The RNA world meets behavior: Adenosine-to-inosine pre-mRNA editing in animals

Trends in Genetics

Volumn 17, Issue 2, 2001, Pages 53-56

  Reenan, Robert A ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DEAMINASE; IONOTROPIC RECEPTOR; SIGNAL PEPTIDE;

BEHAVIOR; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DROSOPHILA; ENZYME DEFICIENCY; ENZYME SPECIFICITY; EVOLUTION; GENE DELETION; GENETIC ANALYSIS; MOUSE; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA BINDING; RNA EDITING; RNA TRANSCRIPTION; SHORT SURVEY; SIGNAL TRANSDUCTION;

ANIMALIA; DROSOPHILA;

EID: 0035252113     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(00)02169-7     Document Type: Review

References (27)

1. Synthetic polynucleotides and the amino acid code, V
2. Adenosinefi inosine conversion in mRNA
3. RNA editing - an evolutionary perspective
4. Inosine exists in mRNA at tissue-specific levels and is most abundant in brain mRNA
5. RNA editing in brain controls a determinant of ion flow in glutamate-gated channels
6. Control of kinetic properties of AMPA receptor channels by nuclear RNA editing
7. Regulation of serotonin-2C receptor G-protein coupling by RNA editing
8. RNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences constitutive activity
9. Regulation of alternative splicing by RNA editing
10. dADAR, a Drosophila double-stranded RNA-specific adenosine deaminase is highly developmentally regulated and is itself a target for RNA editing
11. Substrate specificity of the dsRNA unwinding/modifying activity
12. Preferential selection of adenosines for modification by double-stranded RNA adenosine deaminase
13. The importance of internal loops within RNA substrates of ADAR1
14. RNA editing of AMPA receptor subunit GluR-B: a base-paired intron-exon structure determines position and efficiency
15. Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences
16. + channel transcript in a region of RNA editing
17. Assessing the extent of RNA editing in the TMII regions of GluR5 and GluR6 kainate receptors during rat brain development
18. + channel transcript: evolutionary conservation and developmental regulation
19. RED2, a brain-specific member of the RNA-specific adenosine deaminase family
20. Q/R editing of the rat GluR5 and GluR6 kainate receptors in vivo and in vitro: evidence for independent developmental, pathological and cellular regulation
21. Patterns of developmental expression of the RNA editing enzyme rADAR2
22. Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice
23. Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2
24. A→I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity
25. A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing
26. Characterization of two fish glutamate receptor cDNA molecules: absence of RNA editing at the Q/R site
27. Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis