Paradigm change in anticoagulation: From natural substance to selective factor Xa inhibitor;Paradigmenwechsel in der antikoagulation: Vom naturstoff zum selektiven faktor-Xa-inhibitor

Pharmazie in Unserer Zeit

Volumn 33, Issue 3, 2004, Pages 190-194

  Alban, Susanne ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; BIOLOGICAL PRODUCT; BLOOD CLOTTING FACTOR 10A; FONDAPARINUX; HEPARIN; POLYSACCHARIDE;

ANIMAL; CHEMISTRY; DRUG ANTAGONISM; HUMAN; REVIEW;

ANIMALS; ANTICOAGULANTS; BIOLOGICAL PRODUCTS; FACTOR XA; HEPARIN; HUMANS; POLYSACCHARIDES;

EID: 3042785874     PISSN: 00483664     EISSN: 16151003     Source Type: Journal    
DOI: 10.1002/pauz.200400067     Document Type: Short Survey

References (10)

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4. Choay, J., Petitou, M., Lormeau, J.C., Sinay, P., Casu, B., Gatti, G.: Structure-activity relationship in heparin: a synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity. Biochem Biophys Res Commun 116 (1983), 492-499.
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8. Greinacher, A., Alban, S., Dummel, V., Franz, G., Mueller-Eckhardt, C. Characterization of the structural requirements for a carbohydrate based anticoagulant with a reduced risk of inducing the immunological type of heparin-associated thrombocytopenia. Thromb Haemost 74 (1995), 886-892.
9. Keam, S.J., Goa, K.L.: Fondaparinux sodium. Drugs 62 (2002), 1673-1685.
10. Fachinformation Arixtra® (Fondaparinux), Stand 11/2003