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Volumn 200, Issue 1, 2003, Pages 65-73

Evidence for cell-specific changes with age in expression of oestrogen receptor (ER) α and β in bone fractures from men and women

Author keywords

Fracture callus; Indirect immunocytochemistry; Oestrogen receptor ; Oestrogen receptor ; Osteoblasts osteoclasts; Osteocytes

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY;

EID: 0037649062     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1332     Document Type: Review
Times cited : (64)

References (50)
  • 1
    • 0028143234 scopus 로고
    • Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man
    • Smith EP, Boyd J, Frank GR, et al. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med 1994; 331: 1056-1061.
    • (1994) N. Engl. J. Med. , vol.331 , pp. 1056-1061
    • Smith, E.P.1    Boyd, J.2    Frank, G.R.3
  • 2
    • 0032572929 scopus 로고    scopus 로고
    • Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency
    • Bilezikian JP, Morishima A, Bell J, Grumbach MM. Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency. N Engl J Med 1998; 339: 599-603.
    • (1998) N. Engl. J. Med. , vol.339 , pp. 599-603
    • Bilezikian, J.P.1    Morishima, A.2    Bell, J.3    Grumbach, M.M.4
  • 3
    • 0034457013 scopus 로고    scopus 로고
    • Estrogen replacement therapy in a man with congenital aromatase deficiency: Effects of different doses of transdermal estradiol on bone mineral density and hormonal parameters
    • Rochira V, Faustini-Fustini M, Balestrieri A, Carani C. Estrogen replacement therapy in a man with congenital aromatase deficiency: effects of different doses of transdermal estradiol on bone mineral density and hormonal parameters. J Clin Endocr Metab 2000; 85: 1841-1845.
    • (2000) J. Clin. Endocr. Metab. , vol.85 , pp. 1841-1845
    • Rochira, V.1    Faustini-Fustini, M.2    Balestrieri, A.3    Carani, C.4
  • 5
    • 0031039888 scopus 로고    scopus 로고
    • Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
    • Kuiper GGJM, Carlsson B, Grandien K, et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 1997; 138: 863-870.
    • (1997) Endocrinology , vol.138 , pp. 863-870
    • Kuiper, G.G.J.M.1    Carlsson, B.2    Grandien, K.3
  • 6
    • 0030593681 scopus 로고    scopus 로고
    • ER beta: Identification and characterization of a novel human estrogen receptor
    • Mosselman S, Polman J, Dijkema R. ER beta: identification and characterization of a novel human estrogen receptor. FEBS Lett 1996; 392: 49-53.
    • (1996) FEBS Lett. , vol.392 , pp. 49-53
    • Mosselman, S.1    Polman, J.2    Dijkema, R.3
  • 7
    • 0032481256 scopus 로고    scopus 로고
    • The complete primary structure of human estrogen receptor beta (hER beta) and its heterodimerization with ER alpha in vivo and in vitro
    • Ogawa S, Inoue S, Watanabe T, et al. The complete primary structure of human estrogen receptor beta (hER beta) and its heterodimerization with ER alpha in vivo and in vitro. Biochem Biophys Res Commun 1998; 243: 122-126.
    • (1998) Biochem. Biophys. Res. Commun. , vol.243 , pp. 122-126
    • Ogawa, S.1    Inoue, S.2    Watanabe, T.3
  • 8
    • 0030914163 scopus 로고    scopus 로고
    • Estrogen receptor beta - Getting in on the action?
    • Gustafsson JA. Estrogen receptor beta - getting in on the action? Nature Med 1997; 3: 493-494.
    • (1997) Nature Med. , vol.3 , pp. 493-494
    • Gustafsson, J.A.1
  • 9
    • 0023914660 scopus 로고
    • Estrogen binding, receptor messenger-RNA, and biologic response in osteoblast-like osteo-sarcoma cells
    • Komm BS, Terpening CM, Benz DJ, et al. Estrogen binding, receptor messenger-RNA, and biologic response in osteoblast-like osteo-sarcoma cells. Science 1988; 241: 81-84.
    • (1988) Science , vol.241 , pp. 81-84
    • Komm, B.S.1    Terpening, C.M.2    Benz, D.J.3
  • 10
    • 0032142904 scopus 로고    scopus 로고
    • Age-related changes in human oestrogen receptor alpha function and levels in osteoblasts
    • Ankrom MA, Patterson JA. d'Avis PY, et al. Age-related changes in human oestrogen receptor alpha function and levels in osteoblasts. Biochem J 1998; 333: 787-794.
    • (1998) Biochem. J. , vol.333 , pp. 787-794
    • Ankrom, M.A.1    Patterson, J.A.2    d'Avis, P.Y.3
  • 12
    • 0031728255 scopus 로고    scopus 로고
    • Localization of estrogen receptor-alpha in human and rabbit skeletal tissues
    • Kusec V, Virdi AS, Prince R, Triffitt JT. Localization of estrogen receptor-alpha in human and rabbit skeletal tissues. J Clin Endocr Metab 1998; 83: 2421-2428.
    • (1998) J. Clin. Endocr. Metab. , vol.83 , pp. 2421-2428
    • Kusec, V.1    Virdi, A.S.2    Prince, R.3    Triffitt, J.T.4
  • 13
    • 0031081219 scopus 로고    scopus 로고
    • Demonstration of estrogen receptor mRNA in bone using in situ reverse-transcriptase polymerase chain reaction
    • Hoyland JA, Mee AP, Baird P, Braidman IP, Mawer EB, Freemont AJ. Demonstration of estrogen receptor mRNA in bone using in situ reverse-transcriptase polymerase chain reaction. Bone 1997; 20: 87-92.
    • (1997) Bone , vol.20 , pp. 87-92
    • Hoyland, J.A.1    Mee, A.P.2    Baird, P.3    Braidman, I.P.4    Mawer, E.B.5    Freemont, A.J.6
  • 14
    • 0033026850 scopus 로고    scopus 로고
    • Effect of ovarian steroid deficiency on oestrogen receptor alpha expression in bone
    • Hoyland JA, Baris C, Wood L, et al. Effect of ovarian steroid deficiency on oestrogen receptor alpha expression in bone. J Pathol 1999; 188: 294-303.
    • (1999) J. Pathol. , vol.188 , pp. 294-303
    • Hoyland, J.A.1    Baris, C.2    Wood, L.3
  • 16
    • 0031978099 scopus 로고    scopus 로고
    • Detection of estrogen receptor alpha, carbonic anhydrase II and tartrate-resistant acid phosphatase mRNAs in putative mononuclear osteoclast precursor cells of neonatal rats by fluorescence in situ hybridization
    • Huang WH, Lau ATT, Daniels LL, et al. Detection of estrogen receptor alpha, carbonic anhydrase II and tartrate-resistant acid phosphatase mRNAs in putative mononuclear osteoclast precursor cells of neonatal rats by fluorescence in situ hybridization. J Mol Endocrinol 1998; 20: 211-219.
    • (1998) J. Mol. Endocrinol. , vol.20 , pp. 211-219
    • Huang, W.H.1    Lau, A.T.T.2    Daniels, L.L.3
  • 17
    • 0033054576 scopus 로고    scopus 로고
    • Expression of estrogen receptor-alpha in cells of the osteoclastic lineage
    • Oreffo ROC, Kusec V, Virdi AS, et al. Expression of estrogen receptor-alpha in cells of the osteoclastic lineage. Histochem Cell Biol 1999; 111: 125-133.
    • (1999) Histochem. Cell Biol. , vol.111 , pp. 125-133
    • Oreffo, R.O.C.1    Kusec, V.2    Virdi, A.S.3
  • 18
    • 0034625044 scopus 로고    scopus 로고
    • Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice
    • Vidal O, Lindberg MK, Hollberg K, et al. Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice. Proc Natl Acad Sci U S A 2000; 97: 5474-5479.
    • (2000) Proc. Natl. Acad. Sci. U S A , vol.97 , pp. 5474-5479
    • Vidal, O.1    Lindberg, M.K.2    Hollberg, K.3
  • 19
    • 0036139964 scopus 로고    scopus 로고
    • Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males
    • Sims NA, Dupont S, Krust A, et al. Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males. Bone 2002; 30: 18-25.
    • (2002) Bone , vol.30 , pp. 18-25
    • Sims, N.A.1    Dupont, S.2    Krust, A.3
  • 21
    • 0030729211 scopus 로고    scopus 로고
    • Differential expression of estrogen receptors alpha and beta mRNA during differentiation of human osteoblast SV-HFO cells
    • Arts J, Kuiper GGJM, Janssen JMMF, et al. Differential expression of estrogen receptors alpha and beta mRNA during differentiation of human osteoblast SV-HFO cells. Endocrinology 1997; 138: 5067-5070.
    • (1997) Endocrinology , vol.138 , pp. 5067-5070
    • Arts, J.1    Kuiper, G.G.J.M.2    Janssen, J.M.M.F.3
  • 22
    • 0035010706 scopus 로고    scopus 로고
    • Estrogen receptors alpha and beta are differentially expressed in developing human bone
    • Bord S, Horner A, Beavan S, Compston E. Estrogen receptors alpha and beta are differentially expressed in developing human bone. J Clin Endocrinol Metab 2001; 86: 2309-2314.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 2309-2314
    • Bord, S.1    Horner, A.2    Beavan, S.3    Compston, E.4
  • 23
    • 0033026850 scopus 로고    scopus 로고
    • Effect of ovarian steroid deficiency on oestrogen receptor alpha expression in bone
    • Hoyland JA, Baris C, Wood L, et al. Effect of ovarian steroid deficiency on oestrogen receptor alpha expression in bone. J Pathol 1999; 188: 294-303.
    • (1999) J. Pathol. , vol.188 , pp. 294-303
    • Hoyland, J.A.1    Baris, C.2    Wood, L.3
  • 24
    • 0031733298 scopus 로고    scopus 로고
    • Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta
    • Kuiper GGJM, Lemmen JG, Carlsson B, et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998; 139: 4252-4263.
    • (1998) Endocrinology , vol.139 , pp. 4252-4263
    • Kuiper, G.G.J.M.1    Lemmen, J.G.2    Carlsson, B.3
  • 25
    • 0033806792 scopus 로고    scopus 로고
    • Differential expression of estrogen receptor-alpha and -beta and androgen receptor in the ovaries of marmoset and human
    • Saunders PTK, Millar MR, Macpherson S, et al. Differential expression of estrogen receptor-alpha and -beta and androgen receptor in the ovaries of marmoset and human. Biol Reprod 2000; 63: 1098-1105.
    • (2000) Biol. Reprod. , vol.63 , pp. 1098-1105
    • Saunders, P.T.K.1    Millar, M.R.2    Macpherson, S.3
  • 26
    • 0027410956 scopus 로고
    • Demonstration of TGF-beta-1 messenger-RNA by in situ hybridization in normal human fracture-healing
    • Andrew JG, Hoyland J, Andrew SM, Freemont AJ, Marsh D. Demonstration of TGF-beta-1 messenger-RNA by in situ hybridization in normal human fracture-healing. Calcif Tiss Int 1993; 52: 74-78.
    • (1993) Calcif. Tiss. Int. , vol.52 , pp. 74-78
    • Andrew, J.G.1    Hoyland, J.2    Andrew, S.M.3    Freemont, A.J.4    Marsh, D.5
  • 27
  • 28
    • 0029143554 scopus 로고
    • Platelet-derived growth-factor expression in normally healing human fractures
    • Andrew JG, Hoyland JA, Freemont AJ, Marsh DR. Platelet-derived growth-factor expression in normally healing human fractures. Bone 1995; 16: 455-460.
    • (1995) Bone , vol.16 , pp. 455-460
    • Andrew, J.G.1    Hoyland, J.A.2    Freemont, A.J.3    Marsh, D.R.4
  • 29
    • 0035052903 scopus 로고    scopus 로고
    • Estrogen receptor beta, but not estrogen receptor alpha is present in the vascular endothelium of the human and nonhuman primate endometrium
    • Critchley HOD, Brenner RM, Henderson TA, et al. Estrogen receptor beta, but not estrogen receptor alpha, is present in the vascular endothelium of the human and nonhuman primate endometrium. J Clin Endocrinol Metab 2001; 86: 1370-1378.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 1370-1378
    • Critchley, H.O.D.1    Brenner, R.M.2    Henderson, T.A.3
  • 30
    • 0030601053 scopus 로고    scopus 로고
    • Mammalian mature osteoclasts as estrogen target cells
    • Mano H, Yuasa T, Kameda T, et al. Mammalian mature osteoclasts as estrogen target cells. Biochem Biophys Res Commun 1996; 223: 637-642.
    • (1996) Biochem. Biophys. Res. Commun. , vol.223 , pp. 637-642
    • Mano, H.1    Yuasa, T.2    Kameda, T.3
  • 32
    • 0030918877 scopus 로고    scopus 로고
    • Evidence of a correlation of estrogen receptor level and avian osteoclast estrogen responsiveness
    • Pederson L, Kremer M, Foged NT, et al. Evidence of a correlation of estrogen receptor level and avian osteoclast estrogen responsiveness. J Bone Miner Res 1997; 12: 742-752.
    • (1997) J. Bone Miner. Res. , vol.12 , pp. 742-752
    • Pederson, L.1    Kremer, M.2    Foged, N.T.3
  • 33
    • 0031786785 scopus 로고    scopus 로고
    • Evidence for the colocalization of estrogen receptor-beta mRNA and estrogen receptor-alpha immunoreactivity in neurons of the rat forebrain
    • Shughrue PJ, Scrimo PJ, Merchenthaler I. Evidence for the colocalization of estrogen receptor-beta mRNA and estrogen receptor-alpha immunoreactivity in neurons of the rat forebrain. Endocrinology 1998; 139: 5267-5270.
    • (1998) Endocrinology , vol.139 , pp. 5267-5270
    • Shughrue, P.J.1    Scrimo, P.J.2    Merchenthaler, I.3
  • 34
    • 0030771389 scopus 로고    scopus 로고
    • Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha
    • Pace P, Taylor J, Suntharalingam S, Coombes RC, Ali S. Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha. J Biol Chem 1997; 272: 25 832-25 838.
    • (1997) J. Biol. Chem. , vol.272 , pp. 25832-25838
    • Pace, P.1    Taylor, J.2    Suntharalingam, S.3    Coombes, R.C.4    Ali, S.5
  • 35
    • 0030747070 scopus 로고    scopus 로고
    • Mouse estrogen receptor beta forms estrogen response element-binding heterodimers with estrogen receptor alpha
    • Pettersson K, Grandien K, Kuiper GGJM, Gustafsson JA. Mouse estrogen receptor beta forms estrogen response element-binding heterodimers with estrogen receptor alpha. Mol Endocrinol 1997; 11: 1486-1496.
    • (1997) Mol. Endocrinol. , vol.11 , pp. 1486-1496
    • Pettersson, K.1    Grandien, K.2    Kuiper, G.G.J.M.3    Gustafsson, J.A.4
  • 36
    • 0030801841 scopus 로고    scopus 로고
    • Differential ligand activation of estrogen receptors ER alpha and ER beta at AP1 sites
    • Paech K, Webb P, Kuiper GGJM, et al. Differential ligand activation of estrogen receptors ER alpha and ER beta at AP1 sites. Science 1997; 277: 1508-1510.
    • (1997) Science , vol.277 , pp. 1508-1510
    • Paech, K.1    Webb, P.2    Kuiper, G.G.J.M.3
  • 37
    • 0033304993 scopus 로고    scopus 로고
    • The estrogen receptor beta-isoform (ER beta) of the human estrogen receptor modulates ER alpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens
    • Hall JM, McDonnell DP. The estrogen receptor beta-isoform (ER beta) of the human estrogen receptor modulates ER alpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinology 1999; 140: 5566-5578.
    • (1999) Endocrinology , vol.140 , pp. 5566-5578
    • Hall, J.M.1    McDonnell, D.P.2
  • 38
    • 0034115084 scopus 로고    scopus 로고
    • Preliminary evidence for impaired estrogen receptor alpha protein expression in osteoblasts and osteocytes from men with idiopathic osteoporosis
    • Braidman I, Baris C, Wood L, et al. Preliminary evidence for impaired estrogen receptor alpha protein expression in osteoblasts and osteocytes from men with idiopathic osteoporosis. Bone 2000; 26: 423-427.
    • (2000) Bone , vol.26 , pp. 423-427
    • Braidman, I.1    Baris, C.2    Wood, L.3
  • 39
    • 0024326174 scopus 로고
    • Early strain-related changes in enzyme-activity in osteocytes following bone loading in vivo
    • Skerry TM, Bitensky L, Chayen J, Lanyon LE. Early strain-related changes in enzyme-activity in osteocytes following bone loading in vivo. J Bone Miner Res 1989; 4: 783-788.
    • (1989) J. Bone Miner. Res. , vol.4 , pp. 783-788
    • Skerry, T.M.1    Bitensky, L.2    Chayen, J.3    Lanyon, L.E.4
  • 40
    • 0032971265 scopus 로고    scopus 로고
    • Mechanical strain stimulates nitric oxide production by rapid activation of endothelial nitric oxide synthase in osteocytes
    • Zaman G, Pitsillides AA, Rawlinson SC, et al. Mechanical strain stimulates nitric oxide production by rapid activation of endothelial nitric oxide synthase in osteocytes. J Bone Miner Res 1999; 14: 1123-1131.
    • (1999) J. Bone Miner. Res. , vol.14 , pp. 1123-1131
    • Zaman, G.1    Pitsillides, A.A.2    Rawlinson, S.C.3
  • 42
    • 0030931083 scopus 로고    scopus 로고
    • Sex steroids and bone mass in older men - Positive associations with serum estrogens and negative associations with androgens
    • Slemenda CW, Longcope C, Zhou LF, Hui SL, Peacock M, Johnston CC. Sex steroids and bone mass in older men - positive associations with serum estrogens and negative associations with androgens. J Clin Invest 1997; 100: 1755-1759.
    • (1997) J. Clin. Invest. , vol.100 , pp. 1755-1759
    • Slemenda, C.W.1    Longcope, C.2    Zhou, L.F.3    Hui, S.L.4    Peacock, M.5    Johnston, C.C.6
  • 43
    • 0034521393 scopus 로고    scopus 로고
    • Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men
    • Falahati-Nini A, Riggs BL, Atkinson EJ, O'Fallon WM, Eastell R, Khosla S. Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men. J Clin Invest 2000; 106: 1553-1560.
    • (2000) J. Clin. Invest. , vol.106 , pp. 1553-1560
    • Falahati-Nini, A.1    Riggs, B.L.2    Atkinson, E.J.3    O'Fallon, W.M.4    Eastell, R.5    Khosla, S.6
  • 44
    • 0033678137 scopus 로고    scopus 로고
    • Differential expression of estrogen receptor alpha and beta immunoreactivity in the human supraoptic nucleus in relation to sex and aging
    • Ishunina TA, Kruijver FP, Balesar R, Swaab DF. Differential expression of estrogen receptor alpha and beta immunoreactivity in the human supraoptic nucleus in relation to sex and aging. J Clin Endocrinol Metab 2000; 85: 3283-3291.
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 3283-3291
    • Ishunina, T.A.1    Kruijver, F.P.2    Balesar, R.3    Swaab, D.F.4
  • 46
    • 0028824323 scopus 로고
    • Effects of age on messenger-RNA expression of glucocorticoid thyroid-hormone androgen and estrogen-receptors in postmortem human hippocampus
    • Tohgi H, Utsugisawa K, Yamagata M, Yoshimura M. Effects of age on messenger-RNA expression of glucocorticoid, thyroid-hormone, androgen, and estrogen-receptors in postmortem human hippocampus. Brain Res 1995; 700: 245-253.
    • (1995) Brain Res. , vol.700 , pp. 245-253
    • Tohgi, H.1    Utsugisawa, K.2    Yamagata, M.3    Yoshimura, M.4
  • 47
    • 0029026771 scopus 로고
    • Effects of age and long-term ovariectomy on the estrogen-receptor containing subpopulations of beta-endorphin-immunoreactive neurons in the arcuate nucleus of female C57BL/6J mice
    • Miller MM, Tousignant P, Yang U, Pedvis S, Billiar RB. Effects of age and long-term ovariectomy on the estrogen-receptor containing subpopulations of beta-endorphin-immunoreactive neurons in the arcuate nucleus of female C57BL/6J mice. Neuroendocrinology 1995; 61: 542-551.
    • (1995) Neuroendocrinology , vol.61 , pp. 542-551
    • Miller, M.M.1    Tousignant, P.2    Yang, U.3    Pedvis, S.4    Billiar, R.B.5
  • 49
    • 0032831285 scopus 로고    scopus 로고
    • Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system
    • Post WS, Goldschmidt-Clermont PJ, Wilhide CC, et al. Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system. Cardiovasc Res 1999; 43: 985-991.
    • (1999) Cardiovasc. Res. , vol.43 , pp. 985-991
    • Post, W.S.1    Goldschmidt-Clermont, P.J.2    Wilhide, C.C.3
  • 50
    • 0342468080 scopus 로고    scopus 로고
    • Age and ovariectomy impair both the normalization of mechanical properties and the accretion of mineral by the fracture callus in rats
    • Meyer RA Jr, Tsahakis PJ, Martin DF, Banks DM, Harrow ME, Kiebzak GM. Age and ovariectomy impair both the normalization of mechanical properties and the accretion of mineral by the fracture callus in rats. J Orthop Res 2001; 19: 428-435.
    • (2001) J. Orthop. Res. , vol.19 , pp. 428-435
    • Meyer R.A., Jr.1    Tsahakis, P.J.2    Martin, D.F.3    Banks, D.M.4    Harrow, M.E.5    Kiebzak, G.M.6


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