Metabolism, excretion, and pharmacokinetics of [14C]tigecycline, a first-in-class glycylcycline antibiotic, after intravenous infusion to healthy male subjects

Drug Metabolism and Disposition

Volumn 35, Issue 9, 2007, Pages 1543-1553

  Hoffmann, Matthew ^a   DeMaio, William ^a   Jordan, Ronald A ^a   Talaat, Rasmy ^a   Harper, Dawn ^a   Speth, John ^a   Scatina, JoAnn ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; GLUCURONIDE; GLUCURONIDE METABOLITE; MINOCYCLINE; N ACETYL 9 AMINOMINOCYCLINE; RADIOPHARMACEUTICAL AGENT; TIGECYCLINE; TIGECYCLINE C 14; UNCLASSIFIED DRUG;

ADULT; ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; DRUG ACETYLATION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG FECES LEVEL; DRUG HALF LIFE; DRUG METABOLISM; DRUG URINE LEVEL; GLUCURONIDATION; HUMAN; HYDROLYSIS; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RADIOACTIVITY; VOLUNTEER;

ACETYLATION; ADULT; ANTI-BACTERIAL AGENTS; AREA UNDER CURVE; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; FECES; GLUCURONIDES; HALF-LIFE; HUMANS; INFUSIONS, INTRAVENOUS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MINOCYCLINE;

EID: 34548089728     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.015735     Document Type: Article

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