C-C Chemokines: Novel Mediators of the Profibrotic Inflammatory Response to Bleomycin Challenge

American Journal of Respiratory Cell and Molecular Biology

Volumn 15, Issue 6, 1996, Pages 693-702

  Smith, Robert E ^a   Strieter, Robert M ^a   Phan, Sem H ^a   Kunkel, Steven L ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RODENTIA;

BLEOMYCIN; CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 1;

ANIMAL; CHEMICALLY INDUCED DISORDER; HUMAN; LUNG FIBROSIS; PHYSIOLOGY; REVIEW;

ANIMALS; BLEOMYCIN; CHEMOKINE CCL2; CHEMOKINES; HUMANS; MACROPHAGE INFLAMMATORY PROTEIN-1; PULMONARY FIBROSIS;

EID: 0030332498     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.15.6.8969262     Document Type: Review

References (122)

1. Schwartz, M. I. 1989. Interstitial pulmonary fibrosis. In Textbook of Internal Medicine. W. N. Kelley, editor. J. P. Lippincott Co., Philadelphia, PA. 1902-1905.
2. Chandler, D. B. 1990. Possible mechanisms of bleomycin-induced fibrosis. Clin. Chest Med. 11:21-30.
3. Schrier, D. J., R. G. Kunkel, and S. H. Phan. 1983. The role of strain variation in murine bleomycin-induced pulmonary fibrosis. Am. Rev. Respir. Dis. 127:63-66.
4. Adamson, I. Y., and D. H. Bowden. 1974. The pathogenesis of bleomycin-induced pulmonary fibrosis in mice. Am. J. Pathol. 77:185-197.
5. Aso, Y., and Y. Yoneda. 1976. Morphological and biochemical study of pulmonary changes induced by bleomycin in mice. Lab. Invest. 35:558-568.
6. Bedrossian, C. M. W., S. D. Grennberg, D. H. Yawn, and R. M. O'Neil. 1977. Experimentally induced bleomycin sulfate pulmonary toxicity. Arch. Pathol. Lab. Med. 101:248-254.
7. Bowden, D. H. 1984. Unraveling pulmonary fibrosis: the bleomycin model. Lab. Invest. 50:487-488.
8. Chandler, D. B., D. M. Hyde, and S. N. Giri. 1983. Morphometric estimates of infiltrative cellular changes during the development of bleomycin-induced pulmonary fibrosis in hamsters. Am. J. Pathol. 112:170-177.
9. Smith, R. E., R. M. Strieter, S. H. Phan, N. W. Lukacs, G. B. Huffnagle, C. A. Wilke, M. D. Burdick, P. Lincoln, H. Evanoff, and S. L. Kunkel. 1994. Production and function of murine macrophage inflammatory protein-1α bleomycin-induced lung injury. J. Immunol. 153:4704-4712.
10. Thrall, R. S., R. W. Barton, D. A. D'Amato, and S. B. Sulavik. 1982. Differential cellular analysis of bronchoalveolar lavage fluid obtained at various stages during the development of bleomycin-induced pulmonary fibrosis in the rat. Am. Rev. Respir. Dis. 126:488-492.
11. Piguet, P. F., M. A. Collart, G. E. Grau, Y. Kapanci, and P. Vassalli. 1989. Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J. Exp. Med. 170:655-663.
12. Otsuka, K., S. Murota, and Y. Mori. 1976. Stimulatory effect of bleomycin on the synthesis of acidic glycosaminoglycans in cultured fibroblasts derived from rat carrageenin granuloma. Biochim. Biophys. Acta 444:359-368.
13. Clark, J. G., B. C. Starcher, and J. Uitto. 1976. Bleomycin-induced synthesis of type I procollagen by human lung and skin fibroblasts in culture. Biochem. Biophys. Acta 631:359-370.
14. 2 in mice. J. Pharmacol. Exp. Ther. 228:13-18.
15. Zhang, K., M. Gharaee-Kermani, M. L. Jones, J. S. Warren, and S. H. Phan. 1994. Lung monocyte chemoattractant protein-1 gene expression in bleomycin-induced pulmonary fibrosis. J. Immunol. 153:4733-4741.
16. Zhang, K., M. D. Rekhter, D. Gordon, and S. H. Phan. 1994. Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. Am. J. Pathol. 145:114-125.
17. 14C-proline uptake, its incorporation into proteins and hydroxylation in collagenous proteins of hamster lung slices. J. Appl. Toxicol. 5:89-93.
18. Kunkel, S. L. 1993. Inflammatory cytokines. In Manual of Vascular Mediators. Peter A. Ward, editor. HP Publishing Company, New York, NY.
19. Giri, S. N., Z. L. Chen, W. R. Younker, and M. J. Schiedt. 1983. Effects of intratracheal administration on GSH-shuttle enzymes, catalase, lipid peroxidation, and collagen content in the lungs of hamsters. Toxicol. Appl. Pharmacol. 71:132-141.
20. 2 complex with DNA. J. Antibiot. 33:426-434.
21. Oberly, L. W., and G. R. Buettner. 1979. The production of hydroxyl radical by bleomycin and iron(II). FEBS Lett. 97:47-49.
22. Berend, N. 1984. Protective effect of hypoxia on bleomycin lung toxicity in the rat. Am. Rev Respir. Dis. 130:307-308.
23. Tryka, A. F., W. A. Skornik, J. J. Godleski, and J. D. Brain. 1982. Potentiation of bleomycin-induced lung injury by exposure to 70% oxygen. Am. Rev. Respir. Dis. 126:1074-1079.
24. Chandler, D. B., J. C. Barton, D. D. Briggs, 3rd, T. W. Butler, J. I. Kennedy, W. E. Grizzle, and J. D. Fulmer. 1988. Effect of iron deficiency on bleomycin-induced lung fibrosis in the hamster. Am. Rev. Respir. Dis. 137:85-89.
25. Chandler, D. B., and J. D. Fulmer. 1985. The effect of deferoxamine on bleomycin-induced lung fibrosis in the hamster. Am. Rev. Respir. Dis. 131:596-598.
26. Chandler, D. B., T. W. Butler, D. D. Briggs, 3rd, W. E. Grizzle, J. C. Barton, J. D. Fulmer, and D. D. Briggs. 1988. Modulation of the development of bleomycin-induced pulmonary fibrosis by deferoxamine. Toxicol. Appl. Pharmacol. 92:358-367.
27. Grant, M. E., and D. J. Prockop. 1972. The biosynthesis of collagen. N. Engl. J. Med. 286:194-199, 242-249, 291-300.
28. Bhatnagar, R. S., and T. Z. Liu. 1972. Evidence for free radical involvement in the hydroxylation of proline: inhibition by nitro blue tetrazolium. FEBS Lett. 26:32-34.
29. Chandler, D. B., and S. N. Giri. 1983. Changes in plasma concentrations of prostaglandins and plasma angiotensin-converting enzyme during bleomycin-induced lung fibrosis in hamsters. Am. Rev. Respir. Dis. 128: 71-76.
30. 2 and collagen levels of the lung in hamsters. Exp. Lung Res. 9:119-133.
31. 2 and cyclic adenosine monophosphate and suppresses fibroblast proliferation and collagen synthesis. J. Clin. Invest. 72:2082-2091.
32. 2) on amino acid uptake and protein formation by lung fibroblasts. J. Biol. Chem. 261:8734-8737.
33. Wilhelmsson, L., A. Norstrom, and L. Hamberger. 1981. Influence of 6-keto-PFG1a on collagen synthesis in the human cervix during various phases of the menstrual cycle. Prostaglandins 22:125-130.
34. Thrall, R. S., J. R. McCormick, R. M. Jack, R. A. McReynolds, and P. A. Ward. 1979. Bleomycin-induced pulmonary fibrosis in the rat. Am. J. Pathol. 95:117-130.
35. Phan, S. H., and S. L. Kunkel. 1986. Inhibition of bleomycin-induced pulmonary fibrosis by nordihydroguiaretic acid. Am. J. Pathol. 124:343-352.
36. Kovacs, E. J., and J. Kelley. 1986. Intra-alveolar release of a competence-type growth factor after lung injury. Am. Rev. Respir. Dis. 133:68-72.
37. Kovacs, E. J. 1991. Fibrogenic cytokines: the role of immune mediators in the development of scar tissue. Immunol. Today 12:17-23.
38. Hill, D. J., A. J. Strin, S. F. Elstrow, S. Swenne, and R. G. Milner. 1986. Bi-functional action of transforming growth factor-β on DNA synthesis in early passage human fetal fibroblasts. J. Cell Physiol. 128:322-328.
39. Roberts, A. B., and M. B. Sporn. 1990. The transforming growth factor-betas. In Peptide Growth Factors and Their Receptors. Handbook of Experimental Pharmacology. M. B. Sporn and A. B. Roberts, editors. Marcel Dekker, Inc., New York, NY. 419-472.
40. Bruijn, J. A., A. Roos, B. deGues, and E. deHeer. 1994. Transforming growth factor-β and the glomerular extracellular matrix in renal pathology. J. Lab. Clin. Med. 123:34-47.
41. Phan, S., M. Gharaee-Kermani, F. Wolber, and U. Ryan. 1991. Stimulation of rat endothelial cell transforming growth factor-β production by bleomycin. J. Clin. Invest. 87:148-154.
42. Khalil, N., O. Bereznay, M. B. Sporn, and A. H. Greenberg. 1989. Macrophage production of transforming growth factor-β and fibroblast collagen synthesis in chronic pulmonary inflammation J. Exp. Med. 170:727-737.
43. Haak-Frendscho, M., T. A. Wynn, C. J. Czuprinski, and D. Paulnock. 1990. Transforming growth factor-β1 inhibits activation of macrophage cell line RAW 264.7 for cell killing. Clin. Exp. Immunol. 82:404-410.
44. Tsunawaki, S., M. B. Sporn, A. Ding, and C. Nathan. 1988. Deactivation of macrophages by transforming growth factor-β. Nature 334:260-262.
45. Khalil, N., and R. N. O'Conner. 1995. Cytokine regulation of pulmonary fibrosis. Pulmonary Fibrosis 80:627-646.
46. Martinet, Y., W. M. Rom, G. R. Grotendorst, and G. R. Martin. 1987. Exaggerated spontaneous release of platelet-derived growth factor by alveolar macrophages from patients with idiopathic pulmonary fibrosis N. Engl. J. Med. 317:202-209.
47. Raines, E. W., D. F. Bowen-Pope, and R. Ross. 1991. Platelet-derived growth factor. In Peptide Growth Factors and Their Receptors I. A. B. Sporn and M. B. Roberts, editors. Marcel Dekker, Inc., New York, NY. 173-262.
48. Clemmons, D. R., L. E. Underwood, and J. J. Van Wyk. 1981. Hormonal control of immunoreactive somatomedin production by cultured human fibroblasts. J. Clin. Invest. 67:10-19.
49. Clemmons, D. R., and J. J. Van Wyk. 1985. Evidence for a functional role of endogenously produced somatomedin-like peptides in the regulation of DNA synthesis in cultured human fibroblasts and porcine smooth muscle cells. J. Clin. Invest. 75:1914-1918.
50. Narayanan, A. S., and R. C. Page. 1983. Biosynthesis and regulation of type V collagen in diploid human fibroblasts. J. Biol. Chem. 258:11694-11699.
51. Majack, R. A., S. C. Cook, and P. Bornstein. 1985. Platelet-derived growth factor and heparin-like glycosaminoglycans regulate thrombospondin synthesis and deposition in the matrix by smooth muscle cells. J. Cell Biol. 101:1059-1070.
52. Chua, C. C., D. E. Geiman, G. H. Keller, and R. L. Ladda. 1985. Induction of collagenase secretion in human fibroblast cultures by growth promoting factors. J. Biol. Chem. 260:5213-5216.
53. Deuel, T. F., R. M. Senior, J. S. Huang, and G. L. Griffin. 1982. Chemotaxis of monocytes and neutrophils to platelet-derived growth factor. J. Clin. Invest. 69:1046-1049.
54. Williams, L. T., H. N. Antoniades, and E. J. Goetzl. 1983. Platelet-derived growth factor stimulates mouse 3T3 cell mitogenesis and leukocyte chemotaxis through different structural determinants. J. Clin. Invest. 72:1759-1763.
55. Tzeng, D. Y., T. F. Deuel, J. S. Huang, and R. L. Baehner. 1985. Platelet-derived growth factor promotes human peripheral monocyte activation. Blood 66:179-183.
56. Tzeng, D. Y., T. F. Deuel, J. S. Huang, R. M. Senior, L. A. Boxer, and R. L. Baehner. 1984. Platelet-derived growth factor promotes polymorphonuclear leukocyte activation. Blood 64:1123-1128.
57. Schrier, D. J., S. H. Phan, and B. M. McGarry. 1983. The effects of the nude (nu/nu) mutation on bleomycin-induced pulmonary fibrosis. Am. Rev. Respir. Dis. 127:614-617.
58. Phan, S. H., and S. L. Kunkel. 1992. Lung cytokine production in bleomycin-induced pulmonary fibrosis. Exp. Lung Res. 18:18-43
59. Everson, M. P., and D. B. Chandler. 1992. Changes in distribution, morphology and tumor necrosis factor-α secretion of alveolar macrophage subpopulations during the development of bleomycin-induced pulmonary fibrosis Am. J. Pathol. 140:503-512
60. Piguet, P. F., and C. Vesin. 1994. Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice. Eur. Respir. J. 7:515-518.
61. Piguet, P. F., C. Vesin, G. E. Grau, and R. C. Thompson. 1993. Interleukin 1 receptor antagonist (IL-1ra) prevents or cures pulmonary fibrosis elicited in mice by bleomycin or silica. Cytokine 5:57-61.
62. Mori, H., K. Kawada, P. Zhang, Y. Uesugi, O. Sakamato, and A. Koda. 1991. Bleomycin-induced pulmonary fibrosis in genetically mast-cell deficient WBB6F1-W/W mice and mechanism of the suppressive effect of tranilast, an antiallergic drug inhibiting mediator release from mast cells, on fibrosis. Ins. Arch. Allergy Appl. Immunol. 95:195-201.
63. Thrall, R. S., S. H. Phan, J. R. McCormick, and P. A. Ward. 1981. The development of bleomycin-induced pulmonary fibrosis in neutrophil-depleted and complement-depleted rats. Am. J. Pathol. 105:76-81.
64. Micallef, M., M. Hosokawa, Y. Togashi, and H. Kobayashi. 1992. Rat macrophage activation after treatment with the bleomycin group of antitumour antibiotics in vivo. Cancer Immunol. Immunother. 35:106-112.
65. Thrall, R. S., and R. W. Barton. 1984. Comparison of lymphocyte populations in lung tissue and in bronchoalveolar lavage fluid of rats at various times during the development of bleomycin-induced pulmonary fibrosis. Am. Rev. Respir. Dis. 129:279-283.
66. Dauber, J. H., and R. P. Daniele. 1980. Secretion of chemotaxins by guinea pig lung macrophages. Exp. Lung Res. 1:23-32.
67. Kagan, E., Y. Oghiso, and D. Hartman. 1983. Enhanced release of a chemoattractant for alveolar macrophages after asbestos inhalation. Am. Rev. Respir. Dis. 128:680-687.
68. Kaelin, R. M., D. M. Center, J. Bernardo, M. Grant, and G. L. Snider. 1983. The role of macrophage-derived chemoattractant activities in the early inflammatory events of bleomycin-induced injury. Am. Rev. Respir. Dis. 128:132-137.
69. Denholm, E. M., F. M. Wolber, and S. H. Phan. 1989. Secretion of monocyte chemotactic activity by alveolar macrophages. Am. J. Pathol. 135: 571-580.
70. Denholm, E. M. 1992. Continuous secretion of monocyte chemotactic factors and fibroblast growth factors by alveolar macrophages following a single exposure to bleomycin in vitro. Am. J. Pathol. 141:965-971.
71. Strieter, R. M., and S. L. Kunkel. 1993. The immunopathology of chemotactic cytokines. The Chemokines 19-28.
72. Oppenheim, J. J., C. O. Zachariae, N. Mukaida, and K. Matsusshima. 1991. Properties of the novel proinflammatory supergene "intercrine" cytokine family. Ann. Rev. Immunol. 9:617-648.
73. Fahey, T. J., 3rd, K. J. Tracey, P. Tekamp-Olson, L. S. Cousens, W. G. Jones, G. T. Shires, A. Cerami, and B. Sherry. 1992. Macrophage inflammatory protein 1 modulates macrophage function. J. Immunol. 148:2764-2769.
74. Jiang, Y., D. I. Beller, G. Frendl, and D. T. Graves. 1992. Monocyte chemoattractant protein-1 regulates adhesion molecule expression and cytokine production in human monocytes. J. Immunol. 148:2423-2428.
75. Standiford, T. J., S. L. Kunkel, N. W. Lukacs, M. J. Greenberger, J. M. Danforth, R. G. Kunkel, and R. M. Strieter. 1995. Macrophage inflammatory protein-1α mediates lung leukocyte recruitment, lung capillary leak, and early mortality in murine endotoxemia. J. Immunol. 155:1515-1524.
76. Zhou, Z., Y. Kim, K. Pollok, J. Hurtado, J. Lee, H. E. Broxmeyer, and B. S. Kwon. 1993. Macrophage inflammatory protein-1α rapidly modulates its receptors and inhibits the anti-CD-3 mediated proliferation of T lymphocytes. J. Immunol. 151:4333-4341.
77. Wolpe, S. D., G. Davatelis, B. Sherry, B. Beutler, D. G. Hesse, H. T. Nguyen, L. L. Moldawer, C. F. Nathan, S. F. Lowry, and A. Cerami. 1988. Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties. J. Exp. Med. 167: 570-581.
78. Davatelis, G., P. Tekamp-Olson, S. D. Wolpe, K. Hermsen, C. Luedke, C. Gallegos, D. Coit, J. Merryweather, and A. Cerami. 1988. Cloning and characterization of a cDNA for murine macrophage inflammatory protein (MIP), a novel monokine with inflammatory and chemokinetic properties. J. Exp. Med. 167:1939-1944.
79. Widmer, U., Z. Y. Yang, S. Van Deventer, K. R. Manogue, B. Sherry, and A. Cerami. 1991. Genomic structure of murine macrophage inflammatory protein-1α and conservation of potential regulatory sequences with a human homologue, LD-78. J. Immunol. 146:4031-4040.
80. Widmer, U., K. R. Manogue, A. Cerami, and B. Sherry. 1993. Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1α, and MIP-1β, members of the chemokine superfamily of proinflammatory cytokines. J. Immunol. 150:4996-5012.
81. Alam, R., P. A. Forsythe, S. Stafford, M. A. Lett-Brown, and J. A. Grant. 1992. Macrophage inflammatory protein-1 alpha activates basophils and mast cells. J. Exp. Med. 176:781-786.
82. Taub, D. D., K. Conlon, A. R. Lloyd, J. J. Oppenheim, and D. J. Kelvin. 1993. Preferential migration of activated CD4+ and CD8+ T cells in response to MIP-1 alpha and MIP-1 beta. Science 260:355-358.
83. Schall, T. J., K. Bacon, R. D. Camp, J. W. Kaspari, and D. V. Goeddel. 1993. Human macrophage inflammatory protein alpha (MIP-1 alpha) and MIP-1 beta attract distinct populations of lymphocytes. J. Exp. Med. 177:1821-1826.
84. Rot, A., M. Krieger, T. Brunner, S. C. Bischoff, T. J. Schall, and C. A. Dahinden. 1992. RANTES and macrophage inflammatory protein-1α induce the migration and activation of normal human eosinophil granulocytes. J. Exp. Med. 176:1489-1495.
85. Standiford, T. J., M. W. Rolfe, S. L. Kunkel, J. P. Lynch 3d, M. D. Burdick, A. R. Gilbert, M. B. Orringer, R. I. Whyte, and R. M. Strieter. 1993. Macrophage inflammatory protein-1α expression in interstitial lung disease. J. Immunol. 151:2852-2863.
86. Kasama, T., R. M. Strieter, T. J. Standiford, M. D. Burdick, and S. L. Kunkel. 1993. Expression and regulation of human neutrophil-derived macrophage inflammatory protein-1α. J. Exp. Med. 178:63-72.
87. Lukacs, N. W., S. W. Chensue, R. E. Smith, R. M. Strieter, K. Warmington, C. Wilke, and S. L. Kunkel. 1994. Production of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1α by inflammatory granuloma fibroblasts. Am. J. Pathol. 144:711-718.
88. Fahey, T. J., 3rd, B. Sherry, K. J. Tracey, S. van Deventer, W. G. Jones, 2nd, J. P. Minei, S. Morgello, G. T. Shires, A. Cerami, T. J. Fahey, and W. G. Jones. 1990. Cytokine production in a model of wound healing: the appearance of MIP-1, MIP-2, cachectin/TNF and IL-1. Cytokine 2:92-99.
89. Lukacs, N. W., R. M. Strieter, C. L. Shaklee, S. W. Chensue, and S. L. Kunkel. 1994. Macrophage inflammatory protein-1α influences eosinophil recruitment in antigen-specific airway inflammation. Eur. J. Immunol. 25:245-251.
90. Standiford, T. J., S. L. Kunkel, J. M. Liebler, M. D. Burdick, A. R. Gilbert, and R. M. Strieter. 1993. Gene expression of macrophage inflammatory protein-1 a from human blood monocytes and alveolar macrophages is inhibited by interleukin-4. Am. J. Respir. Cell Mol. Biol. 9:192-198.
91. Lukacs, N. W., S. L. Kunkel, R. Allen, H. L. Evanoff, C. L. Shaklee, J. S. Sherman, M. D. Burdick, and R. M. Strieter. 1995. Stimulus and cell-specific expression of C-X-C and C-C chemokines by pulmonary stromal cell populations. Am. J. Physiol. 268:L856-L861.
92. Costa, J. J., K. Matossian, M. B. Resnick, W. J. Beil, D. T. Wong, J. R. Gordon, A. M. Dvorak, and P. F. Weller. 1993. Human eosinophils can express the cytokines tumor necrosis factor a and macrophage inflammatory protein-1α. J. Clin. Invest. 91:2673-2682.
93. Christman, J. W., T. R. Blackwell, H. B. Cowan, V. L. Shepherd, and J. E. Rinaldo. 1992. Endotoxin induces the expression of macrophage inflammatory protein-1α mRNA by rat alveolar and bone marrow-derived macrophages. Am. J. Respir. Cell Mol. Biol. 7:455-461.
94. Kasama, K., R. M. Strieter, N. W. Lukacs, M. D. Burdick, and S. L. Kunkel. 1994. Regulation of neutrophil-derived chemokine expression by IL-10. J. Immunol. 152:3559-3569.
95. Rollins, B. J., E. D. Morrison, and C. D. Stiles. 1988. Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine like properties. Proc. Natl. Acad. Sci. USA 85: 3738-3742.
96. Strieter, R. M., R. Wiggins, S. H. Phan, B. L. Wharram, H. J. Showell, D. G. Remick, S. W. Chensue, and S. S. Kunkel. 1989. Monocyte chemotactic protein gene expression by cytokine-treated human fibroblasts and endothelial cells. Biochem. Biophys. Res. Commun. 162:694-700.
97. Carr, M. W., S. J. Roth, E. Luther, S. S. Rose, and T. A. Springer. 1994. Monocyte chemoattractant protein-1 acts as a T-lymphocyte chemoattractant. Proc. Natl. Acad. Sci. USA 91:3642-3656.
98. Leonard, E. J., and T. Yoshimura. 1990. Human monocyte chemoattractant protein-1 (MCP-1). Immunol. Today 11:97-101.
99. Kristensen, M. S., B. W. Deleuran, C. G. Larsen, K. Thestrup-Pedersen, and K. Paludan. 1993. Expression of monocyte chemotactic and activating factor (MCAF) in skin related cells. A comparative study. Cytokine 5:520-524.
100. Alam, R., D. Kumar, D. Anderson-Walters, and P. Forsythe. A. 1994. Macrophage inflammatory protein-1α and monocyte chemoattractant peptide-1 elicit immediate and late cutaneous reactions and activate murine mast cells in vivo. J. Immunol. 152:1298-1303.
101. Dipietro, L. A., P. J. Polverini, S. M. Rahbe, and E. J. Kovacs. 1995. Modulation of JE/MCP-1 expression in dermal wound repair. Am. J. Pathol. 146:868-875.
102. Lukacs, N. W., S. L. Kunkel, R. M. Strieter, K. Warmington, and S. W. Chensue. 1993. The role of macrophage inflammatory protein-1α in schistosoma mansoni egg-induced granulomatous inflammation. J. Exp. Med. 177:1551-1559.
103. Chensue, S. W., K. S. Warmington, N. W. Lukacs, P. M. Lincoln, M. D. Burdick, R. M. Strieter, and S. L. Kunkel. 1995. Monocyte chemotactic protein expression during schistosome egg granuloma formation. Am. J. Pathol. 146:130-138.
104. Koch, A. E., S. L., Kunkel, L. A. Harlow, D. D. Mazarakis, G. K. Haines, M. D. Burdick, R. M. Pope, and R. M. Strieter. 1994. Macrophage inflammatory protein-1α: A novel chemotactic cytokine for macrophages in rheumatoid arthritis. J. Clin. Invest. 93:921-928.
105. Kasama, T., R. M. Strieter, N. W. Lukacs, P. M. Lincoln, M. D. Burdick, and S. L. Kunkel. 1995. Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis. J. Clin. Invest. 95:2868-2876.
106. Brieland, J. K., M. L. Jones, C. M. Flory, G. R. Miller, J. S. Warren, S. H. Phan, and J. C. Fantone. 1993. Expression of monocyte chemoattractant protein-1 (MCP-1) by rat alveolar macrophages during chronic lung injury. Am. J. Respir. Cell Mol. Biol. 9:300-305.
107. Calabresi, P., and R. E. Parks, Jr. 1980. Chemotherapy of neoplastic diseases. In Pharmacological Basis of Therapeutics. A. G. Gilman, L. S. Goodman, and A. Gilman, editors. 1256-1258.
108. Coffman, B. 1982, Surface antigen expression and immunoglobin rearrangement during mouse pre-B cell development. Immunological Rev. 69:5-23.
109. Van Riper, G., D. W. Nicholson, M. P. Scheid, .P A. Fischer, M. S. Springer, and H. Rosen. 1994. Induction, characterization, and functional coupling of the high affinity chemokine receptor for RANTES and macrophage inflammatory protein-1α upon differentiation of an eosinophilic HL-60 cell line. J. Immunol. 152:4055-4061.
110. Phan, S. H., R. S. Thrall, and C Williams. 1981. Bleomycin-induced pulmonary fibrosis: effects of steroid on lung collagen metabolism. Am. Rev. Respir. Dis. 124:428-434.
111. Schrier, D. J., and S. H. Phan. 1984. Modulation of bleomycin-induced pulmonary fibrosis in the Balb/c mouse by cyclophosphamide-sensitive T-cells. Am. J. Pathol. 116:270-278.
112. Chensue, S. W., K. Warmington, J. Ruth, P. Lincoln, M. Kuo, and S. L. Kunkel. 1994. Cytokine responses during mycobacterial and schistosomal antigen-induced pulmonary granuloma formation. Am. J. Pathol. 145:1105-1113.
113. Chensue, S. W., K. S. Warmington, A. E. Berger, and D. E. Tracey. 1992. Immunohistochemical demonstration of interleukin-1 receptor antagonist protein and interleukin-1 in human lymphoid tissue and granulomas. Am. J. Pathol. 140:269-275.
114. Driscoll, K. E., D. G. Hassanbein, J. Carter, J. Poynter, T. N. Asquith, R. A. Grant, J. Whitten, M. P. Purdon, and R. Takigiku. 1993. Macrophage inflammatory proteins 1 and 2 expression by rat alveolar macrophages, fibroblasts, and epithelial cells and in rat lung after mineral dust exposure. Am. J. Respir. Cell Mol. Biol. 8:311-318.
115. Crestani, B., P. Cornillet, M. Dehoux, C. Rolland, M. Guenounou, and M. Aubier. 1994. Alveolar type II epithelial cells produce interleukin-6 in vitro and in vivo. Regulation by alveolar macrophage secretory products. J. Clin. Invest. 94:731-740.
116. Cromwell, O., Q. Hamid, C. J. Corrigan, J. Barkans, Q. Meng, P. D. Collins, and A. B. Kay. 1992. Expression and generation of interleukin-8, IL-6, and granulocyte-macrophage colony stimulating factor by bronchial epithelial cells and enhancement by IL-1 beta and tumor necrosis factor alpha. Immunology 77:330-337.
117. Karmiol, S., D. G. Remick, S. L. Kunkel, and S. L. Phan. 1993. Regulation of rat pulmonary endothelial cell interleukin-6 production by bleomycin: effects of cellular fatty acid composition. Am. J. Respir. Cell Mol. Biol. 9:628-636.
118. Schuele, R. K., R. C. Perkins, R. Hamilton, and A. Holian. 1992. Bleomycin stimulation of cytokine secretion by the human alveolar macrophage. Am. J. Physiol. 262:L386-L391.
119. Zhang, K., K. C. Flandeers, and S. H. Phan. 1995. Cellular localization of transforming growth factor-β expression in bleomycin-induced pulmonary fibrosis. Am. J. Pathol. 147:352-361.
120. Jordana, M., C. Richards, L. B. Irving, and J. Gauldie. 1988. Spontaneous in vitro release of alveolar macrophage cytokines after the intratracheal instillation of bleomycin in rats. Characterization and kinetic studies. Am. Rev. Respir. Dis. 137:1135-1140.
121. Cross, C. E., D. Warren, J. E. Gerriets, D. W. Wilson, B. Halliwell, and J. A. Last. 1985. Deferoxamine injection does not affect bleomycin-induced lung fibrosis in rats. J. Lab. Clin. Med. 106:435-438.
122. Smith, R. E., S. H. Phan, R. M. Strieter, M. C. Glass, M. D. Burdick, P. M. Lincoln, H. L. Evanoff, and S. L. Kunkel. 1994. Soluble TNF receptor mediated reduction of MIP-1α expression in bleomycin-induced lung injury. Third Annual International Cytokine Conference, Banff, Alberta, Canada.