In vivo pharmacodynamic activities of two glycylcyclines (GAR-936 and WAY 152,288) against various gram-positive and gram-negative bacteria

Antimicrobial Agents and Chemotherapy

Volumn 44, Issue 4, 2000, Pages 943-949

  Van Ogtrop, M L ^a,b   Andes, D ^c,d   Stamstad, T J ^c   Conklin, B ^c   Weiss, W J ^e   Craig, W A ^c,d   Vesga, O ^c,d  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c WILLIAM S MIDDLETON MEMORIAL VETERANS HOSPITAL   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

^e PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; GLYCYLCYCLINE DERIVATIVE; TIGECYCLINE; UNCLASSIFIED DRUG; WAY 152288;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BACTERIAL INFECTION; BACTERIOSTASIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG ELIMINATION; DRUG PROTEIN BINDING; ESCHERICHIA COLI; FEMALE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; IN VIVO STUDY; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PHARMACODYNAMICS; POSTANTIBIOTIC EFFECT; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

ANIMALS; ANTI-BACTERIAL AGENTS; AREA UNDER CURVE; COLONY COUNT, MICROBIAL; FEMALE; GRAM-NEGATIVE BACTERIAL INFECTIONS; GRAM-POSITIVE BACTERIAL INFECTIONS; HALF-LIFE; MICE; MICE, INBRED ICR; MINOCYCLINE; MUSCLE, SKELETAL; NEUTROPENIA; SURVIVAL ANALYSIS;

EID: 0034075749     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.4.943-949.2000     Document Type: Article

References (15)

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