The dynamic of lipid oxidation in human myotubes

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1791, Issue 1, 2009, Pages 17-24

  Gaster, Michael ^a  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Fuel selection; Human; Lipid oxidation; Myotube; Skeletal muscle

Indexed keywords

ACYL COENZYME A; CARNITINE; CARNITINE PALMITOYLTRANSFERASE I; DIACYLGLYCEROL; FATTY ACID; GLUCOSE; INSULIN; LACTATE DEHYDROGENASE; LIPID; PALMITIC ACID; PHOSPHOLIPID; TRIACYLGLYCEROL;

ADULT; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXICITY; ENDOGENOUS VARIABLE; ESTERIFICATION; EXOGENOUS VARIABLE; FATTY ACID OXIDATION; GLUCOSE OXIDATION; GLYCOLYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIPID OXIDATION; LONG TERM EXPOSURE; MITOCHONDRION; MUSCLE BIOPSY; MYOTUBE; PRIORITY JOURNAL; SKELETAL MUSCLE; VASTUS LATERALIS MUSCLE;

CELLS, CULTURED; FATTY ACIDS, NONESTERIFIED; HUMANS; LIPID METABOLISM; MUSCLE FIBERS, SKELETAL; OXIDATION-REDUCTION; PALMITIC ACID; TRIGLYCERIDES;

EID: 57649173582     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2008.09.003     Document Type: Article

References (42)

1. Boden G., Chen X., Ruiz J., White J.V., and Rossetti L. Mechanisms of fatty acid-induced inhibition of glucose uptake. J. Clin. Invest 93 (1994) 2438
2. Boden G., Jadali F., White J., Liang Y., Mozzoli M., Chen X., Coleman E., and Smith C. Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. J. Clin. Invest 88 (1991) 960
3. Boon H., Blaak E.E., Saris W.H., Keizer H.A., Wagenmakers A.J., and van Loon L.J. Substrate source utilisation in long-term diagnosed type 2 diabetes patients at rest, and during exercise and subsequent recovery. Diabetologia 50 (2007) 103
4. Bouzakri K., Austin R., Rune A., Lassman M.E., Garcia-Roves P.M., Berger J.P., Krook A., Chibalin A.V., Zhang B.B., and Zierath J.R. Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle. Diabetes 57 (2008) 1508
5. Cha B.S., Ciaraldi T.P., Carter L., Nikoulina S.E., Mudaliar S., Mukherjee R., Paterniti Jr. J.R., and Henry R.R. Peroxisome proliferator-activated receptor (PPAR) gamma and retinoid X receptor (RXR) agonists have complementary effects on glucose and lipid metabolism in human skeletal muscle. Diabetologia 44 (2001) 444
6. Gaster M. Metabolic flexibility is conserved in diabetic myotubes. J. Lipid Res. 48 (2007) 207
7. Gaster M., and Beck-Nielsen H. Triacylglycerol accumulation is not primarily affected in myotubes established from type 2 diabetic subjects. Biochim. Biophys. Acta 1761 (2006) 100
8. Gaster M., and Beck-Nielsen H. The reduced insulin mediated glucose oxidation in skeletal muscle from type 2 diabetic subjects may be of genetic origin - evidence from cultured myotubes. Biochim. Biophys. Acta 1690 (2004) 85
9. Gaster M., Kristensen S.R., Beck-Nielsen H., and Schroder H.D. A cellular model system of differentiated human myotubes. APMIS 109 (2001) 735
10. Gaster M., Ottosen P.D., Vach W., Christiansen H., Staehr P., Beck-Nielsen H., and Schroder H.D. GLUT4 expression in human muscle fibres is not correlated with intracellular triglyceride (TG) content. Is TG a maker or a marker of insulin resistance?. APMIS 111 (2003) 338
11. Gaster M., Rustan A., and Beck-Nielsen H. Differential utilization of saturated palmitate and unsaturated oleate. Evidence from cultured myotubes. Diabetes 54 (2005) 648
12. Gaster M., Rustan A.C., Aas V., and Beck-Nielsen H. Reduced lipid oxidation in skeletal muscle from type 2 diabetic subjects may be of genetic origin: evidence from cultured myotubes. Diabetes 53 (2004) 542
13. Gaster M., Schroder H.D., Handberg A., and Beck-Nielsen H. The basal kinetic parameters of glycogen synthase in human myotube cultures are not affected by chronic high insulin exposure. Biochim. Biophys. Acta 1537 (2001) 211
14. Haemmerle G., Lass A., Zimmermann R., Gorkiewicz G., Meyer C., Rozman J., Heldmaier G., Maier R., Theussl C., Eder S., Kratky D., Wagner E.F., Klingenspor M., Hoefler G., and Zechner R. Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 312 (2006) 734
15. Kelley D.E., and Mandarino L.J. Fuel selection in human skeletal muscle in insulin resistance: a reexamination. Diabetes 49 (2000) 677
16. Kelley D.E., Mokan M., Simoneau J.A., and Mandarino L.J. Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J. Clin. Invest 92 (1993) 91
17. Koves T.R., Ussher J.R., Noland R.C., Slentz D., Mosedale M., Ilkayeva O., Bain J., Stevens R., Dyck J.R., Newgard C.B., Lopaschuk G.D., and Muoio D.M. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell. Metab. 7 (2008) 45
18. Kristensen S.R. A critical appraisal of the association between energy charge and cell damage. Biochim. Biophys. Acta 1012 (1989) 272
19. Laughton C. Quantification of attached cells in microtiter plates based on Coomassie brilliant blue G-250 staining of total cellular protein. Anal. Biochem. 140 (1984) 417
20. Laughton C. Measurement of the specific lipid content of attached cells in microtiter cultures. Anal. Biochem. 156 (1986) 307
21. Levin K., Daa S.H., Alford F.P., and Beck-Nielsen H. Morphometric documentation of abnormal intramyocellular fat storage and reduced glycogen in obese patients with Type II diabetes. Diabetologia 44 (2001) 824
22. Listenberger L.L., Han X., Lewis S.E., Cases S., Farese Jr. R.V., Ory D.S., and Schaffer J.E. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 3077
23. Listenberger L.L., Ory D.S., and Schaffer J.E. Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J. Biol. Chem. 276 (2001) 14890
24. Liu L., Zhang Y., Chen N., Shi X., Tsang B., and Yu Y.H. Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance. J. Clin. Invest 117 (2007) 1679
25. Mandarino L.J., Consoli A., Jain A., and Kelley D.E. Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM. Am. J. Physiol. 270 (1996) E463-E470
26. Montell E., Turini M., Marotta M., Roberts M., Noe V., Ciudad C.J., Mace K., and Gomez-Foix A.M. DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells. Am. J. Physiol. Endocrinol. Metab. 280 (2001) E229-E237
27. Moro C., Bajpeyi S., and Smith S.R. Determinants of intramyocellular triglyceride turnover: implications for insulin sensitivity. Am. J. Physiol. Endocrinol. Metab. 294 (2008) E203-E213
28. Oakes N.D., Cooney G.J., Camilleri S., Chisholm D.J., and Kraegen E.W. Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes 46 (1997) 1768
29. Rachek L.I., Musiyenko S.I., LeDoux S.P., and Wilson G.L. Palmitate induced mitochondrial deoxyribonucleic acid damage and apoptosis in l6 rat skeletal muscle cells. Endocrinology 148 (2007) 293
30. Randle P.J., Garland P.B., Hales C.N., and Newsholme E.A. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1 (1963) 785
31. Rasmussen B.B., Holmback U.C., Volpi E., Morio-Liondore B., Paddon-Jones D., and Wolfe R.R. Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle. J. Clin. Invest 110 (2002) 1687
32. Roden M., Price T.B., Perseghin G., Petersen K.F., Rothman D.L., Cline G.W., and Shulman G.I. Mechanism of free fatty acid-induced insulin resistance in humans. J. Clin. Invest 97 (1996) 2859
33. Schenk S., and Horowitz J.F. Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance. J. Clin. Invest 117 (2007) 1690
34. Schrauwen P. High-fat diet, muscular lipotoxicity and insulin resistance. Proc. Nutr. Soc. 66 (2007) 33
35. Sidossis L.S., Stuart C.A., Shulman G.I., Lopaschuk G.D., and Wolfe R.R. Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria. J. Clin. Invest 98 (1996) 2244
36. Sidossis L.S., and Wolfe R.R. Glucose and insulin-induced inhibition of fatty acid oxidation: the glucose-fatty acid cycle reversed. Am. J. Physiol. 270 (1996) E733-E738
37. Skrede S., Bremer J., Berge R.K., and Rustan A.C. Stimulation of fatty acid oxidation by a 3-thia fatty acid reduces triacylglycerol secretion in cultured rat hepatocytes. J. Lipid Res. 35 (1994) 1395
38. Turcotte L.P., Swenberger J.R., and Yee A.J. High carbohydrate availability increases LCFA uptake and decreases LCFA oxidation in perfused muscle. Am. J. Physiol. Endocrinol. Metab. 282 (2002) E177-E183
39. van Loon L.J. Use of intramuscular triacylglycerol as a substrate source during exercise in humans. J. Appl. Physiol. 97 (2004) 1170
40. van Loon L.J., Manders R.J., Koopman R., Kaastra B., Stegen J.H., Gijsen A.P., Saris W.H., and Keizer H.A. Inhibition of adipose tissue lipolysis increases intramuscular lipid use in type 2 diabetic patients. Diabetologia 48 (2005) 2097
41. van Loon L.J., Thomason-Hughes M., Constantin-Teodosiu D., Koopman R., Greenhaff P.L., Hardie D.G., Keizer H.A., Saris W.H., and Wagenmakers A.J. Inhibition of adipose tissue lipolysis increases intramuscular lipid and glycogen use in vivo in humans. Am. J. Physiol. Endocrinol. Metab. 289 (2005) E482-E493
42. Wensaas A.J., Rustan A.C., Lovstedt K., Kull B., Wikstrom S., Drevon C.A., and Hallen S. Cell-based multiwell assays for the detection of substrate accumulation and oxidation. J. Lipid Res. 48 (2007) 961