestimated. Thromb Haemost 1993;70:717-718.
    • (1993) Thromb Haemost , vol.70 , pp. 717-718
    • Hemker, H.C.1    Béguin, S.2
  • 28
    • 0016796678 scopus 로고
    • Heparin co-factor activity measured with an amidolytic method
    • Ødegaard OR, Lie M, Abildgaard U: Heparin co-factor activity measured with an amidolytic method. Thromb Res 1975;6:287-294.
    • (1975) Thromb Res , vol.6 , pp. 287-294
    • Ødegaard, O.R.1    Lie, M.2    Abildgaard, U.3
  • 29
    • 0017228286 scopus 로고
    • Assay of heparin in plasma using a chromogenic substrate
    • Teien AN, Lien M, Abildgaard U: Assay of heparin in plasma using a chromogenic substrate. Thromb Res 1976;8:413-416.
    • (1976) Thromb Res , vol.8 , pp. 413-416
    • Teien, A.N.1    Lien, M.2    Abildgaard, U.3
  • 30
    • 0342440660 scopus 로고
    • Changes in the antithrombin III activity at the interface plasma-phospholipids
    • Josso F, Béguin S: Changes in the antithrombin III activity at the interface plasma-phospholipids. Thromb Haemost 1981;46:285.
    • (1981) Thromb Haemost , vol.46 , pp. 285
    • Josso, F.1    Béguin, S.2
  • 31
    • 0028933965 scopus 로고
    • Inhibition of prothrombinase by antithrombin-heparin at a macroscopic surface
    • Speijer H, Billy D, Willems G, Hemker HC, Lindhout T: Inhibition of prothrombinase by antithrombin-heparin at a macroscopic surface. Thromb Haemost 1995;73:648-653.
    • (1995) Thromb Haemost , vol.73 , pp. 648-653
    • Speijer, H.1    Billy, D.2    Willems, G.3    Hemker, H.C.4    Lindhout, T.5
  • 32
    • 0018835636 scopus 로고
    • Heparin and partial thromboplastin time, an international survey
    • Poller L, Thomson JM, Yee KF: Heparin and partial thromboplastin time, an international survey. Br J Haematol 1980;44:161-165.
    • (1980) Br J Haematol , vol.44 , pp. 161-165
    • Poller, L.1    Thomson, J.M.2    Yee, K.F.3
  • 33
    • 0025174959 scopus 로고
    • Monitoring heparin therapy: Relationship between the activated partial thromboplastin time and heparin assays based on ex-vivo heparin samples
    • van den Besselaar AMHP, Meeuwisse-Braun J, Bertina RM: Monitoring heparin therapy: Relationship between the activated partial thromboplastin time and heparin assays based on ex-vivo heparin samples. Thromb Haemost 1990;63: 16-23.
    • (1990) Thromb Haemost , vol.63 , pp. 16-23
    • Van Den Besselaar, A.M.H.P.1    Meeuwisse-Braun, J.2    Bertina, R.M.3
  • 34
    • 0019948062 scopus 로고
    • Interindividual variation in relationship between plasma heparin concentration and the results of five heparin assays
    • van Putten JJ, van de Ruit M, Beunis M, Hemker HC: Interindividual variation in relationship between plasma heparin concentration and the results of five heparin assays. Clin Chim Acta 1982;122:261-270.
    • (1982) Clin Chim Acta , vol.122 , pp. 261-270
    • Van Putten, J.J.1    Van De Ruit, M.2    Beunis, M.3    Hemker, H.C.4
  • 35
    • 0006070144 scopus 로고
    • The thrombin potential. A parameter to assess the effect of antithrombotic drugs on thrombin generation
    • Bounameaux H, Samama M, ten Cate JW (eds): Recent Pharmacological and Clinical Data. Stuttgart, Schattauer
    • Hemker HC, Wielders S, Béguin S: The thrombin potential. A parameter to assess the effect of antithrombotic drugs on thrombin generation; in Bounameaux H, Samama M, ten Cate JW (eds): Fraxiparine, Second International Symposium. Recent Pharmacological and Clinical Data. Stuttgart, Schattauer, 1990, pp 89-101.
    • (1990) Fraxiparine, Second International Symposium , pp. 89-101
    • Hemker, H.C.1    Wielders, S.2    Béguin, S.3
  • 36
    • 0027377650 scopus 로고
    • Continuous registration of thrombin generation in plasma, its use for the determination of the thrombin potential
    • Hemker HC, Wielders S, Kessels H, Béguin S: Continuous registration of thrombin generation in plasma, its use for the determination of the thrombin potential. Thromb Haemost 1993;70:617-624.
    • (1993) Thromb Haemost , vol.70 , pp. 617-624
    • Hemker, H.C.1    Wielders, S.2    Kessels, H.3    Béguin, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.