Regulation of ion channel/neurotransmitter receptor function by RNA editing

Current Opinion in Neurobiology

Volumn 13, Issue 3, 2003, Pages 279-283

  Seeburg, Peter H ^a   Hartner, Jochen ^a  

^a MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ION CHANNEL; NEUROTRANSMITTER RECEPTOR; POTASSIUM CHANNEL; SEROTONIN RECEPTOR;

DEAMINATION; INVERTEBRATE; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; RNA EDITING; SQUID; VERTEBRATE;

EID: 0038721692     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(03)00062-X     Document Type: Review

References (28)

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18. •] was conducted because fluoxetine has pleiotropic actions. This interesting study conducted in mice shows that serotonin depletion and 5HT2C-R activation lead to differing extents of editing at sites C′ and C relative to controls. This result strengthens the notion that editing of 5HT2C-R transcripts is sensitive to serotonin levels. How this link is wrought in molecular terms needs future attention. Moreover, in this mouse study the extent of editing was correct to keep the response properties of 5HT2C-Rs adjusted to serotonin levels, whereas this was not the case for the depressed suicide victims. In that case, editing exacerbated the effect of low serotonin.
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21. •]).
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