Angiogenesis, Kaposi's sarcoma and Kaposi's sarcoma-associated herpesvirus

Virologica Sinica

Volumn 23, Issue 6, 2008, Pages 449-458

  Kang, Tao ^a,b,c   Ye, Feng Chun ^c   Gao, Shou Jiang ^a,c   Wang, Lin Ding ^a,c  

^a WUHAN INSTITUTE OF VIROLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Angiogenesis; Kaposi's sarcoma (KS); Kaposi's sarcoma associated herpesvirus (KSHV)

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN 2; BASIC FIBROBLAST GROWTH FACTOR; CCL1 CHEMOKINE; CHEMOKINE; CYCLOOXYGENASE 2; CYTOKINE; GENE PRODUCT; INTERFERON REGULATORY FACTOR 2; INTERLEUKIN 8; LATENT NUCLEAR ANTIGEN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PROSTAGLANDIN E2; PROTEIN GPCR; PROTEIN ORF K1; PROTEIN ORF K15; TUMOR ANTIGEN; UNCLASSIFIED DRUG; VASCULOTROPIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANGIOGENESIS; ARTICLE; CELL PROLIFERATION; DISEASE ASSOCIATION; DISEASE COURSE; EDEMA; HIGH RISK PATIENT; HUMAN; HUMAN HERPESVIRUS 8; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOCOMPROMISED PATIENT; INFLAMMATION; KAPOSI SARCOMA; NONHUMAN; PATHOGENESIS; PROTEIN FUNCTION; REGULATORY MECHANISM;

HUMAN HERPESVIRUS 8;

EID: 58049207734     PISSN: 16740769     EISSN: 1995820X     Source Type: Journal    
DOI: 10.1007/s12250-008-2998-8     Document Type: Article

References (72)

1. Aoki Y, Jaffe E S, Chang Y, et al. 1999. Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6. Blood, 93:4034-4043.
2. Ballestas M E, Chatis P A, Kaye K M. 1999. Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen. Science, 284:641-644.
3. Barillari G, Gendelman R, Gallo R C, et al. 1993. The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi's sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence. Proc Natl Acad Sci USA, 90:7941-7945.
4. Barillari G, Sgadari C, Palladino C, et al. 1999. Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin. J Immunol, 163:1929-1935.
5. Boshoff C, Endo Y, Collins P D, et al. 1997. Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines. Science, 278:290-294.
6. Brinkmann M M, Glenn M, Rainbow L, et al. 2003. Activation of mitogen-activated protein kinase and NF-kappaB pathways by a Kaposi's sarcoma-associated herpesvirus K15 membrane protein. J Virol, 77:9346-9358.
7. Brinkmann M M, Pietrek M, Dittrich-Breiholz O, et al. 2007. Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus. J Virol, 81:42-58.
8. Cai Q, Lan K, Verma S C, et al. 2006. Kaposi's sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1 alpha to upregulate RTA expression during hypoxia: Latency control under low oxygen conditions. J Virol, 80:7965-7975.
9. Cai Q, Murakami M, Si H, et al. 2007. A potential alpha-helix motif in the amino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1alpha in normoxia. J Virol, 81:10413-10423.
10. Cai Q L, Knight J S, Verma S C, et al. 2006. EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors. PLoS Pathog, 2:e116.
11. Carroll P A, Kenerson H L, Yeung R S, et al. 2006. Latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factors. J Virol, 80:10802-10812.
12. Chang Y, Cesarman E, Pessin M S, et al. 1994. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science, 266: 1865-1869.
13. Chatterjee M, Osborne J, Bestetti G, et al. 2002. Viral IL-6-induced cell proliferation and immune evasion of interferon activity. Science, 298:1432-1435.
14. Chen S, Bacon K B, Li L, et al. 1998. In vivo inhibition of CC and CX3C chemokine-induced leukocyte infiltration and attenuation of glomerulonephritis in Wistar-Kyoto (WKY) rats by vMIP-II. J Exp Med, 188:193-198.
15. Deryugina E I, Quigley J P. 2006. Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev, 25:9-34.
16. Dourmishev L A, Dourmishev A L, Palmeri D, et al. 2003. Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) epidemiology and pathogenesis. Microbiol Mol Biol Rev, 67:175-212.
17. Esteban M, Garcia M A, Domingo-Gil E, et al. 2003. The latency protein LANA2 from Kaposi's sarcoma-associated herpesvirus inhibits apoptosis induced by dsRNA-activated protein kinase but not RNase L activation. J Gen Virol, 84:1463-1470.
18. Ferrara N, Gerber H P, LeCouter J. 2003. The biology of VEGF and its receptors. Nat Med, 9:669-676.
19. Fiorelli V, Barillari G, Toschi E, et al. 1999. IFN-gamma induces endothelial cells to proliferate and to invade the extracellular matrix in response to the HIV-1 Tat protein: Implications for AIDS-Kaposi's sarcoma pathogenesis. J Immunol, 162:1165-1170.
20. Fiorelli V, Gendelman R, Samaniego F, et al. 1995. Cytokines from activated T cells induce normal endothelial cells to acquire the phenotypic and functional features of AIDS-Kaposi's sarcoma spindle cells. J Clin Invest, 95:1723-1734.
21. + T cells infiltrating Kaposi's sarcoma induces spindle cells with angiogenic phenotype and synergy with human immunodeficiency virus-1 Tat protein: An immune response to human herpesvirus-8 infection? Blood, 91:956-967.
22. Foussat A, Wijdenes J, Bouchet L, et al. 1999. Human interleukin-6 is in vivo an autocrine growth factor for human herpesvirus-8-infected malignant B lymphocytes. Eur Cytokine Netw, 10:501-508.
23. Friborg J Jr, Kong W, Hottiger M O, et al. 1999. p53 inhibition by the LANA protein of KSHV protects against cell death. Nature, 402:889-894.
24. Fujimuro M, Wu F Y, ApRhys C, et al. 2003. A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency. Nat Med, 9:300-306.
25. Gold M R. 2002. To make antibodies or not: Signaling by the B-cell antigen receptor. Trends Pharmacol Sci, 23:316-324.
26. Haddad L, El Hajj H, Abou-Merhi R, et al. 2008. KSHV-transformed primary effusion lymphoma cells induce a VEGF-dependent angiogenesis and establish functional gap junctions with endothelial cells. Leukemia, 22:826-834.
27. Hanahan D, Folkman J. 1996. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell, 86:353-364.
28. Huang Y Q, Li J J, Moscatelli D, et al. 1993. Expression of int-2 oncogene in Kaposi's sarcoma lesions. J Clin Invest, 91:1191-1197.
29. Kakoola D N, Sheldon J, Byabazaire N, et al. 2001. Recombination in human herpesvirus-8 strains from Uganda and evolution of the K15 gene. J Gen Virol, 82:2393-2404.
30. Kledal T N, Rosenkilde M M, Coulin F, et al. 1997. A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science, 277:1656-1659.
31. Lagunoff M, Majeti R, Weiss A, et al. 1999. Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus. Proc Natl Acad Sci USA, 96:5704-5709.
32. Lan K, Kuppers D A, Verma S C, et al. 2004. Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen inhibits lytic replication by targeting Rta: A potential mechanism for virus-mediated control of latency. J Virol, 78:6585-6594.
33. Lee B S, Alvarez X, Ishido S, et al. 2000. Inhibition of intracellular transport of B cell antigen receptor complexes by Kaposi's sarcoma-associated herpesvirus K1. J Exp Med, 192:11-21.
34. Lee H, Guo J, Li M, et al. 1998. Identification of an immunoreceptor tyrosine-based activation motif of K1 transforming protein of Kaposi's sarcoma-associated herpesvirus. Mol Cell Biol, 18:5219-5228.
35. Lemieux C, Maliba R, Favier J, et al. 2005. Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses. Blood, 105:1523-1530.
36. Liu C, Okruzhnov Y, Li H, et al. 2001. Human herpesvirus 8 (HHV-8)-encoded cytokines induce expression of and autocrine signaling by vascular endothelial growth factor (VEGF) in HHV-8-infected primary-effusion lymphoma cell lines and mediate VEGF-independent antiapoptotic effects. J Virol, 75:10933-10940.
37. Lubyova B, Pitha P M. 2000. Characterization of a novel human herpesvirus 8-encoded protein, vIRF-3, that shows homology to viral and cellular interferon regulatory factors. J Virol, 74:8194-8201.
38. Masood R, Cesarman E, Smith D L, et al. 2002. Human herpesvirus-8-transformed endothelial cells have functionally activated vascular endothelial growth factor/vascular endothelial growth factor receptor. Am J Pathol, 160:23-29.
39. Masood R, Xia G, Smith D L, et al. 2005. Ephrin B2 expression in Kaposi sarcoma is induced by human herpesvirus type 8: Phenotype switch from venous to arterial endothelium. Blood, 105:1310-1318.
40. McAllister S C, Hansen S G, Ruhl R A, et al. 2004. Kaposi sarcoma-associated herpesvirus (KSHV) induces heme oxygenase-1 expression and activity in KSHV-infected endothelial cells. Blood, 103:3465-3473.
41. Mitsuyasu R T. 1988. AIDS-related Kaposi's sarcoma: A review of its pathogenesis and treatment. Blood Rev, 2:222-231.
42. Moore P S, Boshoff C, Weiss R A, et al. 1996. Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science, 274:1739-1744.
43. Mori Y, Nishimoto N, Ohno M, et al. 2000. Human herpesvirus 8-encoded interleukin-6 homologue (viral IL-6) induces endogenous human IL-6 secretion. J Med Virol, 61:332-335.
44. Munoz-Fontela C, Marcos-Villar L, Gallego P, et al. 2007. Latent protein LANA2 from Kaposi's sarcoma-associated herpesvirus interacts with 14-3-3 proteins and inhibits FOXO3a transcription factor. J Virol, 81: 1511-1516.
45. Mutlu A D, Cavallin L E, Vincent L, et al. 2007. In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: A cell and animal model of virally induced Kaposi's sarcoma. Cancer Cell, 11:245-258.
46. Naranatt P P, Krishnan H H, Svojanovsky S R, et al. 2004. Host gene induction and transcriptional reprogramming in Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8)-infected endothelial, fibroblast, and B cells: Insights into modulation events early during infection. Cancer Res, 64:72-84.
47. Polson A G, Wang D, DeRisi J, et al. 2002. Modulation of host gene expression by the constitutively active G protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus. Cancer Res, 62:4525-4530.
48. Pugh C W, and Ratcliffe P J. 2003. Regulation of angiogenesis by hypoxia: Role of the HIF system. Nat Med, 9:677-684.
49. Qian L W, Xie J, Ye F, et al. 2007. Kaposi's sarcoma-associated herpesvirus infection promotes invasion of primary human umbilical vein endothelial cells by inducing matrix metalloproteinases. J Virol, 81:7001-7010.
50. Radkov S A, Kellam P, Boshoff C. 2000. The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells. Nat Med, 6:1121-1127.
51. Rivas C, Thlick A E, Parravicini C, et al. 2001. Kaposi's sarcoma-associated herpesvirus LANA2 is a B-cell-specific latent viral protein that inhibits p53. J Virol, 75:429-438.
52. Samaniego F, Markham P D, Gendelman R, et al. 1998. Vascular endothelial growth factor and basic fibroblast growth factor present in Kaposi's sarcoma (KS) are induced by inflammatory cytokines and synergize to promote vascular permeability and KS lesion development. Am J Pathol, 152:1433-1443.
53. Samaniego F, Pati S, Karp J E, et al. 2001. Human herpesvirus 8 K1-associated nuclear factor-kappa B-dependent promoter activity: Role in Kaposi's sarcoma inflammation? J Natl Cancer Inst Monogr, 28:15-23.
54. Samaniego F, Young D, Grimes C, et al. 2002. Vascular endothelial growth factor and Kaposi's sarcoma cells in human skin grafts. Cell Growth Differ, 13:387-395.
55. Shan B, Morris C A, Zhuo Y, et al. 2007. Activation of proMMP-2 and Src by HHV8 vGPCR in human pulmonary arterial endothelial cells. J Mol Cell Cardiol, 42:517-525.
56. Shin Y C, Joo C H, Gack M U, et al. 2008. Kaposi's sarcoma-associated herpesvirus viral IFN regulatory factor 3 stabilizes hypoxia-inducible factor-1 alpha to induce vascular endothelial growth factor expression. Cancer Res, 68: 1751-1759.
57. Sirianni M C, Vincenzi L, Fiorelli V, et al. 1998. gamma-Interferon production in peripheral blood mononu-clear cells and tumor infiltrating lymphocytes from Kaposi's sarcoma patients: Correlation with the presence of human herpesvirus-8 in peripheral blood mononuclear cells and lesional macrophages. Blood, 91:968-976.
58. Sivakumar R, Sharma-Walia N, Raghu H, et al. 2008. Kaposi's sarcoma-associated herpesvirus induces sustained levels of vascular endothelial growth factors A and C early during in vitro infection of human microvascular dermal endothelial cells: Biological implications. J Virol, 82:1759-1776.
59. Soulier J, Grollet L, Oksenhendler E, et al. 1995. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood, 86:1276-1280.
60. Stine J T, Wood C, Hill M, et al. 2000. KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells. Blood, 95:1151-1157.
61. Tappero J W, Conant M A, Wolfe S F, et al. 1993. Kaposi's sarcoma. Epidemiology, pathogenesis, histology, clinical spectrum, staging criteria and therapy. J Am Acad Dermatol, 28:371-395.
62. Tomlinson C C, Damania B. 2004. The K1 protein of Kaposi's sarcoma-associated herpesvirus activates the Akt signaling pathway. J Virol, 78:1918-1927.
63. Vart R J, Nikitenko L L, Lagos D, et al. 2007. Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells. Cancer Res, 67: 4042-4051.
64. Wang G L, Jiang B H, Rue E A, et al. 1995. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA, 92:5510-5514.
65. Wang H W, Trotter M W, Lagos D, et al. 2004. Kaposi's sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. Nat Genet, 36:687-693.
66. Wang L, Brinkmann M M, Pietrek M, et al. 2007. Functional characterization of the M-type K15-encoded membrane protein of Kaposi's sarcoma-associated herpesvirus. J Gen Virol, 88:1698-1707.
67. Wang L, Wakisaka N, Tomlinson C C, et al. 2004. The Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) K1 protein induces expression of angiogenic and invasion factors. Cancer Res, 64:2774-2781.
68. Weindel K, Marme D, Weich H A. 1992. AIDS-associated Kaposi's sarcoma cells in culture express vascular endothelial growth factor. Biochem Biophys Res Commun, 183:1167-1174.
69. Xie J, Pan H, Yoo S, et al. 2005. Kaposi's sarcoma-associated herpesvirus induction of AP-1 and interleukin 6 during primary infection mediated by multiple mitogen-activated protein kinase pathways. J Virol, 79: 15027-15037.
70. Yang T Y, Chen S C, Leach M W, et al. 2000. Transgenic expression of the chemokine receptor encoded by human herpesvirus 8 induces an angioproliferative disease resembling Kaposi's sarcoma. J Exp Med, 191:445-454.
71. Ye F C, Blackbourn D J, Mengel M, et al. 2007. Kaposi's sarcoma-associated herpesvirus promotes angiogenesis by inducing angiopoietin-2 expression via AP-1 and Ets1. J Virol, 81:3980-3991.
72. Zietz C, Hotz B, Sturzl M, et al. 1996. Aortic endothelium in HIV-1 infection: Chronic injury, activation, and increased leukocyte adherence. Am J Pathol, 149: 1887-1898.