Cigarette smoke, inflammation, and lung injury: A mechanistic perspective

Journal of Toxicology and Environmental Health - Part B: Critical Reviews

Volumn 12, Issue 1, 2009, Pages 45-64

  Bhalla, Deepak K ^a   Hirata, Fusao ^a   Rishi, Arun K ^b   Gairola, C Gary ^c  

^a WAYNE STATE UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; CIGARETTE SMOKE; CYTOKINE; FIBRONECTIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; LIPOCORTIN 1;

ASTHMA; CARCINOGENESIS; CELL MIGRATION; CELL PROLIFERATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE ASSOCIATION; DISEASE COURSE; DNA DAMAGE; ENVIRONMENTAL EXPOSURE; FIBROBLAST; HUMAN; LUNG CANCER; LUNG DISEASE; LUNG EMPHYSEMA; LUNG INJURY; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PNEUMONIA; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RESPIRATORY TRACT MUCOSA; REVIEW; RISK FACTOR; TH1 CELL; TH2 CELL;

ANIMALS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; LUNG DISEASES; OXIDATIVE STRESS; PULMONARY EMPHYSEMA; TOBACCO SMOKE POLLUTION;

ANIMALIA;

EID: 58149175349     PISSN: 10937404     EISSN: 15216950     Source Type: Journal    
DOI: 10.1080/10937400802545094     Document Type: Review

References (208)

1. Alati, R., Al Mamun, A., O'Callaghan, M., Najman, J. M., and Williams, G. M. 2006. In utero and postnatal maternal smoking and asthma in adolescence. Epidemiology 17:138-144.
2. Albelda, S. M. 1991. Endothelial and epithelial cell adhesion molecules. Am. J. Respir. Cell. Mol. Biol. 4: 195-203.
3. Alberg, A. J., and Samet, J. M. 2003. Epidemiology of lung cancer. Chest 123(Suppl. 1):21S-49S.
4. Anderson, R., Theron, A. J., Richards, G. A., Myer, M. S., and Van Rensburg, A. J. 1991. Passive smoking by humans sensitizes circulating neutrophils. Am. Rev. Respir. Dis. 144:570-574.
5. Anto, R. J., Mukhopadhyay, A., Shishodia, S., Gairola, C. G., and Aggarwal, B. B. 2002. Cigarette smoke condensate activates nuclear transcription factor-kB through phosphorylation and degradation of Ik-Ba: Correlation with induction of cyclooxygenase-2. Carcinogenesis 23:1511-1518.
6. Bhalla, D. K. 1996. Alteration of alveolar macrophage chemotaxis, cell adhesion and cell adhesion molecules following ozone exposure of rats. J. Cell. Physiol. 169:429-438.
7. Bhalla, D. K. 1999. Ozone-induced lung inflammation and mucosal barrier disruption: Toxicology, mechanisms and implications. J. Toxicol. Environ. Health B 2:31-86.
8. Bhalla, D. K., and Gupta, S. K. 2000. Lung injury, inflammation and inflammatory stimuli in rats exposed to ozone. J. Toxicol. Environ. Health A 59:211-228.
9. Bhalla, D. K., and Hoffman, L. 1997. Time course of airway epithelial and inflammatory changes in rats exposed to moderate levels of ozone. Inhal. Toxicol. 9: 829-842.
10. Bhalla, D. K., Reinhart, P. G., Bai, C., and Gupta, S. K. 2002. Amelioration of ozone-induced lung injury by anti-tumor necrosis factor-α. Toxicol. Sci. 69:400-408.
11. Bittleman, D. B., and Casale, T. B., 1995. Interleukin-8 mediates interleukin-1β-induced neutrophil transcellular migration. Am. J. Respir. Cell Mol. Biol. 13:323-329.
12. Borland, R., Yong, H. H., Siahpush, M., Hyland, A., Campbell, S., Hastings, G., Cummings, K. M., and Fong, G. T. 2006. Support for and reported compliance with smoke-free restaurants and bars by smokers in four countries: findings from the International Tobacco Control (ITC) Four Country Survey. Tobacco Control 15(Suppl. 3):34-41.
13. Boucher, R. C., Johnson, J., Inoue, S., Hulbert, W., and Hogg, J. C. 1980. The effect of cigarette smoke on the permeability of guniea pig airways. Lab. Invest. 43:94-100.
14. Bracke, K. R., D'hulst, A. I., Maes, T., Demedts, K., Moerloose, K. B., Kuzielw, W. A., Joos, G. F., and Brusselle, G. G. 2007. Cigarette smoke-induced pulmonary inflammation, but not airway remodelling, is attenuated in chemokine receptor 5-deficient mice. Clin. Exp. Allergy 37:1467-1479.
15. Bracke, K. R., D'hulst, A. I., Maes, T., Moerloose, K. B., Demedts, I. K., Lebecque, S., Joos, G. F., and Brusselle, G. G. 2006. Cigarette smoke-induced pulmonary inflammation and emphysema are attenuated in CCR6-deficient mice. J. Immunol. 177:4350-4359.
16. Burns, A. B., and Doerschuk, C. M. 1994. L-selectin and CD18 expression on rabbit neutrophils during CD18-independent and CD18-dependent emigration in the lung. J. Immunol. 153:3177-3188.
17. Byron, K. A., Varigos, G. A., and Wootton, A. M. 1994. IL-4 production is increased in cigarette smokers. Clin. Exp. Immunol. 95:954-962.
18. Cao, Y., and Karin, M. 2003. NF-kappaB in mammary gland development and breast cancer. J. Mammary Gland Biol. Neoplasia 8:215-223.
19. Carnevali, S., Nakamura, Y., Mio, T., Liu, X., Takigawa, K., Romberger, D. J., Spurzem, J. R., and Rennard, S. I. 1998. Cigarette smoke extract inhibits fibroblast-mediated collagen gel contraction. Am. J. Physiol. Lung Cell Mol. Physiol. 247:L591-L598.
20. Castro, P., Legora-Machado, A., Cardilo-Reis, L., Valença, S., Porto, L. C., Walker, C., Zuany-Amorim, C., and Gonçalves, V. L. 2004. Inhibition of interleukin-1β reduces mouse lung inflammation induced by exposure to cigarette smoke. Eur. J. Pharmacol. 498:279-286.
21. Centers for Disease Control. 2006. Tobacco use among adults - United States, 2005 United States. Accessed 11 September 2007 at http://www.cdc.gov/ mmwr/preview/mmwrhtml/mm5442a1.htm
22. Chen, F. E., and Ghosh, G. 1999. Regulation of DNA binding by Rel/NFKappaB transcription factors structural views. Oncogene 18:6845-6852.
23. Chow, C. K. 1993 Cigarette smoking and oxidative damage in the lung. Ann. NY Acad. Sci. 686:289-298.
24. Churg, A., Cosio, M., and Wright, J. L. 2008. Mechanisms of cigarette smoke-induced COPD: Insights from animal models. Am. J. Physiol. Lung Cell Mol. Physiol. 294:L612-L631.
25. Churg, A., Wang, R. D., Tai, H., Wang, X., Xie, C., Dai, J., Shapiro, S. D., and Wright, J. L. 2003. Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-α release. Am. J. Respir. Cell Mol. Biol. 167:1083-1089.
26. Churg, A., Wang, R. D., Tai, H., Wang, X., Xie, C., and Wright, J. L. 2004. Tumor necrosis factor-alpha drives 70% of cigarette smokeinduced emphysema in the mouse. Am. J. Respir. Crit. Care Med. 170:492-498.
27. Churg, A., Zay, K., Shay, S., Xie, C., Shaprio, S. D., Hendricks, R., and Wright, J. L. 2002a. Acute cigarette smoke-induced connective tissue breakdown requires both neutrophils and macrophages metalloelastase in mice. Am. J. Respir. Cell Mol. Biol. 27:368-374.
28. Churg, A., Dai, J., Tai, H., Xie, C., and Wright, J. L. 2002b. Tumor necrosis factor-α is central to acute cigarette smoke-induced inflammation and connective tissue breakdown. Am. J. Respir. Crit. Care Med. 166:849-854.
29. Coggins, C. R. 2007. An updated review of inhalation studies with cigarette smoke in laboratory animals. Int. J. Toxicol. 26:331-338.
30. Cohen, M. D., Sisco, M., Li, Y., Zelikoff, J. T., and Schlesinger, R. B. 2001. Ozone-induced modulation of cell-mediated immune responses in the lungs. Toxicol. Appl. Pharmacol. 171:71-84.
31. Cohn, L., Elias, J. A., and Chupp, G. L. 2004. Asthma: Mechanisms of disease persistence and progression. Annu. Rev. Immunol. 22:789-815.
32. Cozen, W., Diaz-Sanchez, D., James Gauderman, W., Zadnick, J., Cockburn, M. G., Gill, P. S., Masood, R., Hamilton, A. S., Jyrala, M., and Mack, T. M. 2004. Th1 and Th2 cytokines and IgE levels in identical twins with varying levels of cigarette consumption. J. Clin. Immunol. 6:617-622.
33. Danahay, H., Atherton, H., Jones, G., Bridges, R. J., and Poll, C. T. 2002. Interleukin-13 induces a hypersecretory ion transport phenotype in human bronchial epithelial cells. Am. J. Physiol. Lung Cell Mol. Physiol. 282:L226-L236.
34. Dean, D. C. 1989. Expression of the fibronectin gene. Am. J. Respir. Cell Mol. Biol. 1:5-10.
35. De Sario, M., Forastiere, F., Viegi, G., Simoni, M., Chellini, E., Piccioni, P., Indinnimeo, L., and Brunetti, L. 2005. Gruppo Collaborativo SIDRIA-2. [Parental smoking and respiratory disorders in childhood]. Epidemiol. Prev. 29(2 Suppl.):52-56.
36. Devesa, S. S., Silverman, D. T., Young, J. L., Pollack, E. S., Brown, C. C., Horm, J. W., Percy, C. L., Myers, M. H., McKay, F. W., and Fraumeni, J. F. 1987. Cancer incidence and mortality trends among whites in the United States, 1947-84. JNCI 79:701-770.
37. de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G., and de Vires, J. E. 1991. Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174:1209-1220.
38. Dezateux, C., Stocks, J., Dundas, I., and Fletcher, M. E. 1999. Impaired airway function and wheezing in infancy: The influence of maternal smoking and a genetic predisposition to asthma. Am. J. Respir. Crit. Care Med. 159:403-410.
39. Dhala, A., Pinsker, K., and Prezant, D. J. 2006. Respiratory health consequences of environmental tobacco smoke. Clin. Occup. Environ. Med. 5:139-156.
40. Dhami, R., Gilks, B., Xie, C., Zay, K., Wright, J. L., and Churg, A. 2000. Acute cigarette smoke-induced connective tissue breakdown is mediated by neutrophils and prevented by α 1-antitrypsin. Am. J. Respir. Cell Mol. Biol. 22:244-252.
41. D'hulst, A. I., Vermaelen, K. Y., Brusselle, G. G., Joos, G. F., and Pauwels, R. A. 2005. Time course of cigarette smoke-induced pulmonary inflammation in mice. Eur. Respir. J. 26:204-213.
42. Department of Health and Human Services. 1964. Smoking and health. Report of the advisory committee to the surgeon general of the public health service PHS Document No. 1103. Washington, D.C.
43. Department of Health and Human Services. 2004. The health consequences of smoking. A Report of the Surgeon General - 2004. Washington, DC: U.S. Department of Health and Human Services.
44. DiFranza, J. R., Aligne, C. A., and Weitzman, M. 2004. Prenatal and postnatal environmental tobacco smoke exposure and children's health. Pediatrics 113(Suppl. 4):1007-1015.
45. Dubar, V., Gosset, P., Aerts, C., Voisin, C., Wallaert, B., and Tonnel, A. B. 1993. In vitro acute effects of tobacco smoke on tumor necrosis factor-alpha and interleukin-6 production by alveolar macrophages. Exp. Lung Res. 19:345-359.
46. Elias, J. 2004. The relationship between asthma and COPD. Lessons from transgenic mice. Chest 126:111S-116S.
47. Elias, J. A., Lee, C. G., Zheng, T., Ma, B., Homer, R. J., and Zhu, Z. 2003. New insights into the pathogenesis of asthma. J. Clin. Invest. 111:291-297.
48. Esamai, F. O. 1998. Relationship between exposure to tobacco smoke and bronchial asthma in children: A review. East Afr. Med. J. 75:47-50.
49. Ey, J. L., Holberg, C. J., Aldous, M. B., Wright, A. L., Martinez, F. D., and Taussig, L. M. 1995. Passive smoke exposure and otitis media in the first year of life. Group Health Medical Associates. Pediatrics 95:670-677.
50. Ferreira, A. M., Rollins, B. J., Faunce, D. E., Burns, A. L., Zhu, X. F., and DiPietro, L. A. 2005. The effect of MCP-1 depletion on chemokine and chemokine-related gene expression: Evidence for a complex network in acute inflammation. Cytokine 30:64-71.
51. Fiorentino, D. F., Zlotnik, A., Mosmann, T. R., Howard, M., and O'Garra, A. 1991. IL-10 inhibits cytokine production by activated macrophages. J. Immunol. 147:3815-3822.
52. Fiorentino, D. F., Bond, M. W., and Mosmann, T. R. 1989. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med. 170:2081-2095.
53. Fröde, T. S., Souza, G. E., and Calixto, J. B. 2001. The modulatory role played by TNF-alpha and IL-1 beta in the inflammatory responses induced by carrageenan in the mouse model of pleurisy. Cytokine 13:162-168.
54. Fuke, S., Betsuyaku, T., Nasuhara, Y., Morikawa, T., Katoh, H., and Nishimura, M. 2004. Chemokines in bronchiolar epithelium in the development of chronic obstructive pulmonary disease. Am. J. Respir. Cell Mol. Biol. 31:405-412.
55. Gabrielson, E. 2006. Worldwide trends in lung cancer pathology. Respirology 11:533-538.
56. Gairola, C. G. 1986. Free lung cell response of mice and rats to mainstream cigarette smoke exposure. Toxicol. Appl. Pharmacol. 84: 567-575.
57. Giddings, S. S., Morgan, W. J., Perry, C., Jones, I., and Bricker, J. T. 1994. Active and passive tobacco use: A serious pediatric health problem (AHA statement). Circulation 90:2581-2690.
58. Gold, R., Oelschlager, M., Pepinsky, R. B., Sommer, C., Hartung, P., and Toyka, K. V. 1999. Increased lipocortin I (annexin I) expression in the sciatic nerve of Lewis rats with experimental autoimmune neuritis. Neuropathology (Berl.) 98:583-589.
59. Goulding, N. J., Euzger, H. S., Butt, S. K., and Perretti, M. 1998. Novel pathways for glucocorticoid effects on neutrophils in chronic inflammation. Inflamm. Res. 47(Suppl. 3):S158-S165.
60. Green, P. G., Strausbaugh, H. J., and Levine, J. D. 1998. Annexin I is a local mediator in neural-endocrine feedback control of inflammation. J. Neurophysiol. 80:3120-3126.
61. Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z. W., Egan, L. J., Kagnoff, M. F., and Karin, M. 2004. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118:285-296.
62. Hasnis, E., Bar-Shai, M., Burbea, Z., and Reznick, A. Z. 2007. Mechanisms underlying cigarette smoke-induced NF-kappaB activation in human lymphocytes: The role of reactive nitrogen species. J. Physiol. Pharmacol. 58: 275-287.
63. Haux, F., Louahed, J., Hudspith, B., Meredith, C., Delos, M, Renauld, J.-C., and Lison, D. 1998. Role of interleukin-10 in the lung response to silica in mice. Am. J. Respir. Cell Mol. Biol. 18:51-59.
64. He, J., Vupputuri, S., Allen, K., Prerost, M. R., Hughes, J., and Whelton, P. K. 1999, Passive smoking and the risk of coronary heart disease - A meta-analysis of epidemiologic studies. N. Engl. J. Med. 340: 920-926.
65. Hellermann, G. R., Nagy, S. B., Kong, X, Lockey, R. F., and Mohapatra, S. S. 2002. Mechanism of cigarette smoke condensate-induced acute inflammatory response in human bronchial epithelial cells. Respir. Res. 3:22-29.
66. Hellings, P. W., Kasran, A., Liu, Z., Vandekerckhove, P., Wuyts, A., Overbergh, L., Mathieu, C., and Ceuppens, J. L. 2003. Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma. Am. J. Respir. Cell Mol. Biol. 28:42-50.
67. Hirata, F. 1984. Roles of lipomodulin, a phospholipase inhibitory protein, in immunoregulation. Adv. Inflam. Res. 7:71-78.
68. Hirata, F. 1989. Role of lipocortins in cellular function as a second messenger of glucocorticoids. In Anti-inflammatory steroid action. Basic and clinical aspects, eds. L. M. Lichtenstein, H. Claman, A. Oronsky, and R. Schleimer, pp. 67-95. San Diego: Academic Press.
69. Hirata, F. 1998. Annexins (lipocortins). In Encyclopedia of immunology, 2nd ed., eds. I. M. Roitt and P. J. Delves, pp. 111-115. London: Academic Press Ltd.
70. Hirata, F., and Iwata, M. 1983. Role of lipomodulin, a phospholipase inhibitory protein, in immunoregulation by thymocytes. J. Immunol. 130:1903-1909.
71. Hoffmann, D., and Hoffmann, I. 1997. The changing cigarette, 1950-1995. J. Toxicol. Environ. Health 50:307-364.
72. Holt, P. G. 1987. Immune and inflammatory function in cigarette smokers. Thorax 42: 241-249.
73. Hoo, A. F., Henschen, M., Dezateux, C., Costeloe, K., and Stocks, J. 1998. Respiratory function among preterm infants whose mothers smoked during pregnancy. Am. J. Respir. Crit. Care Med. 158:700-705.
74. Howard, D. J., Ota, R. B., Briggs, L. A., Hampton, M., and Pritsos, C. A. 1998. Environmental tobacco smoke in the workplace induces oxidative stress in employees, including increased production of 8-hydroxy-2′- deoxyguanosine. Cancer Epidemiol. Biomarkers Prev. 7:141-146.
75. Husgafvel-pursiainen, K. 2004. Genotoxicity of environmental tobacco smoke: A review. Mutat. Res. 567: 427-445.
76. Hynes, R. O. 1990. Fibronectin, pp. 1-6. New York: Springer-Verlag.
77. IARC. 2004. Tobacco smoke and involuntary smoking. IARC Monogr. Eval. Carcinogen. Risks Hum. 83:59-88.
78. Ishizaka, K. 1989. Regulation of the IgE antibody responses. Int. Arch. Allergy Appl. Immunol. 88:8-13.
79. Ishizaka, K., Jardieu, P., Akasaki, M., and Iwata, M. 1987. T cell factors involved in the regulation of the IgE synthesis. Int. Arch. Allergy Appl. Immunol. 82:383-388.
80. Jaiswal, A. K. 1994 Antioxidant response element. Biochem. Pharmacol. 48:439-444.
81. Johnson, J. D., Houchens, D. P., Kluwe, W. M., Craig, D. K., and Fisher, G. L. 1990. Effects of mainstream and environmental tobacco smoke on the immune system in animals and humans: A review. Crit. Rev. Toxicol. 20:369-395.
82. Jones, J. G., Lawler, P., Crawley, J. C. W., Minty, B. D., Hulands, G., and Veall, N. 1980. Increased alveolar epithelial permeability in cigarette smokers. Lancet 1:66-68.
83. Kohn, A. D., Takeuchi, F., and Roth, R. A. 1996. Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation. J. Biol. Chem. 271:2190-21926.
84. Kolls, J. K., Kanaly, S. T., and Ramsay, A. J. 2003. Interleukin-17: An emerging role in lung inflammation. Am. J. Respir. Cell Mol. Biol. 28:9-11.
85. Kooi, E. M., Vrijlandt, E. J., Boezen, H. M., and Duiverman, E. J. 2004. Children with smoking parents have a higher airway resistance measured by the interruption technique. Pediatr. Pulmonol. 38:419-424.
86. Krzysiek, R., Lefevre, E. A., Bernard, J., Foussat, A., Galanaud, P., Louache, F., and Richard, Y. 2000. Regulation of CCR6 chemokine receptor expression and responsiveness to macrophage inflammatory protein-3 alpha/CCL20 in human B cells. Blood 96:2338-2345.
87. Kulik, G., Klippel, A., and Weber, M. J. 1997. Antiapoptotic signaling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol. Cell. Biol. 17:1595-1606.
88. Kuper, H., Boffetta, P., and Adami, H. O. 2002. Tobacco use and cancer causation: association by tumour type. J. Intern. Med. 252:206-224.
89. Kuschner, N. G., D'Alessandro, A., Wong, H., and Blanc, P. D. 1996. Dose-dependent cigarette smoking-related inflammatory responses in healthy adults. Eur. Respir. J. 9:1989-1994.
90. La Fleur, M., Beaulieu, A. D., Kreis, C., and Poubelle, P. 1987. Fibronectin gene expression in polymorphonuclear leukocytes. Accumulation of mRNA in inflammatory cells. J. Biol. Chem. 262:2111-2115.
91. Lancaster, L. H., Christman, J. W., Blackwell, T. R., Koay, M. A., and Blackwell, T. S. 2001. Suppression of lung inflammation in rats by prevention of NF-kappaB activation in the liver. Inflammation 25:25-31.
92. Landau, L. I. 2008. Tobacco smoke exposure and tracking of lung function into adult life. Paediatr. Respir. Rev. 9:39-43.
93. Lannero, E., Wickman, M., Pershagen, G., and Nordvall, L. 2006. Maternal smoking during pregnancy increases the risk of recurrent wheezing during the first years of life (BAMSE). Respir. Res. 5(7):3.
94. Lappalainen, U., Whitsett, J. A., Wert, S. E., Tichelaar, J. W., and Bry, K. 2005. Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung. Am. J. Respir. Cell Mol. Biol. 32: 311-318.
95. Leff, J. A., Wilke, C. P., Hybertson, B. M., Shanley, P. F., Beehler, C. J., and Repine, J. E. 1993. Post-insult treatment with N-acetyl-L- cysteine decreases IL-1-induced neutrophil influx and lung leak in rats. Am. J. Physiol. 265:L501-L506.
96. Lehr, H. A. 1993. Adhesion-promoting effects of cigarette smoke on leukocytes and endothelial cells. Ann. NY Acad. Sci. 686:112-119.
97. Lehr, H. A., Frei, B., and Arfors, K. E. 1994. Vitamin C prevents cigarette smoke-induced leukocyte aggregation and adhesion to endothelium in vivo. Proc. Natl. Acad. Sci. USA 91:7688-7692.
98. Limper, A. H., and Roman, J. 1992. Fibronectin. A versatile matrix protein with roles in thoracic development, repair and infection. Chest 101:1663-1673.
99. Lin, A., and Karin, M. 2003. NF-kappaB in cancer: A marked target. Semin. Cancer Biol. 13:107-114.
100. Liu, J. Y., Sime, P. J., Wu, T., Warshamana, G. S., Pociask, D., Tsai, S. Y., and Brody, A. R. 2001. Transforming growth factor-beta(1) overexpression in tumor necrosis fator-α receptor knockout mice induces fibroproliferative lung disease. Am. J. Respir. Cell Mol. Biol. 25:3-7.
101. Loft, S., Vistisen, K., Ewertz, M., Tjonneland, A., Overvad, K., and Poulsen, H. E. 1992. Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans-Influence of smoking, gender and body mass index. Carcinogenesis 13:2241-2247.
102. Loghmani, F., Mohammed, K. A., Nasreen, N., Van Horn, R. D., Hardwick, J. A., Sanders, K. L., and Antony, V. B. 2002. Inflammatory cytokines mediate C-C (monocyte chemotactic protein 1) and C-X-C (interleukin 8) chemokine expression in human pleural fibroblasts. Inflammation 26:73-82.
103. Lucey, E. C., Keane, J., Kuang, P. P., Snider, G. L., and Goldstein, R. H. 2002. Severity of elastase-induced emphysema is decreased in tumor necrosis factor-α and interleukin-1β receptor-deficient mice. Lab. Invest. 82:79-85.
104. Ludwig, P. W., Schwartz, B. A., Hoidal, J. R., and Niewoehner, D. E. 1985. Cigarette smoking causes accumulation of polymorphonuclear leukocytes in alveolar septum. Am. Rev. Respir. Dis. 131:828-830.
105. Mack, M., Cihak, J., Simonis, C., Luckow, B., Proudfoot, A. E., Plachý, J., Brühl, H., Frink, M., Anders, H. J., Vielhauer, V., Pfirstinger, J., Stangassinger, M., and Schlöndorff, D. 2001. Expression and characterization of the chemokine receptors CCR2 and CCR5 in mice. J. Immunol. 166:4697-4704.
106. MacNee, W. 2007. Pathogenesis of chronic obstructive pulmonary disease. Clin. Chest Med. 28:479-513.
107. MacNee, W. B., Wiggs, A. S., Belzberg, A. S., and Hogg, J. C. 1989. The effect of cigarette smoking on neutrophil kinetics in human lungs. N. Engl. J. Med. 321: 924-928.
108. Maes, T., Bracke, K. R., Vermaelen, K. Y., Demedts, I. K., Joos, G. F., Pauwels, R. A., and Brusselle, G. G. 2006. Murine TLR4 is implicated in cigarette smoke-induced pulmonary inflammation. Int. Arch. Allergy Immunol. 141:354-368.
109. Majori, M., Corradi, M., Caminatti, A., Cacciani, G., Bertacco, S., and Pesci, A. 1999. Predominant Th1 cytokine pattern in peripheral blood from subjects with chronic obstructive pulmonary diseases. J. Allergy Clin. Immunol. 103:451-462.
110. Mannino, D. M., and Buist, A. S. 2007. Global burden of COPD: risk factors, prevalence, and future trends. Lancet 370:765-773.
111. Marwick, J. A., Kirkham, P. A., Stevenson, C. S., Danahay, H., Giddings, J., Butler, K., Donaldson, K., MacNee, W., and Rahman, I. 2004. Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs. Am. J. Respir. Cell Mol. Biol. 31 633-642.
112. Marx, J. 2004. Inflammation and cancer. The link grows stronger. Science 306:966-968.
113. McKeown-Longo, P. J. 1987. Fibronectin-cell surface interactions. Rev. Infect. Dis. 9:S322-S334.
114. Mercer-Jones, M. A., Shrotri, M. S., Heinzelmann, M., Peyton, J. C., and Cheadle, W. G. 1999. Regulation of early peritoneal neutrophil migration by macrophage inflammatory protein-2 and mast cells in experimental peritonitis. J. Leukocyte Biol. 65:249-255.
115. Miller, L. M., Foster, W. M., Dambach, D. M., Doebler, D., McKinnon, M., Killar, L., and Longphre, M. 2002. A murine model of cigarette smoke-induced pulmonary inflammation using intranasally administered smoke-conditioned medium. Exp. Lung Res. 28: 435-455.
116. Milner, A. D., Marsh, M. J., Ingram, D. M., Fox, G. F., and Susiva, C. 1999. Effects of smoking in pregnancy on neonatal lung function. Arch. Dis. Child Fetal Neonatal Ed. 80:F8-F14.
117. Mio, T., Romberger, D. J., Thompson, A. B., Robbins, R. A., Heires, A., and Rennard, S. I. 1997. Cigarette smoke induces interleukin-8 release from human bronchial epithelial cells. Am. J. Respir. Crit. Care Med. 155:1770-1776.
118. Morrison, D., Rahman, I., Lannan, S., and MacNee, W. 1999. Epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers. Am. J. Respir. Crit. Care Med. 159:473-479.
119. Morrow, J. D., Frei, B., Longmire, A. W., Gaziano, J. M., Lynch, S. M., Shyr, Y., Strauss, W. E., Oates, J. A., and Roberts, L. J. 1995. Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. N. Engl. J. Med. 332:1198-1203.
120. Moshammer, H., Hoek, G., Luttmann-Gibson, H., Neuberger, M. A., Antova, T., Gehring, U., Hruba, F., Pattenden, S., Rudnai, P., Slachtova, H., Zlotkowska, R., and Fletcher, T . 2006. Parental smoking and lung function in children: An international study. Am. J. Respir. Crit. Care Med. 173:1255-1263.
121. Mosher, D. F. 1987. Fibronectin, pp. 48-49.San Diego: Academic Press.
122. Mulligan, M. S., Warner, R. L., Foreback, J. L., Shanley, T. P., and Ward, P. A. 1997. Protective effects of IL-4 IL-10, IL-1 and IL-13 in IgG immune complex-induced lung injury. Role of endogenous IL-12. J. Immunol. 159:3483-3489.
123. Mulligan, M. S., Wilson, G. P., Todd, R. F., Smith, C. W., Anderson, D. C., Varani, J., Issekutz, T. B., Miyasaka, M., Tamatani, T., Rusche, J. R., Vaporcyan, A. A., and Ward, P. 1993.Role of beta 1, beta 2 integrins and ICAM-1 in lung injury after deposition of IgG and IgA immune complexes. J. Immunol.150: 2407-2417.
124. Murin, S., Hilbert, J., and Reilly, S. J. 1997. Cigarette smoking and the lung. Clin. Rev. Allergy Immunol. 15:307-361.
125. Nakamura, Y., Romberger, D. J., Tate, L., Ertl, R. F., Kawamoto, M., Adachi, Y., Mio, T., Sisson, J. H., Spurzem, J. R., and Rennard, S. I. 1995. Cigarette smoke inhibits lung fibroblast proliferation and chemotaxis. Am. J. Respir. Crit. Care Med. 151:1497-1503.
126. Newman, S. P., Croxtall, J. D., Choudhury, Q., and Flower, R. J. 1997. The coordinated regulation of lipocortin I, COX2 and cPLA2 by IL1beta in A549 cells. Adv. Exp. Med. Biol. 407:249-253.
127. Nouri-Shirazi, M., Tinajero, R., and Guinet, E. 2007. Nicotine alters the biological activities of developing mouse bone marrow-derived dendritic cells (DCs). Immunol. Lett. 109:155-164.
128. Nuhoglu, C., Gurul, M., Nuhoglu, Y., Karatoprak, N., Sonmez, E. O., Yavrucu, S., Ozguner, A., and Oppermann, M. 2004. Chemokine receptor CCR5: Insights into structure, function, and regulation. Cell Signal. 16:1201-1210.
129. Nuhoglu, C., Gurul, M., Nuhoglu, Y., Karatoprak, N., Sonmez, E. O., Yavrucu, S., and Ozguner, A. 2003. Effects of passive smoking on lung function in children. Pediatr. Int. 45:426-428.
130. Nureki, S., Miyazaki, E., Ando, M., Kumamoto, T., and Tsuda, T. 2005. CC chemokine receptor 4 ligand production by bronchoalveolar lavage fluid cells in cigarette-smoke-associated acute eosinophilic pneumonia. Clin. Immunol. 116:83-93.
131. Ouyang, T., Virasch, N., Hao, P., Aubrey, M. T., Mukerjee, N., Bierrer, B. E., and Freed, B. M. 2000. Suppression of human IL-1 β, IL-2, IFN-γ and TNF α production by cigarette smoke extracts. J. Allergy Clin. Immunol. 106:280-287.
132. Pahl, H. L. 1999. Activator and target genes of Rel/NF-kB transcription factors. Oncogene 18:6853-6866.
133. Patel, J. A., Kunimoto, M., Sim, T. C., Garofalo, R., Eliott, T., Baron, S., Ruuskanen, O., Chonmaitree, T., Ogra, P. L., and Schmalstieg, F. 1995 Interleukin-1a mediates the enhanced expression of intercellular adhesion molecule-1 in pulmonary epithelial cells infected with respiratory syncytial virus. Am. J. Respir. Cell Mol. Biol. 13:602-609.
134. Pattenden, S., Antova, T., Neuberger, M., Nikiforov, B., De Sario, M., Grize, L., Heinrich, J., Hruba, F., Janssen, N., Luttmann-Gibson, H., Privalova, L., Rudnai, P., Splichalova, A., Zlotkowska, R., and Fletcher, T. 2006. Parental smoking and children's respiratory health: Independent effects of prenatal and postnatal exposure. Tobacco Control 15:294-301.
135. Pearson, A. C., and Bhalla, D. K. 1997. Effects of ozone on macrophage adhesion in vitro and epithelial and inflammatory responses in vivo: The role of cytokines. J. Toxicol. Eviron. Health 50:143-157.
136. Perkins, N. D. 2007. Integrating cell-signaling pathways with NF-κB and IKK function. Nat. Rev. Mol. Cell Biol. 8:49-62.
137. Piedboeuf, B., Frenett, J., Petrov, P., Welty, S. E., Kazzaz, J. A., and Horowitz, S. 1996. In vivo expression of intercellular adhesion molecule 1 in type II pneumocytes during hyperoxia. Am. J. Respir. Cell Mol. Biol. 15:71-77.
138. Pryor, W. A., and Stone, K. 1993. Oxidants in cigarette smoke: Radicals, hydrogen peroxides, peroxinitrate and peroxynitrite. Ann. NY Acad. Sci. 686:12-28.
139. Pryor, W. A., Prier, D. G., and Church, D. F. 1983. Electron-spin resonance study of mainstream and sidestream cigarette smoke: Nature of the free radicals in gas-phase smoke and in cigarette tar. Environ. Health Perspect. 47:345-355.
140. Rahman, I. 2002. Oxidative stress, transcription factors and chromatin remodelling in lung inflammation. Biochem. Pharmacol. 64:935-942.
141. Rahman I. 2003. Oxidative stress, chromatin remodeling and gene transcription in inflammation and chronic lung diseases. J. Biochem. Mol. Biol. 31:95-109.
142. Rahman, I., and MacNee, W. 2000. Regulation of redox glutathione levels and gene transcription in lung inflammation: Therapeutic approaches. Free Radical Biol. Med. 28:1405-1420.
143. Rahman, I., Gilmour, P. S., Jimenez, L. A., and MacNee, W. 2002. Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: Potential mechanism in gene transcription in lung inflammation. Mol. Cell. Biochem. 234-235:239-248.
144. Raychaudhuri, B., Fisher, C. J., Farver, C. F., Malur, A., Drazba, J., Kavuru, M. S., and Thomassen, M. J. 2000. Interleukin 10 (IL-10)-mediated inhibition of inflammatory cytokine production by human alveolar macrophages. Cytokine 12:1348-1355.
145. Reardon, J. Z. 2007. Environmental tobacco smoke: Respiratory and other health effects. Clin. Chest Med. 28:559-573.
146. Reinhart, P. G., Gupta, S. K., and Bhalla, D. K. 1999. Attenuation of ozone-induced lung injury by interleukin-10. Toxicol. Lett. 110:35-42.
147. Rennard, S. I., Togo, S., and Holz, O. 2006. Cigarette smoke inhibits alveolar repair: A mechanism for the development of emphysema. Proc. Am. Thorac. Soc. 3:703-708.
148. Rennard, S. I., and Crystal, R. G. 1981. Fibronectin in human bronchopulmonary lavage fluid. Elevation in patients with interstitial lung disease. J. Clin. Invest. 69:113-122.
149. Rhee, H. J., Kim, G. Y., Uh, J. W., Kim, S. W., and Na, D. S. 2000. Annexin I is a stress protein induced by heat, oxidative stress and a sulfhydryl-reactive agents. Eur. J. Biochem. 267:3220-3225.
150. Roth, M. 2008. Pathogenesis of COPD. Part III. Inflammation in COPD. Int. J. Tuberc. Lung Dis. 12:375-380.
151. Rous, R. L., Boudreaux, M. J., and Penn, A. L. 2007. In utero ETS exposure alters gene expression in lungs of adult BALB/c mice. Environ. Health Perspect. 115:1757-1766.
152. Ruoslahti, E. 1988. Fibronectin and its receptors. Annu. Rev. Biochem. 57:375-413.
153. Rushton, L. 2004. Health impact of environmental tobacco smoke in the home. Rev. Environ. Health 19:291-309.
154. Rusznak, C., Mills, P. R., Devalia, J. L., Sapsford, R. J., Davies, R. J., and Lozewicz, S 2000. Effect of cigarette smoke on the permeability and IL-1beta and s ICAM release from cultured human bronchial epithelial cells of never-smokers, smokers, and patients with chronic obstructive pulmonary disease. Am. J. Respir. Cell Mol. Biol. 23:530-536.
155. Ryder, M. I., Saghizadeh, M., Ding, Y., Nguyen, N., and Soskolne, A. 2002. Effect of tobacco smoke on the secretion of interleukin-1 beta, tumor necrosis factor-alpha and transforming growth factor-beta from peripheral blood mononuclear cells. Oral Microbiol. Immunol. 17:331-336.
156. Schick, S., and Glantz, S. A. 2006. Sidestream cigarette smoke toxicity increases with aging and exposure duration. Tobacco Control 15:424-429.
157. Schierhorn, K., Zhang, M., Matthias, C., and Kunkel, G. 1999. Influence of ozone and nitrogen dioxide on histamine and interleukin formation in a human nasal mucosa culture system. Am. J. Respir. Cell Mol. Biol. 20:1013-1019.
158. Sears, M. R. 2000. Consequences of long-term inflammation. The natural history of asthma. Clin. Chest Med. 21:315-329.
159. Shanley, T. P., Vasi, N., and Denenberg, A. 2000. Regulation of chemokine expression by IL-10 in lung inflammation. Cytokine 12:1054-1064.
160. Shields, P. G. 2002. Molecular epidemiology of smoking and lung cancer. Oncogene 21:6870-6876.
161. Sime, P. J., Marr, R. A., Gauldie, D., Xing, Z., Hewlett, B. R., Graham, F. L., and Gauldie, J. 1998. Transfer of tumor necrosis factor-alpha to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-b1 and myofibroblasts. Am. J. Pathol. 153:825-832.
162. Smart, S. J., and Casale, T. B. 1994. Pulmonary epithelia cells facilitate TNF-a-induced neutrophil chemotaxis. A role for cytokine networking. J. Immunol. 152:4087-4094.
163. Smith, C. J., Fischer, T. H., and Sears, S. B. 2000. Environmental tobacco smoke, cardiovascular disease, and the nonlinear dose-response hypothesis. Toxicol. Sci. 54:462-472.
164. Smith, R. E., Strieter, R. M., Phan, S. H., and Kunkel, S. L. 1996. C-C chemokines: Novel mediators of the profibrotic inflammatory response to bleomycin challenge. Am. J. Respir. Cell Mol. Biol. 15:693-702.
165. Solito, E., deCoupade, C., Parente, L., Flower, R. J., and Russo-Marie, F. 1998. IL6 stimulates annexin I expression and translocation and suggests a new biological role as class II acute phase protein. Cytokine 10:514-521.
166. Springer, T. A. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell 76:301-314.
167. Stick, S. 2006. The effects of in-utero tobacco-toxin exposure on the respiratory system in children. Curr. Opin. Allergy Clin. Immunol. 6:312-316.
168. Stocks, J., and Dezateux, C. 2003. The effect of parental smoking on lung function and development during infancy. Respirology 8:266-285.
169. Stokoe, D., Stephens, L. R., Copeland, T., Gaffney, P. R., Reese, C. B., Painter, G. F., Holmes, A. B., McCormick, F., and Hawkins, P. T. 1997. Dual role of phosphatidylinositol-3,4,5-triphosphate in the activation of protein kinase B. Science 277:567-570.
170. Stone, P. C., Fisher, A. C., Rainger, G. E., and Nash, G. B. 2002. Neutrophl capture by selectins on endothelial cells exposed to cigarette smoke. Biochem. Biophys. Res. Commun. 295:1150-1155.
171. Stringer, B., and Kobzik, L. 1998. Environmental particulate-mediated cytokine production in lung epithelial cells (A549): Role of preexisting inflammation and oxidant stress. J. Toxicol. Environ. Health A 55:31-44.
172. Subauste, M. C., Choi, D. C., and Proud, D. 2001. Transient exposure of human bronchial epithelial cells to cytokines leads to persistent increased expression of ICAM-1. Inflammation 25:373-380.
173. Sugawara, T., Gallucci, R. M., Simeonova, P. P., and Luster, M. I. 2001. Regulation and role of interleukin 6 in wounded human epithelial keratinocytes. Cytokine 15:328-336.
174. Sullivan, D. E., Ferris, M., Pociask, D., and Brody, A. R. 2005. Tumor necrosis factor-alpha induces transforming growth factor-beta1 expression in lung fibroblasts through the extracellular signal-regulated kinase pathway. Am. J. Respir. Cell Mol. Biol. 32:342-349.
175. Tager, I. B. 2008. The effects of second-hand and direct exposure to tobacco smoke on asthma and lung function in adolescence. Paediatr. Respir. Rev. 9:29-37.
176. Tager, I. B., Ngo, L., and Hanrahan, J. P. 1995. Maternal smoking during pregnancy: Effects of lung function during the first 18 months of life. Am. J. Respir. Crit. Care Med. 152:977-983.
177. Takubo, Y., Guerassimov, A., Ghezzo, H., Triantafillopoulos, A., Bates, J. H. T., Hoidal, J. R., and Cosio, M. G. 2002. α1-Antitrypsin determines the pattern of emphsema and function in tobacco smoke-exposed mice. Am. J. Respir. Crit. Care Med. 166:1596-1603.
178. Terashima, T., Klut, M. E., English, D., Hards, J., Hogg, J. C., and Van Eeden, S. F. 1999. Cigarette smoking causes sequestration of polymorphonuclear leukocytes released from the bone marrow in lung microvessels. Am. J. Respir. Cell Mol. Biol. 20:171-177.
179. Terashima, T., Wiggs, B., English, D., Hogg, J. C., and van Eeden, S. F. 1997. The effect of cigarette smoking on the bone marrow. Am. J. Respir. Crit. Care Med. 155:1021-1026.
180. Thatcher, T. H., Maggirwar, S. B., Baglole, C. J., Lakatos, H. F., Gasiewicz, T. A., Phipps, R. P., and Sime, P. J. 2007. Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB. Am. J. Pathol. 170:855-864.
181. Tosi, M. F., Stark, J. M., Smith, C. W., Hamedani, A., Gruenert, D. C., and Infeld, M.D. 1992. Induction of ICAM-1 expression on human airway epithelial cells by inflammatory cyokines: Effects on neutrophil epithelial cell adhesion. Am. J. Respir. Cell Mol. Biol. 7:214-221.
182. Tsao, F. H., Meyer, K. C., Chen, X., Rosenthal, N. S., and Hu, J. 1998. Degradation of annexin I in bronchoalveolar lavage fluid from patients with cystic fibrosis. Am. J. Respir. Cell Mol. Biol. 18:120-128.
183. Uede, T., Hirata, F., Hirashima, M., and Ishizaka, K. 1983. Modulation of the biologic activities of IgE-binding factors. I. Identification of glycosylation inhibiting factor as a fragment of lipomodulin. J. Immunol. 130:878-884.
184. van den Berg, R., Haenen, G. R., van den Berg, H., and Bast, A. 2001. Nuclear factor-kappaB activation is higher in peripheral blood mononuclear cells of male smokers. Environ. Toxicol. Pharmacol. 9:147-151.
185. van der Vaart, H., Postma, D. S., Timens, W., and Ten Hacken, N. H. 2004. Acute effects of cigarette smoking on inflammation and oxidative stress: A review. Thorax 59:713-721.
186. Van Miert, C. E., Dumont, X., and Bernard, A. 2005. C16 as a marker of lung epithelial hyperpermeability in an acute model of rats exposed to mainstream cigarette smoke. Toxicol. Lett. 159:115-123.
187. Vassallo, R., Tamada, K., Lau, J. S., Kroening, P. R., and Chen, L. 2005. Cigarette smoke extract suppresses human dendritic cell function leading to preferential induction of Th-2 priming. J. Immunol. 175:2684-2691.
188. Vignola, A. M., Chanez, P., Chiappara, G., Merendino, A., Pace, E., Rizzo, A., la Rocca, A. M., Bellia, V., Bonsignore, G., and Bousquet, J. 1997. Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis. Am. J. Respir. Crit. Care Med. 156:591-599.
189. Vignola, A. M., Chanez, P., Chiappara, G., Merendino, A., Zinnanti, E., Bousquet, J., Bellia, V., and Bonsignore, G. 1996. Release of transforming growth factor-beta (TGF-b) and fibronectin by alveolar macrophages in airway diseases. Clin. Exp. Immunol. 106:114-119.
190. Vishwanantha, J. K., Davis, R. G., Blumberg, S., Gao, X. P., and Rubinstein, I. 1998. Annexin degradation in bronchoalveolar lavage fluids from healthy smokers: A possible mechanism of inflammation. Clin. Cancer Res. 4:2559-2564.
191. Von-Andrian, U. H., Chambers, J. D., McEvoy, L. M., Bargatze, R. F., Arfors, K. E., and Butcher, E. C. 1991. Two-step model of leukocyteendothelial cell interaction in inflammation: Distinct roles for LECAM-1 and the leukocyte beta-2 integrins in vivo. Proc. Natl. Acad. Sci. USA 88:7538-7542.
192. Wang, L., and Pinkerton, K. E. 2008. Detrimental effects of tobacco smoke exposure during development on postnatal lung function and asthma. Birth Defects Res. C Embryo Today 84:54-60.
193. Wang, H., Liu, X., Umino, T., Kohyama, T., Zhu, Y. K., Wen, F. Q., Spurzem, J. R., Romberger, D. J., Kim, H. J., and Rennard, S. I. 2003. Effect of cigarette smoke on fibroblast-mediated gel contraction is dependent on cell density. Am. J. Physiol. Lung. Cell Mol. Physiol. 284:L205-L213.
194. Warren, C. 2006. A cross country comparison of exposure to second hand smoke among youth. Tobacco Control 15(Suppl. 2):ii4-ii19.
195. Warshamana, G. S., Corti, M., and Brody, A. R. 2001. TNF-α, PDGF and TGF-beta(1), expression by primary mouse bronchiolar-alveolar epithelial and mesenchymal cells: TNF-α induces TGF-beta(1). Exp. Mol. Pathol. 71:13-33.
196. Weber, C., Erl, W., Weber, K., and Weber, P. C. 1996. Increased adhesiveness of isolated monocytes to endothelium is prevented by vitamin C intake in smokers. Circulation 93:1488-1492.
197. Witschi, H. 2007. Tobacco smoke-induced lung cancer in animals - A challenge to toxicology (?). Int. J. Toxicol. 26: 339-344.
198. World Health Organization. 1997. Tobacco or health: A global status report. Geneva: WHO.
199. World Health Organization. 2004. Tobacco smoke and involuntary smoking. IARC Monograph 83. Lyon, France.
200. Wouters, E. F. M. 2005. Local and systemic inflammation in chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 2:26-33.
201. Wright, J. L., Tai, H., and Churg, A. 2004. Cigarette smoke induces persisting increases of vasoactive mediators in pulmonary arteries. Am. J. Respir. Cell Mol. Biol. 31:501-509.
202. Yamashiro, S., Wang, J. M., Yang, D., Gong, W. H., Kamohara, H., and Yoshimura, T. 2000. Expression of CCR6 and CD83 by cytokine-activated human neutrophils. Blood 96:3958-3963.
203. Yang, S. R., Valvo, S., Yao, H., Kode, A., Rajendrasozhan, S., Edirisinghe, I., Caito, S., Adenuga, D., Henry, R., Fromm, G., Maggirwar, S., Li, J. D., Bulger, M., and Rahman, I. 2008. IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung. Am. J. Respir. Cell Mol. Biol. 38:689-698.
204. Yang, S. R., Chida, A. S., Bauter, M. R., Shafiq, N., Seweryniak, K., Maggirwar, S. B., Kilty, I., and Rahman, I. 2006. Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages. Am. J. Physiol. Lung Cell Mol. Physiol. 291:L46-L57.
205. Yu, M., Pinkerton, K. E., and Witschi, H. 2002. Short-term exposure to aged and diluted sidestream cigarette smoke enhances ozone-induced lung injury in B6C3F1 mice. Toxicol. Sci. 65:99-106.
206. Zhu, Z., Homer, R. J., Wang, Z., Chen, Q., Geba, G. P., Wang, J., Zhang, Y., and Elias, J. A. 1999. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J. Clin Invest. 103:779-788.
207. Zhu, Z., Ma, B., Zheng, T., Homer, R. J., Lee, C. G., Charo, I. F., Noble, P., and Elias, J. A. 2002. IL-13-induced chemokine responses in the lung: Role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling. J. Immunol. 168:2953-2962.
208. Zuany-Amorim, C., Haile, S., Leduc, D., Dumarey, C., Huerre, M., Vargaftig, B. B., and Pretolani, M. 1995. Interleukin-10 inhibits antigeninduced cellular recruitment into the airways of sensitized mice. J. Clin. Invest. 95:2644-2651.