Comparison of tetracycline and tigecycline binding to ribosomes mapped by dimethylsulphate and drug-directed Fe2+ cleavage of 16S rRNA

Journal of Antimicrobial Chemotherapy

Volumn 53, Issue 4, 2004, Pages 592-599

  Bauer, Gesine ^a   Berens, Christian ^a   Projan, Steven J ^b   Hillen, Wolfgang ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b PFIZER INC   (United States)

Author keywords

Glycylcyclines; Mode of action; Tetracycline resistance

Indexed keywords

ANTIBIOTIC AGENT; DIMETHYL SULFATE; FERROUS ION; HYDROXYL RADICAL; MAGNESIUM ION; RNA; RNA 16S; TETRACYCLINE; TIGECYCLINE;

ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BINDING SITE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; ESCHERICHIA COLI; GENE MUTATION; MUTATIONAL ANALYSIS; NONHUMAN; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RIBOSOME; RIBOSOME SUBUNIT; RNA CLEAVAGE; STRUCTURE ANALYSIS;

BASE SEQUENCE; BINDING SITES; FERROUS COMPOUNDS; MINOCYCLINE; RIBOSOMES; RNA, RIBOSOMAL, 16S; SULFURIC ACID ESTERS; TETRACYCLINE;

EID: 3042810717     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkh125     Document Type: Article

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