Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat mass

Journal of Neuroscience

Volumn 28, Issue 48, 2008, Pages 12834-12844

  Kawahara, Yukio ^a   Grimberg, Adda ^a   Teegarden, Sarah ^b   Mombereau, Cedric ^b   Liu, Sui ^a   Bale, Tracy L ^b   Blendy, Julie A ^b   Nishikura, Kazuko ^a,c  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c WISTAR INSTITUTE   (United States)

Author keywords

ADAR; Energy homeostasis; Melanocortin 4C receptor; Obesity; RNA editing; Serotonin receptor 2C

Indexed keywords

GLYCINE; GROWTH HORMONE; MELANOCORTIN 4 RECEPTOR; MESSENGER RNA; SEROTONIN 2C RECEPTOR; VALINE;

ALLELE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY HEIGHT; BODY MASS; BODY TEMPERATURE; BODY WEIGHT; CELL SURFACE; CONTROLLED STUDY; ENERGY EXPENDITURE; FEMALE; FOOD INTAKE; GROWTH HORMONE DEFICIENCY; GROWTH RETARDATION; HOMEOSTASIS; HYPERPHAGIA; HYPOTHERMIA; LIPID STORAGE; LOCOMOTION; MALE; MOUSE; NEUROTRANSMISSION; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RNA EDITING; SEROTONINERGIC NERVE CELL;

ADIPOSE TISSUE; AMINO ACID SEQUENCE; ANIMALS; ENERGY METABOLISM; FEMALE; GENE KNOCK-IN TECHNIQUES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; PROTEIN ISOFORMS; RECEPTOR, MELANOCORTIN, TYPE 4; RECEPTOR, SEROTONIN, 5-HT2C; RNA EDITING; RNA, MESSENGER; SEROTONIN; SIGNAL TRANSDUCTION; SYMPATHETIC NERVOUS SYSTEM; SYNAPTIC TRANSMISSION;

EID: 58149400027     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3896-08.2008     Document Type: Article

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