Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims

Neuron

Volumn 34, Issue 3, 2002, Pages 349-356

  Gurevich, Ilona ^a   Tamir, Hadassah ^b   Arango, Victoria ^b   Dwork, Andrew J ^b   Mann, J John ^b   Schmauss, Claudia ^b  

^a Graduate School of Biological Sciences   (United States)

^b The New York Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; FLUOXETINE; MESSENGER RNA; SEROTONIN 2C RECEPTOR;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; DRUG MECHANISM; HUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RNA EDITING; SUICIDE; TREATMENT OUTCOME;

EID: 0037171846     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(02)00660-8     Document Type: Article

References (22)

1. Regulation of serotonin-2C receptor G-protein coupling by RNA editing
2. 2C receptor produced by alternative splicing
3. Messenger RNA editing of the human serotonin 5-HT2C receptor
4. Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2
5. Altered ratios of alternatively spliced long and short γ2 subunit mRNAs of the γ-amino butyrate type A receptor in the prefrontal cortex of schizophrenics
6. Molecular Characterization of a functional cDNA encoding the serotonin 1c receptor
7. Serotonin-2C receptor pre-mRNA editing in rat brain and in vitro by splice site variants of the interferon-inducible double-stranded RNA-specific adenosine-deaminase ADAR1
8. The neurobiology of suicide
9. A serotonin transporter gene promotor polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide
10. 5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system
11. Hydrophobic amino acid in the i2 loop plays a key role in receptor G-protein coupling
12. RNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences constitutive activity
13. RNA editing of the human serotonin 5-HT2C receptor: Alterations in suicide and implications for serotonergic pharmacology
14. 2C): Where structure meets function
15. Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes
16. 3-receptor pre-mRNA in chronic schizophrenia
17. Plasma membrane localization and functional rescue of truncated forms of a G protein-coupled receptor
18. RNA helicase participates in the editing game
19. RNA editing of the 5-HT2C receptor is reduced in schizophrenia
20. RNA editing in brain controls a determinant of ion flow in glutamate-gated channels
21. Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis
22. Altered G protein-coupling functions of RNA editing isoform and splicing variant serotonin 2C receptors