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Volumn 6, Issue 6, 2008, Pages 531-538

Increased levels of human beta-defensins mRNA in sexually HIV-1 exposed but uninfected individuals

Author keywords

HIV 1 (Human immunodeficiency virus type 1); HIV 1 exposed sero negatives; Human beta defensins; Mucosa; Natural resistance; Polymorphism

Indexed keywords

BETA DEFENSIN 1; BETA DEFENSIN 2; BETA DEFENSIN 3; MESSENGER RNA; BETA DEFENSIN;

EID: 58149260512     PISSN: 1570162X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157016208786501463     Document Type: Review
Times cited : (71)

References (51)
  • 1
    • 0003462242 scopus 로고    scopus 로고
    • Joint United Nations Programme on HIV/AIDS: Geneva [Available at
    • UNAIDS. 2007 Report on the global AIDS epidemic. Joint United Nations Programme on HIV/AIDS: Geneva [Available at: http:// www.unaids.org/en/ KnowledgeCentre/HIVData/EpiUpdate/EpiUpd Archive/2007/default.asp].
    • (2007) Report on the global AIDS epidemic
  • 2
    • 0030067739 scopus 로고    scopus 로고
    • Protective immunity against HIV infection: Has nature done the experiment for us?
    • Shearer GM, Clerici M. Protective immunity against HIV infection: has nature done the experiment for us? Immunol Today 1996; 17: 21-4.
    • (1996) Immunol Today , vol.17 , pp. 21-24
    • Shearer, G.M.1    Clerici, M.2
  • 3
    • 0035912222 scopus 로고    scopus 로고
    • Cellular immune responses to HIV
    • McMichael AJ, Rowland-Jones SL. Cellular immune responses to HIV. Nature 2001; 410: 980-7.
    • (2001) Nature , vol.410 , pp. 980-987
    • McMichael, A.J.1    Rowland-Jones, S.L.2
  • 4
    • 27744520100 scopus 로고    scopus 로고
    • Basics of the virology of HIV-1 and its replication
    • Sierra S, Kupfer B, Kaiser R. Basics of the virology of HIV-1 and its replication. J Clin Virol 2005; 34: 233-44.
    • (2005) J Clin Virol , vol.34 , pp. 233-244
    • Sierra, S.1    Kupfer, B.2    Kaiser, R.3
  • 5
    • 33746039265 scopus 로고    scopus 로고
    • Increased IFN-gamma production by NK and CD3+/CD56+ cells in sexually HIV-1-exposed but uninfected individuals
    • Montoya CJ, Velilla PA, Chougnet C, Landay AL, Rugeles MT. Increased IFN-gamma production by NK and CD3+/CD56+ cells in sexually HIV-1-exposed but uninfected individuals. Clin Immunol 2006; 120(2): 138-46.
    • (2006) Clin Immunol , vol.120 , Issue.2 , pp. 138-146
    • Montoya, C.J.1    Velilla, P.A.2    Chougnet, C.3    Landay, A.L.4    Rugeles, M.T.5
  • 6
    • 0344585525 scopus 로고    scopus 로고
    • Cutting edge: Increased NK cell activity in HIV-1-exposed but uninfected Vietnamese intravascular drug users
    • Scott-Algara D, Truong LX, Versmisse P, et al. Cutting edge: increased NK cell activity in HIV-1-exposed but uninfected Vietnamese intravascular drug users. J Immunol 2003; 171: 5663-7.
    • (2003) J Immunol , vol.171 , pp. 5663-5667
    • Scott-Algara, D.1    Truong, L.X.2    Versmisse, P.3
  • 7
    • 15244350144 scopus 로고    scopus 로고
    • Apoptosis as a mechanism of natural resistance to HIV-1 infection in an exposed but uninfected population
    • Velilla PA, Hoyos A, Rojas M, Patino PJ, Velez LA, Rugeles MT. Apoptosis as a mechanism of natural resistance to HIV-1 infection in an exposed but uninfected population. J Clin Virol 2005; 32: 329-35.
    • (2005) J Clin Virol , vol.32 , pp. 329-335
    • Velilla, P.A.1    Hoyos, A.2    Rojas, M.3    Patino, P.J.4    Velez, L.A.5    Rugeles, M.T.6
  • 8
    • 0035126472 scopus 로고    scopus 로고
    • Characterization of high-risk HIV-1 seronegative hemophiliacs
    • Salkowitz JR, Purvis SF, Meyerson H, et al. Characterization of high-risk HIV-1 seronegative hemophiliacs. Clin Immunol 2001; 98: 200-11.
    • (2001) Clin Immunol , vol.98 , pp. 200-211
    • Salkowitz, J.R.1    Purvis, S.F.2    Meyerson, H.3
  • 9
    • 16044367526 scopus 로고    scopus 로고
    • The role of a mutant CCR5 allele in HIV-1 transmission and disease progression
    • Huang Y, Paxton WA, Wolinsky SM, et al. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med 1996; 2: 1240-3.
    • (1996) Nat Med , vol.2 , pp. 1240-1243
    • Huang, Y.1    Paxton, W.A.2    Wolinsky, S.M.3
  • 10
    • 85069099317 scopus 로고    scopus 로고
    • Centers for Disease Control & Prevention NCfH, STD, and TB Prevention, Divisions of HIV/AIDS Prevention. Fact Sheet - HIV and Its Transmission - CDC-NCHSTP-Divisions of HIV/AIDS Prevention. In: Centers for Disease Control & Prevention 2003. Available at: http://www.cdc.gov/hiv/resources/factsheets/PDF/transmiss ion.pdf
    • Centers for Disease Control & Prevention NCfH, STD, and TB Prevention, Divisions of HIV/AIDS Prevention. Fact Sheet - HIV and Its Transmission - CDC-NCHSTP-Divisions of HIV/AIDS Prevention. In: Centers for Disease Control & Prevention 2003. Available at: http://www.cdc.gov/hiv/resources/factsheets/PDF/transmiss ion.pdf
  • 11
    • 0035857959 scopus 로고    scopus 로고
    • Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda
    • Gray RH, Wawer MJ, Brookmeyer R, et al. Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda. Lancet 2001; 357: 1149-53.
    • (2001) Lancet , vol.357 , pp. 1149-1153
    • Gray, R.H.1    Wawer, M.J.2    Brookmeyer, R.3
  • 12
    • 0001378811 scopus 로고    scopus 로고
    • Autocrine/ paracrine IFN-alphabeta mediates the lipopolysaccharide-induced activation of transcription factor Stat1alpha in mouse macrophages: Pivotal role of Stat1alpha in induction of the inducible nitric oxide synthase gene
    • Gao JJ, Filla MB, Fultz MJ, Vogel SN, Russell SW, Murphy WJ. Autocrine/ paracrine IFN-alphabeta mediates the lipopolysaccharide-induced activation of transcription factor Stat1alpha in mouse macrophages: pivotal role of Stat1alpha in induction of the inducible nitric oxide synthase gene. J Immunol 1998; 161: 4803-10.
    • (1998) J Immunol , vol.161 , pp. 4803-4810
    • Gao, J.J.1    Filla, M.B.2    Fultz, M.J.3    Vogel, S.N.4    Russell, S.W.5    Murphy, W.J.6
  • 15
    • 0027412158 scopus 로고
    • Patients infected with human immunodeficiency virus type 1 have low levels of virus in saliva even in the presence of periodontal disease
    • Yeung SC, Kazazi F, Randle CG, et al. Patients infected with human immunodeficiency virus type 1 have low levels of virus in saliva even in the presence of periodontal disease. J Infect Dis 1993; 167: 803-9.
    • (1993) J Infect Dis , vol.167 , pp. 803-809
    • Yeung, S.C.1    Kazazi, F.2    Randle, C.G.3
  • 16
    • 0030995540 scopus 로고    scopus 로고
    • Detection of HIV in oral mucosal cells
    • Qureshi MN, Barr CE, Hewlitt I, et al. Detection of HIV in oral mucosal cells. Oral Dis 1997; 3(Suppl 1): S73-8.
    • (1997) Oral Dis , vol.3 , Issue.SUPPL. 1
    • Qureshi, M.N.1    Barr, C.E.2    Hewlitt, I.3
  • 17
    • 2442595897 scopus 로고    scopus 로고
    • Control of HIV-1 infection by soluble factors of the immune response
    • DeVico AL, Gallo RC. Control of HIV-1 infection by soluble factors of the immune response. Nat Rev Microbiol 2004; 2: 401-13.
    • (2004) Nat Rev Microbiol , vol.2 , pp. 401-413
    • DeVico, A.L.1    Gallo, R.C.2
  • 18
    • 0036606951 scopus 로고    scopus 로고
    • Mammalian defensins in immunity: More than just microbicidal
    • Yang D, Biragyn A, Kwak LW, Oppenheim JJ. Mammalian defensins in immunity: more than just microbicidal. Trends Immunol 2002; 23: 291-6.
    • (2002) Trends Immunol , vol.23 , pp. 291-296
    • Yang, D.1    Biragyn, A.2    Kwak, L.W.3    Oppenheim, J.J.4
  • 19
    • 25144453335 scopus 로고    scopus 로고
    • Regulation of mammalian defensin expression by Toll-like receptor-dependent and independent signalling pathways
    • Froy O. Regulation of mammalian defensin expression by Toll-like receptor-dependent and independent signalling pathways. Cell Microbiol 2005; 7: 1387-97.
    • (2005) Cell Microbiol , vol.7 , pp. 1387-1397
    • Froy, O.1
  • 20
    • 0036467390 scopus 로고    scopus 로고
    • Defensins of vertebrate animals
    • Lehrer RI, Ganz T. Defensins of vertebrate animals. Curr Opin Immunol 2002; 14: 96-102.
    • (2002) Curr Opin Immunol , vol.14 , pp. 96-102
    • Lehrer, R.I.1    Ganz, T.2
  • 21
    • 2542480000 scopus 로고    scopus 로고
    • Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense
    • Yang D, Biragyn A, Hoover DM, Lubkowski J, Oppenheim JJ. Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense. Annu Rev Immunol 2004; 22: 181-215.
    • (2004) Annu Rev Immunol , vol.22 , pp. 181-215
    • Yang, D.1    Biragyn, A.2    Hoover, D.M.3    Lubkowski, J.4    Oppenheim, J.J.5
  • 22
    • 3242778563 scopus 로고    scopus 로고
    • Defensins: Antimicrobial peptides of vertebrates
    • Ganz T. Defensins: antimicrobial peptides of vertebrates. C R Biol 2004; 327: 539-49.
    • (2004) C R Biol , vol.327 , pp. 539-549
    • Ganz, T.1
  • 23
    • 9144240994 scopus 로고    scopus 로고
    • Human epithelial beta-defensins 2 and 3 inhibit HIV-1 replication
    • Quinones-Mateu ME, Lederman MM, Feng Z, et al. Human epithelial beta-defensins 2 and 3 inhibit HIV-1 replication. AIDS 2003;17: F39-48.
    • (2003) AIDS , vol.17
    • Quinones-Mateu, M.E.1    Lederman, M.M.2    Feng, Z.3
  • 24
    • 27644571478 scopus 로고    scopus 로고
    • Human beta-defensins suppress human immunodeficiency virus infection: Potential role in mucosal protection
    • Sun L, Finnegan CM, Kish-Catalone T, et al. Human beta-defensins suppress human immunodeficiency virus infection: potential role in mucosal protection. J Virol 2005; 79: 14318-29.
    • (2005) J Virol , vol.79 , pp. 14318-14329
    • Sun, L.1    Finnegan, C.M.2    Kish-Catalone, T.3
  • 25
    • 0036916405 scopus 로고    scopus 로고
    • Single-nucleotide polymorphisms and haplotype analysis in beta-defensin genes in different ethnic populations
    • Jurevic RJ, Chrisman P, Mancl L, Livingston R, Dale BA. Single-nucleotide polymorphisms and haplotype analysis in beta-defensin genes in different ethnic populations. Genet Test 2002; 6: 261-9.
    • (2002) Genet Test , vol.6 , pp. 261-269
    • Jurevic, R.J.1    Chrisman, P.2    Mancl, L.3    Livingston, R.4    Dale, B.A.5
  • 26
    • 3843064497 scopus 로고    scopus 로고
    • A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children
    • Braida L, Boniotto M, Pontillo A, Tovo PA, Amoroso A, Crovella S. A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children. AIDS 2004; 18: 1598-600.
    • (2004) AIDS , vol.18 , pp. 1598-1600
    • Braida, L.1    Boniotto, M.2    Pontillo, A.3    Tovo, P.A.4    Amoroso, A.5    Crovella, S.6
  • 27
  • 28
    • 33644601321 scopus 로고    scopus 로고
    • DEFB-1 genetic polymorphism screening in HIV-1 positive pregnant women and their children
    • Segat L, Milanese M, Boniotto M, et al. DEFB-1 genetic polymorphism screening in HIV-1 positive pregnant women and their children. J Matern Fetal Neonatal Med 2006; 19: 13-6.
    • (2006) J Matern Fetal Neonatal Med , vol.19 , pp. 13-16
    • Segat, L.1    Milanese, M.2    Boniotto, M.3
  • 29
    • 17144454549 scopus 로고    scopus 로고
    • Protection against human immunodeficiency virus type 1 infection in persons with repeated exposure: Evidence for T cell immunity in the absence of inherited CCR5 coreceptor defects
    • Goh WC, Markee J, Akridge RE, et al. Protection against human immunodeficiency virus type 1 infection in persons with repeated exposure: evidence for T cell immunity in the absence of inherited CCR5 coreceptor defects. J Infect Dis 1999; 179: 548-57.
    • (1999) J Infect Dis , vol.179 , pp. 548-557
    • Goh, W.C.1    Markee, J.2    Akridge, R.E.3
  • 30
    • 0034145423 scopus 로고    scopus 로고
    • Frequency of CCR5 delta-32 mutation in human immunodeficiency virus (HIV)-seropositive and HIV-exposed seronegative individuals and in general population of Medellin, Colombia
    • Diaz FJ, Vega JA, Patino PJ, et al. Frequency of CCR5 delta-32 mutation in human immunodeficiency virus (HIV)-seropositive and HIV-exposed seronegative individuals and in general population of Medellin, Colombia. Mem Inst Oswaldo Cruz 2000; 95: 237-42.
    • (2000) Mem Inst Oswaldo Cruz , vol.95 , pp. 237-242
    • Diaz, F.J.1    Vega, J.A.2    Patino, P.J.3
  • 31
    • 0035136684 scopus 로고    scopus 로고
    • A real-time quantitative reverse transcriptase polymerase chain reaction (RT-PCR) to detect breast carcinoma cells in peripheral blood
    • Aerts J, Wynendaele W, Paridaens R, et al. A real-time quantitative reverse transcriptase polymerase chain reaction (RT-PCR) to detect breast carcinoma cells in peripheral blood. Ann Oncol 2001; 12: 39-46.
    • (2001) Ann Oncol , vol.12 , pp. 39-46
    • Aerts, J.1    Wynendaele, W.2    Paridaens, R.3
  • 32
    • 0037130950 scopus 로고    scopus 로고
    • Expression of human beta-defensins 1 and 2 in kidneys with chronic bacterial infection
    • Lehmann J, Retz M, Harder J, et al. Expression of human beta-defensins 1 and 2 in kidneys with chronic bacterial infection. BMC Infect Dis 2002; 2: 20.
    • (2002) BMC Infect Dis , vol.2 , pp. 20
    • Lehmann, J.1    Retz, M.2    Harder, J.3
  • 33
    • 85069089128 scopus 로고    scopus 로고
    • Rousset MRaF. GENEPOP version 1.2, population genetics software for exact tests and ecumenicism. J Heredity 1995; 86: 248-9
    • Rousset MRaF. GENEPOP (version 1.2): population genetics software for exact tests and ecumenicism. J Heredity 1995; 86: 248-9.
  • 34
    • 85069099764 scopus 로고    scopus 로고
    • Excoffier LGL, S. Schneider Arlequin ver. 3.0: An integrated software package for population genetics data analysis. Evol Bioinform Online 2005; 1: 47-50
    • Excoffier LGL, S. Schneider Arlequin ver. 3.0: An integrated software package for population genetics data analysis. Evol Bioinform Online 2005; 1: 47-50.
  • 35
    • 16044373004 scopus 로고    scopus 로고
    • Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
    • Samson M, Libert F, Doranz BJ, et al. Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 1996; 382: 722-5.
    • (1996) Nature , vol.382 , pp. 722-725
    • Samson, M.1    Libert, F.2    Doranz, B.J.3
  • 36
    • 15844388931 scopus 로고    scopus 로고
    • Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection
    • Liu R, Paxton WA, Choe S, et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 1996; 86: 367-77.
    • (1996) Cell , vol.86 , pp. 367-377
    • Liu, R.1    Paxton, W.A.2    Choe, S.3
  • 38
    • 0035881173 scopus 로고    scopus 로고
    • Homozygous and heterozygous CCR5-Delta32 genotypes are associated with resistance to HIV infection
    • Marmor M, Sheppard HW, Donnell D, et al. Homozygous and heterozygous CCR5-Delta32 genotypes are associated with resistance to HIV infection. J Acquir Immune Defic Syndr 2001; 27: 472-81.
    • (2001) J Acquir Immune Defic Syndr , vol.27 , pp. 472-481
    • Marmor, M.1    Sheppard, H.W.2    Donnell, D.3
  • 39
    • 0030861904 scopus 로고    scopus 로고
    • Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study
    • Smith MW, Dean M, Carrington M, et al. Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study. Science 1997; 277: 959-65.
    • (1997) Science , vol.277 , pp. 959-965
    • Smith, M.W.1    Dean, M.2    Carrington, M.3
  • 40
    • 0037380297 scopus 로고    scopus 로고
    • Hormonal contraception can suppress natural antimicrobial gene transcription in human endometrium
    • Fleming DC, King AE, Williams AR, Critchley HO, Kelly RW. Hormonal contraception can suppress natural antimicrobial gene transcription in human endometrium. Fertil Steril 2003; 79: 856-63.
    • (2003) Fertil Steril , vol.79 , pp. 856-863
    • Fleming, D.C.1    King, A.E.2    Williams, A.R.3    Critchley, H.O.4    Kelly, R.W.5
  • 41
    • 0035430147 scopus 로고    scopus 로고
    • Human beta-defensin 4: A novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity
    • Garcia JR, Krause A, Schulz S, et al. Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity. FASEB J 2001;15: 1819-21.
    • (2001) FASEB J , vol.15 , pp. 1819-1821
    • Garcia, J.R.1    Krause, A.2    Schulz, S.3
  • 42
    • 0042668474 scopus 로고    scopus 로고
    • Differential expression of the natural antimicrobials, beta-defensins 3 and 4, in human endometrium
    • King AE, Fleming DC, Critchley HO, Kelly RW. Differential expression of the natural antimicrobials, beta-defensins 3 and 4, in human endometrium. J Reprod Immunol 2003; 59: 1-16.
    • (2003) J Reprod Immunol , vol.59 , pp. 1-16
    • King, A.E.1    Fleming, D.C.2    Critchley, H.O.3    Kelly, R.W.4
  • 43
    • 0344483901 scopus 로고    scopus 로고
    • Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands
    • Mathews M, Jia HP, Guthmiller JM, et al. Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands. Infect Immun 1999; 67: 2740-5.
    • (1999) Infect Immun , vol.67 , pp. 2740-2745
    • Mathews, M.1    Jia, H.P.2    Guthmiller, J.M.3
  • 44
    • 4143094791 scopus 로고    scopus 로고
    • Correlated expression of human beta defensin-1, -2 and -3 mRNAs in gingival tissues of young children
    • Saitoh M, Abiko Y, Shimabukuro S, et al. Correlated expression of human beta defensin-1, -2 and -3 mRNAs in gingival tissues of young children. Arch Oral Biol 2004; 49: 799-803.
    • (2004) Arch Oral Biol , vol.49 , pp. 799-803
    • Saitoh, M.1    Abiko, Y.2    Shimabukuro, S.3
  • 45
    • 0034992657 scopus 로고    scopus 로고
    • Bacterial diversity in human subgingival plaque
    • Paster BJ, Boches SK, Galvin JL, et al. Bacterial diversity in human subgingival plaque. J Bacteriol 2001;183: 3770-83.
    • (2001) J Bacteriol , vol.183 , pp. 3770-3783
    • Paster, B.J.1    Boches, S.K.2    Galvin, J.L.3
  • 48
    • 13444261223 scopus 로고    scopus 로고
    • Association of defensin beta-1 gene polymorphisms with asthma
    • Levy H, Raby BA, Lake S, et al. Association of defensin beta-1 gene polymorphisms with asthma. J Allergy Clin Immunol 2005; 115: 252-8.
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 252-258
    • Levy, H.1    Raby, B.A.2    Lake, S.3
  • 49
    • 0036040263 scopus 로고    scopus 로고
    • Expression of beta-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells
    • Duits LA, Ravensbergen B, Rademaker M, Hiemstra PS, Nibbering PH. Expression of beta-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells. Immunology 2002; 106: 517-25.
    • (2002) Immunology , vol.106 , pp. 517-525
    • Duits, L.A.1    Ravensbergen, B.2    Rademaker, M.3    Hiemstra, P.S.4    Nibbering, P.H.5
  • 50
    • 0041976029 scopus 로고    scopus 로고
    • The use of real-time reverse transcriptase PCR for the quantification of cytokine gene expression
    • Overbergh L, Giulietti A, Valckx D, Decallonne R, Bouillon R, Mathieu C. The use of real-time reverse transcriptase PCR for the quantification of cytokine gene expression. J Biomol Tech 2003; 14: 33-43.
    • (2003) J Biomol Tech , vol.14 , pp. 33-43
    • Overbergh, L.1    Giulietti, A.2    Valckx, D.3    Decallonne, R.4    Bouillon, R.5    Mathieu, C.6
  • 51
    • 0042387792 scopus 로고    scopus 로고
    • Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster
    • Hollox EJ, Armour JA, Barber JC. Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster. Am J Hum Genet 2003; 73(3): 591-600.
    • (2003) Am J Hum Genet , vol.73 , Issue.3 , pp. 591-600
    • Hollox, E.J.1    Armour, J.A.2    Barber, J.C.3


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