Prostaglandin H2 induces the migration of human eosinophils through the chemoattractant receptor homologous molecule of Th2 cells, CRTH2

Journal of Leukocyte Biology

Volumn 85, Issue 1, 2009, Pages 136-145

  Schuligoi, Rufina ^a   Sedej, Miriam ^a   Waldhoer, Maria ^a   Vukoja, Anela ^a   Sturm, Eva M ^a   Lippe, Irmgard T ^a   Peskar, Bernhard A ^a   Heinemann, Akos ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Allergy; D type prostanoid; D type prostanoid receptor; Degranulation; HEK293; Platelet aggregation

Indexed keywords

3 [[(4 FLUOROPHENYL)SULFONYL]METHYLAMINO] 1,2,3,4 TETRAHYDRO 9H CARBAZOLE 9 ACETIC ACID; 3 BENZYL 5 (6 CARBOXYHEXYL) 1 (2 CYCLOHEXYL 2 HYDROXYETHYLAMINO)HYDANTOIN; 4 BENZHYDRYLOXY 1 [3 (1H TETRAZOL 5 YL)PROPYL]PIPERIDINE; ACETIC ACID DERIVATIVE; ALBUMIN; CALCIUM ION; CAY 10471; CHEMOATTRACTANT; CHEMOATTRACTANT RECEPTOR HOMOLOGOUS MOLECULE OF TH2 CELL; COLLAGEN; PLASMA PROTEIN; PROSTAGLANDIN H2; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; PROSTANOID RECEPTOR; UNCLASSIFIED DRUG; 4 BENZHYDRYLOXY 1 (3 (1H TETRAZOL 5 YL ) PROPYL)PIPERIDINE; 4-BENZHYDRYLOXY-1-(3-(1H-TETRAZOL-5-YL-)-PROPYL)PIPERIDINE; CALCIUM; CARBAZOLE DERIVATIVE; DIVALENT CATION; HYDANTOIN DERIVATIVE; IMMUNOGLOBULIN RECEPTOR; ISOMERASE; LIPOCALIN; PIPERIDINE DERIVATIVE; PROSTAGLANDIN D2 RECEPTOR; PROSTAGLANDIN R2 D ISOMERASE; PROSTAGLANDIN R2 D-ISOMERASE; PROSTAGLANDIN RECEPTOR; SULFONAMIDE;

ARTICLE; BASOPHIL; CALCIUM TRANSPORT; CATALYSIS; CELL STIMULATION; CELL STRAIN HEK293; CHEMOTAXIS; CONTROLLED STUDY; DEGRANULATION; DESENSITIZATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; EOSINOPHIL; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LEUKOCYTE MIGRATION; NEUTROPHIL; PLASMA; PRIORITY JOURNAL; STIMULUS RESPONSE; TH2 CELL; THROMBOCYTE AGGREGATION; THROMBOCYTE RICH PLASMA; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; METABOLISM; PHYSIOLOGY;

TETRA;

BASOPHILS; BLOOD PROTEINS; CALCIUM; CARBAZOLES; CATIONS, DIVALENT; CELL DEGRANULATION; CELL LINE; CHEMOTAXIS; COLLAGEN; EOSINOPHILS; HUMANS; HYDANTOINS; INTRAMOLECULAR OXIDOREDUCTASES; LIPOCALINS; NEUTROPHILS; PIPERIDINES; PROSTAGLANDIN H2; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; SULFONAMIDES;

EID: 58149236750     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0608387     Document Type: Article

References (78)

1. Schleimer, R. P., Fox, C. C, Naclerio, R. M., Plaut, M., Creticos, P. S., Togias, A. G., Warner, J. A., Kagey-Sobotka, A., Liechtenstein, L. M. (1985) Role of human basophils and mast cells in the pathogenesis of allergic diseases. J. Allergy Clin. Immunol. 76, 369-374.
2. Lewis, R. A., Soter, N. A., Diamond, P. T., Austen, K. F., Oates, J. A., Roberts II, L. J. (1982) Prostaglandin D2 generation after activation of rat and human mast cells with anti-lgE. J. Immunol. 129, 1627-1631.
3. Kanaoka, Y., Urade, Y. (2003) Hematopoietic prostaglandin D synthase. Prostaglandins Leukot. Essent Fatty Acids 69, 163-167.
4. Mohri, I., Eguchi, N., Suzuki. K., Urade, Y., Taniike, M. (2003) Hema-topoietic prostaglandin D synthase is expressed in microglia in the developing postnatal mouse brain. Glia 42, 263-274.
5. Urade, Y., Hayaishi, O. (2000) Biochemical, structural, genetic. physiological, and pathophysiological features of lipocalin-type prostaglandin D synthase. Biochim. Biophys. Acta 1482, 259-271.
6. Grill, M., Heinemann, A., Hoefler, G., Peskar, B. A., Schuligoi, R. (2008) Effect of endotoxin treatmenl on the expression and localization of spinal cyclooxygenase, prostaglandin synthases, and PGD2 receptors. J. Neuro-chem. 104, 1345-1357.
7. Schuligoi, R., Grill, M., Heinemann, A., Peskar, B. A., Amann, R. (2005) Sequential induction of prostaglandin E and D synthases in inflammation. Biochem. Biophys. Res. Commun. 335, 684-689.
8. Gallant, M. A., Samadfam, R., Hackett, J. A., Antoniou, J., Parent, J. L., de Brum-Fernandes, A. J. (2005) Production of prostaglandin D(2) by human osteoblasts and modulation of osteoprotegerin, RANKL, and cellular migration by DP and CRTH2 receptors. J. Bone Miner. Res. 20, 672-681.
9. Hirai, H., Tanaka, K., Yoshie, O., Ogawa, K., Kenmotsu, K., Takamori, Y., Ichimasa, M., Sugamura, K., Nakamura, M., Takano, S., Nagata, K. (2001) Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J. Exp. Med. 193, 255-261.
10. Monnerel, G., Li, H., Vasilescu, J., Rokach, J., Powell, W. S. (2002) 15-Deoxy-δ 12, 14-prostaglandins D2 and J2 are potent activators of human eosinophils. J. Immunol. 168, 3563-3569.
11. Heinemann, A., Schuligoi, R., Sabroe, I., Hartnell, A., Peskar, B. A. (2003) δ12-Prostaglandin J2, a plasma metabolite of prostaglandin D2, causes eosinophil mobilization from the bone marrow and primes eosinophils for chemotaxis. J. Immunol. 170, 4752-4758.
12. Sandig, H., Andrew, D., Barnes, A. A., Sabroe, I., Pease, J. (2006) 9α,11β-PGF2 and its stereoisomer PGF2&aL are novel agonisls of the chemoattractant receptor, CRTH2. FEBS Lett. 580, 373-379.
13. Bohm, E., Sturm, G. J., Weiglhofer, J., Sandig, H., Shichijo, M., McNamee, A., Pease, J. E., Kollroser, M., Peskar, B. A., Heinemann, A. (2004) 11-Dehydro-thromhoxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils. J. Biol. Chem. 279, 7663-7670.
14. Monneret, G., Gravel, S., Diamond, M., Rokach, J., Powell, W. S. (2001) Prostaglandin D2 is a polent chemoattraetant for human eosinophils that acts via a novel DP receptor. Blood 98, 1942-1948.
15. 2., blocks the locomotion of eosinophils and basophils. Eur. J. Clin. Invest. 38, 663- 671.
16. Yoshimura-Uchiyama, C., Iikura, M., Yamaguchi, M., Nagase, H., Ishii, A., Matsushima, K., Yamamoto, K., Shichijo, M., Bacon, K. B., Hirai, K. (2004) Differential modulation of human basophil functions through prostaglandin D2 receptors DP and chemoattractant receptor-homologous molecule expressed on Th2 cells/DP2. Clin. Exp. Allergy 34, 1283-1290.
17. Durand, M., Gallant, M. A., de Brum-Fernandes, A. j. (2008) Prostaglandin D(2) receptors control osteoclastogenesis and the activity of human osteoclasts. J. Bone Miner. Res. 23, 1097-1105.
18. Schratl, P., Sturm, E. M., Royer, J. F., Sturm, G. J., Lippe, I. T., Peskar, B. A., Heinemann, A. (2006) Hierarchy of eosinophil chemoattractants: role of p38 mitogen-activated protein kinase. Eur. J. Immunol. 36, 2401-2409.
19. Almishri, W., Cossette, C., Rokach, J., Martin, J. G., Hamid, Q., Powell, W. (2005) Effects of prostaglandin D2, 15-deoxy-δ12, 14-prostaglandin J2, and selective DPI and DP2 receptor agonists on pulmonary infiltration of eosinophils in Brown Norway rats. J. Pharmacol. Exp. Ther. 313, 64-69.
20. Shiraishi, Y., Asano, K., Nakajima, T., Oguma, T., Suzuki, Y., Shiomi, T., Sayama, K., Niimi, K., Wakaki, M., Kagyo, J., Ikeda, E., Hirai, H., Yamaguchi, K., Ishizaka, A. (2005) Prostaglandin D2-induced eosino-philic airway inflammation is mediated by CRTH2 receptor. J. Pharmacol. Exp. Ther. 312, 954-960.
21. Spik, L, Brenuchon, C. Angeli, V., Slaumont, D., Fleury, S., Capron, M., Trottein, F., Dombrowicz, D. (2005) Activation of the prostaglandin D2 receptor" DP2/CRTH2 increases allergic inflammation in mouse. J. Immunol. 174, 3703-3708.
22. Satoh, T., Moroi, R., Aritake, K., Urade, Y., Kanai, Y., Sumi, K., Yokoz-eki, H., Hirai, H., Nagata, K., Hara, T., Utsuyama, M., Hirokawa, K., Sugamura, K., Nishioka, K., Nakamura, M. (2006) Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor. J. Immunol. 177, 2621-2629.
23. Oiwa, M., Satoh, T., Watanabe, M., Niwa, H., Hirai, H., Nakamura, M., Yokozeki, H. (2008) CRTH2-dependent, STAT6-independent induction of cedar pollen dermatitis. Clin. Exp. Allergy 38, 1357-1366.
24. Nomiya, R., Okano, M., Fujiwara, T., Maeda, M., Kimura, Y., Kino, K., Yokoyama, M., Hirai, H., Nagata, K., Hara, T., Nishizaki, K., Nakamura, M. (2008) CRTH2 plays an essential role in the pathophysiology of Cry j 1-induced pollinosis in mice. J. Immunol. 180, 5680-5688.
25. Shiraishi, Y., Asano, K., Niimi, K., Fukunaga, K., Wakaki, M., Kagyo, J., Takihara, T., Ueda, S., Nakajima, T., Oguma, T., Suzuki, Y., Shiomi, T., Sayama, K., Kagawa, S., Ikeda, E., Hirai, H., Nagata, K., Nakamura, M., Miyasho, T., Ishizaka, A. (2008) Cyelooxygenase-2/prostaglandm D2/ GRTH2 pathway mediates double-stranded RNA-induced enhancement of allergic airway inflammation. J. Immunol. 180, 541-549.
26. Uller, L., Mathiesen, J. M., Alenmyr, L., Korsgren, M., Ulven, T., Hogberg, T., Andersson, G., Persson, C. G., Kostenis, E. (2007) Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation. Respir. Res. 8, 16.
27. Boie, Y., Sawyer, N., Slipetz, D. M., Metters, K. M., Abramovitz, M. (1995) Molecular cloning and characterization of the human prostanoid DP receptor., J. Biol. Chem. 270, 18910-18916.
28. Gerashchenko, D., Beuckmann, C. T., Kanaoka, Y., Eguchi, N., Gordon, W. C Urade, Y., Bazan, N. G., Hayaishi, O. (1998) Dominant expression of rat prostanoid DP receptor mRNA in leptomeninges, inner segments of photoreceptor cells, iris epithelium, and ciliary processes. J. Neurochem, 71, 937-945.
29. Nantel, F., Fong, C., Lamontagne, S., Wright, D. H., Giaid, A., Desrosiers, M., Metters, K. M., O'Neill, G. P., Gervais, F. G, (2004) Expression of prostaglandin D synthase and the prostaglandin D2 receptors DP and CRTH2 in human nasal mucosa. Prostaglandins Other Lipid Mediat. 73, 87-101.
30. Wright, D. H., Ford-Hutchinson, A. W., Chadee, K., Metters, K. M. (2000) The human prostanoid DP receptor stimulates mucin secretion in LS1 74T cells. Br. J. Pharmacol. 131, 1537-1545.
31. Woodward, D. F., Hawley, S. R., Williams, L. S., Ralston, T. R., Protzman, C. E., Spada, C. S., Nieves, A. L. (1990) Studies on the ocular pharmacology of prostaglandin D2. Invest. Ophthalmol. Vis. Sci. 31, 138-146.
32. Woodward, D. F., Spada, C. S., Hawley, S. B., Williams, L. S., Protzman, C. E., Nieves, A. L. (1993) Further studies on ocular responses to DP receptor stimulation. Eur. J. Pharmacol. 230, 327-333.
33. Wheeldon, A., Vardey, C. J. (1993) Characterization of the inhibitory prostanoid receptors on human neutrophils. Br. J. Pharmacol. 108, 1051-1054.
34. Rossi, A. G., Cousin, J. M., Dransfield, I., Lawson, M. F., Chilvers, E. R., Haslett, C. (1995) Agents that elevate cAMP inhibit human neutrophil apoptosis. Biochem. Biophys. Res. Commun. 217, 892-899.
35. Gosset, P., Bureau, F., Angeli, V., Pichavant, M., Faveeuw, C., Tonnel, A. B., Trottein, F. (2003) Prostaglandin D2 affects the maturation of human monoeyte-derived dendritic cells: consequence on the polarization of naive Th cells. J. Immunol. 170, 4943-4952.
36. Fitzpatrick, F. A., Wynalda, M. A. (1983) Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro, J. Biol. Chem. 258, 11713-11718.
37. Gervais, F. G., Cruz, R. P., Chateauneuf, A., Gale, S., Sawyer, N., Nantel, F., Metters, K. M., O'Neill, G. P. (2001) Selective modulation of chemo-kinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP. J. Allergy Clin. Immunol 108, 982-988.
38. Schratl, P., Royer, J. F., Kostenis, E., Ulven, T., Sturm. E. M., Waldhoer, M., Hoefler, G., Schuligoi, R., Lippe, I. T., Peskar, B. A., Heinemann. A. (2007) The role of the prostaglandin D2 receptor, DP, in eosinophil trafficking. J. Immunol 179, 4792-4799. 57.
39. Arimura, A., Yasui, K., Kishino, J., Asanuma, F., Hasegawa, H., Kakudo, S., Ohtani, M., Arita, H. (2001) Prevention of allergic inflammation by a novel prostaglandin receptor antagonist, S-5751. J. Pharmacol. Exp. Ther. 298, 411-419.
40. Matsuoka, T., Hirala, M., Tanaka, H., Takahashi, Y., Murata, T., Ka-bashima, K., Sugimoto, Y., Kobayashi, T., Ushikubi, F., Aze, Y., Eguchi, N., Urade, Y., Yoshida, N., Kimura, K., Mizoguchi, A., Honda, Y., Nagai, H., Narumiya, S. (2000) Prostaglandin D2 as a mediator of allergic asthma. Science 287, 2013-2017.
41. Royer, J. F., Schratl, P., Lorenz, S., Kostenis, E., Ulven, T., Schuligoi, R., Peskar, B. A., Heinemann, A. (2007) A novel antagonist of CRTH2 blocks eosinophil release from bone marrow, chemotaxis and respiratory burst. Allergy 62, 1401-1409.
42. Sugimoto, H., Shichijo, M., lino, T., Manabe, Y., Watanabe, A., Shimazaki, M., Gantner, F., Bacon, K. B. (2003) An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-indueed eosinophil migration in vitro. J. Pharmacol. Exp. Ther. 305, 347-352.
43. Ulven, T., Kostenis, E. (2005) Minor" structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist. J. Med. Chem. 48, 897-900.
44. Mathiesen, J. M., Ulven, T., Martini, L., Gerlach, L. O., Heinemann, A., Kostenis. E. (2005) Identification of indole derivatives exclusively interfering with a G protein-independent signaling pathway of the prostaglandin D2 receptor CRTH2. Mol. Pharmacol 68, 393-402.
45. Sandham, D. A., Aldcroft, C., Baettig, U., Barker, L., Beer, D., Bhalay, G., Brown, Z., Dubois, G., Budd, D., Bidlake, E., Campbell, E., Cox, B., Everatt, B., Harrison, D., Leblanc, C. J., Manini, J., Profit, B., Stringer, R., Thompson, K. S., Turner, K. L., Tweed, M. F., Walker, C., Watson, S. J., Whitebread, S., Willis, J., Williams, G., Wilson, C. (2007) 2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists. Bioorg. Med. Chem. Lett. 17, 4347-4350.
46. Crosignani, S., Page, P., Missotten, M., Colovray, V., Cleva, C., Arrighi, J. F., Atherall, J., Macritchie, J., Martin, T., Humbert, Y., Gaudet, M., Pupowicz, D., Maio, M., Pittet, P. A., Golzio, L., Giachetti, C., Rocha, C., Bernardinelli, G., Filinchuk, Y., Scheer, A., Schwarz, M. K., Chollet, A. (2008) Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases. J. Med. Chem., 51, 2227-2243.
47. Armer, R. E., Ashton, M. R., Boyd, E. A., Brennan, C. J., Brookfield, F. A., Gazi, L., Gyles, S. L., Hay, P. A., Hunter, M. G., Middlemiss, D., Whittaker, M., Xue, E., Pettipher, R. (2005) Indole-3-acetie acid antagonists of the prostaglandin D2 receptor CRTH2. J. Med. Chem. 48, 6174-6177.
48. Liu, E., Gonzalo, J. A., Manning, S., O'Connell, L. E., Fedyk, E. R., Burke, K. E., Elder, A. M., Pulido, J. C., Cao, W., Tayber, O., Qiu, Y., Ghosh, S., Ocain, T. D., Hodge, M. R., Suzuki-Yagawa, Y. (2005) Pharmacological characterization of guinea pig chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). Prostaglandins Other Lipid Mediat. 76, 133-147.
49. Trist, D. G., Collins, R. A., Wood, J., Kelly, M. G., Robertson, A. D. (1989) The antagonism by BW A868C of PGD2 and BW245C activation of human platelet adenylate cyclase. Br. J. Pharmacol 96, 301-306.
50. Hohwy, M., Spadola, L., Lundquist, B., Hawtin, P., Dahmen, J., Groth-Clausen, I., Nilsson, E., Persdotter, S., von Wachenfeldt, K., Folmer, R. H., Edman, K. (2008) Novel prostaglandin D synthase inhibitors generated by fragment-based drug design. J. Med. Chem. 51, 2178-2186.
51. Urade, Y. (2008) [Structure and function of prostaglandin D synthase.] Tanpakushilsu Kakusan Kosa 53, 217-226.
52. Aritake, K., Kado, Y., Inoue, T., Miyano, M., Urade, Y. (2006) Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J. Biol. Chem. 281, 15277-15286.
53. Soler, M., Camacho, M., Sola, R., Vila, L. (2001) Mesangial cells release untransformed prostaglandin H2 as a major prostanoid. Kidney Int. 59, 1283-1289.
54. Camacho, M., Lopez-Belmonte, J., Vila, L. (1998) Rate of vasoconstrictor prostanoids released by endothelial cells depends on cyclooKvgenase-2 expression and prostaglandin I synthase activity. Circ. Res. 83, 353-365.
55. Corey, E. J., Nicolaou, K. C., Machida, Y., Malmsten, C. L., Samuelsson, B. (1975) Synthesis and biological properties of a 9, 11-azo-prostanoid: highly active biochemical mimic of prostaglandin endoperoxides. Proc. Natl. Acad. Sci. USA 72, 3355-3358.
56. Martini, E., Waldhoer, M., Pusch, M., Kharazia, V., Fong, J., Lee, J. H., Freissmuth, C., Whistler, J. L. (2007) Ligand-induced down-regulation of the cannabinoid l receptor is mediated by the G-protein-coupled receptor-associated sorting protein GASP1. FASEB J. 21, 802-811.
57. Sturm, G. J., Schuligoi, R., Sturm, E. M., Royer, J. F., Lang-Loidolt, D., Stammberger, H., Amann, R., Peskar, B. A., Heinemann, A. (2005) 5-oxo-6, 8.11,14-Eicosatetraenoic acid is a potent chemoattractant for human basophils. J. Allergy Clin Immunol. 116, 1014-1019.
58. Stubbs, V. E., Schratl, P., Harlnell, A., Williams, T. J., Peskar, B. A., Heinemann, A., Sabroe, I. (2002) Indomethacin causes prostaglandin D(2)-like and eotaxin-like selective responses in eosinophils and basophils. J. Biol. Chem, 277, 26012-26020.
59. Heinemann, A., Ofner, M., Amann, R., Peskar, B. A. (2003) A novel assay to measure the calcium flux in human basophils: effects of chemokines and nerve growth factor. Pharmacology 67, 49-54.
60. Menegazzi, R., Zabucchi, G., Knowles, A., Cramer, R., Patriarca, P. (1992) A new, one-step assay on whole cell suspensions for peroxidase secretion by human neutrophils and eosinophils. J. Leukoc. Biol. 52, 619-624.
61. Schuligoi, R., Schmidt, R., Geisslinger, G., Kollroser, M., Peskar, B. A., Heinemann, A. (2007) PGD2 metabolism in plasma: kinetics and relationship with bioactivity on DP1 and CRTH2 receptors. Biochem. Pharmacol. 74, 107-117.
62. Logan, M. R., Odemuyiwa, S. O., Moqbel, R. (2003) Understanding exocylosis in immune and inflammatory cells: the molecular basis of mediator secretion. J. Allergy Clin. Immunol 111, 923-932.
63. Waldhoer, M., Fong, J., Jones, R. M., Lunzer, M. M., Sharma, S. K., Kostenis, E., Portoghese, P. S., Whistler, J. L. (2005) A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers. Proc. Natl. Acad. Sci. USA 102, 9050-9055.
64. Svensson, J., Hamberg, M., Samuelsson, B. (1975) Prostaglandin endoperoxides IX. Characterization of rabbit aorta contracting substance (RCS) from guinea pig lung and human platelets. Acta Physiol Scand. 94, 222-228.
65. Hamberg, M., Svensson, J., Samuelsson, B. (1974) Prostaglandin endoperoxides. A new concept concerning the mode of action and release of prostaglandins. Proc. Natl. Acad. Sci. USA 71, 3824-3828.
66. Saito, M., Tanabe, Y., Kudo, I., Nakayama, K. (2003) Endothelium-derived prostaglandin H2 evokes the stretch-induced contraction of rabbit pulmonary artery. Eur. J. Pharmacol 467, 151-161.
67. Asano, H., Shimizu, K., Muramatsu, M., Iwama, Y., Toki, Y., Miyazaki, Y., Okumura, K., Hashimoto, H., Ito, T. (1994) Prostaglandin H2 as an endothelium-derived contracting factor modulates endothelin-1-induced contraction. J. Hypertens. 12, 383-390.
68. Kato, T., Iwama, Y., Okumura, K., Hashimoto, H., Ito, T., Satake, T. (1990) Prostaglandsn H2 may be the endothelium-derived contracting factor released by acetylcholine in the aorta of the rat. Hypertension 15, 475-481.
69. Folco, G., Murphy, R. C. (2006) Eicosanoid transcellular biosynthesis: from cell-cell interactions to in vivo tissue responses. Pharmacol. Rev. 58, 375-388.
70. Bousquet, J., Chanez, P., Lacoste, J. Y., Barneon, G., Ghavanian, N., Enander, I., Venge, P., xAhlstedt, S., Simony-Lafontaine, J., Godard, P., et al. (1990) Eosinophilic inflammation m asthma. N. Engl. J. Med. 323, 1033-1039.
71. Green, R. H., Brightling, C. E., McKenna, S., Hargadon, B., Parker, D., Bradding, P., Wardlaw, A. J., Pavord, 1. D. (2002) Asthma exacerbations and sputum eosinophil counts: a randomized controlled trial. Lancet 360, 1715-1721.
72. Humbles, A. A., Lloyd, C. M., McMillan, S. J., Friend, D. S., Xanthou, G., McKenna, E. E., Ghiran, S., Gerard, N. P., Yu, C, Orkin, S. H., Gerard, C. (2004) A critical role for eosinophils in allergic airways remodeling. Science 305, 1776-1779.
73. Lee, J. J., Dimina, D., Macias, M. P., Ochkur, S. L, McGarry, M. P., O'Neill, K. R., Protheroe, G., Pero, R., Nguyen, T., Cormier, S. A., Lenkiewicz, E., Colbert, D., Rinaldi, L., Ackerman, S. J., Irvin, C. G., Lee, N. A. (2004) Defining a link with asthma in mice congenitally deficient in eosinophils. Science 305, 1773-1776.
74. Hamberg, M., Fredholm, B. B. (1976) Isomerization of prostaglandin H2 into prostaglandin D2 m the presence of serum albumin. Biochim. Bio-phys. Acta 431, 189-193.
75. Urade, Y., Eguchi, Y., Eguehi, N., Kijima. Y., Matsuura, Y., Oda, FT., Seiki, K., Hayaishi, O. (1999) Secretion of lipocalin-type prostaglandin D synthase ([3-trace) from human heart to plasma during coronary circulation. Adv. Exp. Med. Biol. 469, 49-54.
76. Melegos, D. N., Diamandis, E. P., Oda, H., Urade. Y., Hayaishi. O. (1996) Immunofluorometric assay of prostaglandin D synthase in human tissue extracts and fluids. Clin. Chem. 42, 1984-1991.
77. Hamberg, M., Svensson, J., Wakabayashi, T., Samuelsson, B. (1974) Isolation and structure of two proslaglandin endoperoxides that cause platelet aggregation. Proc. Natl. Acad. Sci. USA 71, 345-349.
78. Bryan, S. A., Jose, P. J., Topping, J. R., Wilhelm, R., Soderberg, C., Kerlesz, D., Barnes, P. J., Williams, T. J., Hansel, T. T., Sabroe, T. (2002) Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists. Am. j. Respir. Crit. Care Med. 165, 1602-1609.