How stress and fluoxetine modulate serotonin 2C receptor pre-mRNA editing

Journal of Neuroscience

Volumn 25, Issue 3, 2005, Pages 648-651

  Englander, Michael T ^a,b   Dulawa, Stephanie C ^a   Bhansali, Punita ^b   Schmauss, Claudia ^a,b,c  

^a Columbia Univ Coll Phys Surgs ^*  (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Antidepressants; Forebrain; Inbred mouse strains; RNA editing; Serotonin 2C receptor; Stress

Indexed keywords

FLUOXETINE; MESSENGER RNA; SEROTONIN 2C RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; CONTROLLED STUDY; DEPRESSION; FOREBRAIN; GENETIC CODE; INBRED STRAIN; MALE; MOUSE; MOUSE STRAIN; NEOCORTEX; NONHUMAN; PRIORITY JOURNAL; RNA EDITING; STRESS;

ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; DEPRESSION; FLUOXETINE; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED STRAINS; NEOCORTEX; RECEPTOR, SEROTONIN, 5-HT2C; RNA EDITING; RNA PRECURSORS; SPECIES SPECIFICITY; STRESS; SWIMMING; TIME FACTORS;

EID: 12744273085     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3895-04.2005     Document Type: Article

References (14)

1. Anisman H, Zaharia MD, Meaney MJ, Merali Z (1998) Do early-life events alter behavioral and hormonal responses to stressors? Int J Dev Neurosci 16:149-164.
2. Beizung C, Griebel G (2001) Measuring normal and pathological anxiety-like behaviors in mice: a review. Behav Brain Res 125:141-149.
3. Burns C, Chu H, Rueter SM, Hutchinson LK, Canton H, Sanders-Bush E, Emeson RB (1997) Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Nature 387:303-308.
4. Dulawa SC, Holick KA Gundersen B, Hen R (2004) Effects of chronic fluoxetine in animal models of anxiety and depression. Neuropsychopharmacology 29:1321-1330.
5. Gurevich I, Tamir H, Arango V, Dwork AJ, Mann JJ, Schmauss C (2002a) Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims. Neuron 34:349-356.
6. Gurevich I, Englander MT, Adlersberg M, Siegal N, Schmauss C (2002b) Modulation of serotonin 2C receptor editing by sustained changes in serotonergic neurotransmission. J Neurosci 22:10529-10532.
7. Nemeroff CB, Owens MJ (2002) Treatment of mood disorders. Nat Neurosci [Suppl] 5:1068-1070.
8. Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM (2002) Neurobiology of depression. Neuron 34:13-25.
9. Niswender C, Copeland SC, Herrik-Davis K, Emeson RB, Sanders-Bush E (1999) RNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences constitutive activity. J Biol Chem 274:9472-9478.
10. Penza KM, Heim C, Nemeroff CB (2003) Neurobiological effects of childhood abuse: implications for the pathophysiology of depression and anxiety. Arch Women Ment Health 6:15-22.
11. Porsolt RD, Bertin A, Jalfre M (1977) Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther 229:327-336.
12. Tang X, Orchard SM, Sanford LD (2002) Home cage activity and behavioral performance in inbred and hybrid mice. Behav Brain Res 136:555-569.
13. Wang Q, O'Brien P, Chen C-X, Cho D-SC, Murray JM, Nishikura K (2000) Altered G protein-coupling functions of RNA editing isoform and splicing variant serotonin 2C receptors. J Neurochem 74:1290-1300.
14. Zhang X, Beaulieu J-M, Sotnikova TD, Gainetdinov RR, Caron MG (2004) Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science 305:217.