Rapamycin inhibits growth factor-induced cell cycle regulation in pancreatic β cells

Journal of Investigative Medicine

Volumn 56, Issue 8, 2008, Pages 985-996

  Aronovitz, Amy ^a   Josefson, Jami ^a   Fisher, Amanda ^a   Newman, Marsha ^a   Hughes, Elizabeth ^a   Chen, Fei ^a   Moons, David S ^b   Kiyokawa, Hiroaki ^a,b   Lowe Jr , William L ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Betacellulin; Insulin like growth factor I; Islet; Rapamycin

Indexed keywords

BETACELLULIN; BROXURIDINE; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; RAPAMYCIN; S6 KINASE; SOMATOMEDIN C; CDKN1A PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL GROWTH; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IMMUNOSUPPRESSIVE TREATMENT; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL CYCLE; CYTOLOGY;

MAMMALIA; MURINAE;

ANIMALS; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; INSULIN-LIKE GROWTH FACTOR I; INSULIN-SECRETING CELLS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, INBRED C57BL; RATS; SIGNAL TRANSDUCTION; SIROLIMUS;

EID: 58149330978     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: 10.2310/JIM.0b013e31818ce763     Document Type: Article

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