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Volumn 5, Issue 4, 2007, Pages 234-248

Estrogen receptors critically regulate bones' adaptive responses to loading

Author keywords

Bone loading; Estrogen; Estrogen receptor; Exercise; Osteoporosis

Indexed keywords

ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA;

EID: 57849147253     PISSN: 15348644     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12018-008-9011-9     Document Type: Review
Times cited : (11)

References (198)
  • 1
    • 0023173665 scopus 로고
    • The mechanostat: A proposed pathogenic mechanism of osteoporoses and the bone mass effects of mechanical and nonmechanical agents
    • HM Frost 1987 The mechanostat: a proposed pathogenic mechanism of osteoporoses and the bone mass effects of mechanical and nonmechanical agents Bone Miner. 2 73 85
    • (1987) Bone Miner. , vol.2 , pp. 73-85
    • Frost, H.M.1
  • 2
    • 0023492075 scopus 로고
    • Bone "mass" and the "mechanostat": A proposal
    • HM Frost 1987 Bone "mass" and the "mechanostat": a proposal Anat Rec. 219 1 9
    • (1987) Anat Rec. , vol.219 , pp. 1-9
    • Frost, H.M.1
  • 3
    • 0036756329 scopus 로고    scopus 로고
    • Validation of a technique for studying functional adaptation of the mouse ulna in response to mechanical loading
    • KC Lee A Maxwell LE. Lanyon 2002 Validation of a technique for studying functional adaptation of the mouse ulna in response to mechanical loading Bone. 31 407 12
    • (2002) Bone. , vol.31 , pp. 407-12
    • Lee, K.C.1    Maxwell, A.2    Lanyon, L.E.3
  • 4
    • 0032190413 scopus 로고    scopus 로고
    • Strain rate as a controlling influence on adaptive modeling in response to dynamic loading of the ulna in growing male rats
    • JR Mosley LE. Lanyon 1998 Strain rate as a controlling influence on adaptive modeling in response to dynamic loading of the ulna in growing male rats Bone. 23 313 8
    • (1998) Bone. , vol.23 , pp. 313-8
    • Mosley, J.R.1    Lanyon, L.E.2
  • 5
    • 0030985643 scopus 로고    scopus 로고
    • Strain magnitude related changes in whole bone architecture in growing rats
    • JR Mosley BM March J Lynch LE. Lanyon 1997 Strain magnitude related changes in whole bone architecture in growing rats Bone. 20 191 8
    • (1997) Bone. , vol.20 , pp. 191-8
    • Mosley, J.R.1    March, B.M.2    Lynch, J.3    Lanyon, L.E.4
  • 6
    • 0036192588 scopus 로고    scopus 로고
    • Mechanical strain, induced noninvasively in the high-frequency domain, is anabolic to cancellous bone, but not cortical bone
    • C Rubin AS Turner C Mallinckrodt C Jerome K McLeod S Bain 2002 Mechanical strain, induced noninvasively in the high-frequency domain, is anabolic to cancellous bone, but not cortical bone Bone. 30 445 52
    • (2002) Bone. , vol.30 , pp. 445-52
    • Rubin, C.1    Turner, A.S.2    Mallinckrodt, C.3    Jerome, C.4    McLeod, K.5    Bain, S.6
  • 7
    • 0036708150 scopus 로고    scopus 로고
    • Low-magnitude mechanical loading becomes osteogenic when rest is inserted between each load cycle
    • S Srinivasan DA Weimer SC Agans SD Bain TS Gross 2002 Low-magnitude mechanical loading becomes osteogenic when rest is inserted between each load cycle J Bone Miner Res. 17 1613 20
    • (2002) J Bone Miner Res. , vol.17 , pp. 1613-20
    • Srinivasan, S.1    Weimer, D.A.2    Agans, S.C.3    Bain, S.D.4    Gross, T.S.5
  • 8
    • 0028267333 scopus 로고
    • Noninvasive loading of the rat ulna in vivo induces a strain-related modeling response uncomplicated by trauma or periostal pressure
    • AG Torrance JR Mosley RF Suswillo LE Lanyon 1994 Noninvasive loading of the rat ulna in vivo induces a strain-related modeling response uncomplicated by trauma or periostal pressure Calcif Tissue Int. 54 241 7
    • (1994) Calcif Tissue Int. , vol.54 , pp. 241-7
    • Torrance, A.G.1    Mosley, J.R.2    Suswillo, R.F.3    Lanyon, L.E.4
  • 9
    • 0033915646 scopus 로고    scopus 로고
    • Partitioning a daily mechanical stimulus into discrete loading bouts improves the osteogenic response to loading
    • AG Robling DB Burr CH Turner 2000 Partitioning a daily mechanical stimulus into discrete loading bouts improves the osteogenic response to loading J Bone Miner Res. 15 1596 602
    • (2000) J Bone Miner Res. , vol.15 , pp. 1596-602
    • Robling, A.G.1    Burr, D.B.2    Turner, C.H.3
  • 10
    • 0035745927 scopus 로고    scopus 로고
    • Recovery periods restore mechanosensitivity to dynamically loaded bone
    • AG Robling DB Burr CH Turner 2001 Recovery periods restore mechanosensitivity to dynamically loaded bone J Exp Biol. 204 3389 99
    • (2001) J Exp Biol. , vol.204 , pp. 3389-99
    • Robling, A.G.1    Burr, D.B.2    Turner, C.H.3
  • 11
    • 0035992661 scopus 로고    scopus 로고
    • Improved bone structure and strength after long-term mechanical loading is greatest if loading is separated into short bouts
    • AG Robling FM Hinant DB Burr CH Turner 2002 Improved bone structure and strength after long-term mechanical loading is greatest if loading is separated into short bouts J Bone Miner Res. 17 1545 54
    • (2002) J Bone Miner Res. , vol.17 , pp. 1545-54
    • Robling, A.G.1    Hinant, F.M.2    Burr, D.B.3    Turner, C.H.4
  • 13
    • 33748071110 scopus 로고    scopus 로고
    • Association between bone mass and fractures in children: A prospective cohort study
    • EM Clark AR Ness NJ Bishop JH Tobias 2006 Association between bone mass and fractures in children: a prospective cohort study J Bone Miner Res. 21 1489 95
    • (2006) J Bone Miner Res. , vol.21 , pp. 1489-95
    • Clark, E.M.1    Ness, A.R.2    Bishop, N.J.3    Tobias, J.H.4
  • 14
    • 0037684754 scopus 로고    scopus 로고
    • The association between bone mineral density, metacarpal morphometry, and upper limb fractures in children: A population-based case-control study
    • D Ma G Jones 2003 The association between bone mineral density, metacarpal morphometry, and upper limb fractures in children: a population-based case-control study J Clin Endocrinol Metab. 88 1486 91
    • (2003) J Clin Endocrinol Metab. , vol.88 , pp. 1486-91
    • Ma, D.1    Jones, G.2
  • 15
    • 0028577210 scopus 로고
    • The two faces of growth: Benefits and risks to bone integrity
    • AM Parfitt 1994 The two faces of growth: benefits and risks to bone integrity Osteoporos Int. 4 382 98
    • (1994) Osteoporos Int. , vol.4 , pp. 382-98
    • Parfitt, A.M.1
  • 16
    • 0030929284 scopus 로고    scopus 로고
    • Epidemiology of children's fractures
    • LA Landin 1997 Epidemiology of children's fractures J Pediatr Orthop B 6 79 83
    • (1997) J Pediatr Orthop B , vol.6 , pp. 79-83
    • Landin, L.A.1
  • 17
    • 0029243810 scopus 로고
    • How many women have osteoporosis now?
    • LJ Melton 3rd 1995 How many women have osteoporosis now? J Bone Miner Res. 10 175 7
    • (1995) J Bone Miner Res. , vol.10 , pp. 175-7
    • Melton III, L.J.1
  • 18
    • 0030685090 scopus 로고    scopus 로고
    • Endogenous sex steroids and bone mineral density in older women and men: The Rancho Bernardo Study
    • GA Greendale S Edelstein E Barrett-Connor 1997 Endogenous sex steroids and bone mineral density in older women and men: the Rancho Bernardo Study J Bone Miner Res. 12 1833 43
    • (1997) J Bone Miner Res. , vol.12 , pp. 1833-43
    • Greendale, G.A.1    Edelstein, S.2    Barrett-Connor, E.3
  • 19
    • 0031756218 scopus 로고    scopus 로고
    • Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: A key role for bioavailable estrogen
    • S Khosla LJ Melton 3rd EJ Atkinson WM O'Fallon GG Klee BL Riggs 1998 Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen J Clin Endocrinol Metab. 83 2266 74
    • (1998) J Clin Endocrinol Metab. , vol.83 , pp. 2266-74
    • Khosla, S.1    Melton III, L.J.2    Atkinson, E.J.3    O'Fallon, W.M.4    Klee, G.G.5    Riggs, B.L.6
  • 20
    • 0030931083 scopus 로고    scopus 로고
    • Sex steroids and bone mass in older men. Positive associations with serum estrogens and negative associations with androgens
    • CW Slemenda C Longcope L Zhou SL Hui M Peacock CC Johnston 1997 Sex steroids and bone mass in older men. Positive associations with serum estrogens and negative associations with androgens J Clin Invest. 100 1755 9
    • (1997) J Clin Invest. , vol.100 , pp. 1755-9
    • Slemenda, C.W.1    Longcope, C.2    Zhou, L.3    Hui, S.L.4    Peacock, M.5    Johnston, C.C.6
  • 21
    • 84967614664 scopus 로고    scopus 로고
    • Sex steroids and the construction and conservation of the adult skeleton
    • BL Riggs S Khosla LJ Melton 3rd 2002 Sex steroids and the construction and conservation of the adult skeleton Endocr Rev. 23 279 302
    • (2002) Endocr Rev. , vol.23 , pp. 279-302
    • Riggs, B.L.1    Khosla, S.2    Melton III, L.J.3
  • 25
    • 0026671788 scopus 로고
    • Mechanism of action of estrogen on intramembranous bone formation: Regulation of osteoblast differentiation and activity
    • RT Turner P Backup PJ Sherman E Hill GL Evans TC Spelsberg 1992 Mechanism of action of estrogen on intramembranous bone formation: regulation of osteoblast differentiation and activity Endocrinology. 131 883 9
    • (1992) Endocrinology. , vol.131 , pp. 883-9
    • Turner, R.T.1    Backup, P.2    Sherman, P.J.3    Hill, E.4    Evans, G.L.5    Spelsberg, T.C.6
  • 28
    • 0023690523 scopus 로고
    • Estrogen treatment prevents osteopenia and depresses bone turnover in ovariectomized rats
    • TJ Wronski M Cintron AL Doherty LM Dann 1988 Estrogen treatment prevents osteopenia and depresses bone turnover in ovariectomized rats Endocrinology. 123 681 6
    • (1988) Endocrinology. , vol.123 , pp. 681-6
    • Wronski, T.J.1    Cintron, M.2    Doherty, A.L.3    Dann, L.M.4
  • 30
    • 0029783770 scopus 로고    scopus 로고
    • Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis
    • R Pacifici 1996 Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis J Bone Miner Res. 11 1043 51
    • (1996) J Bone Miner Res. , vol.11 , pp. 1043-51
    • Pacifici, R.1
  • 31
    • 0035831020 scopus 로고    scopus 로고
    • Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: Dissociation from transcriptional activity
    • S Kousteni T Bellido LI Plotkin CA O'Brien DL Bodenner L Han 2001 Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity Cell. 104 719 30
    • (2001) Cell. , vol.104 , pp. 719-30
    • Kousteni, S.1    Bellido, T.2    Plotkin, L.I.3    O'Brien, C.A.4    Bodenner, D.L.5    Han, L.6
  • 32
    • 0026641955 scopus 로고
    • Cytokines, hematopoiesis, osteoclastogenesis, and estrogens
    • SC Manolagas RL Jilka 1992 Cytokines, hematopoiesis, osteoclastogenesis, and estrogens Calcif Tissue Int. 50 199 202
    • (1992) Calcif Tissue Int. , vol.50 , pp. 199-202
    • Manolagas, S.C.1    Jilka, R.L.2
  • 33
    • 0030884639 scopus 로고    scopus 로고
    • The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone
    • A Tomkinson J Reeve RW Shaw BS Noble 1997 The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone J Clin Endocrinol Metab. 82 3128 35
    • (1997) J Clin Endocrinol Metab. , vol.82 , pp. 3128-35
    • Tomkinson, A.1    Reeve, J.2    Shaw, R.W.3    Noble, B.S.4
  • 34
    • 0036894709 scopus 로고    scopus 로고
    • The effect of mechanical loading on the size and shape of bone in pre-, peri-, and postpubertal girls: A study in tennis players
    • SL Bass L Saxon RM Daly CH Turner AG Robling E Seeman 2002 The effect of mechanical loading on the size and shape of bone in pre-, peri-, and postpubertal girls: a study in tennis players J Bone Miner Res. 17 2274 80
    • (2002) J Bone Miner Res. , vol.17 , pp. 2274-80
    • Bass, S.L.1    Saxon, L.2    Daly, R.M.3    Turner, C.H.4    Robling, A.G.5    Seeman, E.6
  • 35
    • 0033847014 scopus 로고    scopus 로고
    • Exercise-induced bone gain is due to enlargement in bone size without a change in volumetric bone density: A peripheral quantitative computed tomography study of the upper arms of male tennis players
    • H Haapasalo S Kontulainen H Sievanen P Kannus M Jarvinen I Vuori 2000 Exercise-induced bone gain is due to enlargement in bone size without a change in volumetric bone density: a peripheral quantitative computed tomography study of the upper arms of male tennis players Bone. 27 351 7
    • (2000) Bone. , vol.27 , pp. 351-7
    • Haapasalo, H.1    Kontulainen, S.2    Sievanen, H.3    Kannus, P.4    Jarvinen, M.5    Vuori, I.6
  • 37
    • 0021783755 scopus 로고
    • The effect of athletic activity on the bone mass in human diaphyseal bone
    • N Dalen P Laftman H Ohlsen L Stromberg 1985 The effect of athletic activity on the bone mass in human diaphyseal bone Orthopedics. 8 1139 41
    • (1985) Orthopedics. , vol.8 , pp. 1139-41
    • Dalen, N.1    Laftman, P.2    Ohlsen, H.3    Stromberg, L.4
  • 40
    • 0030000903 scopus 로고    scopus 로고
    • Dimensions and estimated mechanical characteristics of the humerus after long-term tennis loading
    • H Haapasalo H Sievanen P Kannus A Heinonen P Oja I Vuori 1996 Dimensions and estimated mechanical characteristics of the humerus after long-term tennis loading J Bone Miner Res. 11 864 72
    • (1996) J Bone Miner Res. , vol.11 , pp. 864-72
    • Haapasalo, H.1    Sievanen, H.2    Kannus, P.3    Heinonen, A.4    Oja, P.5    Vuori, I.6
  • 41
    • 0036139736 scopus 로고    scopus 로고
    • Growth rate rather than gender determines the size of the adaptive response of the growing skeleton to mechanical strain
    • JR Mosley LE Lanyon 2002 Growth rate rather than gender determines the size of the adaptive response of the growing skeleton to mechanical strain Bone. 30 314 9
    • (2002) Bone. , vol.30 , pp. 314-9
    • Mosley, J.R.1    Lanyon, L.E.2
  • 42
    • 32544438281 scopus 로고    scopus 로고
    • Clinical Review: Sex steroids and the periosteum-reconsidering the roles of androgens and estrogens in periosteal expansion
    • D Vanderschueren K Venken J Ophoff R Bouillon S Boonen 2006 Clinical Review: sex steroids and the periosteum-reconsidering the roles of androgens and estrogens in periosteal expansion J Clin Endocrinol Metab. 91 378 82
    • (2006) J Clin Endocrinol Metab. , vol.91 , pp. 378-82
    • Vanderschueren, D.1    Venken, K.2    Ophoff, J.3    Bouillon, R.4    Boonen, S.5
  • 44
    • 0035158257 scopus 로고    scopus 로고
    • Jumping improves hip and lumbar spine bone mass in prepubescent children: A randomized controlled trial
    • RK Fuchs JJ Bauer CM Snow 2001 Jumping improves hip and lumbar spine bone mass in prepubescent children: a randomized controlled trial J Bone Miner Res. 16 148 56
    • (2001) J Bone Miner Res. , vol.16 , pp. 148-56
    • Fuchs, R.K.1    Bauer, J.J.2    Snow, C.M.3
  • 46
    • 0037214256 scopus 로고    scopus 로고
    • Regional specificity of exercise and calcium during skeletal growth in girls: A randomized controlled trial
    • S Iuliano-Burns L Saxon G Naughton K Gibbons SL Bass 2003 Regional specificity of exercise and calcium during skeletal growth in girls: a randomized controlled trial J Bone Miner Res. 18 156 62
    • (2003) J Bone Miner Res. , vol.18 , pp. 156-62
    • Iuliano-Burns, S.1    Saxon, L.2    Naughton, G.3    Gibbons, K.4    Bass, S.L.5
  • 47
    • 34247261570 scopus 로고    scopus 로고
    • Is a school-based physical activity intervention effective for increasing tibial bone strength in boys and girls?
    • HM Macdonald SA Kontulainen KM Khan HA McKay 2007 Is a school-based physical activity intervention effective for increasing tibial bone strength in boys and girls? J Bone Miner Res. 22 434 46
    • (2007) J Bone Miner Res. , vol.22 , pp. 434-46
    • MacDonald, H.M.1    Kontulainen, S.A.2    Khan, K.M.3    McKay, H.A.4
  • 48
    • 0642364463 scopus 로고    scopus 로고
    • A school-based exercise intervention elicits substantial bone health benefits: A 2-year randomized controlled trial in girls
    • KJ MacKelvie KM Khan MA Petit PA Janssen HA McKay 2003 A school-based exercise intervention elicits substantial bone health benefits: a 2-year randomized controlled trial in girls Pediatrics. 112 e447
    • (2003) Pediatrics. , vol.112 , pp. 447
    • MacKelvie, K.J.1    Khan, K.M.2    Petit, M.A.3    Janssen, P.A.4    McKay, H.A.5
  • 49
    • 23144461652 scopus 로고    scopus 로고
    • "bounce at the Bell": A novel program of short bouts of exercise improves proximal femur bone mass in early pubertal children
    • HA McKay L MacLean M Petit K MacKelvie-O'Brien P Janssen T Beck 2005 "Bounce at the Bell": a novel program of short bouts of exercise improves proximal femur bone mass in early pubertal children Br J Sports Med. 39 521 6
    • (2005) Br J Sports Med. , vol.39 , pp. 521-6
    • McKay, H.A.1    MacLean, L.2    Petit, M.3    MacKelvie-O'Brien, K.4    Janssen, P.5    Beck, T.6
  • 50
    • 0034040835 scopus 로고    scopus 로고
    • Effects of plyometric jump training on bone mass in adolescent girls
    • KA Witzke CM Snow 2000 Effects of plyometric jump training on bone mass in adolescent girls Med Sci Sports Exerc. 32 1051 7
    • (2000) Med Sci Sports Exerc. , vol.32 , pp. 1051-7
    • Witzke, K.A.1    Snow, C.M.2
  • 51
    • 0031758939 scopus 로고    scopus 로고
    • Pre- and postmenopausal women have different bone mineral density responses to the same high-impact exercise
    • EJ Bassey MC Rothwell JJ Littlewood DW Pye 1998 Pre- and postmenopausal women have different bone mineral density responses to the same high-impact exercise J Bone Miner Res. 13 1805 13
    • (1998) J Bone Miner Res. , vol.13 , pp. 1805-13
    • Bassey, E.J.1    Rothwell, M.C.2    Littlewood, J.J.3    Pye, D.W.4
  • 52
    • 0036050686 scopus 로고    scopus 로고
    • Effects of skeletal loading on bone mass and compensation mechanism in bone: A new insight into the "mechanostat" theory
    • T Sugiyama A Yamaguchi S Kawai 2002 Effects of skeletal loading on bone mass and compensation mechanism in bone: a new insight into the "mechanostat" theory J Bone Miner Metab. 20 196 200
    • (2002) J Bone Miner Metab. , vol.20 , pp. 196-200
    • Sugiyama, T.1    Yamaguchi, A.2    Kawai, S.3
  • 53
    • 0033941492 scopus 로고    scopus 로고
    • Systematic review of randomized trials of the effect of exercise on bone mass in pre- and postmenopausal women
    • BA Wallace RG Cumming 2000 Systematic review of randomized trials of the effect of exercise on bone mass in pre- and postmenopausal women Calcif Tissue Int. 67 10 8
    • (2000) Calcif Tissue Int. , vol.67 , pp. 10-8
    • Wallace, B.A.1    Cumming, R.G.2
  • 54
    • 12444346410 scopus 로고    scopus 로고
    • Effect of alendronate and exercise on bone and physical performance of postmenopausal women: A randomized controlled trial
    • K Uusi-Rasi P Kannus S Cheng H Sievanen M Pasanen A Heinonen 2003 Effect of alendronate and exercise on bone and physical performance of postmenopausal women: a randomized controlled trial Bone. 33 132 43
    • (2003) Bone. , vol.33 , pp. 132-43
    • Uusi-Rasi, K.1    Kannus, P.2    Cheng, S.3    Sievanen, H.4    Pasanen, M.5    Heinonen, A.6
  • 55
    • 34547623094 scopus 로고    scopus 로고
    • Low-dose estrogen treatment suppresses periosteal bone formation in response to mechanical loading
    • LK Saxon CH Turner 2006 Low-dose estrogen treatment suppresses periosteal bone formation in response to mechanical loading Bone. 39 1261 7
    • (2006) Bone. , vol.39 , pp. 1261-7
    • Saxon, L.K.1    Turner, C.H.2
  • 56
    • 0042209644 scopus 로고    scopus 로고
    • Estrogen and "exercise" have a synergistic effect in preventing bone loss in the lumbar vertebra and femoral neck of the ovariectomized rat
    • CY Li WS Jee JL Chen A Mo RB Setterberg M Su 2003 Estrogen and "exercise" have a synergistic effect in preventing bone loss in the lumbar vertebra and femoral neck of the ovariectomized rat Calcif Tissue Int. 72 42 9
    • (2003) Calcif Tissue Int. , vol.72 , pp. 42-9
    • Li, C.Y.1    Jee, W.S.2    Chen, J.L.3    Mo, A.4    Setterberg, R.B.5    Su, M.6
  • 57
    • 0034902150 scopus 로고    scopus 로고
    • Bipedal stance exercise enhances antiresorption effects of estrogen and counteracts its inhibitory effect on bone formation in sham and ovariectomized rats
    • JL Chen W Yao HM Frost CY Li RB Setterberg WS Jee 2001 Bipedal stance exercise enhances antiresorption effects of estrogen and counteracts its inhibitory effect on bone formation in sham and ovariectomized rats Bone. 29 126 33
    • (2001) Bone. , vol.29 , pp. 126-33
    • Chen, J.L.1    Yao, W.2    Frost, H.M.3    Li, C.Y.4    Setterberg, R.B.5    Jee, W.S.6
  • 58
    • 0242496297 scopus 로고    scopus 로고
    • Estrogen and bone-a reproductive and locomotive perspective
    • TL Jarvinen P Kannus H Sievanen 2003 Estrogen and bone-a reproductive and locomotive perspective J Bone Miner Res. 18 1921 31
    • (2003) J Bone Miner Res. , vol.18 , pp. 1921-31
    • Jarvinen, T.L.1    Kannus, P.2    Sievanen, H.3
  • 60
    • 0042423526 scopus 로고    scopus 로고
    • High-impact exercise strengthens bone in osteopenic ovariectomized rats with the same outcome as Sham rats
    • A Honda N Sogo S Nagasawa T Shimizu Y Umemura 2003 High-impact exercise strengthens bone in osteopenic ovariectomized rats with the same outcome as Sham rats J Appl Physiol. 95 1032 7
    • (2003) J Appl Physiol. , vol.95 , pp. 1032-7
    • Honda, A.1    Sogo, N.2    Nagasawa, S.3    Shimizu, T.4    Umemura, Y.5
  • 61
    • 33845904886 scopus 로고    scopus 로고
    • Additional weight bearing during exercise and estrogen in the rat: The effect on bone mass, turnover, and structure
    • AM Tromp N Bravenboer E Tanck A Oostlander PJ Holzmann PJ Kostense 2006 Additional weight bearing during exercise and estrogen in the rat: the effect on bone mass, turnover, and structure Calcif Tissue Int. 79 404 15
    • (2006) Calcif Tissue Int. , vol.79 , pp. 404-15
    • Tromp, A.M.1    Bravenboer, N.2    Tanck, E.3    Oostlander, A.4    Holzmann, P.J.5    Kostense, P.J.6
  • 62
    • 41949132327 scopus 로고    scopus 로고
    • Effects of jump training on bone are preserved after detraining regardless of estrogen secretion state in rats
    • Umemura Y, Nagasawa S, Sogo N, Honda A. Effects of jump training on bone are preserved after detraining regardless of estrogen secretion state in rats. J Appl Physiol. 2008;104(4):1116-20.
    • (2008) J Appl Physiol , vol.104 , Issue.4 , pp. 1116-1120
    • Umemura, Y.1    Nagasawa, S.2    Sogo, N.3    Honda, A.4
  • 63
    • 0344030682 scopus 로고    scopus 로고
    • Enhancement by sex hormones of the osteoregulatory effects of mechanical loading and prostaglandins in explants of rat ulnae
    • MZ Cheng G Zaman SC Rawlinson AA Pitsillides RF Suswillo LE Lanyon 1997 Enhancement by sex hormones of the osteoregulatory effects of mechanical loading and prostaglandins in explants of rat ulnae J Bone Miner Res. 12 1424 30
    • (1997) J Bone Miner Res. , vol.12 , pp. 1424-30
    • Cheng, M.Z.1    Zaman, G.2    Rawlinson, S.C.3    Pitsillides, A.A.4    Suswillo, R.F.5    Lanyon, L.E.6
  • 65
    • 0029804794 scopus 로고    scopus 로고
    • Estrogen suppresses activation but enhances formation phase of osteogenic response to mechanical stimulation in rat bone
    • CJ Jagger JW Chow TJ Chambers 1996 Estrogen suppresses activation but enhances formation phase of osteogenic response to mechanical stimulation in rat bone J Clin Invest. 98 2351 7
    • (1996) J Clin Invest. , vol.98 , pp. 2351-7
    • Jagger, C.J.1    Chow, J.W.2    Chambers, T.J.3
  • 66
    • 0036862205 scopus 로고    scopus 로고
    • Mechanotransduction in bone: Genetic effects on mechanosensitivity in mice
    • AG Robling CH Turner 2002 Mechanotransduction in bone: genetic effects on mechanosensitivity in mice Bone. 31 562 9
    • (2002) Bone. , vol.31 , pp. 562-9
    • Robling, A.G.1    Turner, C.H.2
  • 68
    • 0035282968 scopus 로고    scopus 로고
    • Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
    • W Balemans M Ebeling N Patel E Van Hul P Olson M Dioszegi 2001 Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST) Hum Mol Genet. 10 537 43
    • (2001) Hum Mol Genet. , vol.10 , pp. 537-43
    • Balemans, W.1    Ebeling, M.2    Patel, N.3    Van Hul, E.4    Olson, P.5    Dioszegi, M.6
  • 69
    • 18244403197 scopus 로고    scopus 로고
    • Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease
    • W Balemans N Patel M Ebeling E Van Hul W Wuyts C Lacza 2002 Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease J Med Genet. 39 91 7
    • (2002) J Med Genet. , vol.39 , pp. 91-7
    • Balemans, W.1    Patel, N.2    Ebeling, M.3    Van Hul, E.4    Wuyts, W.5    Lacza, C.6
  • 72
    • 0036138175 scopus 로고    scopus 로고
    • A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
    • RD Little JP Carulli RG Del Mastro J Dupuis M Osborne C Folz 2002 A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait Am J Hum Genet. 70 11 9
    • (2002) Am J Hum Genet. , vol.70 , pp. 11-9
    • Little, R.D.1    Carulli, J.P.2    Del Mastro, R.G.3    Dupuis, J.4    Osborne, M.5    Folz, C.6
  • 73
    • 0025371909 scopus 로고
    • Estrogen binding is a noncooperative process in primary rat uterine cells
    • JH Walent J Gorski 1990 Estrogen binding is a noncooperative process in primary rat uterine cells Endocrinology. 126 2383 91
    • (1990) Endocrinology. , vol.126 , pp. 2383-91
    • Walent, J.H.1    Gorski, J.2
  • 74
    • 0018826259 scopus 로고
    • Differential response of individual uterine cell types from immature rats treated with estradiol
    • SA McCormack SR Glasser 1980 Differential response of individual uterine cell types from immature rats treated with estradiol Endocrinology. 106 1634 49
    • (1980) Endocrinology. , vol.106 , pp. 1634-49
    • McCormack, S.A.1    Glasser, S.R.2
  • 76
    • 0023914660 scopus 로고
    • Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells
    • BS Komm CM Terpening DJ Benz KA Graeme A Gallegos M Korc 1988 Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells Science. 241 81 4
    • (1988) Science. , vol.241 , pp. 81-4
    • Komm, B.S.1    Terpening, C.M.2    Benz, D.J.3    Graeme, K.A.4    Gallegos, A.5    Korc, M.6
  • 77
    • 0026631691 scopus 로고
    • Estrogens modulate the responsiveness of osteoblast-like cells (ROS 17/2.8) stably transfected with estrogen receptor
    • S Migliaccio VL Davis MK Gibson TK Gray KS Korach 1992 Estrogens modulate the responsiveness of osteoblast-like cells (ROS 17/2.8) stably transfected with estrogen receptor Endocrinology. 130 2617 24
    • (1992) Endocrinology. , vol.130 , pp. 2617-24
    • Migliaccio, S.1    Davis, V.L.2    Gibson, M.K.3    Gray, T.K.4    Korach, K.S.5
  • 78
    • 33746451702 scopus 로고    scopus 로고
    • Osteocytes use estrogen receptor alpha to respond to strain but their ERalpha content is regulated by estrogen
    • G Zaman HL Jessop M Muzylak RL De Souza AA Pitsillides JS Price 2006 Osteocytes use estrogen receptor alpha to respond to strain but their ERalpha content is regulated by estrogen J Bone Miner Res. 21 1297 306
    • (2006) J Bone Miner Res. , vol.21 , pp. 1297-306
    • Zaman, G.1    Jessop, H.L.2    Muzylak, M.3    De Souza, R.L.4    Pitsillides, A.A.5    Price, J.S.6
  • 79
    • 38349181025 scopus 로고    scopus 로고
    • Estrogen modulates estrogen receptor alpha and beta expression, osteogenic activity, and apoptosis in mesenchymal stem cells (MSCs) of osteoporotic mice
    • S Zhou Y Zilberman K Wassermann SD Bain Y Sadovsky D Gazit 2001 Estrogen modulates estrogen receptor alpha and beta expression, osteogenic activity, and apoptosis in mesenchymal stem cells (MSCs) of osteoporotic mice J Cell Biochem. 81 144 55
    • (2001) J Cell Biochem. , vol.81 , pp. 144-55
    • Zhou, S.1    Zilberman, Y.2    Wassermann, K.3    Bain, S.D.4    Sadovsky, Y.5    Gazit, D.6
  • 80
    • 0033026850 scopus 로고    scopus 로고
    • Effect of ovarian steroid deficiency on oestrogen receptor alpha expression in bone
    • JA Hoyland C Baris L Wood P Baird PL Selby AJ Freemont 1999 Effect of ovarian steroid deficiency on oestrogen receptor alpha expression in bone J Pathol. 188 294 303
    • (1999) J Pathol. , vol.188 , pp. 294-303
    • Hoyland, J.A.1    Baris, C.2    Wood, L.3    Baird, P.4    Selby, P.L.5    Freemont, A.J.6
  • 81
    • 0022653964 scopus 로고
    • Human oestrogen receptor cDNA: Sequence, expression and homology to v-erb-A
    • S Green P Walter V Kumar A Krust JM Bornert P Argos 1986 Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A Nature. 320 134 9
    • (1986) Nature. , vol.320 , pp. 134-9
    • Green, S.1    Walter, P.2    Kumar, V.3    Krust, A.4    Bornert, J.M.5    Argos, P.6
  • 83
    • 0030593681 scopus 로고    scopus 로고
    • ER beta: Identification and characterization of a novel human estrogen receptor
    • S Mosselman J Polman R Dijkema 1996 ER beta: identification and characterization of a novel human estrogen receptor FEBS Lett. 392 49 53
    • (1996) FEBS Lett. , vol.392 , pp. 49-53
    • Mosselman, S.1    Polman, J.2    Dijkema, R.3
  • 84
    • 0023628759 scopus 로고
    • Structural organization and expression of the mouse estrogen receptor
    • R White JA Lees M Needham J Ham M Parker 1987 Structural organization and expression of the mouse estrogen receptor Mol Endocrinol. 1 735 44
    • (1987) Mol Endocrinol. , vol.1 , pp. 735-44
    • White, R.1    Lees, J.A.2    Needham, M.3    Ham, J.4    Parker, M.5
  • 85
    • 0025784949 scopus 로고
    • Estrogen binding and estrogenic responses in normal human osteoblast-like cells
    • DJ Benz MR Haussler BS Komm 1991 Estrogen binding and estrogenic responses in normal human osteoblast-like cells J Bone Miner Res. 6 531 41
    • (1991) J Bone Miner Res. , vol.6 , pp. 531-41
    • Benz, D.J.1    Haussler, M.R.2    Komm, B.S.3
  • 86
    • 0034115084 scopus 로고    scopus 로고
    • Preliminary evidence for impaired estrogen receptor-alpha protein expression in osteoblasts and osteocytes from men with idiopathic osteoporosis
    • I Braidman C Baris L Wood P Selby J Adams A Freemont 2000 Preliminary evidence for impaired estrogen receptor-alpha protein expression in osteoblasts and osteocytes from men with idiopathic osteoporosis Bone. 26 423 7
    • (2000) Bone. , vol.26 , pp. 423-7
    • Braidman, I.1    Baris, C.2    Wood, L.3    Selby, P.4    Adams, J.5    Freemont, A.6
  • 87
    • 0028334187 scopus 로고
    • Correlation between low levels of estrogen receptors and estrogen responsiveness in two rat osteoblast-like cell lines
    • VL Davis JF Couse TK Gray KS Korach 1994 Correlation between low levels of estrogen receptors and estrogen responsiveness in two rat osteoblast-like cell lines J Bone Miner Res. 9 983 91
    • (1994) J Bone Miner Res. , vol.9 , pp. 983-91
    • Davis, V.L.1    Couse, J.F.2    Gray, T.K.3    Korach, K.S.4
  • 89
    • 0031081219 scopus 로고    scopus 로고
    • Demonstration of estrogen receptor mRNA in bone using in situ reverse-transcriptase polymerase chain reaction
    • JA Hoyland AP Mee P Baird IP Braidman EB Mawer AJ Freemont 1997 Demonstration of estrogen receptor mRNA in bone using in situ reverse-transcriptase polymerase chain reaction Bone. 20 87 92
    • (1997) Bone. , vol.20 , pp. 87-92
    • Hoyland, J.A.1    Mee, A.P.2    Baird, P.3    Braidman, I.P.4    Mawer, E.B.5    Freemont, A.J.6
  • 90
    • 0031728255 scopus 로고    scopus 로고
    • Localization of estrogen receptor-alpha in human and rabbit skeletal tissues
    • V Kusec AS Virdi R Prince JT Triffitt 1998 Localization of estrogen receptor-alpha in human and rabbit skeletal tissues J Clin Endocrinol Metab. 83 2421 8
    • (1998) J Clin Endocrinol Metab. , vol.83 , pp. 2421-8
    • Kusec, V.1    Virdi, A.S.2    Prince, R.3    Triffitt, J.T.4
  • 96
    • 0030752456 scopus 로고    scopus 로고
    • Estrogen receptors alpha and beta form heterodimers on DNA
    • SM Cowley S Hoare S Mosselman MG Parker 1997 Estrogen receptors alpha and beta form heterodimers on DNA J Biol Chem. 272 19858 62
    • (1997) J Biol Chem. , vol.272 , pp. 19858-62
    • Cowley, S.M.1    Hoare, S.2    Mosselman, S.3    Parker, M.G.4
  • 98
    • 0023808861 scopus 로고
    • The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer
    • V Kumar P Chambon 1988 The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer Cell. 55 145 56
    • (1988) Cell. , vol.55 , pp. 145-56
    • Kumar, V.1    Chambon, P.2
  • 99
  • 100
    • 0035813112 scopus 로고    scopus 로고
    • The multifaceted mechanisms of estradiol and estrogen receptor signaling
    • JM Hall JF Couse KS Korach 2001 The multifaceted mechanisms of estradiol and estrogen receptor signaling J Biol Chem. 276 36869 72
    • (2001) J Biol Chem. , vol.276 , pp. 36869-72
    • Hall, J.M.1    Couse, J.F.2    Korach, K.S.3
  • 101
    • 0031859351 scopus 로고    scopus 로고
    • The estrogen receptor's involvement in osteoblasts' adaptive response to mechanical strain
    • E Damien JS Price LE Lanyon 1998 The estrogen receptor's involvement in osteoblasts' adaptive response to mechanical strain J Bone Miner Res. 13 1275 82
    • (1998) J Bone Miner Res. , vol.13 , pp. 1275-82
    • Damien, E.1    Price, J.S.2    Lanyon, L.E.3
  • 102
    • 0033791733 scopus 로고    scopus 로고
    • Mechanical strain stimulates osteoblast proliferation through the estrogen receptor in males as well as females
    • E Damien JS Price LE Lanyon 2000 Mechanical strain stimulates osteoblast proliferation through the estrogen receptor in males as well as females J Bone Miner Res. 15 2169 77
    • (2000) J Bone Miner Res. , vol.15 , pp. 2169-77
    • Damien, E.1    Price, J.S.2    Lanyon, L.E.3
  • 104
    • 0023822251 scopus 로고
    • Increased 3H-uridine levels in osteocytes following a single short period of dynamic bone loading in vivo
    • MJ Pead R Suswillo TM Skerry S Vedi LE Lanyon 1988 Increased 3H-uridine levels in osteocytes following a single short period of dynamic bone loading in vivo Calcif Tissue Int. 43 92 6
    • (1988) Calcif Tissue Int. , vol.43 , pp. 92-6
    • Pead, M.J.1    Suswillo, R.2    Skerry, T.M.3    Vedi, S.4    Lanyon, L.E.5
  • 105
    • 3142755633 scopus 로고    scopus 로고
    • Mechanical strain on osteoblasts activates autophosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 tyrosine sites involved in ERK activation
    • N Boutahar A Guignandon L Vico MH Lafage-Proust 2004 Mechanical strain on osteoblasts activates autophosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 tyrosine sites involved in ERK activation J Biol Chem. 279 30588 99
    • (2004) J Biol Chem. , vol.279 , pp. 30588-99
    • Boutahar, N.1    Guignandon, A.2    Vico, L.3    Lafage-Proust, M.H.4
  • 106
    • 0037345529 scopus 로고    scopus 로고
    • Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways
    • S Kapur DJ Baylink KH Lau 2003 Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways Bone. 32 241 51
    • (2003) Bone. , vol.32 , pp. 241-51
    • Kapur, S.1    Baylink, D.J.2    Lau, K.H.3
  • 107
    • 33646902229 scopus 로고    scopus 로고
    • Up-regulation of the Wnt, estrogen receptor, insulin-like growth factor-I, and bone morphogenetic protein pathways in C57BL/6J osteoblasts as opposed to C3H/HeJ osteoblasts in part contributes to the differential anabolic response to fluid shear
    • KH Lau S Kapur C Kesavan DJ Baylink 2006 Up-regulation of the Wnt, estrogen receptor, insulin-like growth factor-I, and bone morphogenetic protein pathways in C57BL/6J osteoblasts as opposed to C3H/HeJ osteoblasts in part contributes to the differential anabolic response to fluid shear J Biol Chem. 281 9576 88
    • (2006) J Biol Chem. , vol.281 , pp. 9576-88
    • Lau, K.H.1    Kapur, S.2    Kesavan, C.3    Baylink, D.J.4
  • 108
    • 33645452566 scopus 로고    scopus 로고
    • MAP kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation
    • RC Riddle AF Taylor DC Genetos HJ Donahue 2006 MAP kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation Am J Physiol Cell Physiol. 290 C776 84
    • (2006) Am J Physiol Cell Physiol. , vol.290 , pp. 776-84
    • Riddle, R.C.1    Taylor, A.F.2    Genetos, D.C.3    Donahue, H.J.4
  • 109
    • 0042265549 scopus 로고    scopus 로고
    • Endocrinology: Bone adaptation requires oestrogen receptor-alpha
    • K Lee H Jessop R Suswillo G Zaman L Lanyon 2003 Endocrinology: bone adaptation requires oestrogen receptor-alpha Nature. 424 389
    • (2003) Nature. , vol.424 , pp. 389
    • Lee, K.1    Jessop, H.2    Suswillo, R.3    Zaman, G.4    Lanyon, L.5
  • 110
    • 4444314796 scopus 로고    scopus 로고
    • The adaptive response of bone to mechanical loading in female transgenic mice is deficient in the absence of oestrogen receptor-alpha and -beta
    • KC Lee H Jessop R Suswillo G Zaman LE Lanyon 2004 The adaptive response of bone to mechanical loading in female transgenic mice is deficient in the absence of oestrogen receptor-alpha and -beta J Endocrinol. 182 193 201
    • (2004) J Endocrinol. , vol.182 , pp. 193-201
    • Lee, K.C.1    Jessop, H.2    Suswillo, R.3    Zaman, G.4    Lanyon, L.E.5
  • 111
    • 4444236062 scopus 로고    scopus 로고
    • Osteoblast-like cells from estrogen receptor alpha knockout mice have deficient responses to mechanical strain
    • H Jessop R Suswillo S Rawlinson G Zaman K Lee V Das-Gupta 2004 Osteoblast-like cells from estrogen receptor alpha knockout mice have deficient responses to mechanical strain J Bone Miner Res. 19 938 46
    • (2004) J Bone Miner Res. , vol.19 , pp. 938-46
    • Jessop, H.1    Suswillo, R.2    Rawlinson, S.3    Zaman, G.4    Lee, K.5    Das-Gupta, V.6
  • 112
    • 0033911094 scopus 로고    scopus 로고
    • Mechanical strain activates estrogen response elements in bone cells
    • G Zaman MZ Cheng HL Jessop R White LE Lanyon 2000 Mechanical strain activates estrogen response elements in bone cells Bone. 27 233 9
    • (2000) Bone. , vol.27 , pp. 233-9
    • Zaman, G.1    Cheng, M.Z.2    Jessop, H.L.3    White, R.4    Lanyon, L.E.5
  • 114
    • 0036312822 scopus 로고    scopus 로고
    • Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways
    • HL Jessop SC Rawlinson AA Pitsillides LE Lanyon 2002 Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways Bone. 31 186 94
    • (2002) Bone. , vol.31 , pp. 186-94
    • Jessop, H.L.1    Rawlinson, S.C.2    Pitsillides, A.A.3    Lanyon, L.E.4
  • 115
    • 0036128710 scopus 로고    scopus 로고
    • Human osteoblasts' proliferative responses to strain and 17beta-estradiol are mediated by the estrogen receptor and the receptor for insulin-like growth factor I
    • MZ Cheng SC Rawlinson AA Pitsillides G Zaman S Mohan DJ Baylink 2002 Human osteoblasts' proliferative responses to strain and 17beta-estradiol are mediated by the estrogen receptor and the receptor for insulin-like growth factor I J Bone Miner Res. 17 593 602
    • (2002) J Bone Miner Res. , vol.17 , pp. 593-602
    • Cheng, M.Z.1    Rawlinson, S.C.2    Pitsillides, A.A.3    Zaman, G.4    Mohan, S.5    Baylink, D.J.6
  • 116
    • 3042780392 scopus 로고    scopus 로고
    • Directional dependence of osteoblastic calcium response to mechanical stimuli
    • T Adachi K Sato Y Tomita 2003 Directional dependence of osteoblastic calcium response to mechanical stimuli Biomech Model Mechanobiol. 2 73 82
    • (2003) Biomech Model Mechanobiol. , vol.2 , pp. 73-82
    • Adachi, T.1    Sato, K.2    Tomita, Y.3
  • 117
    • 0030463534 scopus 로고    scopus 로고
    • Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain
    • SC Rawlinson AA Pitsillides LE Lanyon 1996 Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain Bone. 19 609 14
    • (1996) Bone. , vol.19 , pp. 609-14
    • Rawlinson, S.C.1    Pitsillides, A.A.2    Lanyon, L.E.3
  • 118
    • 0033065061 scopus 로고    scopus 로고
    • Mechanotransduction pathways in bone: Calcium fluxes and the role of voltage-operated calcium channels
    • AJ el Haj LM Walker MR Preston SJ Publicover 1999 Mechanotransduction pathways in bone: calcium fluxes and the role of voltage-operated calcium channels Med Biol Eng Comput. 37 403 9
    • (1999) Med Biol Eng Comput. , vol.37 , pp. 403-9
    • El Haj, A.J.1    Walker, L.M.2    Preston, M.R.3    Publicover, S.J.4
  • 119
    • 15544386594 scopus 로고    scopus 로고
    • Extracellular nucleotides activate Runx2 in the osteoblast-like HOBIT cell line: A possible molecular link between mechanical stress and osteoblasts' response
    • A Costessi A Pines P D'Andrea M Romanello G Damante L Cesaratto 2005 Extracellular nucleotides activate Runx2 in the osteoblast-like HOBIT cell line: a possible molecular link between mechanical stress and osteoblasts' response Bone. 36 418 32
    • (2005) Bone. , vol.36 , pp. 418-32
    • Costessi, A.1    Pines, A.2    D'Andrea, P.3    Romanello, M.4    Damante, G.5    Cesaratto, L.6
  • 120
  • 121
    • 0033022861 scopus 로고    scopus 로고
    • Bone's early responses to mechanical loading differ in distinct genetic strains of chick: Selection for enhanced growth reduces skeletal adaptability
    • AA Pitsillides SC Rawlinson JR Mosley LE Lanyon 1999 Bone's early responses to mechanical loading differ in distinct genetic strains of chick: selection for enhanced growth reduces skeletal adaptability J Bone Miner Res. 14 980 7
    • (1999) J Bone Miner Res. , vol.14 , pp. 980-7
    • Pitsillides, A.A.1    Rawlinson, S.C.2    Mosley, J.R.3    Lanyon, L.E.4
  • 122
    • 0032971265 scopus 로고    scopus 로고
    • Mechanical strain stimulates nitric oxide production by rapid activation of endothelial nitric oxide synthase in osteocytes
    • G Zaman AA Pitsillides SC Rawlinson RF Suswillo JR Mosley MZ Cheng 1999 Mechanical strain stimulates nitric oxide production by rapid activation of endothelial nitric oxide synthase in osteocytes J Bone Miner Res. 14 1123 31
    • (1999) J Bone Miner Res. , vol.14 , pp. 1123-31
    • Zaman, G.1    Pitsillides, A.A.2    Rawlinson, S.C.3    Suswillo, R.F.4    Mosley, J.R.5    Cheng, M.Z.6
  • 124
    • 0029820699 scopus 로고    scopus 로고
    • Nitric oxide is an early mediator of the increase in bone formation by mechanical stimulation
    • SW Fox TJ Chambers JW Chow 1996 Nitric oxide is an early mediator of the increase in bone formation by mechanical stimulation Am J Physiol. 270 E955 60
    • (1996) Am J Physiol. , vol.270 , pp. 955-60
    • Fox, S.W.1    Chambers, T.J.2    Chow, J.W.3
  • 125
    • 0026331462 scopus 로고
    • Loading-related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: A role for prostacyclin in adaptive bone remodeling?
    • SC Rawlinson AJ el-Haj SL Minter IA Tavares A Bennett LE Lanyon 1991 Loading-related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: a role for prostacyclin in adaptive bone remodeling? J Bone Miner Res. 6 1345 51
    • (1991) J Bone Miner Res. , vol.6 , pp. 1345-51
    • Rawlinson, S.C.1    El-Haj, A.J.2    Minter, S.L.3    Tavares, I.A.4    Bennett, A.5    Lanyon, L.E.6
  • 126
    • 0027521175 scopus 로고
    • Exogenous prostacyclin, but not prostaglandin E2, produces similar responses in both G6PD activity and RNA production as mechanical loading, and increases IGF-II release, in adult cancellous bone in culture
    • SC Rawlinson S Mohan DJ Baylink LE Lanyon 1993 Exogenous prostacyclin, but not prostaglandin E2, produces similar responses in both G6PD activity and RNA production as mechanical loading, and increases IGF-II release, in adult cancellous bone in culture Calcif Tissue Int. 53 324 9
    • (1993) Calcif Tissue Int. , vol.53 , pp. 324-9
    • Rawlinson, S.C.1    Mohan, S.2    Baylink, D.J.3    Lanyon, L.E.4
  • 127
    • 0033941227 scopus 로고    scopus 로고
    • Arachidonic acid for loading induced prostacyclin and prostaglandin E(2) release from osteoblasts and osteocytes is derived from the activities of different forms of phospholipase A(2)
    • SC Rawlinson CP Wheeler-Jones LE Lanyon 2000 Arachidonic acid for loading induced prostacyclin and prostaglandin E(2) release from osteoblasts and osteocytes is derived from the activities of different forms of phospholipase A(2) Bone. 27 241 7
    • (2000) Bone. , vol.27 , pp. 241-7
    • Rawlinson, S.C.1    Wheeler-Jones, C.P.2    Lanyon, L.E.3
  • 128
    • 0030968233 scopus 로고    scopus 로고
    • Early responses to dynamic strain change and prostaglandins in bone-derived cells in culture
    • G Zaman RF Suswillo MZ Cheng IA Tavares LE Lanyon 1997 Early responses to dynamic strain change and prostaglandins in bone-derived cells in culture J Bone Miner Res. 12 769 77
    • (1997) J Bone Miner Res. , vol.12 , pp. 769-77
    • Zaman, G.1    Suswillo, R.F.2    Cheng, M.Z.3    Tavares, I.A.4    Lanyon, L.E.5
  • 129
    • 0036551229 scopus 로고    scopus 로고
    • Suppression of prostaglandin synthesis with NS-398 has different effects on endocortical and periosteal bone formation induced by mechanical loading
    • J Li DB Burr CH Turner 2002 Suppression of prostaglandin synthesis with NS-398 has different effects on endocortical and periosteal bone formation induced by mechanical loading Calcif Tissue Int. 70 320 9
    • (2002) Calcif Tissue Int. , vol.70 , pp. 320-9
    • Li, J.1    Burr, D.B.2    Turner, C.H.3
  • 130
    • 0029998565 scopus 로고    scopus 로고
    • Inducible cyclo-oxygenase (COX-2) mediates the induction of bone formation by mechanical loading in vivo
    • MR Forwood 1996 Inducible cyclo-oxygenase (COX-2) mediates the induction of bone formation by mechanical loading in vivo J Bone Miner Res. 11 1688 93
    • (1996) J Bone Miner Res. , vol.11 , pp. 1688-93
    • Forwood, M.R.1
  • 131
    • 33947116489 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition delays the attainment of peak woven bone formation following four-point bending in the rat
    • LS Gregory MR Forwood 2007 Cyclooxygenase-2 inhibition delays the attainment of peak woven bone formation following four-point bending in the rat Calcif Tissue Int. 80 176 83
    • (2007) Calcif Tissue Int. , vol.80 , pp. 176-83
    • Gregory, L.S.1    Forwood, M.R.2
  • 132
    • 0029940159 scopus 로고    scopus 로고
    • Nitric oxide inhibitor L-NAME suppresses mechanically induced bone formation in rats
    • CH Turner Y Takano I Owan GA Murrell 1996 Nitric oxide inhibitor L-NAME suppresses mechanically induced bone formation in rats Am J Physiol. 270 E634 9
    • (1996) Am J Physiol. , vol.270 , pp. 634-9
    • Turner, C.H.1    Takano, Y.2    Owan, I.3    Murrell, G.A.4
  • 133
    • 8444220819 scopus 로고    scopus 로고
    • Interactions between estrogen and mechanical strain effects on U2OS human osteosarcoma cells are not influenced by estrogen receptor type
    • F Lima L Vico MH Lafage-Proust P van der Saag C Alexandre T Thomas 2004 Interactions between estrogen and mechanical strain effects on U2OS human osteosarcoma cells are not influenced by estrogen receptor type Bone. 35 1127 35
    • (2004) Bone. , vol.35 , pp. 1127-35
    • Lima, F.1    Vico, L.2    Lafage-Proust, M.H.3    Van Der Saag, P.4    Alexandre, C.5    Thomas, T.6
  • 134
    • 34548500327 scopus 로고    scopus 로고
    • A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction
    • JI Aguirre LI Plotkin AR Gortazar MM Millan CA O'Brien SC Manolagas 2007 A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction J Biol Chem. 282 25501 8
    • (2007) J Biol Chem. , vol.282 , pp. 25501-8
    • Aguirre, J.I.1    Plotkin, L.I.2    Gortazar, A.R.3    Millan, M.M.4    O'Brien, C.A.5    Manolagas, S.C.6
  • 135
    • 39049083128 scopus 로고    scopus 로고
    • Loss of ERE binding activity by estrogen receptor-alpha alters basal and estrogen-stimulated bone-related gene expression by osteoblastic cells
    • V Rudnik A Sanyal FA Syed DG Monroe TC Spelsberg MJ Oursler 2008 Loss of ERE binding activity by estrogen receptor-alpha alters basal and estrogen-stimulated bone-related gene expression by osteoblastic cells J Cell Biochem. 103 896 907
    • (2008) J Cell Biochem. , vol.103 , pp. 896-907
    • Rudnik, V.1    Sanyal, A.2    Syed, F.A.3    Monroe, D.G.4    Spelsberg, T.C.5    Oursler, M.J.6
  • 137
    • 27444444611 scopus 로고    scopus 로고
    • Skeletal effects of estrogen are mediated by opposing actions of classical and nonclassical estrogen receptor pathways
    • FA Syed UI Mödder DG Fraser TC Spelsberg CJ Rosen A Krust 2005 Skeletal effects of estrogen are mediated by opposing actions of classical and nonclassical estrogen receptor pathways J Bone Miner Res. 20 1992 2001
    • (2005) J Bone Miner Res. , vol.20 , pp. 1992-2001
    • Syed, F.A.1    Mödder, U.I.2    Fraser, D.G.3    Spelsberg, T.C.4    Rosen, C.J.5    Krust, A.6
  • 138
    • 18044386744 scopus 로고    scopus 로고
    • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    • Y Gong RB Slee N Fukai G Rawadi S Roman-Roman AM Reginato 2001 LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development Cell. 107 513 23
    • (2001) Cell. , vol.107 , pp. 513-23
    • Gong, Y.1    Slee, R.B.2    Fukai, N.3    Rawadi, G.4    Roman-Roman, S.5    Reginato, A.M.6
  • 139
    • 0029937085 scopus 로고    scopus 로고
    • Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is assigned to chromosome region 11q12-13
    • Y Gong M Vikkula L Boon J Liu P Beighton R Ramesar 1996 Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is assigned to chromosome region 11q12-13 Am J Hum Genet. 59 146 51
    • (1996) Am J Hum Genet. , vol.59 , pp. 146-51
    • Gong, Y.1    Vikkula, M.2    Boon, L.3    Liu, J.4    Beighton, P.5    Ramesar, R.6
  • 141
    • 33747674263 scopus 로고    scopus 로고
    • The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment
    • K Sawakami AG Robling M Ai ND Pitner D Liu SJ Warden 2006 The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment J Biol Chem. 281 23698 711
    • (2006) J Biol Chem. , vol.281 , pp. 23698-711
    • Sawakami, K.1    Robling, A.G.2    Ai, M.3    Pitner, N.D.4    Liu, D.5    Warden, S.J.6
  • 143
    • 34547111836 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha
    • VJ Armstrong M Muzylak A Sunters G Zaman LK Saxon JS Price 2007 Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha J Biol Chem. 282 20715 27
    • (2007) J Biol Chem. , vol.282 , pp. 20715-27
    • Armstrong, V.J.1    Muzylak, M.2    Sunters, A.3    Zaman, G.4    Saxon, L.K.5    Price, J.S.6
  • 144
    • 20844449569 scopus 로고    scopus 로고
    • TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro
    • JR Hens KM Wilson P Dann X Chen MC Horowitz JJ Wysolmerski 2005 TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro J Bone Miner Res. 20 1103 13
    • (2005) J Bone Miner Res. , vol.20 , pp. 1103-13
    • Hens, J.R.1    Wilson, K.M.2    Dann, P.3    Chen, X.4    Horowitz, M.C.5    Wysolmerski, J.J.6
  • 148
    • 35448941398 scopus 로고    scopus 로고
    • Downregulation of beta-catenin and transdifferentiation of human osteoblasts to adipocytes under estrogen deficiency
    • Foo C, Frey S, Yang HH, Zellweger R, Filgueira L. Downregulation of beta-catenin and transdifferentiation of human osteoblasts to adipocytes under estrogen deficiency. Gynecol Endocrinol. 2007;1-6.
    • (2007) Gynecol Endocrinol , pp. 1-6
    • Foo, C.1    Frey, S.2    Yang, H.H.3    Zellweger, R.4    Filgueira, L.5
  • 149
    • 0033518310 scopus 로고    scopus 로고
    • Cross-regulation of beta-catenin-LEF/TCF and retinoid signaling pathways
    • Easwaran V, Pishvaian M, Salimuddin, Byers S. Cross-regulation of beta-catenin-LEF/TCF and retinoid signaling pathways. Curr Biol. 1999;9:1415-8.
    • (1999) Curr Biol , vol.9 , pp. 1415-1418
    • Easwaran, V.1    Pishvaian, M.2    Salimuddin3    Byers, S.4
  • 150
    • 5044238220 scopus 로고    scopus 로고
    • Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells
    • D Masiello SY Chen Y Xu MC Verhoeven E Choi AN Hollenberg 2004 Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells Mol Endocrinol. 18 2388 401
    • (2004) Mol Endocrinol. , vol.18 , pp. 2388-401
    • Masiello, D.1    Chen, S.Y.2    Xu, Y.3    Verhoeven, M.C.4    Choi, E.5    Hollenberg, A.N.6
  • 151
    • 0037036393 scopus 로고    scopus 로고
    • Liganded androgen receptor interaction with beta-catenin: Nuclear co-localization and modulation of transcriptional activity in neuronal cells
    • JE Pawlowski JR Ertel MP Allen M Xu C Butler EM Wilson 2002 Liganded androgen receptor interaction with beta-catenin: nuclear co-localization and modulation of transcriptional activity in neuronal cells J Biol Chem. 277 20702 10
    • (2002) J Biol Chem. , vol.277 , pp. 20702-10
    • Pawlowski, J.E.1    Ertel, J.R.2    Allen, M.P.3    Xu, M.4    Butler, C.5    Wilson, E.M.6
  • 152
    • 0034283030 scopus 로고    scopus 로고
    • Beta-catenin affects androgen receptor transcriptional activity and ligand specificity
    • CI Truica S Byers EP Gelmann 2000 Beta-catenin affects androgen receptor transcriptional activity and ligand specificity Cancer Res. 60 4709 13
    • (2000) Cancer Res. , vol.60 , pp. 4709-13
    • Truica, C.I.1    Byers, S.2    Gelmann, E.P.3
  • 154
    • 33646791491 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and glycogen synthase kinase 3 regulate estrogen receptor-mediated transcription in neuronal cells
    • P Mendez LM Garcia-Segura 2006 Phosphatidylinositol 3-kinase and glycogen synthase kinase 3 regulate estrogen receptor-mediated transcription in neuronal cells Endocrinology. 147 3027 39
    • (2006) Endocrinology. , vol.147 , pp. 3027-39
    • Mendez, P.1    Garcia-Segura, L.M.2
  • 155
    • 33846900615 scopus 로고    scopus 로고
    • Induction of osteoblast differentiation by selective activation of kinase-mediated actions of the estrogen receptor
    • S Kousteni M Almeida L Han T Bellido RL Jilka SC Manolagas 2007 Induction of osteoblast differentiation by selective activation of kinase-mediated actions of the estrogen receptor Mol Cell Biol. 27 1516 30
    • (2007) Mol Cell Biol. , vol.27 , pp. 1516-30
    • Kousteni, S.1    Almeida, M.2    Han, L.3    Bellido, T.4    Jilka, R.L.5    Manolagas, S.C.6
  • 157
    • 0028929151 scopus 로고
    • Increased insulin-like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation
    • JM Lean CJ Jagger TJ Chambers JW Chow 1995 Increased insulin-like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation Am J Physiol. 268 E318 27
    • (1995) Am J Physiol. , vol.268 , pp. 318-27
    • Lean, J.M.1    Jagger, C.J.2    Chambers, T.J.3    Chow, J.W.4
  • 158
  • 159
    • 34548319400 scopus 로고    scopus 로고
    • Mechanical loading by fluid shear stress enhances IGF-1 receptor signaling in osteoblasts in a PKCzeta-dependent manner
    • JW Triplett R O'Riley K Tekulve SM Norvell FM Pavalko 2007 Mechanical loading by fluid shear stress enhances IGF-1 receptor signaling in osteoblasts in a PKCzeta-dependent manner Mol Cell Biomech. 4 13 25
    • (2007) Mol Cell Biomech. , vol.4 , pp. 13-25
    • Triplett, J.W.1    O'Riley, R.2    Tekulve, K.3    Norvell, S.M.4    Pavalko, F.M.5
  • 160
    • 0028244227 scopus 로고
    • Cellular and clinical perspectives on skeletal insulin-like growth factor I
    • AM Delany JM Pash E Canalis 1994 Cellular and clinical perspectives on skeletal insulin-like growth factor I J Cell Biochem. 55 328 33
    • (1994) J Cell Biochem. , vol.55 , pp. 328-33
    • Delany, A.M.1    Pash, J.M.2    Canalis, E.3
  • 163
    • 0028284815 scopus 로고
    • Insulin-like growth factors and bone: The osteoporosis connection
    • CJ Rosen LR Donahue SJ Hunter 1994 Insulin-like growth factors and bone: the osteoporosis connection Proc Soc Exp Biol Med. 206 83 102
    • (1994) Proc Soc Exp Biol Med. , vol.206 , pp. 83-102
    • Rosen, C.J.1    Donahue, L.R.2    Hunter, S.J.3
  • 167
    • 34547119320 scopus 로고    scopus 로고
    • Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloading
    • BM Boudignon DD Bikle P Kurimoto H Elalieh S Nishida Y Wang 2007 Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloading J Appl Physiol. 103 125 31
    • (2007) J Appl Physiol. , vol.103 , pp. 125-31
    • Boudignon, B.M.1    Bikle, D.D.2    Kurimoto, P.3    Elalieh, H.4    Nishida, S.5    Wang, Y.6
  • 168
    • 2942711895 scopus 로고    scopus 로고
    • Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways
    • T Sakata Y Wang BP Halloran HZ Elalieh J Cao DD Bikle 2004 Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways J Bone Miner Res. 19 436 46
    • (2004) J Bone Miner Res. , vol.19 , pp. 436-46
    • Sakata, T.1    Wang, Y.2    Halloran, B.P.3    Elalieh, H.Z.4    Cao, J.5    Bikle, D.D.6
  • 170
    • 34547095246 scopus 로고    scopus 로고
    • Estrogen signaling via a linear pathway involving insulin-like growth factor I receptor, matrix metalloproteinases, and epidermal growth factor receptor to activate mitogen-activated protein kinase in MCF-7 breast cancer cells
    • RX Song Z Zhang Y Chen Y Bao RJ Santen 2007 Estrogen signaling via a linear pathway involving insulin-like growth factor I receptor, matrix metalloproteinases, and epidermal growth factor receptor to activate mitogen-activated protein kinase in MCF-7 breast cancer cells Endocrinology. 148 4091 101
    • (2007) Endocrinology. , vol.148 , pp. 4091-101
    • Song, R.X.1    Zhang, Z.2    Chen, Y.3    Bao, Y.4    Santen, R.J.5
  • 171
    • 34547956513 scopus 로고    scopus 로고
    • Estrogen receptor alpha (ERalpha) and insulin-like growth factor I receptor (IGF-IR) cross-talk in the gonadotropic alphaT3-1 cell line
    • F Eertmans W Dhooge O De Wever M Bracke F Comhaire JM Kaufman 2007 Estrogen receptor alpha (ERalpha) and insulin-like growth factor I receptor (IGF-IR) cross-talk in the gonadotropic alphaT3-1 cell line J Cell Physiol. 212 583 90
    • (2007) J Cell Physiol. , vol.212 , pp. 583-90
    • Eertmans, F.1    Dhooge, W.2    De Wever, O.3    Bracke, M.4    Comhaire, F.5    Kaufman, J.M.6
  • 172
    • 40849120759 scopus 로고    scopus 로고
    • Abnormalities of insulin-like growth factor-I signaling and impaired cell proliferation in osteoblasts from subjects with osteoporosis
    • S Perrini A Natalicchio L Laviola A Cignarelli M Melchiorre F De Stefano 2008 Abnormalities of insulin-like growth factor-I signaling and impaired cell proliferation in osteoblasts from subjects with osteoporosis Endocrinology. 149 1302 13
    • (2008) Endocrinology. , vol.149 , pp. 1302-13
    • Perrini, S.1    Natalicchio, A.2    Laviola, L.3    Cignarelli, A.4    Melchiorre, M.5    De Stefano, F.6
  • 173
    • 34547620497 scopus 로고    scopus 로고
    • The skeletal responsiveness to mechanical loading is enhanced in mice with a null mutation in estrogen receptor-beta
    • LK Saxon AG Robling AB Castillo S Mohan CH Turner 2007 The skeletal responsiveness to mechanical loading is enhanced in mice with a null mutation in estrogen receptor-beta Am J Physiol Endocrinol Metab. 293 E484 91
    • (2007) Am J Physiol Endocrinol Metab. , vol.293 , pp. 484-91
    • Saxon, L.K.1    Robling, A.G.2    Castillo, A.B.3    Mohan, S.4    Turner, C.H.5
  • 174
    • 14144249535 scopus 로고    scopus 로고
    • Estrogen receptor beta: The antimechanostat?
    • LK Saxon CH Turner 2005 Estrogen receptor beta: the antimechanostat? Bone. 36 185 92
    • (2005) Bone. , vol.36 , pp. 185-92
    • Saxon, L.K.1    Turner, C.H.2
  • 175
  • 178
    • 0028792229 scopus 로고
    • Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens
    • A Morishima MM Grumbach ER Simpson C Fisher K Qin 1995 Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens J Clin Endocrinol Metab. 80 3689 98
    • (1995) J Clin Endocrinol Metab. , vol.80 , pp. 3689-98
    • Morishima, A.1    Grumbach, M.M.2    Simpson, E.R.3    Fisher, C.4    Qin, K.5
  • 179
    • 0032499704 scopus 로고    scopus 로고
    • Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene
    • CR Fisher KH Graves AF Parlow ER Simpson 1998 Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene Proc Natl Acad Sci USA. 95 6965 70
    • (1998) Proc Natl Acad Sci USA. , vol.95 , pp. 6965-70
    • Fisher, C.R.1    Graves, K.H.2    Parlow, A.F.3    Simpson, E.R.4
  • 180
    • 0033832459 scopus 로고    scopus 로고
    • Preliminary report of impaired oestrogen receptor-alpha expression in bone, but no involvement of androgen receptor, in male idiopathic osteoporosis
    • IP Braidman C Baris PL Selby JE Adams AJ Freemont JA Hoyland 2000 Preliminary report of impaired oestrogen receptor-alpha expression in bone, but no involvement of androgen receptor, in male idiopathic osteoporosis J Pathol. 192 90 6
    • (2000) J Pathol. , vol.192 , pp. 90-6
    • Braidman, I.P.1    Baris, C.2    Selby, P.L.3    Adams, J.E.4    Freemont, A.J.5    Hoyland, J.A.6
  • 182
    • 0037649062 scopus 로고    scopus 로고
    • Evidence for cell-specific changes with age in expression of oestrogen receptor (ER) alpha and beta in bone fractures from men and women
    • GS Batra L Hainey AJ Freemont G Andrew PT Saunders JA Hoyland 2003 Evidence for cell-specific changes with age in expression of oestrogen receptor (ER) alpha and beta in bone fractures from men and women J Pathol. 200 65 73
    • (2003) J Pathol. , vol.200 , pp. 65-73
    • Batra, G.S.1    Hainey, L.2    Freemont, A.J.3    Andrew, G.4    Saunders, P.T.5    Hoyland, J.A.6
  • 183
    • 0033305245 scopus 로고    scopus 로고
    • Estrogen receptor gene polymorphism, but not estradiol levels, is related to bone density in healthy adolescent boys: A cross-sectional and longitudinal study
    • M Lorentzon R Lorentzon T Backstrom P Nordstrom 1999 Estrogen receptor gene polymorphism, but not estradiol levels, is related to bone density in healthy adolescent boys: a cross-sectional and longitudinal study J Clin Endocrinol Metab. 84 4597 601
    • (1999) J Clin Endocrinol Metab. , vol.84 , pp. 4597-601
    • Lorentzon, M.1    Lorentzon, R.2    Backstrom, T.3    Nordstrom, P.4
  • 184
    • 0037383154 scopus 로고    scopus 로고
    • Aerobic exercise and bone mineral density in middle-aged finnish men: A controlled randomized trial with reference to androgen receptor, aromatase, and estrogen receptor alpha gene polymorphisms small star, filled
    • T Remes SB Vaisanen A Mahonen J Huuskonen H Kroger JS Jurvelin 2003 Aerobic exercise and bone mineral density in middle-aged finnish men: a controlled randomized trial with reference to androgen receptor, aromatase, and estrogen receptor alpha gene polymorphisms small star, filled Bone. 32 412 20
    • (2003) Bone. , vol.32 , pp. 412-20
    • Remes, T.1    Vaisanen, S.B.2    Mahonen, A.3    Huuskonen, J.4    Kroger, H.5    Jurvelin, J.S.6
  • 185
  • 187
    • 44449134234 scopus 로고    scopus 로고
    • ERalpha and AP-1 interact in vivo with a specific sequence of the F promoter of the human ERalpha gene in osteoblasts
    • Ahead of print.
    • Lambertini E, Tavanti E, Torreggiani E, Penolazzi L, Gambari R, Piva R. ERalpha and AP-1 interact in vivo with a specific sequence of the F promoter of the human ERalpha gene in osteoblasts. J Cell Physiol. 2008; Ahead of print.
    • (2008) J Cell Physiol
    • Lambertini, E.1    Tavanti, E.2    Torreggiani, E.3    Penolazzi, L.4    Gambari, R.5    Piva, R.6
  • 188
    • 4444250379 scopus 로고    scopus 로고
    • Mechanical stimulation promotes osteocyte survival: Requirement of nuclear targets of the Src/ERK pathway
    • LI Plotkin JI Aguirre B Strotman SC Manolagas T Bellido 2003 Mechanical stimulation promotes osteocyte survival: requirement of nuclear targets of the Src/ERK pathway J Bone Miner Res. 18 S44
    • (2003) J Bone Miner Res. , vol.18 , pp. 44
    • Plotkin, L.I.1    Aguirre, J.I.2    Strotman, B.3    Manolagas, S.C.4    Bellido, T.5
  • 189
    • 0033569924 scopus 로고    scopus 로고
    • Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002
    • B Gallis GL Corthals DR Goodlett H Ueba F Kim SR Presnell 1999 Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002 J Biol Chem. 274 30101 8
    • (1999) J Biol Chem. , vol.274 , pp. 30101-8
    • Gallis, B.1    Corthals, G.L.2    Goodlett, D.R.3    Ueba, H.4    Kim, F.5    Presnell, S.R.6
  • 190
    • 0034711335 scopus 로고    scopus 로고
    • Estrogen receptor alpha and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae
    • KL Chambliss IS Yuhanna C Mineo P Liu Z German TS Sherman 2000 Estrogen receptor alpha and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae Circ Res. 87 E44 52
    • (2000) Circ Res. , vol.87 , pp. 44-52
    • Chambliss, K.L.1    Yuhanna, I.S.2    Mineo, C.3    Liu, P.4    German, Z.5    Sherman, T.S.6
  • 192
    • 18044403985 scopus 로고    scopus 로고
    • Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells
    • K Hisamoto M Ohmichi H Kurachi J Hayakawa Y Kanda Y Nishio 2001 Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells J Biol Chem. 276 3459 67
    • (2001) J Biol Chem. , vol.276 , pp. 3459-67
    • Hisamoto, K.1    Ohmichi, M.2    Kurachi, H.3    Hayakawa, J.4    Kanda, Y.5    Nishio, Y.6
  • 194
    • 0347719530 scopus 로고    scopus 로고
    • Membrane estrogen receptor-dependent extracellular signal-regulated kinase pathway mediates acute activation of endothelial nitric oxide synthase by estrogen in uterine artery endothelial cells
    • DB Chen IM Bird J Zheng RR Magness 2004 Membrane estrogen receptor-dependent extracellular signal-regulated kinase pathway mediates acute activation of endothelial nitric oxide synthase by estrogen in uterine artery endothelial cells Endocrinology. 145 113 25
    • (2004) Endocrinology. , vol.145 , pp. 113-25
    • Chen, D.B.1    Bird, I.M.2    Zheng, J.3    Magness, R.R.4
  • 195
    • 0034603858 scopus 로고    scopus 로고
    • Roles for insulin receptor, PI3-kinase, and AKT in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells
    • G Zeng FH Nystrom LV Ravichandran L Cong M Kirby H Mostowski 2000 Roles for insulin receptor, PI3-kinase, and AKT in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells Circulation. 101 1539 45
    • (2000) Circulation. , vol.101 , pp. 1539-45
    • Zeng, G.1    Nystrom, F.H.2    Ravichandran, L.V.3    Cong, L.4    Kirby, M.5    Mostowski, H.6
  • 196
    • 0344549854 scopus 로고    scopus 로고
    • Nongenomic stimulation of nitric oxide release by estrogen is mediated by estrogen receptor alpha localized in caveolae
    • HP Kim JY Lee JK Jeong SW Bae HK Lee I Jo 1999 Nongenomic stimulation of nitric oxide release by estrogen is mediated by estrogen receptor alpha localized in caveolae Biochem Biophys Res Commun. 263 257 62
    • (1999) Biochem Biophys Res Commun. , vol.263 , pp. 257-62
    • Kim, H.P.1    Lee, J.Y.2    Jeong, J.K.3    Bae, S.W.4    Lee, H.K.5    Jo, I.6
  • 198
    • 34250836804 scopus 로고    scopus 로고
    • Direct interactions with G alpha i and G betagamma mediate nongenomic signaling by estrogen receptor alpha
    • P Kumar Q Wu KL Chambliss IS Yuhanna SM Mumby C Mineo 2007 Direct interactions with G alpha i and G betagamma mediate nongenomic signaling by estrogen receptor alpha Mol Endocrinol. 21 1370 80
    • (2007) Mol Endocrinol. , vol.21 , pp. 1370-80
    • Kumar, P.1    Wu, Q.2    Chambliss, K.L.3    Yuhanna, I.S.4    Mumby, S.M.5    Mineo, C.6


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