Immunohistochemical expression of fatty acid synthase, Ki-67 and p53 in squamous cell carcinomas of the larynx

International Journal of Biological Markers

Volumn 23, Issue 3, 2008, Pages 176-181

  De Vincentiis, M ^a   Di Cello, P ^a   Censi, F ^b   Leopizzi, M ^b   Natalizi, S ^b   Sardella, B ^b   Gallo, A ^a   Soldo, P ^a   Also P L ^b   Zotti, G C ^b   Della Rocca, C ^b   Pietrasanta, D ^a   Castelli, M ^c   Izzo, Luciano ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Local Health Service ASL   (Italy)

^c REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Fatty acid synthase; Ki 67; Larynx; P53; SCC

Indexed keywords

FATTY ACID SYNTHASE; KI 67 ANTIGEN; PROTEIN P53; TP53 PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL FEATURE; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARYNX CARCINOMA; MALE; OVERALL SURVIVAL; PROGNOSIS; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; BIOSYNTHESIS; FOLLOW UP; GENE EXPRESSION REGULATION; LARYNX TUMOR; METABOLISM; METHODOLOGY; MIDDLE AGED; TUMOR SUPPRESSOR GENE;

ADULT; AGED; CARCINOMA, SQUAMOUS CELL; FATTY ACID SYNTHETASE COMPLEX; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; LARYNGEAL NEOPLASMS; MALE; MIDDLE AGED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 58149396352     PISSN: 03936155     EISSN: None     Source Type: Journal    
DOI: 10.5301/JBM.2008.4936     Document Type: Article

References (31)

1. Broders AC. The grading of carcinoma. Minn Med 1925; 8: 726-30.
2. Pizer ES, Lax SF, Kuhajda FP, Pasternack GR, Kurman RJ. Fatty acid synthase expression in endometrial carcinoma. Cancer 1998; 83: 528-37.
3. World Health Organization. Bulletin of the World Health Organization. Geneva: World Health Organization, 2005.
4. Kuhajda FP. Fatty acid synthase in human cancer: new perspectives on its role in tumor biology. Nutrition 2000; 16: 202-8.
5. Baron A, Migita T, Tang D, Loda M. Fatty acid synthase: a metabolic oncogene in prostate cancer? J Cell Biochem 2004; 91: 47-53.
6. Weiss L, Hoffmann GE, Schreiber R, et al. Fatty acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty acid synthase. Biol Chem Hoppe Seyler 1986; 367: 905-12.
7. Kuhajda FP, Jenner K, Wood FW, et al. Fatty acid synthesis: a potential selective target for anti-neoplastic therapy. Proc Natl Acad Sci USA 1994; 91: 6379-83.
8. Pizer ES, Wood FD, Heine HS, Romantsev FE, Pasternack GR, Kuhajda FP. Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer. Cancer Res 1996; 56: 1189-93.
9. Krontiras H, Roye GD, Beenken SE, et al. Fatty acid synthase expression is increased in neoplastic lesions of the oral tongue. Head Neck 1999; 21: 325-9.
10. Oskouian B. Overexpression of fatty acid synthase in SKBR3 breast cancer cell line is mediated via a transcriptional mechanism. Cancer Lett 2000; 149: 43-51.
11. Piyathilake CJ, Frost AR, Manne U, et al. The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung. Hum Pathol 2000; 31: 1068-73.
12. Dhanasekaran SM, Barrette TR, Ghosh D, et al. Delineation of prognostic biomarkers in prostate cancer. Nature 2001; 412: 822-6.
13. Shurbaji MS, Kalbfleish JH, Thurmond TS. Immunohistochemical detection of a fatty acid synthase (AO-519) as a predictor of progression of prostate cancer. Hum Pathol 1996; 27: 917-21.
14. Kusakabe T, Nashimoto A, Honma K, Suzuki T. Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach. Histophatology 2002; 40: 71-9.
15. Swinnen JV, Roskams T, Joniau S, et al. Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer. Int J Cancer 2002; 98: 19-22.
16. Innocenzi D, Alò PL, Balzani A, et al. Fatty acid synthase expression in melanoma. J Cutan Pathol 2003; 30: 23-8.
17. Rossi S, Graner E, Febbo P, et al. Fatty acid synthase expression defines distinct molecular signatures in prostate cancer. Mol Cancer Res 2003; 1: 707-15.
18. Visca P, Sebastiani V, Pizer ES, et al. Immunohistochemical expression and prognostic significance of FAS and GLUT1 in bladder carcinoma. Anticancer Res 2003; 23: 335-9.
19. Takahiro T, Shinichi K, Toshimitsu S. Expression of fatty acid synthase as a prognostic indicator in soft tissue sarcomas. Clin Cancer Res 2003; 9: 2204-12.
20. Alò PL, Visca P, Marci A, Mangoni A, Botti C, Di Tondo U. Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients. Cancer 1996; 77: 474-82.
21. Alò PL, Visca P, Framarino ML, et al. Immunohistochemical study of fatty acid synthase in ovarian neoplasm. Oncol Rep 2000; 7: 1383-8.
22. Furuya Y, Akimoto S, Yasuda K, Ito H. Apoptosis in androgen-independent prostate cell line induced by inhibition of fatty acid synthesis. Anticancer Res 1997; 17: 4589-93.
23. Pizer ES, Chrest FJ, Di Giuseppe JA, Han WF. Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines. Cancer Res 1998; 58: 4611-5.
24. Li JN, Gorospe M, Chrest FJ, et al. Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53. Cancer Res 2001; 61: 1493-9.
25. Baron A, Migita T, Tang D, Loda M. Fatty acid synthase: a metabolic oncogene in prostate cancer? J Cell Biochem 2004; 91: 47-53.
26. Menendez JA, Decker JP, Lupu R. In support of fatty acid synthase (FAS) as a metabolic oncogene: extracellular acidosis acts in an epigenetic fashion activating FAS gene expression in cancer cells. J Cell Biochem 2005; 94: 1-4.
27. Lu S, Archer MC. Fatty acid synthase is a potential molecular target for the chemoprevention of breast cancer. Carcinogenesis 2005; 26: 153-7.
28. Gabrielson EW, Pinn ML, Testa JR, Kuhajda FP. Increased fatty acid synthase is a therapeutic target in mesothelioma. Clin Cancer Res 2001; 7: 153-7.
29. Silva SD, Agostini M, Nishimoto IN, et al. Expression of fatty acid synthase, ErbB2 and Ki-67 in head and neck squamous cell carcinoma. A clinicopathological study. Oral Oncol 2004; 40: 688-96
30. Agostini M, Silva SD, Zecchin KG, et al. Fatty acid synthase is required for the proliferation of human oral squamous carcinoma cells. Oral Oncol 2004; 40: 728-35
31. Kusakabe T, Maeda M, Hoshi N, et al. Fatty acid synthase is expressed mainly in adult hormone-sensitive cells or cells with high lipid metabolism and in proliferating fetal cells. J Histochem Cytochem 2000; 48: 613-22.