Fitness cost due to mutations in the 16S rRNA associated with spectinomycin resistance in Chlamydia psittaci 6BC

Antimicrobial Agents and Chemotherapy

Volumn 49, Issue 11, 2005, Pages 4455-4464

  Binet, Rachel ^a   Maurelli, Anthony T ^a,b  

^a Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; GENTAMICIN; KANAMYCIN; RNA 16S; SPECTINOMYCIN; TETRACYCLINE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; BACTERIUM CULTURE; CHLAMYDIASIS; CHLAMYDOPHILA PSITTACI; CONTROLLED STUDY; GENE MUTATION; GENOTYPE; LIFE CYCLE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; WILD TYPE;

ALLELES; ANTI-BACTERIAL AGENTS; CHLAMYDOPHILA PSITTACI; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; MUTATION; PHENOTYPE; PLASMIDS; RNA, RIBOSOMAL, 16S; SPECTINOMYCIN; TETRACYCLINE RESISTANCE;

EID: 27644586215     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.49.11.4455-4464.2005     Document Type: Article

References (50)

1. Adams, E. J., D. S. LaMontagne, A. R. Johnston, J. M. Pimenta, K. A. Fenton, and W. J. Edmunds. 2004. Modelling the Healthcare costs of an opportunistic chlamydia screening programme. Sex. Transm. Infect. 80:363-370.
2. Anderson, J. L. 2005. Infection, antibiotics, and atherothrombosis-end of the road or new beginnings? N. Engl. J. Med. 352:1706-1709.
3. Andersson, D. I. 2003. Persistence of antibiotic resistant bacteria. Curr. Opin. Microbiol. 6:452-456.
4. Andersson, D. I., and B. R. Levin. 1999. The biological cost of antibiotic resistance. Curr. Opin. Microbiol. 2:489-493.
5. Asai, T., D. Zaporojets, C. Squires, and C. L. Squires. 1999. An Escherichia coli strain with all chromosomal rRNA operons inactivated: complete exchange of rRNA genes between bacteria. Proc. Natl. Acad. Sci. USA 96:1971-1976.
6. Belland, R. J., G. Zhong, D. D. Crane, D. Hogan, D. Sturdevant, J. Sharma, W. L. Beatty, and H. D. Caldwell. 2003. Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatis. Proc. Natl. Acad. Sci. USA 100:8478-8483.
7. Billington, O. J., T. D. McHugh, and S. H. Gillespie. 1999. Physiological cost of rifampin resistance induced in vitro in Mycobactenum tuberculosis. Antimicrob. Agents Chemother. 43:1866-1869.
8. Binet, R., and A. T. Maurelli. 2005. Frequency of spontaneous mutations that confer antibiotic resistance in Chlamydia spp. Antimicrob. Agents Chemother. 49:2865-2873.
9. Brink, M. F., G. Brink, M. P. Verbeet, and H. A. de Boer. 1994. Spectinomycin interacts specifically with the residues G1064 and C1192 in 16S rRNA, thereby potentially freezing this molecule into an inactive conformation. Nucleic Acids Res. 22:325-331.
10. Brinkman, F. S., J. L. Blanchard, A. Cherkasov, Y. Av-Gay, R. C. Brunham, R. C. Fernandez, B. B. Finlay, S. P. Otto, B. F. Ouellette, P. J. Keeling, A. M. Rose, R. E. Hancock, S. J. Jones, and H. Greberg. 2002. Evidence that plant-like genes in Chlamydia species reflect an ancestral relationship between Chlamydiaceae, cyanobacteria, and the chloroplast. Genome Res. 12:1159-1167.
11. Corsaro, D., and D. Venditti. 2004. Emerging chlamydial infections. Crit. Rev. Microbiol. 30:75-106.
12. Dailidiene, D., M. T. Bertoli, J. Miciuleviciene, A. K. Mukhopadhyay, G. Dailide, M. A. Pascasio, L. Kupcinskas, and D. E. Berg. 2002. Emergence of tetracycline resistance in Helicobacter pylori: multiple mutational changes in 16S rihosomal DNA and other genetic loci. Antimicrob. Agents Chemother. 46:3940-3946.
13. Dugan, J., D. D. Rockey, L. Jones, and A. A. Andersen. 2004. Tetracycline resistance in Chlamydia suis mediated by genomic islands inserted into the chlamydial mv-like gene. Antimicrob. Agents Chemother. 48:3989-3995.
14. Flashner, Y., E. Mamroud, A. Tidhar, R. Ber, M. Aftalion, D. Gur, S. Lazar, A. Zvi, T. Bino, N. Ariel, B. Velan, A. Shafferman, and S. Cohen. 2004. Generation of Yersinia pestis attenuated strains by signature-tagged mutagenesis in search of novel vaccine candidates. Infect. Immun. 72:908-915.
15. Frick, K. D., M. A. Colchero, and D. Dean. 2004. Modeling the economic net benefit of a potential vaccination program against ocular infection with Chlamydia trachomatis. Vaccine 22:689-696.
16. Gerrits, M. M., M. Berning, A. H. van Vliet, E. J. Kuipers, and J. G. Kusters. 2003. Effects of 16S rRNA gene mutations on tetracycline resistance in Helicobacter pylori. Antimicrob. Agents Chemother. 47:2984-2986.
17. Grayston, J. T., R. A. Kronmal, L. A. Jackson, A. F. Parisi, J. B. Muhlestein, J. D. Cohen, W. J. Rogers, J. R. Crouse, S. L. Borrowdale, E. Schron, and C. Knirsch. 2005. Azithromycin for the secondary prevention of coronary events. N. Engl. J. Med. 352:1637-1645.
18. Guzman, L. M., D. Belin, M. J. Carson, and J. Beckwith. 1995. Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. J. Bacteriol. 177:4121-4130.
19. Hammerschlag, M. R. 2002. The intracellular life of chlamydiae. Semin. Pcdiatr. Infect. Dis. 13:239-248.
20. Hanahan, D. 1983. Studies on transformation of Escherichia coli with plasmids. J. Mol. Biol. 166:557-580.
21. Hogan, R. J., S. A. Mathews, S. Mukhopadhyay, J. T. Summersgill, and P. Timms. 2004. Chlamydial persistence: beyond the biphasic paradigm. Infect. Immun. 72:1843-1855.
22. Jones, R. B., B. Van der Pol, D. H. Martin, and M. K. Shepard. 1990. Partial characterization of Chlamydia trachomatis isolates resistant to multiple antibiotics. J. Infect. Dis. 162:1309-1315.
23. Lefevre, J. C., J. P. Lepargneur, D. Guion, and S. Bei. 1997. Tetracyclinc-resistant Chlamydia trachomatis in Toulouse, France. Pathol. Biol. (Paris) 45:376-378.
24. Lenski, R. E. 1998. Bacterial evolution and the cost of antibiotic resistance. Int. Microbiol. 1:265-270.
25. Linde, K., G. C. Fthenakis, and A. Fichtner. 1998. Bacterial live vaccines with graded level of attenuation achieved by antibiotic resistance mutations: transduction experiments on the functional unit of resistance, attenuation and further accompanying markers. Vet. Microbiol. 62:121-134.
26. Macvanin, M., J. Bjorkman, S. Eriksson, M. Rhen, D. I. Andersson, and D. Hughes. 2003. Fusidic acid-resistant mutants of Salmonella enterica serovar Typhimurium with low fitness in vivo are defective in RpoS induction. Antimicrob. Agents Chemother. 47:3743-3749.
27. Maisnier-Patin, S., and D. I. Andersson. 2004. Adaptation to the deleterious effects of antimicrobial drug resistance mutations by compensatory evolution. Res. Microbiol. 155:360-369.
28. Makosky, P. C., and A. E. Dahlberg. 1987. Spectinomycin resistance at site 1192 in 16S ribosomal RNA of E. coli: an analysis of three mutants. Biochimic 69:885-889.
29. Mariam, D. H., Y. Mengistu, S. E. Hoffner, and D. I. Andersson. 2004. Effect of rpoB mutations conferring rifampin resistance on fitness of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 48:1289-1294.
30. Maul, J. E., J. W. Lilly, L. Cui, C. W. dePamphilis, W. Miller, E. H. Harris, and D. B. Stern. 2002. The Chlamydomonas reinhardtii plastid chromosome: islands of genes in a sea of repeats. Plant Cell 14:2659-2679.
31. Melese, M., J. D. Chidambaram, W. Alemayehu, D. C. Lee, E. H. Yi, V. Cevallos, Z. Zhou, C. Donnellan, M. Saidel, J. P. Whitcher, B. D. Gaynor, and T. M. Lietman. 2004. Feasibility of eliminating ocular Chlamydia trachomatis with repeat mass antibiotic treatments. JAMA 292:721-725.
32. Misyurina, O. Y., E. V. Chipitsyna, Y. P. Finashutina, V. N. Lazarev, T. A. Akopian, A. M. Savicheva, and V. M. Govorun. 2004. Mutations in a 23S rRNA gene of Chlamydia trachomatis associated with resistance to macrolides. Antimicrob. Agents Chemother. 48:1347-1349.
33. Nicholson, T. L., L. Olinger, K. Chong, G. Schoolnik, and R. S. Stephens. 2003. Global stage-specific gene regulation during the developmental cycle of Chlamydia trachomatis. J. Bacteriol. 185:3179-3189.
34. O'Connor, M., and A. E. Dahlberg. 2002. Isolation of spcctinomycin resistance mutations in the 16S rRNA of Salmonella enterica serovar Typhimurium and expression in Escherichia coli and Salmonella. Curr. Microbiol. 45:429-433.
35. Pflster, P., N. Corti, S. Hobbie, C. Bruell, R. Zarivach, A. Yonath, and E. C. Bottger. 2005. 23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A→G. Proc. Natl. Acad. Sci. USA 102:5180-5185.
36. Prammananan, T., P. Sander, B. Springer, and E. C. Bottger. 1999. RecA-mediated gene conversion and aminoglycoside resistance in strains heterozygous for rRNA. Antimicrob. Agents Chemother. 43:447-453.
37. Roberts, M. C. 2003. Tetracycline therapy: update. Clin. Infect. Dis. 36:462-467.
38. Ross, J. I., E. A. Eady, J. H. Cove, and W. J. Cunliffe. 1998. 16S rRNA mutation associated with tetracycline resistance in a gram-positive bacterium. Antimicrob. Agents Chemother. 42:1702-1705.
39. Sander, P., L. Belova, Y. G. Kidan, P. Pfister, A. S. Mankin, and E. C. Bottger. 2002. Ribosomal and non-ribosomal resistance to oxazolidinones: species-specific idiosyncrasy of ribosomal alterations. Mol. Microbiol. 46:1295-1304.
40. Sander, P., B. Springer, T. Prammananan, A. Sturmfels, M. Kappler, M. Pletschette, and E. C. Bottger. 2002. Fitness cost of chromosomal drug resistance-conferring mutations. Antimicrob. Agents Chemother. 46:1204-1211.
41. Shaw, E. I., C. A. Dooley, E. R. Fischer, M. A. Scidmore, K. A. Fields, and T. Hackstadt. 2000. Three temporal classes of gene expression during the Chlamydia trachomatis developmental cycle. Mol. Microbiol. 37:913-925.
42. Somani, J., V. B. Bhullar, K. A. Workowski, C. E. Farshy, and C. M. Black. 2000. Multiple drug-resistant Chlamydia trachomatis associated with clinical treatment failure. J. Infect. Dis. 181:1421-1427.
43. Stamm, W. E. 2000. Potential for antimicrobial resistance in Chlamydia pneumoniae. J. Infect. Dis. 181(Suppl. 3):S456-S459.
44. Su, H., R. Messer, W. Whitmire, S. Hughes, and H. D. Caldwell. 2000. Subclinical chlamydial infection of the female mouse genital tract generates a potent protective immune response: implications for development of live attenuated chlamydial vaccine strains. Infect. Immun. 68:192-196.
45. Trieber, C. A., and D. E. Taylor. 2002. Mutations in the 16S rRNA genes of Helicobacterpylori mediate resistance to tetracycline. J. Bacteriol. 184:2131-2140.
46. Vandahl, B. B., S. Birkelund, and G. Christiansen. 2004. Genome and proteome analysis of Chlamydia. Proteomics 4:2831-2842.
47. Wang, S. A., J. R. Papp, W. E. Stamm, R. W. Peeling, D. H. Martin, and K. K. Holmes. 2005. Evaluation of antimicrobial resistance and treatment failures for Chlamydia trachomatis: a meeting report. J. Infect. Dis. 191:917-923.
48. Wilson, D. P., S. Mathews, C. Wan, A. N. Pettitt, and D. L. McElwain. 2004. Use of a quantitative gene expression assay based on micro-array techniques and a mathematical model for the investigation of chlamydial generation time. Bull. Math. Biol. 66:523-537.
49. Wyrick, P. B. 2000. Intracellular survival by Chlamydia. Cell Microbiol. 2:275-282.
50. Yanisch-Perron, C., J. Vieira, and J. Messing. 1985. Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 33:103-119.