메뉴 건너뛰기




Volumn 20, Issue SUPPL. 1, 2008, Pages 3-11

A review of tigecycline

Author keywords

Glycylcylines; Mode of action; Tetracyclines; Tigecycline

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AZITHROMYCIN; BETA LACTAM ANTIBIOTIC; CARBAPENEM; CHLORAMPHENICOL; CHLORTETRACYCLINE; COLISTIN; DOXYCYCLINE; ERYTHROMYCIN; IMIPENEM; MACROLIDE; MINOCYCLINE; OXYTETRACYCLINE; PENICILLIN G; POLYPEPTIDE ANTIBIOTIC AGENT; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TETRACYCLINE; TIGECYCLINE;

EID: 57749177153     PISSN: 1120009X     EISSN: None     Source Type: Journal    
DOI: 10.1179/joc.2008.20.supplement-1.3     Document Type: Review
Times cited : (8)

References (86)
  • 1
    • 0034973583 scopus 로고    scopus 로고
    • Tetracycline antibiotics: Mode of action, applications, molecular biology, and epidemiology of bacterial resistance
    • Chopra I. Roberts M. Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol. Mol. Biol. Rev. 2001; 65: 232-260.
    • (2001) Microbiol. Mol. Biol. Rev , vol.65 , pp. 232-260
    • Chopra, I.1    Roberts, M.2
  • 2
    • 24044514016 scopus 로고    scopus 로고
    • Efflux-mediated antimicrobial resistance
    • Poole K. Efflux-mediated antimicrobial resistance. J Antimicrob Chemother 2005; 56: 20-51.
    • (2005) J Antimicrob Chemother , vol.56 , pp. 20-51
    • Poole, K.1
  • 5
    • 22144471145 scopus 로고    scopus 로고
    • Bacterial resistance to antibiotics: Active efflux and reduced uptake
    • Kumar A. Schweizer HP. Bacterial resistance to antibiotics: active efflux and reduced uptake. Adv Drug Deliv Rev 2005; 57: 1486-1513.
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 1486-1513
    • Kumar, A.1    Schweizer, H.P.2
  • 6
    • 20444376938 scopus 로고    scopus 로고
    • Efflux pumps and nosocomial antibiotic resistance: A primer for hospital epidemiologists
    • Hooper DC. Efflux pumps and nosocomial antibiotic resistance: a primer for hospital epidemiologists. Clin Infect Dis 2005; 40: 1811-1817.
    • (2005) Clin Infect Dis , vol.40 , pp. 1811-1817
    • Hooper, D.C.1
  • 7
    • 0028030082 scopus 로고
    • Mechanisms underlying expression of Tn10 encoded tetracycline resistance
    • Hillen W. Berens C. Mechanisms underlying expression of Tn10 encoded tetracycline resistance. Annu Rev Microbiol 1994; 48: 345-369.
    • (1994) Annu Rev Microbiol , vol.48 , pp. 345-369
    • Hillen, W.1    Berens, C.2
  • 8
    • 0002003240 scopus 로고
    • Resistance to the tetracyclines
    • Bryan, L. E, Ed, Academic Press, Orlando, Fl
    • Levy SB (1984). Resistance to the tetracyclines. In Antimicrobial drug resistance. (Bryan, L. E., Ed). Academic Press, Orlando, Fl.
    • (1984) Antimicrobial drug resistance
    • Levy, S.B.1
  • 9
    • 0030029513 scopus 로고    scopus 로고
    • AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants
    • Okusu H, Ma D. Nikaido H. AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants. J Bacteriol 1996; 178: 306-308.
    • (1996) J Bacteriol , vol.178 , pp. 306-308
    • Okusu, H.1    Ma, D.2    Nikaido, H.3
  • 10
    • 0027494050 scopus 로고
    • Multiple antibiotic resistance in Pseudomonas aeruginosa: Evidence for involvement of an efflux operon
    • Poole K, Krebes K, McNally C et al. Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon. J Bacteriol 1993; 175: 7363-7372.
    • (1993) J Bacteriol , vol.175 , pp. 7363-7372
    • Poole, K.1    Krebes, K.2    McNally, C.3
  • 11
    • 0034426126 scopus 로고    scopus 로고
    • Substrate specificities of MexAB-OprM, MexCD-OprJ, and MexXY-oprM efflux pumps in Pseudomonas aeruginosa
    • Masuda N, Sakagawa E, Ohya S et al. Substrate specificities of MexAB-OprM, MexCD-OprJ, and MexXY-oprM efflux pumps in Pseudomonas aeruginosa. Antimicrob Agents Chemother 2000; 44: 3322-3327.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 3322-3327
    • Masuda, N.1    Sakagawa, E.2    Ohya, S.3
  • 12
    • 0035139556 scopus 로고    scopus 로고
    • Cross-resistance between triclosan and antibiotics in Pseudomonas aeruginosa is mediated by multidrug efflux pumps: Exposure of a susceptible mutant strain to triclosan selects nfxB mutants overexpressing MexCD-OprJ
    • Chuanchuen R, Beinlich K, Hoang TT et al. Cross-resistance between triclosan and antibiotics in Pseudomonas aeruginosa is mediated by multidrug efflux pumps: exposure of a susceptible mutant strain to triclosan selects nfxB mutants overexpressing MexCD-OprJ. Antimicrob Agents Chemother 2001; 45: 428-432.
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 428-432
    • Chuanchuen, R.1    Beinlich, K.2    Hoang, T.T.3
  • 13
    • 0344443255 scopus 로고    scopus 로고
    • Ribosomal protection proteins and their mechanism of tetracycline resistance
    • Connell SR, Tracz DM, Nierhaus KH et al. Ribosomal protection proteins and their mechanism of tetracycline resistance. Antimicrob Agents Chemother 2003; 47: 3675-3681.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 3675-3681
    • Connell, S.R.1    Tracz, D.M.2    Nierhaus, K.H.3
  • 14
    • 0026070787 scopus 로고
    • Evidence that a novel tetracycline resistance gene found on two Bacteroides transposons encodes an NADP-requiring oxidoreductase
    • Speer BS, Bedzyk L. Salyers AA. Evidence that a novel tetracycline resistance gene found on two Bacteroides transposons encodes an NADP-requiring oxidoreductase. J Bacteriol 1991; 173: 176-183.
    • (1991) J Bacteriol , vol.173 , pp. 176-183
    • Speer, B.S.1    Bedzyk, L.2    Salyers, A.A.3
  • 15
    • 0029046947 scopus 로고
    • Unconstrained bacterial promiscuity: The Tn916-Tn1545 family of conjugative transposons
    • Clewell DB, Flannagan SE. Jaworski DD. Unconstrained bacterial promiscuity: the Tn916-Tn1545 family of conjugative transposons. Trends Microbiol 1995; 3: 229-236.
    • (1995) Trends Microbiol , vol.3 , pp. 229-236
    • Clewell, D.B.1    Flannagan, S.E.2    Jaworski, D.D.3
  • 16
    • 27644586215 scopus 로고    scopus 로고
    • Fitness cost due to mutations in the 16S rRNA associated with spectinomycin resistance in Chlamydia psittaci 6BC
    • Binet R. Maurelli AT. Fitness cost due to mutations in the 16S rRNA associated with spectinomycin resistance in Chlamydia psittaci 6BC. Antimicrob Agents Chemother 2005; 49: 4455-4464.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 4455-4464
    • Binet, R.1    Maurelli, A.T.2
  • 17
    • 0034331364 scopus 로고    scopus 로고
    • Obligate intracellular bacteria and antibiotic resistance
    • McOrist S. Obligate intracellular bacteria and antibiotic resistance. Trends Microbiol 2000; 8: 483-486.
    • (2000) Trends Microbiol , vol.8 , pp. 483-486
    • McOrist, S.1
  • 19
    • 0027958117 scopus 로고
    • Glycylcyclines. 1. A new generation of potent antibacterial agents through modification of 9-aminotetracyclines
    • Sum PE, Lee VJ, Testa RT et al. Glycylcyclines. 1. A new generation of potent antibacterial agents through modification of 9-aminotetracyclines. J Med Chem. 1994; 37: 184-188.
    • (1994) J Med Chem , vol.37 , pp. 184-188
    • Sum, P.E.1    Lee, V.J.2    Testa, R.T.3
  • 20
    • 0033577725 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationship of novel glycylcycline derivatives leading to the discovery of GAR-936
    • Sum PE, Petersen P. Synthesis and structure-activity relationship of novel glycylcycline derivatives leading to the discovery of GAR-936. Bioorganic Med Chem Lett 1999; 9: 1459-1462.
    • (1999) Bioorganic Med Chem Lett , vol.9 , pp. 1459-1462
    • Sum, P.E.1    Petersen, P.2
  • 21
    • 0027358590 scopus 로고
    • In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclines
    • Testa RT, Petersen PJ, Jacobus NV et al. In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclines. Antimicrob Agents Chemother 1993; 37: 2270-2277.
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 2270-2277
    • Testa, R.T.1    Petersen, P.J.2    Jacobus, N.V.3
  • 22
    • 3042810717 scopus 로고    scopus 로고
    • Comparison of tetracycline and tigecycline binding to ribosomes mapped by dimethylsulphate and drug-directed Fe2+ cleavage of 16S rRNA
    • Bauer G, Berens C, Projan SJ et al. Comparison of tetracycline and tigecycline binding to ribosomes mapped by dimethylsulphate and drug-directed Fe2+ cleavage of 16S rRNA. J Antimicrob Chemother 2004; 53: 592-599.
    • (2004) J Antimicrob Chemother , vol.53 , pp. 592-599
    • Bauer, G.1    Berens, C.2    Projan, S.J.3
  • 23
    • 9544247854 scopus 로고    scopus 로고
    • Glycylcyclines bind to the high-affinity tetracycline ribosomal binding site and evade Tet(M)- and Tet(O)-mediated ribosomal protection
    • Bergeron J, Ammirati M, Danley D et al. Glycylcyclines bind to the high-affinity tetracycline ribosomal binding site and evade Tet(M)- and Tet(O)-mediated ribosomal protection. Antimicrob Agents Chemother 1996; 40: 2226-2228.
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 2226-2228
    • Bergeron, J.1    Ammirati, M.2    Danley, D.3
  • 24
    • 0028275776 scopus 로고
    • Inhibition of protein synthesis occurring on tetracycline-resistant, TetM-protected ribosomes by a novel class of tetracyclines, the glycylcyclines
    • Rasmussen BA, Gluzman Y. Tally FP. Inhibition of protein synthesis occurring on tetracycline-resistant, TetM-protected ribosomes by a novel class of tetracyclines, the glycylcyclines. Antimicrob Agents Chemother. 1994; 38: 1658-1660.
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 1658-1660
    • Rasmussen, B.A.1    Gluzman, Y.2    Tally, F.P.3
  • 25
    • 0028019770 scopus 로고
    • Glycylcyclines. 3.9-Aminodoxycyclinecarboxamides
    • Barden TC, Buckwalter BL, Testa RT et al. "Glycylcyclines". 3.9-Aminodoxycyclinecarboxamides. J Med Chem 1994; 37: 3205-3211.
    • (1994) J Med Chem , vol.37 , pp. 3205-3211
    • Barden, T.C.1    Buckwalter, B.L.2    Testa, R.T.3
  • 26
    • 0033555296 scopus 로고    scopus 로고
    • Crystal structure of the tet repressor in complex with a novel tetracycline, 9-(N,N-dimethylglycylamido)- n-6-demethyl-6-deoxy-tetracycline
    • Orth P, Schnappinger D, Sum PE et al. Crystal structure of the tet repressor in complex with a novel tetracycline, 9-(N,N-dimethylglycylamido)- n-6-demethyl-6-deoxy-tetracycline. J Mol Biol 1999; 285: 455-461.
    • (1999) J Mol Biol , vol.285 , pp. 455-461
    • Orth, P.1    Schnappinger, D.2    Sum, P.E.3
  • 27
    • 12944289673 scopus 로고    scopus 로고
    • AcrAB efflux pump plays a role in decreased susceptibility to tigecycline in Morganella morganii
    • Ruzin A, Keeney D, Bradford PA. AcrAB efflux pump plays a role in decreased susceptibility to tigecycline in Morganella morganii. Antimicrob Agents Chemother 2005; 49: 791-793.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 791-793
    • Ruzin, A.1    Keeney, D.2    Bradford, P.A.3
  • 28
    • 0037417013 scopus 로고    scopus 로고
    • Efflux-mediated resistance to tigecycline (GAR-936) in Pseudomonas aeruginosa PAO1
    • Dean CR, Visalli MA, Projan SJ et al. Efflux-mediated resistance to tigecycline (GAR-936) in Pseudomonas aeruginosa PAO1. Antimicrob Agents Chemother 2003; 47: 972-978.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 972-978
    • Dean, C.R.1    Visalli, M.A.2    Projan, S.J.3
  • 29
    • 57749203076 scopus 로고    scopus 로고
    • Tigecycline, EUCAST clinical MIC breakpoints
    • (2006). Tigecycline - EUCAST clinical MIC breakpoints
  • 30
    • 57749191649 scopus 로고    scopus 로고
    • Tygacil tigecycline, package insert
    • (2006). Tygacil (tigecycline): package insert.
  • 31
    • 24144487712 scopus 로고    scopus 로고
    • Effect of medium age and supplementation with the biocatalytic oxygen-reducing reagent oxyrase on in vitro activities of tigecycline against recent clinical isolates
    • Petersen PJ, Bradford PA. Effect of medium age and supplementation with the biocatalytic oxygen-reducing reagent oxyrase on in vitro activities of tigecycline against recent clinical isolates. Antimicrob Agents Chemother 2005; 49: 3910-3918.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 3910-3918
    • Petersen, P.J.1    Bradford, P.A.2
  • 32
    • 24144445122 scopus 로고    scopus 로고
    • Tigecycline MIC testing by broth dilution requires use of fresh medium or addition of the biocatalytic oxygen-reducing reagent oxyrase to standardize the test method
    • Bradford PA, Petersen PJ, Young M et al. Tigecycline MIC testing by broth dilution requires use of fresh medium or addition of the biocatalytic oxygen-reducing reagent oxyrase to standardize the test method. Antimicrob Agents Chemother 2005; 49: 3903-3909.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 3903-3909
    • Bradford, P.A.1    Petersen, P.J.2    Young, M.3
  • 33
    • 34547621925 scopus 로고    scopus 로고
    • Comparative in vitro antimicrobial activity of tigecycline, a new glycylcycline compound, in freshly prepared medium and quality control
    • Brown SD. Traczewski MM. Comparative in vitro antimicrobial activity of tigecycline, a new glycylcycline compound, in freshly prepared medium and quality control. J Clin Microbiol 2007; 45: 2173-2179.
    • (2007) J Clin Microbiol , vol.45 , pp. 2173-2179
    • Brown, S.D.1    Traczewski, M.M.2
  • 34
    • 0033954848 scopus 로고    scopus 로고
    • Antimicrobial activity and spectrum of the new glycylcycline, GAR-936 tested against 1,203 recent clinical bacterial isolates
    • Gales AC, Jones RN. Antimicrobial activity and spectrum of the new glycylcycline, GAR-936 tested against 1,203 recent clinical bacterial isolates. Diagn Microbiol Infect Dis 2000; 36: 19-36.
    • (2000) Diagn Microbiol Infect Dis , vol.36 , pp. 19-36
    • Gales, A.C.1    Jones, R.N.2
  • 35
    • 14744267574 scopus 로고    scopus 로고
    • Influence of transcriptional activator RamA on expression of multidrug efflux pump AcrAB and tigecycline susceptibility in Klebsiella pneumoniae
    • Ruzin A, Visalli MA, Keeney D et al. Influence of transcriptional activator RamA on expression of multidrug efflux pump AcrAB and tigecycline susceptibility in Klebsiella pneumoniae. Antimicrob Agents Chemother 2005; 49: 1017-1022.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 1017-1022
    • Ruzin, A.1    Visalli, M.A.2    Keeney, D.3
  • 36
    • 0037309748 scopus 로고    scopus 로고
    • AcrAB multidrug efflux pump is associated with reduced levels of susceptibility to tigecycline (GAR-936) in Proteus mirabilis
    • Visalli MA, Murphy E, Projan SJ et al. AcrAB multidrug efflux pump is associated with reduced levels of susceptibility to tigecycline (GAR-936) in Proteus mirabilis. Antimicrob Agents Chemother 2003; 47: 665-669.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 665-669
    • Visalli, M.A.1    Murphy, E.2    Projan, S.J.3
  • 37
    • 0033926236 scopus 로고    scopus 로고
    • In vitro activities of the glycylcycline GAR-936 against Gram-positive bacteria
    • Boucher HW, Wennersten CB. Eliopoulos GM. In vitro activities of the glycylcycline GAR-936 against Gram-positive bacteria. Antimicrob Agents Chemother 2000; 44: 2225-2229.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 2225-2229
    • Boucher, H.W.1    Wennersten, C.B.2    Eliopoulos, G.M.3
  • 38
    • 6744248904 scopus 로고    scopus 로고
    • Two-year assessment of the pathogen frequency and antimicrobial resistance patterns among organisms isolated from skin and soft tissue infections in Latin American hospitals: Results from the SENTRY antimicrobial surveillance program, 1997-98. SENTRY Study Group
    • Gales A, Jones R, Pfaller M. Two-year assessment of the pathogen frequency and antimicrobial resistance patterns among organisms isolated from skin and soft tissue infections in Latin American hospitals: results from the SENTRY antimicrobial surveillance program, 1997-98. SENTRY Study Group. Int J Infect Dis 2000; 4.
    • (2000) Int J Infect Dis , pp. 4
    • Gales, A.1    Jones, R.2    Pfaller, M.3
  • 39
    • 7544231416 scopus 로고    scopus 로고
    • Tigecycline: A first in class glycylcycline
    • 26
    • Bradford PA. Tigecycline: a first in class glycylcycline. Clin Microiol News 2004; 26: 163-168.
    • (2004) Clin Microiol News , pp. 163-168
    • Bradford, P.A.1
  • 40
    • 0033818355 scopus 로고    scopus 로고
    • Preclinical pharmacology of GAR-936, a novel glycylcycline antibacterial agent
    • discussion 224S-228S
    • Projan SJ. Preclinical pharmacology of GAR-936, a novel glycylcycline antibacterial agent. Pharmacotherapy 2000; 20: 219S-223S; discussion 224S-228S.
    • (2000) Pharmacotherapy , vol.20
    • Projan, S.J.1
  • 41
    • 0036167886 scopus 로고    scopus 로고
    • In vitro activities of tigecycline (GAR-936) against recently isolated clinical bacteria in Spain
    • Betriu C, Rodriguez-Avial I, Sanchez BA et al. In vitro activities of tigecycline (GAR-936) against recently isolated clinical bacteria in Spain. Antimicrob Agents Chemother. 2002; 46: 892-895.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 892-895
    • Betriu, C.1    Rodriguez-Avial, I.2    Sanchez, B.A.3
  • 42
    • 0036850660 scopus 로고    scopus 로고
    • Comparative in vitro activities of tigecycline (GAR-936) and other antimicrobial agents against Stenotrophomonas maltophilia
    • Betriu C, Rodriguez-Avial I, Sanchez BA et al. Comparative in vitro activities of tigecycline (GAR-936) and other antimicrobial agents against Stenotrophomonas maltophilia. J Antimicrob Chemother 2002; 50: 758-759.
    • (2002) J Antimicrob Chemother , vol.50 , pp. 758-759
    • Betriu, C.1    Rodriguez-Avial, I.2    Sanchez, B.A.3
  • 43
    • 0034807550 scopus 로고    scopus 로고
    • In vitro antimicrobial activity of GAR-936 tested against antibiotic-resistant Gram-positive blood stream infection isolates and strains producing extended-spectrum beta-lactamases
    • Biedenbach DJ, Beach ML, Jones RN. In vitro antimicrobial activity of GAR-936 tested against antibiotic-resistant Gram-positive blood stream infection isolates and strains producing extended-spectrum beta-lactamases. Diagn Microbiol Infect Dis 2001; 40: 173-177.
    • (2001) Diagn Microbiol Infect Dis , vol.40 , pp. 173-177
    • Biedenbach, D.J.1    Beach, M.L.2    Jones, R.N.3
  • 44
    • 0034158460 scopus 로고    scopus 로고
    • In-vitro susceptibility of anaerobic bacteria to GAR-936, a new glycylcycline
    • Edlund C, Nord CE. In-vitro susceptibility of anaerobic bacteria to GAR-936, a new glycylcycline. Clin Microbiol Infect 2000; 6: 159-163.
    • (2000) Clin Microbiol Infect , vol.6 , pp. 159-163
    • Edlund, C.1    Nord, C.E.2
  • 45
    • 0033807573 scopus 로고    scopus 로고
    • Comparative in vitro activities of GAR-936 against aerobic and anaerobic animal and human bite wound pathogens
    • Goldstein EJC, Citron DM, Merriam CV et al. Comparative in vitro activities of GAR-936 against aerobic and anaerobic animal and human bite wound pathogens. Antimicrob Agents Chemother 2000; 44: 2747-2751.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 2747-2751
    • Goldstein, E.J.C.1    Citron, D.M.2    Merriam, C.V.3
  • 46
    • 0036121065 scopus 로고    scopus 로고
    • Antibiotic resistance among clinical isolates of Acinetobacter in the UK, and in vitro evaluation of tigecycline (GAR-936)
    • Henwood SJ, Gatward T, Warner M et al. Antibiotic resistance among clinical isolates of Acinetobacter in the UK, and in vitro evaluation of tigecycline (GAR-936). J Antimicrob Chemother 2002; 49: 479-487.
    • (2002) J Antimicrob Chemother , vol.49 , pp. 479-487
    • Henwood, S.J.1    Gatward, T.2    Warner, M.3
  • 47
    • 0036896559 scopus 로고    scopus 로고
    • Antimicrobial activity of tigecycline (GAR-936) against Enterococcus faecium and Staphylococcus aureus used alone and in combination
    • Mercier R-C, Kennedy C. Meadows C. Antimicrobial activity of tigecycline (GAR-936) against Enterococcus faecium and Staphylococcus aureus used alone and in combination. Pharmacotherapy 2002; 22: 1517-1523.
    • (2002) Pharmacotherapy , vol.22 , pp. 1517-1523
    • Mercier, R.-C.1    Kennedy, C.2    Meadows, C.3
  • 48
    • 0037229072 scopus 로고    scopus 로고
    • Activities of the glycylcycline tigecycline (GAR-936) against 1,924 recent European clinical bacterial isolates
    • Milatovic D, Schmitz F-J, Verhoef J et al. Activities of the glycylcycline tigecycline (GAR-936) against 1,924 recent European clinical bacterial isolates. Antimicrob Agents Chemother 2003; 47: 400-404.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 400-404
    • Milatovic, D.1    Schmitz, F.-J.2    Verhoef, J.3
  • 49
    • 0035991964 scopus 로고    scopus 로고
    • In vitro and in vivo activities of tigecycline (GAR-936), daptomycin, and comparative antimicrobial agents against glycopeptide-intermediate Staphylococcus aureus and other resistant Gram-positive pathogens
    • Petersen PJ, Bradford PA, Weiss WJ et al. In vitro and in vivo activities of tigecycline (GAR-936), daptomycin, and comparative antimicrobial agents against glycopeptide-intermediate Staphylococcus aureus and other resistant Gram-positive pathogens. Antimicrob Agents Chemother 2002; 46: 2595-2601.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 2595-2601
    • Petersen, P.J.1    Bradford, P.A.2    Weiss, W.J.3
  • 50
    • 0032918653 scopus 로고    scopus 로고
    • In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936)
    • Petersen PJ, Jacobus NV, Weiss WJ et al. In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936). Antimicrob Agents Chemother 1999; 43: 738-744.
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 738-744
    • Petersen, P.J.1    Jacobus, N.V.2    Weiss, W.J.3
  • 51
    • 0036175430 scopus 로고    scopus 로고
    • In vitro activity of 11 antimicrobial agents, including gatifloxacin and GAR936, tested against clinical isolates of Mycobacterium marinum
    • Rhomberg PR, Jones RN. In vitro activity of 11 antimicrobial agents, including gatifloxacin and GAR936, tested against clinical isolates of Mycobacterium marinum. Diagn Microbiol Infect Dis 2002; 42: 145-147.
    • (2002) Diagn Microbiol Infect Dis , vol.42 , pp. 145-147
    • Rhomberg, P.R.1    Jones, R.N.2
  • 52
    • 0033843634 scopus 로고    scopus 로고
    • In vitro activity of GAR-936 against Chlamydia pneumoniae and Chlamydia trachomatis
    • Roblin PM, Hammerschlag MR. In vitro activity of GAR-936 against Chlamydia pneumoniae and Chlamydia trachomatis, Int J Antimicrob Agents 2000; 16: 61-63.
    • (2000) Int J Antimicrob Agents , vol.16 , pp. 61-63
    • Roblin, P.M.1    Hammerschlag, M.R.2
  • 53
    • 0038262639 scopus 로고    scopus 로고
    • In vitro activity of tigecycline (GAR-936), a novel glycylcycline, against vancomycin-resistant enterococci and staphylococci with diminished susceptibility to glycopeptides
    • Cercenado E, Cercenado S, Gomez JA, Bouza E. In vitro activity of tigecycline (GAR-936), a novel glycylcycline, against vancomycin-resistant enterococci and staphylococci with diminished susceptibility to glycopeptides. J Antimicrob Chemother 2003; 52: 138-139.
    • (2003) J Antimicrob Chemother , vol.52 , pp. 138-139
    • Cercenado, E.1    Cercenado, S.2    Gomez, J.A.3    Bouza, E.4
  • 54
    • 0037764675 scopus 로고    scopus 로고
    • Antimicrobial resistance in Haemophilus influenzae and Moraxella catarrhalis respiratory tract isolates: Results of the Canadian Respiratory Organism Susceptibility Study, 1997 to 2002
    • Zhanel GG, Palatnick L, Nichol KA et al. Antimicrobial resistance in Haemophilus influenzae and Moraxella catarrhalis respiratory tract isolates: results of the Canadian Respiratory Organism Susceptibility Study, 1997 to 2002. Antimicrob Agents Chemother 2003; 47: 1875-1881.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 1875-1881
    • Zhanel, G.G.1    Palatnick, L.2    Nichol, K.A.3
  • 55
    • 0038441345 scopus 로고    scopus 로고
    • Antimicrobial resistance in respiratory tract Streptococcus pneumoniae isolates: Results of the Canadian Respiratory Organism Susceptibility Study, 1997 to 2002
    • Zhanel GG, Palatnick L, Nichol KA et al. Antimicrobial resistance in respiratory tract Streptococcus pneumoniae isolates: results of the Canadian Respiratory Organism Susceptibility Study, 1997 to 2002. Antimicrob Agents Chemother 2003; 47: 1867-1874.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 1867-1874
    • Zhanel, G.G.1    Palatnick, L.2    Nichol, K.A.3
  • 56
    • 0036783671 scopus 로고    scopus 로고
    • Comparison of the in vitro activity of the glycylcycline tigecycline (formerly GAR-936) with those of tetracycline, minocycline, and doxycycline against isolates of Nontuberculous mycobacteria
    • Wallace Jr RJ, Brown-Elliot BA, Crist CJ et al. Comparison of the in vitro activity of the glycylcycline tigecycline (formerly GAR-936) with those of tetracycline, minocycline, and doxycycline against isolates of Nontuberculous mycobacteria. Antimicrob Agents Chemother 2002; 46: 3164-3167.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 3164-3167
    • Wallace Jr, R.J.1    Brown-Elliot, B.A.2    Crist, C.J.3
  • 57
    • 0034065855 scopus 로고    scopus 로고
    • Antipneumococcal activity of GAR 936, a new glycylcycline, compared to those of nine other agents against penicillin susceptible and resistant pneumococci
    • Hoellman DB, Pankuch GA, Jacobs MR et al. Antipneumococcal activity of GAR 936, a new glycylcycline, compared to those of nine other agents against penicillin susceptible and resistant pneumococci. Antimicrob Agents Chemother 2000; 44: 1085-1088.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 1085-1088
    • Hoellman, D.B.1    Pankuch, G.A.2    Jacobs, M.R.3
  • 58
    • 0041767444 scopus 로고    scopus 로고
    • in vitro activities of tigecycline (GAR-936) and 12 other antimicrobial agents against 90 Eikenella corrodens clinical isolates
    • Cercenado E, Cercenado S, Bouza E. in vitro activities of tigecycline (GAR-936) and 12 other antimicrobial agents against 90 Eikenella corrodens clinical isolates. Antimicrob Agents Chemother 2003; 47: 2644-2645.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 2644-2645
    • Cercenado, E.1    Cercenado, S.2    Bouza, E.3
  • 59
    • 34249708519 scopus 로고    scopus 로고
    • Keeney D, Ruzin A, Bradford PA. RamA, a transcriptional regulator, and AcrAB, an RND-type efflux pump, are associated with decreased susceptibility to tigecycline in Enterobacter cloacae. Microb Drug Resist 2007; 13: 1-6.
    • Keeney D, Ruzin A, Bradford PA. RamA, a transcriptional regulator, and AcrAB, an RND-type efflux pump, are associated with decreased susceptibility to tigecycline in Enterobacter cloacae. Microb Drug Resist 2007; 13: 1-6.
  • 60
    • 34249977996 scopus 로고    scopus 로고
    • High tigecycline resistance in multidrug-resistant Acinetobacter baumannii
    • Navon-Venezia S, Leavitt A. Carmeli Y. High tigecycline resistance in multidrug-resistant Acinetobacter baumannii. J Antimicrob Chemother 2007; 59: 772-774.
    • (2007) J Antimicrob Chemother , vol.59 , pp. 772-774
    • Navon-Venezia, S.1    Leavitt, A.2    Carmeli, Y.3
  • 61
    • 7244238100 scopus 로고    scopus 로고
    • Activity of tigecycline (GAR-936) against Acinetobacter baumannii strains, including those resistant to imipenem
    • Pachón-Ibáñez ME, Jiménez-Mejías ME, Pichardo C et al. Activity of tigecycline (GAR-936) against Acinetobacter baumannii strains, including those resistant to imipenem. Antimicrob Agents Chemother 2004; 48: 4479-4481.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 4479-4481
    • Pachón-Ibáñez, M.E.1    Jiménez-Mejías, M.E.2    Pichardo, C.3
  • 62
    • 34347375642 scopus 로고    scopus 로고
    • Comparative in vitro activities of tigecycline and 11 other antimicrobial agents against 215 epidemiologically defined multidrug-resistant Acinetobacter baumannii isolates
    • Seifert H, Stefanik D, Wisplinghoff H. Comparative in vitro activities of tigecycline and 11 other antimicrobial agents against 215 epidemiologically defined multidrug-resistant Acinetobacter baumannii isolates. J Antimicrob Chemother 2006; 58: 1099-1100.
    • (2006) J Antimicrob Chemother , vol.58 , pp. 1099-1100
    • Seifert, H.1    Stefanik, D.2    Wisplinghoff, H.3
  • 63
    • 34248189094 scopus 로고    scopus 로고
    • Occurrence of carbapenem-resistant Acinetobacter baumannii clones at multiple hospitals in London and Southeast England
    • Coelho JM, Turton JF, Kaufmann ME et al. Occurrence of carbapenem-resistant Acinetobacter baumannii clones at multiple hospitals in London and Southeast England. J Clin Microbiol 2006; 44: 3623-3627.
    • (2006) J Clin Microbiol , vol.44 , pp. 3623-3627
    • Coelho, J.M.1    Turton, J.F.2    Kaufmann, M.E.3
  • 64
    • 33748700252 scopus 로고    scopus 로고
    • Multicity outbreak of carbapenem-resistant Acinetobacter baumannii isolates producing the carbapenemase OXA-40
    • Lolans K, Rice TW, Munoz-Price LS et al. Multicity outbreak of carbapenem-resistant Acinetobacter baumannii isolates producing the carbapenemase OXA-40. Antimicrob Agents Chemother 2006; 50: 2941-2945.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 2941-2945
    • Lolans, K.1    Rice, T.W.2    Munoz-Price, L.S.3
  • 65
    • 0242437814 scopus 로고    scopus 로고
    • Antibacterial susceptibility of a vancomycin-resistant Staphylococcus aureus strain isolated at the Hershey Medical Center
    • Bozdogan B, Esel D, Whitener C et al. Antibacterial susceptibility of a vancomycin-resistant Staphylococcus aureus strain isolated at the Hershey Medical Center. J Antimicrob Chemother 2003; 52: 864-868.
    • (2003) J Antimicrob Chemother , vol.52 , pp. 864-868
    • Bozdogan, B.1    Esel, D.2    Whitener, C.3
  • 66
    • 0034863518 scopus 로고    scopus 로고
    • Kenny GE, Cartwright FD. Susceptibilities of Mycoplasma hominis, M. pneumoniae, and Ureaplasma urealyticum to GAR-936, dalfopristin, dirithromycin, evernimicin, gatifloxacin, linezolid, moxifloxacin, quinupristin-dalfopristin, and telithromycin compared to their susceptibilities to reference macrolides, tetracyclines, and quinolones. Antimicrob Agents Chemother 2001; 45: 2604-2608.
    • Kenny GE, Cartwright FD. Susceptibilities of Mycoplasma hominis, M. pneumoniae, and Ureaplasma urealyticum to GAR-936, dalfopristin, dirithromycin, evernimicin, gatifloxacin, linezolid, moxifloxacin, quinupristin-dalfopristin, and telithromycin compared to their susceptibilities to reference macrolides, tetracyclines, and quinolones. Antimicrob Agents Chemother 2001; 45: 2604-2608.
  • 67
    • 0037311180 scopus 로고    scopus 로고
    • Activities of tigecycline (GAR-936) against Legionella pneumophila in vitro and in guinea pigs with L. pneumophila pneumonia
    • Edelstein PH, Weiss WJ, Edelstein MA. Activities of tigecycline (GAR-936) against Legionella pneumophila in vitro and in guinea pigs with L. pneumophila pneumonia. Antimicrob Agents Chemother. 2003; 47: 533-540.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 533-540
    • Edelstein, P.H.1    Weiss, W.J.2    Edelstein, M.A.3
  • 68
    • 34250861565 scopus 로고    scopus 로고
    • AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex
    • Ruzin A, Keeney D, Bradford PA. AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex. J Antimicrob Chemother 2007; 59: 1001-1004.
    • (2007) J Antimicrob Chemother , vol.59 , pp. 1001-1004
    • Ruzin, A.1    Keeney, D.2    Bradford, P.A.3
  • 69
    • 37549027624 scopus 로고    scopus 로고
    • MarA-mediated overexpression of the AcrAB efflux pump results in decreased susceptibility to tigecycline in Escherichia coli
    • Keeney D, Ruzin A, McAleese F et al. MarA-mediated overexpression of the AcrAB efflux pump results in decreased susceptibility to tigecycline in Escherichia coli. J Antimicrob Chemother 2008; 61: 46-53.
    • (2008) J Antimicrob Chemother , vol.61 , pp. 46-53
    • Keeney, D.1    Ruzin, A.2    McAleese, F.3
  • 70
    • 2542444502 scopus 로고    scopus 로고
    • Effects of efflux transporter genes on susceptibility of Escherichia coli to tigecycline (GAR-936)
    • Hirata T, Saito A, Nishino K et al. Effects of efflux transporter genes on susceptibility of Escherichia coli to tigecycline (GAR-936). Antimicrob Agents Chemother 2004; 48: 2179-2184.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 2179-2184
    • Hirata, T.1    Saito, A.2    Nishino, K.3
  • 71
    • 33845892102 scopus 로고    scopus 로고
    • Acinetobacter baumannii bloodstream infection while receiving tigecycline: A cautionary report
    • Peleg AY, Potoski BA, Rea R et al. Acinetobacter baumannii bloodstream infection while receiving tigecycline: a cautionary report. J Antimicrob Chemother 2007; 59: 128-131.
    • (2007) J Antimicrob Chemother , vol.59 , pp. 128-131
    • Peleg, A.Y.1    Potoski, B.A.2    Rea, R.3
  • 72
    • 34547468409 scopus 로고    scopus 로고
    • Rapid development of Acinetobacter baumannii resistance to tigecycline
    • Reid GE, Grim SA, Aldeza CA et al. Rapid development of Acinetobacter baumannii resistance to tigecycline. Pharmacotherapy 2007; 27: 1198-1201.
    • (2007) Pharmacotherapy , vol.27 , pp. 1198-1201
    • Reid, G.E.1    Grim, S.A.2    Aldeza, C.A.3
  • 73
    • 23644460187 scopus 로고    scopus 로고
    • Pharmacokinetic/ pharmacodynamic profile for tigecycline-a new glycylcycline antimicrobial agent
    • Meagher AK, Ambrose PG, Grasela TH et al. Pharmacokinetic/ pharmacodynamic profile for tigecycline-a new glycylcycline antimicrobial agent. Diagn Microbiol Infect Dis 2005; 52: 165-171.
    • (2005) Diagn Microbiol Infect Dis , vol.52 , pp. 165-171
    • Meagher, A.K.1    Ambrose, P.G.2    Grasela, T.H.3
  • 74
    • 11244353707 scopus 로고    scopus 로고
    • Pharmacokinetics of tigecycline after single and multiple doses in healthy subjects
    • Muralidharan G, Micalizzi M, Speth J et al. Pharmacokinetics of tigecycline after single and multiple doses in healthy subjects. Antimicrob Agents Chemother 2005; 49: 220-229.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 220-229
    • Muralidharan, G.1    Micalizzi, M.2    Speth, J.3
  • 75
    • 34548089728 scopus 로고    scopus 로고
    • Metabolism, excretion, and pharmacokinetics of [14C]tigecycline, a first-in-class glycylcycline antibiotic, after intravenous infusion to healthy male subjects
    • Hoffmann M, DeMaio W, Jordan RA et al. Metabolism, excretion, and pharmacokinetics of [14C]tigecycline, a first-in-class glycylcycline antibiotic, after intravenous infusion to healthy male subjects. Drug Metab Dispos 2007; 35: 1543-1553.
    • (2007) Drug Metab Dispos , vol.35 , pp. 1543-1553
    • Hoffmann, M.1    DeMaio, W.2    Jordan, R.A.3
  • 76
    • 54049093688 scopus 로고    scopus 로고
    • Tigecycline pharmacokinetic/pharmacodynamic update
    • MacGowan AP. Tigecycline pharmacokinetic/pharmacodynamic update. J Antimicrob Chemother 2008; 62 Suppl 1: i11-16.
    • (2008) J Antimicrob Chemother , Issue.SUPPL. 1 , pp. 62
    • MacGowan, A.P.1
  • 77
    • 0034075749 scopus 로고    scopus 로고
    • in vivo pharmacodynamic activities of two glycylcyclines (GAR-936 and WAY 152,288) against various Gram-positive and Gram-negative bacteria
    • van Ogtrop ML, Andes D, Stamstad TJ et al. in vivo pharmacodynamic activities of two glycylcyclines (GAR-936 and WAY 152,288) against various Gram-positive and Gram-negative bacteria. Antimicrob. Agents Chemother. 2000; 44: 943-949.
    • (2000) Antimicrob. Agents Chemother , vol.44 , pp. 943-949
    • van Ogtrop, M.L.1    Andes, D.2    Stamstad, T.J.3
  • 78
    • 19544371022 scopus 로고    scopus 로고
    • Steady-state serum and intrapulmonary pharmacokinetics and pharmacodynamics of tigecycline
    • Conte JE, Jr., Golden JA, Kelly MG et al. Steady-state serum and intrapulmonary pharmacokinetics and pharmacodynamics of tigecycline. Int J Antimicrob Agents 2005; 25: 523-529.
    • (2005) Int J Antimicrob Agents , vol.25 , pp. 523-529
    • Conte Jr., J.E.1    Golden, J.A.2    Kelly, M.G.3
  • 79
    • 34250164635 scopus 로고    scopus 로고
    • Exposure-response analyses of tigecycline efficacy in patients with complicated skin and skin-structure infections
    • Meagher AK, Passarell JA, Cirincione BB et al. Exposure-response analyses of tigecycline efficacy in patients with complicated skin and skin-structure infections. Antimicrob Agents Chemother 2007; 51: 1939-1945.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 1939-1945
    • Meagher, A.K.1    Passarell, J.A.2    Cirincione, B.B.3
  • 80
    • 23844486729 scopus 로고    scopus 로고
    • The efficacy and safety of tigecycline for the treatment of complicated intra-abdominal infections: Analysis of pooled clinical trial data
    • Babinchak T, Ellis-Grosse E, Dartois N et al. The efficacy and safety of tigecycline for the treatment of complicated intra-abdominal infections: analysis of pooled clinical trial data. Clin Infect Dis 2005; 41 Suppl 5: S354-367.
    • (2005) Clin Infect Dis , vol.41 , Issue.SUPPL. 5
    • Babinchak, T.1    Ellis-Grosse, E.2    Dartois, N.3
  • 81
    • 23844479577 scopus 로고    scopus 로고
    • The efficacy and safety of tigecycline in the treatment of skin and skin-structure infections: Results of 2 double-blind phase 3 comparison studies with vancomycin-aztreonam
    • Ellis-Grosse EJ, Babinchak T, Dartois N et al. The efficacy and safety of tigecycline in the treatment of skin and skin-structure infections: results of 2 double-blind phase 3 comparison studies with vancomycin-aztreonam. Clin Infect Dis 2005; 41 Suppl 5: S341-353.
    • (2005) Clin Infect Dis , vol.41 , Issue.SUPPL. 5
    • Ellis-Grosse, E.J.1    Babinchak, T.2    Dartois, N.3
  • 82
    • 34250335092 scopus 로고    scopus 로고
    • Tigecycline does not induce proliferation or cytotoxin production by epidemic Clostridium difficile strains in a human gut model
    • Baines SD, Saxton K, Freeman J et al. Tigecycline does not induce proliferation or cytotoxin production by epidemic Clostridium difficile strains in a human gut model. J Antimicrob Chemother 2006; 58: 1062-1065.
    • (2006) J Antimicrob Chemother , vol.58 , pp. 1062-1065
    • Baines, S.D.1    Saxton, K.2    Freeman, J.3
  • 83
    • 33749525173 scopus 로고    scopus 로고
    • Effect of tigecycline on normal oropharyngeal and intestinal microflora
    • Nord CE, Sillerstrom E, Wahlund E. Effect of tigecycline on normal oropharyngeal and intestinal microflora. Antimicrob Agents Chemother 2006; 50: 3375-3380.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 3375-3380
    • Nord, C.E.1    Sillerstrom, E.2    Wahlund, E.3
  • 84
    • 34548537873 scopus 로고    scopus 로고
    • Evidence for low risk of Clostridium difficile infection associated with tigecycline
    • Wilcox MH. Evidence for low risk of Clostridium difficile infection associated with tigecycline. Clin Microbiol Infect 2007; 13: 949-952.
    • (2007) Clin Microbiol Infect , vol.13 , pp. 949-952
    • Wilcox, M.H.1
  • 85
    • 4444220133 scopus 로고    scopus 로고
    • Bergstrom CT, Lo M.Lipsitch M. Ecological theory suggests that antimicrobial cycling will not reduce antimicrobial resistance in hospitals. Proc Natl Acad Sci USA 2004; 101: 13285-13290.
    • Bergstrom CT, Lo M.Lipsitch M. Ecological theory suggests that antimicrobial cycling will not reduce antimicrobial resistance in hospitals. Proc Natl Acad Sci USA 2004; 101: 13285-13290.
  • 86
    • 34547102011 scopus 로고    scopus 로고
    • A novel antibiotic bone assay by liquid chromatography/tandem mass spectrometry for quantitation of tigecycline in rat bone
    • Ji AJ, Saunders JP, Wadgaonkar ND et al. A novel antibiotic bone assay by liquid chromatography/tandem mass spectrometry for quantitation of tigecycline in rat bone. J Pharm Biomed Anal 2007; 44: 970-979.
    • (2007) J Pharm Biomed Anal , vol.44 , pp. 970-979
    • Ji, A.J.1    Saunders, J.P.2    Wadgaonkar, N.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.