Heparinase I acts on a synthetic heparin pentasaccharide corresponding to the antithrombin III binding site

Thrombosis Research

Volumn 100, Issue 6, 2000, Pages 549-556

  Yu, Guangli ^a   LeBrun, Laurie ^a,b   Gunay, Nur Sibel ^a,b   Hoppensteadt, Debra ^c   Walenga, Jeanine M ^c   Fareed, Jawed ^c   Linhardt, Robert J ^a,b,d  

^a UNIVERSITY OF IOWA   (United States)

^b IA United States   (United States)

^c LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^d E11 SSH   (United States)

Author keywords

Heparin lyase; Heparinase; Neutralization; Pentasaccharide; Reversal

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBIN III; BLOOD CLOTTING FACTOR 10A; DISACCHARIDE; FONDAPARINUX; HEPARIN ANTAGONIST; HEPARIN LYASE; LOW MOLECULAR WEIGHT HEPARIN; PENTASACCHARIDE; PROTAMINE SULFATE; TRISACCHARIDE;

ANTICOAGULANT THERAPY; ARTICLE; BINDING SITE; CHEMICAL REACTION KINETICS; CLINICAL TRIAL; CONCENTRATION RESPONSE; DRUG DEGRADATION; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG STRUCTURE; ENZYME SUBSTRATE; FLAVOBACTERIUM; HUMAN; NONHUMAN; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; THROMBOEMBOLISM;

ANTITHROMBIN III; BINDING SITES; CARBOHYDRATE SEQUENCE; DOSE-RESPONSE RELATIONSHIP, DRUG; FACTOR XA; FLAVOBACTERIUM; HEPARIN; HEPARIN LYASE; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; OLIGOSACCHARIDES; SERINE PROTEINASE INHIBITORS;

EID: 0034671656     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(00)00368-6     Document Type: Article

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