Cytotoxic effects of 3,4-methylenedioxy-N-alkylamphetamines, MDMA and its analogues, on isolated rat hepatocytes

Archives of Toxicology

Volumn 83, Issue 1, 2009, Pages 69-80

  Nakagawa, Yoshio ^a   Suzuki, Toshinari ^a   Tayama, Sumiko ^a   Ishii, Hidemi ^b   Ogata, Akio ^a  

^a TOKYO METROPOLITAN INSTITUTE OF PUBLIC HEALTH   (Japan)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Amphetamines; Cytotoxicity; Designer drugs; Hepatotoxicity; MBDB; MDMA; Mitochondrial dysfunction; Rat hepatocytes

Indexed keywords

1,3 BENZODIOXOLE DERIVATIVE; 2 METHYLAMINO 1 (3,4 METHYLENEDIOXYPHENYL)PROPANE 1 ONE(METHYLONE); 3,4 (METHYLENEDIOXYPHENYL) 2 BUTANAMINE; 3,4 METHYLENEDIOXYAMPHETAMINE; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; ADENINE NUCLEOTIDE; ADENOSINE TRIPHOSPHATE; GLUTATHIONE; N METHYL 1 (3,4 METHYLENEDIOXYPHENYL) 2 BUTANAMINE; OXYGEN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL ISOLATION; CELL LOSS; CONTROLLED STUDY; CYTOTOXICITY; LIVER MITOCHONDRION; LIVER TOXICITY; MALE; MITOCHONDRIAL PERMEABILITY; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT;

3,4-METHYLENEDIOXYAMPHETAMINE; ADENOSINE TRIPHOSPHATE; ANIMALS; CELL DEATH; DNA DAMAGE; HALLUCINOGENS; HEPATOCYTES; MALE; METHAMPHETAMINE; MITOCHONDRIA, LIVER; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; OXIDATIVE PHOSPHORYLATION; RATS; RATS, INBRED F344; TIME FACTORS;

RATTUS;

EID: 58149460019     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-008-0323-9     Document Type: Article

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