Human interleukin-6 is in vivo an autocrine growth factor for human herpesvirus-8-infected malignant B lymphocytes

European Cytokine Network

Volumn 10, Issue 4, 1999, Pages 501-508

  Foussat, Arnaud ^a   Wijdenes, John ^b   Bouchet, Laurence ^a   Gaidano, Gianluca ^c   Neipel, Frank ^d   Balabanian, Karl ^a   Galanaud, Pierre ^a   Couderc, Jacques ^a   Emilie, Dominique ^a  

^a INSERM   (France)

^b Diaclone   (France)

^c UNIVERSITY OF TURIN   (Italy)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Aids lymphomas; Human herpesvirus 8; Interleukin 6; SCID mice

Indexed keywords

CYTOKINE; GROWTH FACTOR; INTERLEUKIN 10; INTERLEUKIN 6; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B CELL LYMPHOMA; CANCER SURVIVAL; CELL PROLIFERATION; CONTROLLED STUDY; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; LYMPHOMA; MOUSE; NONHUMAN; SCID MOUSE; TUMOR GROWTH;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; AUTOCRINE COMMUNICATION; B-LYMPHOCYTES; CELL DIVISION; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; HERPESVIRUS 8, HUMAN; HUMANS; INTERLEUKIN-10; INTERLEUKIN-6; LYMPHOMA, B-CELL; MEMBRANE GLYCOPROTEINS; MICE; MICE, SCID; NEOPLASM TRANSPLANTATION; NEUTRALIZATION TESTS; PROTEOGLYCANS; RECEPTORS, INTERLEUKIN-6; SYNDECAN-1; SYNDECANS; TUMOR CELLS, CULTURED;

ANIMALIA; DNA VIRUSES; HERPESVIRIDAE; HERPESVIRUS 8; HUMAN HERPESVIRUS 4; HUMAN HERPESVIRUS 8;

EID: 0032735983     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. 1. Klein B, Zhang X G, Lu Z Y, Bataille R. 1995. Interleukin-6 in human multiple myeloma. (Review) Blood 85: 863.
2. 2. Bataille R, Barlogie B, Lu Z Y, Rossi J F, Lavabre-Bertrand T, Beck T, Wijdenes J, Brochier J, Klein B. 1995. Biologic effects of anti-interleukin-6 murine monoclonal antibody in advanced multiple myeloma. Blood 86: 685.
3. 3. Durandy A, Emilie D, Peuchmaur M, Forveille M, Clement C, Wijdenes J, Fischer A. 1994. Role of IL-6 in promoting growth of human EBV-induced B cell tumors in severe combined immunodeficient mice. J. Immunol. 152: 5361.
4. 4. Tohyama N, Karasuyama H, Tada T. 1990. Growth autonomy and tumorigenicity of interleukin-6 dependent B cells transfected with interleukin-6 cDNA. J. Exp. Med. 171: 389.
5. 5. Scala G, Quinto I, Ruocco M R, Arcucci A, Mallardo M, Caretto P, Forni G, Venuta S. 1990. Expression of an exogeneous IL-6 gene in human EBV B cells confers growth advantage and in vivo tumorigenicity. J. Exp. Med. 172: 61.
6. 6. Emilie D, Coumbaras J, Raphael M, Devergne O, Delecluse H J, Gisselbrecht C, Michiels J F, Van Damme J, Taga T, Kishimoto T, Crevon M C, Galanaud P. Interleukin-6 production in high-grade B lymphomas: correlation with the presence of malignant immonublastes in acquired immunodeficiency syndrome and in human immunodeficiency virus-negative patients. Blood 80: 498.
7. 7. Emilie D, Wijdenes J, Gisselbrecht C, Jarrousse B, Billaud E, Blay J Y, Gabarre J, Gaillard J P, Brochier J, Raphael M, Boué F, Galanaud P. 1994 Administration of an anti-interleukin-6 monoclonal antibody to patients with acquired immunodeficiency syndrome and lymphoma: effect on lymphoma growth and on B clinical symptoms. Blood 84: 2472.
8. 8. Cesarman E, Chang Y, Moore P S, Said J W, Knowles D M. 1995. Kaposi's sarcoma-associated herpes virus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N. Engl. J. Med. 332: 1186.
9. 9. Nador R G, Cesarman E, Chadburn A, Dawson D B, Ansari M Q, Said J, Knowles D M. 1996. Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus. Blood 88: 645.
10. 10. Strauchen J A, Hauser A D, Burstein D, Jimenez R, Moore P S, Chang Y. 1996. Body cavity-based malignant lymphoma containing Kaposi sarcoma-associated herpesvirus in an HIV-negative man with previous Kaposi sarcoma. Ann. Intern. Med. 125: 822.
11. 11. Said J W, Tasaka T, Takeuchi S, Asou H, De Vos S, Cesarman E, Knowles D M, Koeffler H P. 1996. Primary effusion lymphoma in women: report of two cases of Kaposi's sarcoma herpes virus-associated effusion-based lymphoma in human immunodeficiency virus-negative women. Blood 88: 312.
12. 12. Neipel F, Albrecht J C, Ensser A, Huang Y Q, Li J J, Friedman-Kien A E, Fleckenstein B. 1997. Human herpesvirus-8 encodes a homolog of interleukin-6. J. Virol. 71: 839.
13. 13. Nicholas J, Ruvola V R, Burns W H, Sandford G, Wan X, Ciufo D, Hendrickson S B, Guo H G, Hayward G S, Reitz M. Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6. Nat. Med. 3: 287.
14. 14. Neipel F, Albrecht J C, Fleckenstein B. 1997. Cell-homologous genes in the Kaposi's sarcoma-associated rhadinovirus human herpesvirus-8: determinants of its pathogenicity? (Review) J. Virol. 71: 4187.
15. 15. Ganem D. 1997. KSHV and Kaposi's sarcoma: the end of the beginning? (Review) Cell 91: 157.
16. 16. Moore P S, Boshoff C, Weiss R A, Chang Y. Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science 274: 1739.
17. 17. Bais C, Santomasso B, Coso O, Arvanitakis L, Raaka E G, Gutkind J S, Asch A S, Cesarman E, Gerhengorn M C, Mesri E A. 1998. G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature 391: 86.
18. 18. Molden J, Chang Y, You Y, Moore P S, Goldsmith M A. 1997. A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit. J. Biol Chem. 272: 19625.
19. 19. Foussat A, Fior R, Girard T, Boue F, Wijdenes J, Galanaud P, Emilie D. 1999. Involvement of human interleukin-6 in systemic manifestations of human herpesvirus type 8-associated multicentric Castleman's disease. AIDS 13: 150.
20. 20. Cesarman E, Moore P S, Rao P H, Inghirami G, Knowles D M, Chang Y. 1995. In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences. Blood 86: 2708.
21. 21. Arvanitakis L, Mesri E A, Nador R G, Said J W, Asch A S, Knowles D M, Cesarman E. 1996. Establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (BC-3) harboring Kaposi's sarcoma associated-herpesvirus (KSHV/HHV-8) in the absence of Epstein-Barr virus. Blood 88: 2648.
22. 22. Renne R, Zhong W, Herndier B, McGrath M, Abbey N, Kedes D, Ganem D. 1996. Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) in culture. Nat. Med. 2: 342.
23. 23. Gaidano G, Cechova K, Chang Y, Moore P S, Knowles D M, Dalla-Favera R. 1996. Establishment of AIDS-related lymphoma cell lines from lymphomatous effusions. Leukemia 10: 1237.
24. + cell line (BCP-1) from peripheral blood and characterizing its growth in Nod/SCID mice. Blood 91: 1671.
25. 25. Fior R, Vita N, Raphael M, Minty A, Maillot M C, Crevon M C, Caput D, Biberfeld P, Ferrara P, Galanaud P, Emilie D. 1994. Interleukin-13 gene expression by EBV-transformed and malignant B lymphocytes. Eur. Cytokine Netw. 5: 593.
26. 26. Ishii H H, Gobe G C. 1993. Epstein-Barr virus infection is associated with increased apoptosis in untreated and phorbol ester-treated human Burkitt's lymphoma (AW-Ramos) cells. Biochem. Biophys. Res. Commun. 192: 1415.
27. 27. Burger R, Neipel F, Fleckenstein B, Savino R, Ciliberto G, Kalden J R, Gramatzki M. 1998. Human herpesvirus type 8 interleukin-6 homologue is functionally active on human myeloma cells. Blood 91: 1858.
28. 28. Zou W, Lackner A A, Simon M, Durand-Gasselin I, Galanaud P, Desrosiers R, Emilie D. 1997. Early cytokine and chemokine gene expression in lymph nodes of macaques infected with simian immunodeficiency virus is predictive of disease outcome and immunogenicity. J. Virol. 71: 1227.
29. 29. Gaidano G, Gloghini A, Gattei V, Rossi M F, Cilia A M, Godeas C, Degan M, Perin T, Canzionieri V, Aldinucci D, Saglio G, Carbone A, Pinto A. 1997. Association of Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma with expression of the CD138/syndecan-1 antigen. Blood 90: 4894.
30. 30. Picchio G R, Sabbe R E, Gulizia R J, McGrath M, Herndier B G, Mosier D E. 1997. The KSVH/HHV-8-infected BCBL-1 lymphoma line cause tumors in SCID but fails to transmit viras to a human peripheral blood mononuclear cell graft. Virology 238: 22.
31. 31. Asou H, Said J W, Yang R, Munker R, Park D J, Kamada N, Koeffler HR 1998. Mechanisms of growth of Kaposi's sarcome-associated herpes virus-associated primary effusion lymphoma cells. Blood 91: 2475.
32. 32. Drexler H G, Meyer C, Gaidano G, Carbone A. 1999. Constitutive cytokine production by primary effusion (body cavity-based) lymphoma-derived cell lines. Leukemia 13: 634.
33. 33. Leger-Ravet M B, Peuchtmaur M, Devergne O, Audouin J, Raphael M, Van Damme J, Galanaud P, Diebold J, Emilie D. 1991. Interleukin-6 gene expression in Castleman's disease. Blood 78: 2923.
34. 34. Ensoli B, Barillari G, Gallo R C. 1992. Cytokines and growth factors in the pathogenesis of AIDS-associated Kaposi's sarcoma. (Review) Immunol. Rev. 127: 147.
35. 35. Baiocchi R A, Ross M E, Tan J C, Chou C C, Sullivan L, Haldar S, Monne M, Seiden M V, Narula S K, Sklar J, Croce C M, Caligiuri M A. 1995. Lymphomagenesis in the SCID-hu mouse involves abundant production of human interleukin-10. Blood 85: 1063.
36. 36. Burdin N, Péronne C, Banchereau J, Rousset F. 1993. Epstein-Barr virus transformation induces B lymphocytes to produce human interleukin-10. J. Exp. Med. 177: 295.
37. 37. Swaminathan S, Hesselton R, Sullivan J, Kieff E. 1993. Epstein-Barr virus recombinants with specifically mutated BCRFI genes. J. Virol. 67: 7406.