Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase

Journal of Biological Chemistry

Volumn 281, Issue 22, 2006, Pages 15277-15286

  Aritake, Kosuke ^a   Kado, Yuji ^b   Inoue, Tsuyoshi ^b   Miyano, Masashi ^c   Urade, Yoshihiro ^a  

^a OSAKA BIOSCIENCE INSTITUTE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c Harima Institute ^*  (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; COMPLEXATION; CRYSTAL STRUCTURE; ENZYME INHIBITION; HYDROGEN BONDS; SURFACE PLASMON RESONANCE;

ANTI-INFLAMMATORY DRUGS; FUNCTIONAL CHARACTERIZATION; HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE; QUATERNARY COMPLEXES;

ENZYMES;

4 BENZHYDRYLOXY 1 [3 (1H TETRAZOL 5 YL)PROPYL]PIPERIDINE; ARGININE; ENZYME INHIBITOR; GLUTATHIONE; PIPERIDINE; PROSTAGLANDIN D SYNTHASE; PROSTAGLANDIN SYNTHASE; PROSTANOID; TRYPTOPHAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CATALYSIS; CELL STRAIN HEK293; CRYSTAL STRUCTURE; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; INFLAMMATION; MALE; MASTOCYTOMA; MEGAKARYOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN QUATERNARY STRUCTURE; RAT;

ADMINISTRATION, ORAL; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CELL LINE; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HEMATOPOIETIC SYSTEM; HUMANS; HYDROGEN BONDING; INTRAMOLECULAR OXIDOREDUCTASES; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPERIDINES; PROTEIN CONFORMATION; RATS;

EID: 33744948143     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M506431200     Document Type: Article

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