Prothrombin protects factor Xa in the prothrombinase complex from inhibition by the heparin-antithrombin complex

Blood

Volumn 97, Issue 8, 2001, Pages 2308-2313

  Rezaie, Alireza R ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN; BLOOD CLOTTING FACTOR 10A; CALCIUM ION; HEPARIN; PROTHROMBIN; THROMBIN ANTITHROMBIN COMPLEX;

ANTICOAGULATION; ARTICLE; BLOOD CLOTTING; CATALYSIS; CELL SURFACE; DISSOCIATION CONSTANT; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL;

EID: 0035871772     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.8.2308     Document Type: Article

References (33)

1. Anticoagulant action of heparin
2. Mechanism of action of heparin and heparin-like antithrombotics
3. The mode of action of heparin in plasma
4. Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions: Resolution of the antithrombin conformational change contribution to heparin rate enhancement
5. Demonstration of a two-step reaction mechanism for inhibition of α-thrombin by antithrombin III and identification of the step affected by heparin
6. A mechanism for heparin-induced potentiation of antithrombin III
7. Two-substrate reaction model for the heparin-catalyzed bovine antithrombin/protease reaction
8. Heparin-catalyzed inhibitor/protease reactions: Kinetic evidence for a common mechanism of action of heparin
9. The anticoagulant activation of antithrombin by heparin
10. Transmission of conformational change from the heparin binding site to the reactive center of antithrombin
11. Role of ternary complexes, in which heparin binds both antithrombin and proteinase, in the acceleration of the reactions between antithrombin and thrombin or factor Xa
12. Molecular mapping of the heparin-binding exosite of thrombin
13. Identification of basic amino acid residues in thrombin essential for heparin-catalyzed inactivation by antithrombin III
14. Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101
15. Calcium enhances heparin catalysis of the antithrombin-factor Xa reaction by a template mechanism: Evidence that calcium alleviates Gla-domain antagonism of heparin binding to factor Xa
16. The role of phospholipids and factor Va in the prothrombinase complex
17. Surface-dependent reactions of the vitamin K-dependent enzyme complexes
18. Factor Xa inactivation by antithrombin III: Evidence for biological stabilization of factor Xa by factor V-phospholipid complex
19. Properties of the Factor Xa binding site on human platelets
20. The effects of phospholipid and factor Va on the inhibition of factor Xa by antithrombin III
21. Protection of factor Xa from neutralization by the heparin-antithrombin complex
22. Antithrombin III-dependent anti-prothrombinase activity of heparin and heparin fragments
23. The acceleration of the inhibition of platelet prothrombinase complex by heparin
24. The effect of calcium, phospholipid and factor V on the anti-(factor Xa) activity of heparin and its high-affinity oligosaccharide
25. On the size of the active site in proteases, I: Papain
26. The function of calcium in protein C activation by thrombin and the thrombin-thrombomodulin complex can be distinguished by mutational analysis of protein C derivatives
27. Kinetic characterization of heparin-catalyzed and uncatalyzed inhibition of blood coagulation proteinases by antithrombin
28. Phosphatidylethanolamine incorporation into vesicles selectively enhances factor Va inactivation by activated protein C
29. Identification of basic residues in the heparin-binding exosite of factor Xa critical for heparin and factor Va binding
30. Calcium enhances heparin catalysis of the antithrombin-factor Xa reaction by promoting the assembly of an intermediate heparin-antithrombin-factor Xa binding complex: Demonstration by rapid kinetics studies
31. Cofactor proteins in the assembly and expression of blood clotting enzyme complexes
32. Transient kinetics of heparin-catalyzed protease inactivation by antithrombin III: Characterization of assembly, product formation and heparin dissociation in the factor Xa reaction
33. Prothrombinase complex assembly: Contributions of protein-protein and protein-membrane interactions toward complex formation