-
1
-
-
0030609861
-
CIP1/WAF1 gene in normal diploid human fibroblasts
-
CIP1/WAF1 gene in normal diploid human fibroblasts. Science 277: 831-834
-
(1997)
Science
, vol.277
, pp. 831-834
-
-
Brown, J.P.1
Wei, W.2
Sedivy, J.M.3
-
2
-
-
0029097759
-
Radiation-induced cell cycle arrest compromised by p21 deficiency
-
Brugarolas J, Chandrasekaran C, Gordon JI, Beach D, Jacks T, Hannon GJ (1995) Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 377: 552-557
-
(1995)
Nature
, vol.377
, pp. 552-557
-
-
Brugarolas, J.1
Chandrasekaran, C.2
Gordon, J.I.3
Beach, D.4
Jacks, T.5
Hannon, G.J.6
-
3
-
-
0032553485
-
Requirement for p53 and p21 to sustain G2 arrest after DNA damage
-
Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP, Sedivy JM, Kinzler KW, Vogelstein B (1998) Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282: 1497-1501
-
(1998)
Science
, vol.282
, pp. 1497-1501
-
-
Bunz, F.1
Dutriaux, A.2
Lengauer, C.3
Waldman, T.4
Zhou, S.5
Brown, J.P.6
Sedivy, J.M.7
Kinzler, K.W.8
Vogelstein, B.9
-
4
-
-
13944270339
-
Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
-
Campisi J (2005) Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors. Cell 120: 513-522
-
(2005)
Cell
, vol.120
, pp. 513-522
-
-
Campisi, J.1
-
5
-
-
0034234211
-
Cooperative effects of genes controlling the G2/M checkpoint
-
Chan TA, Hwang PM, Hermeking H, Kinzler KW, Vogelstein B (2000) Cooperative effects of genes controlling the G2/M checkpoint. Genes Dev 14: 1584-1588
-
(2000)
Genes Dev
, vol.14
, pp. 1584-1588
-
-
Chan, T.A.1
Hwang, P.M.2
Hermeking, H.3
Kinzler, K.W.4
Vogelstein, B.5
-
7
-
-
33845892109
-
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
-
Choudhury AR et al (2007) Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet 39: 99-105
-
(2007)
Nat Genet
, vol.39
, pp. 99-105
-
-
Choudhury, A.R.1
-
9
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
Dimri GP et al (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92: 9363-9367
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
-
10
-
-
0033528830
-
Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53
-
Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53. Oncogene 18: 2789-2797
-
(1999)
Oncogene
, vol.18
, pp. 2789-2797
-
-
Fang, L.1
Igarashi, M.2
Leung, J.3
Sugrue, M.M.4
Lee, S.W.5
Aaronson, S.A.6
-
11
-
-
0027144126
-
The gene responsible for Werner syndrome may be a cell division 'counting' gene
-
Faragher RG, Kill IR, Hunter JA, Pope FM, Tannock C, Shall S (1993) The gene responsible for Werner syndrome may be a cell division 'counting' gene. Proc Natl Acad Sci USA 90: 12030-12034
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 12030-12034
-
-
Faragher, R.G.1
Kill, I.R.2
Hunter, J.A.3
Pope, F.M.4
Tannock, C.5
Shall, S.6
-
12
-
-
0033634973
-
DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway
-
Frank KM, Sharpless NE, Gao Y, Sekiguchi JM, Ferguson DO, Zhu C, Manis JP, Horner J, DePinho RA, Alt FW (2000) DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol Cell 5: 993-1002
-
(2000)
Mol Cell
, vol.5
, pp. 993-1002
-
-
Frank, K.M.1
Sharpless, N.E.2
Gao, Y.3
Sekiguchi, J.M.4
Ferguson, D.O.5
Zhu, C.6
Manis, J.P.7
Horner, J.8
DePinho, R.A.9
Alt, F.W.10
-
13
-
-
33751116534
-
Ku80 and p53 suppress medulloblastoma that arise independent of Rag-1-induced DSBs
-
Holcomb VB, Vogel H, Marple T, Kornegay RW, Hasty P (2006) Ku80 and p53 suppress medulloblastoma that arise independent of Rag-1-induced DSBs. Oncogene 25: 7159-7165
-
(2006)
Oncogene
, vol.25
, pp. 7159-7165
-
-
Holcomb, V.B.1
Vogel, H.2
Marple, T.3
Kornegay, R.W.4
Hasty, P.5
-
14
-
-
37349074760
-
Deletion of Ku80 causes early aging independent of chronic inflammation and Rag-1-induced DSBs
-
Holcomb VB, Vogel H, Hasty P (2007) Deletion of Ku80 causes early aging independent of chronic inflammation and Rag-1-induced DSBs. Mech Ageing Dev 128: 601-608
-
(2007)
Mech Ageing Dev
, vol.128
, pp. 601-608
-
-
Holcomb, V.B.1
Vogel, H.2
Hasty, P.3
-
15
-
-
0037112505
-
DNA ligase IV suppresses medulloblastoma formation
-
Lee Y, McKinnon PJ (2002) DNA ligase IV suppresses medulloblastoma formation. Cancer Res 62: 6395-6399
-
(2002)
Cancer Res
, vol.62
, pp. 6395-6399
-
-
Lee, Y.1
McKinnon, P.J.2
-
16
-
-
36849088515
-
Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer
-
Li H, Vogel H, Holcomb VB, Gu Y, Hasty P (2007) Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer. Mol Cell Biol 27: 8205-8214
-
(2007)
Mol Cell Biol
, vol.27
, pp. 8205-8214
-
-
Li, H.1
Vogel, H.2
Holcomb, V.B.3
Gu, Y.4
Hasty, P.5
-
17
-
-
3242879122
-
The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination
-
Lieber MR, Ma Y, Pannicke U, Schwarz K (2004) The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination. DNA Repair 3: 817-826
-
(2004)
DNA Repair
, vol.3
, pp. 817-826
-
-
Lieber, M.R.1
Ma, Y.2
Pannicke, U.3
Schwarz, K.4
-
18
-
-
0034106125
-
Analysis of ku80-mutant mice and cells with deficient levels of p53
-
Lim DS, Vogel H, Willerford DM, Sands AT, Platt KA, Hasty P (2000) Analysis of ku80-mutant mice and cells with deficient levels of p53. Mol Cell Biol 20: 3772-3780
-
(2000)
Mol Cell Biol
, vol.20
, pp. 3772-3780
-
-
Lim, D.S.1
Vogel, H.2
Willerford, D.M.3
Sands, A.T.4
Platt, K.A.5
Hasty, P.6
-
20
-
-
0032510327
-
Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts
-
McConnell BB, Starborg M, Brookes S, Peters G (1998) Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts. Curr Biol 8: 351-354
-
(1998)
Curr Biol
, vol.8
, pp. 351-354
-
-
McConnell, B.B.1
Starborg, M.2
Brookes, S.3
Peters, G.4
-
21
-
-
0029778191
-
Requirement for Ku80 in growth and immunoglobulin V(D)J recombination
-
Nussenzweig A, Chen C, da Costa Soares V, Sanchez M, Sokol K, Nussenzweig MC, Li GC (1996) Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature 382: 551-555
-
(1996)
Nature
, vol.382
, pp. 551-555
-
-
Nussenzweig, A.1
Chen, C.2
da Costa Soares, V.3
Sanchez, M.4
Sokol, K.5
Nussenzweig, M.C.6
Li, G.C.7
-
22
-
-
0033517357
-
Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras
-
Pantoja C, Serrano M (1999) Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras. Oncogene 18: 4974-4982
-
(1999)
Oncogene
, vol.18
, pp. 4974-4982
-
-
Pantoja, C.1
Serrano, M.2
-
23
-
-
0042195820
-
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
-
Parrinello S, Samper E, Krtolica A, Goldstein J, Melov S, Campisi J (2003) Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol 5: 741-747
-
(2003)
Nat Cell Biol
, vol.5
, pp. 741-747
-
-
Parrinello, S.1
Samper, E.2
Krtolica, A.3
Goldstein, J.4
Melov, S.5
Campisi, J.6
-
24
-
-
34250007142
-
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
-
Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL (2007) Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 447: 725-729
-
(2007)
Nature
, vol.447
, pp. 725-729
-
-
Rossi, D.J.1
Bryder, D.2
Seita, J.3
Nussenzweig, A.4
Hoeijmakers, J.5
Weissman, I.L.6
-
25
-
-
0030021748
-
Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant
-
Rowan S, Ludwig RL, Haupt Y, Bates S, Lu X, Oren M, Vousden KH (1996) Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant. EMBO J 15: 827-838
-
(1996)
EMBO J
, vol.15
, pp. 827-838
-
-
Rowan, S.1
Ludwig, R.L.2
Haupt, Y.3
Bates, S.4
Lu, X.5
Oren, M.6
Vousden, K.H.7
-
26
-
-
33646745137
-
Lamin A-dependent nuclear defects in human aging
-
Scaffidi P, Misteli T (2006) Lamin A-dependent nuclear defects in human aging. Science 312: 1059-1063
-
(2006)
Science
, vol.312
, pp. 1059-1063
-
-
Scaffidi, P.1
Misteli, T.2
-
27
-
-
0032191393
-
Tumor surveillance via the ARF-p53 pathway
-
Sherr CJ (1998) Tumor surveillance via the ARF-p53 pathway. Genes Dev 12: 2984-2991
-
(1998)
Genes Dev
, vol.12
, pp. 2984-2991
-
-
Sherr, C.J.1
-
28
-
-
34250315824
-
DNA damage-induced cellular senescence is sufficient to suppress tumorigenesis: A mouse model
-
Van Nguyen T, Puebla-Osorio N, Pang H, Dujka ME, Zhu C (2007) DNA damage-induced cellular senescence is sufficient to suppress tumorigenesis: A mouse model. J Exp Med 204: 1453-1461
-
(2007)
J Exp Med
, vol.204
, pp. 1453-1461
-
-
Van Nguyen, T.1
Puebla-Osorio, N.2
Pang, H.3
Dujka, M.E.4
Zhu, C.5
-
30
-
-
0032827888
-
Deletion of Ku86 causes early onset of senescence in mice
-
Vogel H, Lim DS, Karsenty G, Finegold M, Hasty P (1999) Deletion of Ku86 causes early onset of senescence in mice. Proc Natl Acad Sci USA 96: 10770-10775
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 10770-10775
-
-
Vogel, H.1
Lim, D.S.2
Karsenty, G.3
Finegold, M.4
Hasty, P.5
-
31
-
-
0031474756
-
Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice
-
Wang YA, Elson A, Leder P (1997) Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice. Proc Natl Acad Sci USA 94: 14590-14595
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 14590-14595
-
-
Wang, Y.A.1
Elson, A.2
Leder, P.3
|