메뉴 건너뛰기




Volumn 86, Issue 5, 2008, Pages 495-506

Molecular and cellular aspects of sepsis-induced immunosuppression

Author keywords

Cytokines; Immunosuppression; Sepsis

Indexed keywords

AFELIMOMAB; CASPASE 12; CD11B ANTIGEN; CD14 ANTIGEN; CHEMOKINE RECEPTOR CXCR2; CORTICOSTEROID; CYTOKINE; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; GLUCOCORTICOID; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HLA DR3 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; NEUTRALIZING ANTIBODY; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG;

EID: 43049087343     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-007-0300-4     Document Type: Review
Times cited : (82)

References (121)
  • 1
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
    • Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR (2001) Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29:1303-1310
    • (2001) Crit Care Med , vol.29 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 2
    • 0037451929 scopus 로고    scopus 로고
    • The epidemiology of sepsis in the United States from 1979 through 2000
    • Martin GS, Mannino DM, Eaton S, Moss M (2003) The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 348:1546-1554
    • (2003) N Engl J Med , vol.348 , pp. 1546-1554
    • Martin, G.S.1    Mannino, D.M.2    Eaton, S.3    Moss, M.4
  • 3
    • 0026051892 scopus 로고
    • Gram-negative sepsis. Background, clinical features, and intervention
    • Bone RC (1991) Gram-negative sepsis. Background, clinical features, and intervention. Chest 100:802-808
    • (1991) Chest , vol.100 , pp. 802-808
    • Bone, R.C.1
  • 4
    • 0015506169 scopus 로고
    • Germs
    • Thomas L (1972) Germs. N Engl J Med 287:553-555
    • (1972) N Engl J Med , vol.287 , pp. 553-555
    • Thomas, L.1
  • 5
    • 0026710191 scopus 로고
    • Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. the ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine
    • Bone RC, Balk RA, Cerra FB et al (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101:1644-1655
    • (1992) Chest , vol.101 , pp. 1644-1655
    • Bone, R.C.1    Balk, R.A.2    Cerra, F.B.3
  • 6
    • 0023749693 scopus 로고
    • Tumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpura
    • Girardin E, Grau GE, Dayer JM, Roux-Lombard P, Lambert PH (1988) Tumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpura. N Engl J Med 319:397-400
    • (1988) N Engl J Med , vol.319 , pp. 397-400
    • Girardin, E.1    Grau, G.E.2    Dayer, J.M.3    Roux-Lombard, P.4    Lambert, P.H.5
  • 7
    • 0029090390 scopus 로고
    • Corticosteroid treatment for sepsis: A critical appraisal and meta-analysis of the literature
    • Cronin L, Cook DJ, Carlet J et al (1995) Corticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature. Crit Care Med 23:1430-1439
    • (1995) Crit Care Med , vol.23 , pp. 1430-1439
    • Cronin, L.1    Cook, D.J.2    Carlet, J.3
  • 8
    • 0029900294 scopus 로고    scopus 로고
    • Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. the Soluble TNF Receptor Sepsis Study Group
    • Fisher CJ Jr., Agosti JM, Opal SM et al (1996) Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group. N Engl J Med 334:1697-1702
    • (1996) N Engl J Med , vol.334 , pp. 1697-1702
    • Fisher Jr., C.J.1    Agosti, J.M.2    Opal, S.M.3
  • 9
    • 0037239057 scopus 로고    scopus 로고
    • Cytokine therapeutics for the treatment of sepsis: Why has nothing worked?
    • Remick DG (2003) Cytokine therapeutics for the treatment of sepsis: why has nothing worked? Curr Pharm Des 9:75-82
    • (2003) Curr Pharm des , vol.9 , pp. 75-82
    • Remick, D.G.1
  • 10
    • 0030587937 scopus 로고    scopus 로고
    • Immunologic dissonance: A continuing evolution in our understanding of the systemic inflammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS)
    • Bone RC (1996) Immunologic dissonance: a continuing evolution in our understanding of the systemic inflammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS). Ann Intern Med 125:680-687
    • (1996) Ann Intern Med , vol.125 , pp. 680-687
    • Bone, R.C.1
  • 12
    • 0025354406 scopus 로고
    • Laboratory models of sepsis and septic shock
    • Fink MP, Heard SO (1990) Laboratory models of sepsis and septic shock. J Surg Res 49:186-196
    • (1990) J Surg Res , vol.49 , pp. 186-196
    • Fink, M.P.1    Heard, S.O.2
  • 13
    • 0029823055 scopus 로고    scopus 로고
    • Monocyte deactivation-rationale for a new therapeutic strategy in sepsis
    • Suppl 4
    • Volk HD, Reinke P, Krausch D et al (1996) Monocyte deactivation-rationale for a new therapeutic strategy in sepsis. Intensive Care Med 22(Suppl 4):S474-481
    • (1996) Intensive Care Med , vol.22 , pp. 474-481
    • Volk, H.D.1    Reinke, P.2    Krausch, D.3
  • 14
    • 0037426726 scopus 로고    scopus 로고
    • The pathophysiology and treatment of sepsis
    • Hotchkiss RS, Karl IE (2003) The pathophysiology and treatment of sepsis. N Engl J Med 348:138-150
    • (2003) N Engl J Med , vol.348 , pp. 138-150
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 15
    • 0024822480 scopus 로고
    • Differential expression of interleukin-1 and tumor necrosis factor in murine septic shock models
    • Evans GF, Snyder YM, Butler LD, Zuckerman SH (1989) Differential expression of interleukin-1 and tumor necrosis factor in murine septic shock models. Circ Shock 29:279-290
    • (1989) Circ Shock , vol.29 , pp. 279-290
    • Evans, G.F.1    Snyder, Y.M.2    Butler, L.D.3    Zuckerman, S.H.4
  • 16
    • 0029080432 scopus 로고
    • Pattern of cytokines and pharmacomodulation in sepsis induced by cecal ligation and puncture compared with that induced by endotoxin
    • Villa P, Sartor G, Angelini M et al (1995) Pattern of cytokines and pharmacomodulation in sepsis induced by cecal ligation and puncture compared with that induced by endotoxin. Clin Diagn Lab Immunol 2:549-553
    • (1995) Clin Diagn Lab Immunol , vol.2 , pp. 549-553
    • Villa, P.1    Sartor, G.2    Angelini, M.3
  • 17
    • 33746190736 scopus 로고    scopus 로고
    • Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality
    • Osuchowski MF, Welch K, Siddiqui J, Remick DG (2006) Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J Immunol 177:1967-1974
    • (2006) J Immunol , vol.177 , pp. 1967-1974
    • Osuchowski, M.F.1    Welch, K.2    Siddiqui, J.3    Remick, D.G.4
  • 18
    • 33748072117 scopus 로고    scopus 로고
    • Mechanisms of mortality in early and late sepsis
    • Xiao H, Siddiqui J, Remick DG (2006) Mechanisms of mortality in early and late sepsis. Infect Immun 74:5227-5235
    • (2006) Infect Immun , vol.74 , pp. 5227-5235
    • Xiao, H.1    Siddiqui, J.2    Remick, D.G.3
  • 19
    • 0032997973 scopus 로고    scopus 로고
    • Cytokines and anticytokines in the pathogenesis of sepsis
    • ix
    • van der Poll T, van Deventer SJ (1999) Cytokines and anticytokines in the pathogenesis of sepsis. Infect Dis Clin North Am 13:413-426 ix
    • (1999) Infect Dis Clin North Am , vol.13 , pp. 413-426
    • Van Der Poll, T.1    Van Deventer, S.J.2
  • 20
    • 0034090602 scopus 로고    scopus 로고
    • Anti-inflammatory cytokines
    • Opal SM, DePalo VA (2000) Anti-inflammatory cytokines. Chest 117:1162-1172
    • (2000) Chest , vol.117 , pp. 1162-1172
    • Opal, S.M.1    Depalo, V.A.2
  • 21
    • 0033969341 scopus 로고    scopus 로고
    • Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: A marker for prognosis and future therapeutic options
    • Gogos CA, Drosou E, Bassaris HP, Skoutelis A (2000) Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options. J Infect Dis 181:176-180
    • (2000) J Infect Dis , vol.181 , pp. 176-180
    • Gogos, C.A.1    Drosou, E.2    Bassaris, H.P.3    Skoutelis, A.4
  • 22
    • 4544231442 scopus 로고    scopus 로고
    • The anti-inflammatory response dominates after septic shock: Association of low monocyte HLA-DR expression and high interleukin-10 concentration
    • Monneret G, Finck ME, Venet F et al (2004) The anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentration. Immunol Lett 95:193-198
    • (2004) Immunol Lett , vol.95 , pp. 193-198
    • Monneret, G.1    Finck, M.E.2    Venet, F.3
  • 25
    • 2342457148 scopus 로고    scopus 로고
    • Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms
    • Saleh M, Vaillancourt JP, Graham RK et al (2004) Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature 429:75-79
    • (2004) Nature , vol.429 , pp. 75-79
    • Saleh, M.1    Vaillancourt, J.P.2    Graham, R.K.3
  • 26
    • 33646175602 scopus 로고    scopus 로고
    • Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice
    • Saleh M, Mathison JC, Wolinski MK et al (2006) Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice. Nature 440:1064-1068
    • (2006) Nature , vol.440 , pp. 1064-1068
    • Saleh, M.1    Mathison, J.C.2    Wolinski, M.K.3
  • 28
    • 0030369193 scopus 로고    scopus 로고
    • Monocyte response to bacterial toxins, expression of cell surface receptors, and release of anti-inflammatory cytokines during sepsis
    • Astiz M, Saha D, Lustbader D, Lin R, Rackow E (1996) Monocyte response to bacterial toxins, expression of cell surface receptors, and release of anti-inflammatory cytokines during sepsis. J Lab Clin Med 128:594-600
    • (1996) J Lab Clin Med , vol.128 , pp. 594-600
    • Astiz, M.1    Saha, D.2    Lustbader, D.3    Lin, R.4    Rackow, E.5
  • 30
    • 0026558195 scopus 로고
    • Does endotoxin tolerance prevent the release of inflammatory monokines (interleukin 1, interleukin 6, or tumor necrosis factor) during sepsis?
    • discussion 196-197
    • Ayala A, Kisala JM, Felt JA, Perrin MM, Chaudry IH (1992) Does endotoxin tolerance prevent the release of inflammatory monokines (interleukin 1, interleukin 6, or tumor necrosis factor) during sepsis? Arch Surg 127:191-196 discussion 196-197
    • (1992) Arch Surg , vol.127 , pp. 191-196
    • Ayala, A.1    Kisala, J.M.2    Felt, J.A.3    Perrin, M.M.4    Chaudry, I.H.5
  • 31
    • 0036892751 scopus 로고    scopus 로고
    • Role of interleukin-10 in the intracellular sequestration of human leukocyte antigen-DR in monocytes during septic shock
    • Fumeaux T, Pugin J (2002) Role of interleukin-10 in the intracellular sequestration of human leukocyte antigen-DR in monocytes during septic shock. Am J Respir Crit Care Med 166:1475-1482
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 1475-1482
    • Fumeaux, T.1    Pugin, J.2
  • 32
    • 0027326831 scopus 로고
    • Altered leukocyte immunophenotypes in septic shock. Studies of HLA-DR, CD11b, CD14, and IL-2R expression
    • Lin RY, Astiz ME, Saxon JC, Rackow EC (1993) Altered leukocyte immunophenotypes in septic shock. Studies of HLA-DR, CD11b, CD14, and IL-2R expression. Chest 104:847-853
    • (1993) Chest , vol.104 , pp. 847-853
    • Lin, R.Y.1    Astiz, M.E.2    Saxon, J.C.3    Rackow, E.C.4
  • 33
    • 33747156890 scopus 로고    scopus 로고
    • Is the measurement of monocytes HLA-DR expression useful in patients with sepsis?
    • Fumeaux T, Pugin J (2006) Is the measurement of monocytes HLA-DR expression useful in patients with sepsis? Intensive Care Med 32:1106-1108
    • (2006) Intensive Care Med , vol.32 , pp. 1106-1108
    • Fumeaux, T.1    Pugin, J.2
  • 34
    • 33747156889 scopus 로고    scopus 로고
    • Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock
    • Monneret G, Lepape A, Voirin N et al (2006) Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock. Intensive Care Med 32:1175-1183
    • (2006) Intensive Care Med , vol.32 , pp. 1175-1183
    • Monneret, G.1    Lepape, A.2    Voirin, N.3
  • 35
    • 34547697348 scopus 로고    scopus 로고
    • Decreased monocyte human leukocyte antigen-DR expression after severe burn injury: Correlation with severity and secondary septic shock
    • Venet F, Tissot S, Debard AL et al (2007) Decreased monocyte human leukocyte antigen-DR expression after severe burn injury: correlation with severity and secondary septic shock. Crit Care Med 35:1910-1917
    • (2007) Crit Care Med , vol.35 , pp. 1910-1917
    • Venet, F.1    Tissot, S.2    Debard, A.L.3
  • 36
    • 0034547960 scopus 로고    scopus 로고
    • Intrapulmonary TNF gene therapy reverses sepsis-induced suppression of lung antibacterial host defense
    • Chen GH, Reddy RC, Newstead MW, Tateda K, Kyasapura BL, Standiford TJ (2000) Intrapulmonary TNF gene therapy reverses sepsis-induced suppression of lung antibacterial host defense. J Immunol 165:6496-6503
    • (2000) J Immunol , vol.165 , pp. 6496-6503
    • Chen, G.H.1    Reddy, R.C.2    Newstead, M.W.3    Tateda, K.4    Kyasapura, B.L.5    Standiford, T.J.6
  • 37
    • 0030917203 scopus 로고    scopus 로고
    • Monocyte deactivation in septic patients: Restoration by IFN-gamma treatment
    • Docke WD, Randow F, Syrbe U et al (1997) Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med 3:678-681
    • (1997) Nat Med , vol.3 , pp. 678-681
    • Docke, W.D.1    Randow, F.2    Syrbe, U.3
  • 38
    • 0031054684 scopus 로고    scopus 로고
    • Interferon gamma-1b in the treatment of compensatory anti-inflammatory response syndrome. a new approach: Proof of principle
    • Kox WJ, Bone RC, Krausch D et al (1997) Interferon gamma-1b in the treatment of compensatory anti-inflammatory response syndrome. A new approach: proof of principle. Arch Intern Med 157:389-393
    • (1997) Arch Intern Med , vol.157 , pp. 389-393
    • Kox, W.J.1    Bone, R.C.2    Krausch, D.3
  • 39
    • 0041929516 scopus 로고    scopus 로고
    • Regulation of the class II MHC pathway in primary human monocytes by granulocyte-macrophage colony-stimulating factor
    • Hornell TM, Beresford GW, Bushey A, Boss JM, Mellins ED (2003) Regulation of the class II MHC pathway in primary human monocytes by granulocyte- macrophage colony-stimulating factor. J Immunol 171:2374-2383
    • (2003) J Immunol , vol.171 , pp. 2374-2383
    • Hornell, T.M.1    Beresford, G.W.2    Bushey, A.3    Boss, J.M.4    Mellins, E.D.5
  • 40
    • 33645830525 scopus 로고    scopus 로고
    • Down-modulation of granulocyte macrophage-colony stimulating factor receptor on monocytes during human septic shock
    • Pangault C, Le Tulzo Y, Tattevin P, Guilloux V, Bescher N, Drenou B (2006) Down-modulation of granulocyte macrophage-colony stimulating factor receptor on monocytes during human septic shock. Crit Care Med 34:1193-1201
    • (2006) Crit Care Med , vol.34 , pp. 1193-1201
    • Pangault, C.1    Le Tulzo, Y.2    Tattevin, P.3    Guilloux, V.4    Bescher, N.5    Drenou, B.6
  • 41
    • 0037397030 scopus 로고    scopus 로고
    • Reversal of immunoparalysis by recombinant human granulocyte-macrophage colony-stimulating factor in patients with severe sepsis
    • Nierhaus A, Montag B, Timmler N et al (2003) Reversal of immunoparalysis by recombinant human granulocyte-macrophage colony-stimulating factor in patients with severe sepsis. Intensive Care Med 29:646-651
    • (2003) Intensive Care Med , vol.29 , pp. 646-651
    • Nierhaus, A.1    Montag, B.2    Timmler, N.3
  • 42
    • 0037099153 scopus 로고    scopus 로고
    • A randomized phase II trial of granulocyte-macrophage colony-stimulating factor therapy in severe sepsis with respiratory dysfunction
    • Presneill JJ, Harris T, Stewart AG, Cade JF, Wilson JW (2002) A randomized phase II trial of granulocyte-macrophage colony-stimulating factor therapy in severe sepsis with respiratory dysfunction. Am J Respir Crit Care Med 166:138-143
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 138-143
    • Presneill, J.J.1    Harris, T.2    Stewart, A.G.3    Cade, J.F.4    Wilson, J.W.5
  • 43
    • 9644312767 scopus 로고    scopus 로고
    • Polymicrobial sepsis induces divergent effects on splenic and peritoneal dendritic cell function in mice
    • Ding Y, Chung CS, Newton S et al (2004) Polymicrobial sepsis induces divergent effects on splenic and peritoneal dendritic cell function in mice. Shock 22:137-144
    • (2004) Shock , vol.22 , pp. 137-144
    • Ding, Y.1    Chung, C.S.2    Newton, S.3
  • 44
    • 0036499162 scopus 로고    scopus 로고
    • Depletion of dendritic cells, but not macrophages, in patients with sepsis
    • Hotchkiss RS, Tinsley KW, Swanson PE et al (2002) Depletion of dendritic cells, but not macrophages, in patients with sepsis. J Immunol 168:2493-2500
    • (2002) J Immunol , vol.168 , pp. 2493-2500
    • Hotchkiss, R.S.1    Tinsley, K.W.2    Swanson, P.E.3
  • 45
    • 0038106475 scopus 로고    scopus 로고
    • Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells
    • Tinsley KW, Grayson MH, Swanson PE et al (2003) Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells. J Immunol 171:909-914
    • (2003) J Immunol , vol.171 , pp. 909-914
    • Tinsley, K.W.1    Grayson, M.H.2    Swanson, P.E.3
  • 46
    • 4344711657 scopus 로고    scopus 로고
    • Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis
    • Efron PA, Martins A, Minnich D et al (2004) Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis. J Immunol 173:3035-3043
    • (2004) J Immunol , vol.173 , pp. 3035-3043
    • Efron, P.A.1    Martins, A.2    Minnich, D.3
  • 47
    • 33744764623 scopus 로고    scopus 로고
    • Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile
    • Wen H, Hogaboam CM, Gauldie J, Kunkel SL (2006) Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile. Am J Pathol 168:1940-1950
    • (2006) Am J Pathol , vol.168 , pp. 1940-1950
    • Wen, H.1    Hogaboam, C.M.2    Gauldie, J.3    Kunkel, S.L.4
  • 48
    • 18244376372 scopus 로고    scopus 로고
    • Reversal of long-term sepsis-induced immunosuppression by dendritic cells
    • Benjamim CF, Lundy SK, Lukacs NW, Hogaboam CM, Kunkel SL (2005) Reversal of long-term sepsis-induced immunosuppression by dendritic cells. Blood 105:3588-3595
    • (2005) Blood , vol.105 , pp. 3588-3595
    • Benjamim, C.F.1    Lundy, S.K.2    Lukacs, N.W.3    Hogaboam, C.M.4    Kunkel, S.L.5
  • 49
    • 33646087221 scopus 로고    scopus 로고
    • Dendritic cells during polymicrobial sepsis rapidly mature but fail to initiate a protective Th1-type immune response
    • Flohe SB, Agrawal H, Schmitz D, Gertz M, Flohe S, Schade FU (2006) Dendritic cells during polymicrobial sepsis rapidly mature but fail to initiate a protective Th1-type immune response. J Leukoc Biol 79:473-481
    • (2006) J Leukoc Biol , vol.79 , pp. 473-481
    • Flohe, S.B.1    Agrawal, H.2    Schmitz, D.3    Gertz, M.4    Flohe, S.5    Schade, F.U.6
  • 51
    • 0033854152 scopus 로고    scopus 로고
    • Leukocyte activation in sepsis; Correlations with disease state and mortality
    • Muller Kobold AC, Tulleken JE, Zijlstra JG et al (2000) Leukocyte activation in sepsis; correlations with disease state and mortality. Intensive Care Med 26:883-892
    • (2000) Intensive Care Med , vol.26 , pp. 883-892
    • Muller Kobold, A.C.1    Tulleken, J.E.2    Zijlstra, J.G.3
  • 52
    • 0033929552 scopus 로고    scopus 로고
    • Role of nitric oxide in the failure of neutrophil migration in sepsis
    • Benjamim CF, Ferreira SH, Cunha FQ (2000) Role of nitric oxide in the failure of neutrophil migration in sepsis. J Infect Dis 182:214-223
    • (2000) J Infect Dis , vol.182 , pp. 214-223
    • Benjamim, C.F.1    Ferreira, S.H.2    Cunha, F.Q.3
  • 53
    • 0036256051 scopus 로고    scopus 로고
    • Failure of neutrophil chemotactic function in septic patients
    • Tavares-Murta BM, Zaparoli M, Ferreira RB et al (2002) Failure of neutrophil chemotactic function in septic patients. Crit Care Med 30:1056-1061
    • (2002) Crit Care Med , vol.30 , pp. 1056-1061
    • Tavares-Murta, B.M.1    Zaparoli, M.2    Ferreira, R.B.3
  • 54
    • 0031029109 scopus 로고    scopus 로고
    • Impaired neutrophil adherence as an early marker of systemic inflammatory response syndrome and severe sepsis
    • Terregino CA, Lubkin CL, Thom SR (1997) Impaired neutrophil adherence as an early marker of systemic inflammatory response syndrome and severe sepsis. Ann Emerg Med 29:400-403
    • (1997) Ann Emerg Med , vol.29 , pp. 400-403
    • Terregino, C.A.1    Lubkin, C.L.2    Thom, S.R.3
  • 55
    • 0032779710 scopus 로고    scopus 로고
    • Functional significance of CXCR2 downregulation on neutrophils from patients with severe sepsis
    • Goodman R, Cummings C, Frevert C, Quan J, Martin T (1999) Functional significance of CXCR2 downregulation on neutrophils from patients with severe sepsis. Chest 116:111S-112S
    • (1999) Chest , vol.116
    • Goodman, R.1    Cummings, C.2    Frevert, C.3    Quan, J.4    Martin, T.5
  • 57
    • 0033945725 scopus 로고    scopus 로고
    • CXC chemokine receptor CXCR2 is essential for protective innate host response in murine Pseudomonas aeruginosa pneumonia
    • Tsai WC, Strieter RM, Mehrad B, Newstead MW, Zeng X, Standiford TJ (2000) CXC chemokine receptor CXCR2 is essential for protective innate host response in murine Pseudomonas aeruginosa pneumonia. Infect Immun 68:4289-4296
    • (2000) Infect Immun , vol.68 , pp. 4289-4296
    • Tsai, W.C.1    Strieter, R.M.2    Mehrad, B.3    Newstead, M.W.4    Zeng, X.5    Standiford, T.J.6
  • 58
    • 21744461598 scopus 로고    scopus 로고
    • Harmful and protective roles of neutrophils in sepsis
    • Hoesel LM, Neff TA, Neff SB et al (2005) Harmful and protective roles of neutrophils in sepsis. Shock 24:40-47
    • (2005) Shock , vol.24 , pp. 40-47
    • Hoesel, L.M.1    Neff, T.A.2    Neff, S.B.3
  • 59
    • 0037323852 scopus 로고    scopus 로고
    • Multicenter, double-blind, placebo-controlled study of the use of filgrastim in patients hospitalized with pneumonia and severe sepsis
    • Root RK, Lodato RF, Patrick W et al (2003) Multicenter, double-blind, placebo-controlled study of the use of filgrastim in patients hospitalized with pneumonia and severe sepsis. Crit Care Med 31:367-373
    • (2003) Crit Care Med , vol.31 , pp. 367-373
    • Root, R.K.1    Lodato, R.F.2    Patrick, W.3
  • 60
    • 0032770246 scopus 로고    scopus 로고
    • Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction
    • Hotchkiss RS, Swanson PE, Freeman BD et al (1999) Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 27:1230-1251
    • (1999) Crit Care Med , vol.27 , pp. 1230-1251
    • Hotchkiss, R.S.1    Swanson, P.E.2    Freeman, B.D.3
  • 61
    • 0033431682 scopus 로고    scopus 로고
    • Prevention of lymphocyte cell death in sepsis improves survival in mice
    • Hotchkiss RS, Tinsley KW, Swanson PE et al (1999) Prevention of lymphocyte cell death in sepsis improves survival in mice. Proc Natl Acad Sci U S A 96:14541-14546
    • (1999) Proc Natl Acad Sci U S a , vol.96 , pp. 14541-14546
    • Hotchkiss, R.S.1    Tinsley, K.W.2    Swanson, P.E.3
  • 62
    • 0035338993 scopus 로고    scopus 로고
    • Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans
    • Hotchkiss RS, Tinsley KW, Swanson PE et al (2001) Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans. J Immunol 166:6952-6963
    • (2001) J Immunol , vol.166 , pp. 6952-6963
    • Hotchkiss, R.S.1    Tinsley, K.W.2    Swanson, P.E.3
  • 63
    • 0031263064 scopus 로고    scopus 로고
    • Lymphocyte counts and the development of nosocomial sepsis
    • Rajan G, Sleigh JW (1997) Lymphocyte counts and the development of nosocomial sepsis. Intensive Care Med 23:1187
    • (1997) Intensive Care Med , vol.23 , pp. 1187
    • Rajan, G.1    Sleigh, J.W.2
  • 64
    • 5944251623 scopus 로고    scopus 로고
    • Caspase inhibitors improve survival in sepsis: A critical role of the lymphocyte
    • Hotchkiss RS, Chang KC, Swanson PE et al (2000) Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte. Nat Immunol 1:496-501
    • (2000) Nat Immunol , vol.1 , pp. 496-501
    • Hotchkiss, R.S.1    Chang, K.C.2    Swanson, P.E.3
  • 65
    • 5644241698 scopus 로고    scopus 로고
    • Dysregulation of the immune response in severe sepsis
    • Pinsky MR (2004) Dysregulation of the immune response in severe sepsis. Am J Med Sci 328:220-229
    • (2004) Am J Med Sci , vol.328 , pp. 220-229
    • Pinsky, M.R.1
  • 66
    • 0017737597 scopus 로고
    • Delayed hypersensitivity: Indicator of acquired failure of host defenses in sepsis and trauma
    • Meakins JL, Pietsch JB, Bubenick O et al (1977) Delayed hypersensitivity: indicator of acquired failure of host defenses in sepsis and trauma. Ann Surg 186:241-250
    • (1977) Ann Surg , vol.186 , pp. 241-250
    • Meakins, J.L.1    Pietsch, J.B.2    Bubenick, O.3
  • 67
    • 0342751267 scopus 로고    scopus 로고
    • Differential effects of necrotic or apoptotic cell uptake on antigen presentation by macrophages
    • Barker RN, Erwig L, Pearce WP, Devine A, Rees AJ (1999) Differential effects of necrotic or apoptotic cell uptake on antigen presentation by macrophages. Pathobiology 67:302-305
    • (1999) Pathobiology , vol.67 , pp. 302-305
    • Barker, R.N.1    Erwig, L.2    Pearce, W.P.3    Devine, A.4    Rees, A.J.5
  • 69
    • 0038312126 scopus 로고    scopus 로고
    • Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis
    • Hotchkiss RS, Chang KC, Grayson MH et al (2003) Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis. Proc Natl Acad Sci U S A 100:6724-6729
    • (2003) Proc Natl Acad Sci U S a , vol.100 , pp. 6724-6729
    • Hotchkiss, R.S.1    Chang, K.C.2    Grayson, M.H.3
  • 70
    • 0032509295 scopus 로고    scopus 로고
    • Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
    • Poltorak A, He X, Smirnova I et al (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085-2088
    • (1998) Science , vol.282 , pp. 2085-2088
    • Poltorak, A.1    He, X.2    Smirnova, I.3
  • 71
    • 0034084438 scopus 로고    scopus 로고
    • TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
    • Arbour NC, Lorenz E, Schutte BC et al (2000) TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 25:187-191
    • (2000) Nat Genet , vol.25 , pp. 187-191
    • Arbour, N.C.1    Lorenz, E.2    Schutte, B.C.3
  • 72
    • 15544369643 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease
    • Schroder NW, Schumann RR (2005) Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease. Lancet Infect Dis 5:156-164
    • (2005) Lancet Infect Dis , vol.5 , pp. 156-164
    • Schroder, N.W.1    Schumann, R.R.2
  • 73
    • 0037111078 scopus 로고    scopus 로고
    • Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections
    • Agnese DM, Calvano JE, Hahm SJ et al (2002) Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J Infect Dis 186:1522-1525
    • (2002) J Infect Dis , vol.186 , pp. 1522-1525
    • Agnese, D.M.1    Calvano, J.E.2    Hahm, S.J.3
  • 74
    • 0037071251 scopus 로고    scopus 로고
    • Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock
    • Lorenz E, Mira JP, Frees KL, Schwartz DA (2002) Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch Intern Med 162:1028-1032
    • (2002) Arch Intern Med , vol.162 , pp. 1028-1032
    • Lorenz, E.1    Mira, J.P.2    Frees, K.L.3    Schwartz, D.A.4
  • 75
    • 0033794461 scopus 로고    scopus 로고
    • A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection
    • Lorenz E, Mira JP, Cornish KL, Arbour NC, Schwartz DA (2000) A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect Immun 68:6398-6401
    • (2000) Infect Immun , vol.68 , pp. 6398-6401
    • Lorenz, E.1    Mira, J.P.2    Cornish, K.L.3    Arbour, N.C.4    Schwartz, D.A.5
  • 76
    • 34250869345 scopus 로고    scopus 로고
    • Bench-to-bedside review: Endotoxin tolerance as a model of leukocyte reprogramming in sepsis
    • Cavaillon JM, Adib-Conquy M (2006) Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis. Crit Care 10:233
    • (2006) Crit Care , vol.10 , pp. 233
    • Cavaillon, J.M.1    Adib-Conquy, M.2
  • 77
    • 0035871626 scopus 로고    scopus 로고
    • Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediators
    • Lehner MD, Morath S, Michelsen KS, Schumann RR, Hartung T (2001) Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediators. J Immunol 166:5161-5167
    • (2001) J Immunol , vol.166 , pp. 5161-5167
    • Lehner, M.D.1    Morath, S.2    Michelsen, K.S.3    Schumann, R.R.4    Hartung, T.5
  • 78
    • 0037151080 scopus 로고    scopus 로고
    • Gram-negative flagellin-induced self-tolerance is associated with a block in interleukin-1 receptor-associated kinase release from toll-like receptor 5
    • Mizel SB, Snipes JA (2002) Gram-negative flagellin-induced self-tolerance is associated with a block in interleukin-1 receptor-associated kinase release from toll-like receptor 5. J Biol Chem 277:22414-22420
    • (2002) J Biol Chem , vol.277 , pp. 22414-22420
    • Mizel, S.B.1    Snipes, J.A.2
  • 79
    • 0034671772 scopus 로고    scopus 로고
    • Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways
    • Sato S, Nomura F, Kawai T et al (2000) Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways. J Immunol 165:7096-7101
    • (2000) J Immunol , vol.165 , pp. 7096-7101
    • Sato, S.1    Nomura, F.2    Kawai, T.3
  • 81
    • 0036319517 scopus 로고    scopus 로고
    • A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways
    • Sato S, Takeuchi O, Fujita T, Tomizawa H, Takeda K, Akira S (2002) A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways. Int Immunol 14:783-791
    • (2002) Int Immunol , vol.14 , pp. 783-791
    • Sato, S.1    Takeuchi, O.2    Fujita, T.3    Tomizawa, H.4    Takeda, K.5    Akira, S.6
  • 82
    • 10744223303 scopus 로고    scopus 로고
    • Involvement of IRAK-M in peptidoglycan-induced tolerance in macrophages
    • Nakayama K, Okugawa S, Yanagimoto S et al (2004) Involvement of IRAK-M in peptidoglycan-induced tolerance in macrophages. J Biol Chem 279:6629-6634
    • (2004) J Biol Chem , vol.279 , pp. 6629-6634
    • Nakayama, K.1    Okugawa, S.2    Yanagimoto, S.3
  • 83
    • 0037183979 scopus 로고    scopus 로고
    • Induction of bacterial lipoprotein tolerance is associated with suppression of toll-like receptor 2 expression
    • Wang JH, Doyle M, Manning BJ, Di Wu Q, Blankson S, Redmond HP (2002) Induction of bacterial lipoprotein tolerance is associated with suppression of toll-like receptor 2 expression. J Biol Chem 277:36068-36075
    • (2002) J Biol Chem , vol.277 , pp. 36068-36075
    • Wang, J.H.1    Doyle, M.2    Manning, B.J.3    Di Wu, Q.4    Blankson, S.5    Redmond, H.P.6
  • 84
    • 0034725584 scopus 로고    scopus 로고
    • Characterization of interleukin-1 receptor-associated kinase in normal and endotoxin-tolerant cells
    • Li L, Cousart S, Hu J, McCall CE (2000) Characterization of interleukin-1 receptor-associated kinase in normal and endotoxin-tolerant cells. J Biol Chem 275:23340-23345
    • (2000) J Biol Chem , vol.275 , pp. 23340-23345
    • Li, L.1    Cousart, S.2    Hu, J.3    McCall, C.E.4
  • 85
    • 0036838930 scopus 로고    scopus 로고
    • Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells
    • Medvedev AE, Lentschat A, Wahl LM, Golenbock DT, Vogel SN (2002) Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells. J Immunol 169:5209-5216
    • (2002) J Immunol , vol.169 , pp. 5209-5216
    • Medvedev, A.E.1    Lentschat, A.2    Wahl, L.M.3    Golenbock, D.T.4    Vogel, S.N.5
  • 86
    • 0033623495 scopus 로고    scopus 로고
    • NF-kappaB expression in mononuclear cells of patients with sepsis resembles that observed in lipopolysaccharide tolerance
    • Adib-Conquy M, Adrie C, Moine P et al (2000) NF-kappaB expression in mononuclear cells of patients with sepsis resembles that observed in lipopolysaccharide tolerance. Am J Respir Crit Care Med 162:1877-1883
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 1877-1883
    • Adib-Conquy, M.1    Adrie, C.2    Moine, P.3
  • 87
    • 0028229050 scopus 로고
    • Tolerance to lipopolysaccharide involves mobilization of nuclear factor kappa B with predominance of p50 homodimers
    • Ziegler-Heitbrock HW, Wedel A, Schraut W et al (1994) Tolerance to lipopolysaccharide involves mobilization of nuclear factor kappa B with predominance of p50 homodimers. J Biol Chem 269:17001-17004
    • (1994) J Biol Chem , vol.269 , pp. 17001-17004
    • Ziegler-Heitbrock, H.W.1    Wedel, A.2    Schraut, W.3
  • 88
    • 33748317968 scopus 로고    scopus 로고
    • Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M
    • Deng JC, Cheng G, Newstead MW et al (2006) Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M. J Clin Invest 116:2532-2542
    • (2006) J Clin Invest , vol.116 , pp. 2532-2542
    • Deng, J.C.1    Cheng, G.2    Newstead, M.W.3
  • 89
    • 0242362818 scopus 로고    scopus 로고
    • Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients
    • Escoll P, del Fresno C, Garcia L et al (2003) Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients. Biochem Biophys Res Commun 311:465-472
    • (2003) Biochem Biophys Res Commun , vol.311 , pp. 465-472
    • Escoll, P.1    Del Fresno, C.2    Garcia, L.3
  • 90
    • 0036188871 scopus 로고    scopus 로고
    • Response of tumour necrosis factor-alpha to delayed in vitro monocyte stimulation in patients with septic shock is related to outcome
    • Appoloni O, Vincent JL, Duchateau J (2002) Response of tumour necrosis factor-alpha to delayed in vitro monocyte stimulation in patients with septic shock is related to outcome. Clin Sci (Lond) 102:315-320
    • (2002) Clin Sci (Lond) , vol.102 , pp. 315-320
    • Appoloni, O.1    Vincent, J.L.2    Duchateau, J.3
  • 91
    • 0041919526 scopus 로고    scopus 로고
    • Lower levels of whole blood LPS-stimulated cytokine release are associated with poorer clinical outcomes in surgical ICU patients
    • Heagy W, Nieman K, Hansen C, Cohen M, Danielson D, West MA (2003) Lower levels of whole blood LPS-stimulated cytokine release are associated with poorer clinical outcomes in surgical ICU patients. Surg Infect (Larchmt) 4:171-180
    • (2003) Surg Infect (Larchmt) , vol.4 , pp. 171-180
    • Heagy, W.1    Nieman, K.2    Hansen, C.3    Cohen, M.4    Danielson, D.5    West, M.A.6
  • 92
    • 33748567413 scopus 로고    scopus 로고
    • Toll-like receptor (TLR) response tolerance: A key physiological "damage limitation" effect and an important potential opportunity for therapy
    • Broad A, Jones DE, Kirby JA (2006) Toll-like receptor (TLR) response tolerance: a key physiological "damage limitation" effect and an important potential opportunity for therapy. Curr Med Chem 13:2487-2502
    • (2006) Curr Med Chem , vol.13 , pp. 2487-2502
    • Broad, A.1    Jones, D.E.2    Kirby, J.A.3
  • 93
    • 0037008716 scopus 로고    scopus 로고
    • Gamma interferon and granulocyte/monocyte colony-stimulating factor prevent endotoxin tolerance in human monocytes by promoting interleukin-1 receptor-associated kinase expression and its association to MyD88 and not by modulating TLR4 expression
    • Adib-Conquy M, Cavaillon JM (2002) Gamma interferon and granulocyte/monocyte colony-stimulating factor prevent endotoxin tolerance in human monocytes by promoting interleukin-1 receptor-associated kinase expression and its association to MyD88 and not by modulating TLR4 expression. J Biol Chem 277:27927-27934
    • (2002) J Biol Chem , vol.277 , pp. 27927-27934
    • Adib-Conquy, M.1    Cavaillon, J.M.2
  • 94
    • 0036565888 scopus 로고    scopus 로고
    • Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-gamma: A molecular basis for priming and synergism with bacterial lipopolysaccharide
    • Bosisio D, Polentarutti N, Sironi M et al (2002) Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-gamma: a molecular basis for priming and synergism with bacterial lipopolysaccharide. Blood 99:3427-3431
    • (2002) Blood , vol.99 , pp. 3427-3431
    • Bosisio, D.1    Polentarutti, N.2    Sironi, M.3
  • 96
    • 26244452958 scopus 로고    scopus 로고
    • Genetic polymorphisms and sepsis
    • Arcaroli J, Fessler MB, Abraham E (2005) Genetic polymorphisms and sepsis. Shock 24:300-312
    • (2005) Shock , vol.24 , pp. 300-312
    • Arcaroli, J.1    Fessler, M.B.2    Abraham, E.3
  • 97
    • 0031033476 scopus 로고    scopus 로고
    • Genetic influence on cytokine production and fatal meningococcal disease
    • Westendorp RG, Langermans JA, Huizinga TW et al (1997) Genetic influence on cytokine production and fatal meningococcal disease. Lancet 349:170-173
    • (1997) Lancet , vol.349 , pp. 170-173
    • Westendorp, R.G.1    Langermans, J.A.2    Huizinga, T.W.3
  • 98
    • 33845955757 scopus 로고    scopus 로고
    • Genetics of individualizing patient care
    • Pinsky MR (2007) Genetics of individualizing patient care. Crit Care Med 35:287-280
    • (2007) Crit Care Med , vol.35 , pp. 287-280
    • Pinsky, M.R.1
  • 99
    • 33846531198 scopus 로고    scopus 로고
    • Innate immunity SNPs are associated with risk for severe sepsis after burn injury
    • Barber RC, Chang LY, Arnoldo BD et al (2006) Innate immunity SNPs are associated with risk for severe sepsis after burn injury. Clin Med Res 4:250-255
    • (2006) Clin Med Res , vol.4 , pp. 250-255
    • Barber, R.C.1    Chang, L.Y.2    Arnoldo, B.D.3
  • 100
    • 34249283440 scopus 로고    scopus 로고
    • Gender differences in the innate immune response and vascular reactivity following the administration of endotoxin to human volunteers
    • van Eijk LT, Dorresteijn MJ, Smits P, van der Hoeven JG, Netea MG, Pickkers P (2007) Gender differences in the innate immune response and vascular reactivity following the administration of endotoxin to human volunteers. Crit Care Med 35:1464-1469
    • (2007) Crit Care Med , vol.35 , pp. 1464-1469
    • Van Eijk, L.T.1    Dorresteijn, M.J.2    Smits, P.3    Van Der Hoeven, J.G.4    Netea, M.G.5    Pickkers, P.6
  • 101
    • 34547700084 scopus 로고    scopus 로고
    • Effects of CD14-159 C/T polymorphism on CD14 expression and the balance between proinflammatory and anti-inflammatory cytokines in whole blood culture
    • Lin J, Yao YM, Yu Y et al (2007) Effects of CD14-159 C/T polymorphism on CD14 expression and the balance between proinflammatory and anti-inflammatory cytokines in whole blood culture. Shock 28:148-153
    • (2007) Shock , vol.28 , pp. 148-153
    • Lin, J.1    Yao, Y.M.2    Yu, Y.3
  • 102
    • 0036025221 scopus 로고    scopus 로고
    • The -260 C→T promoter polymorphism of the lipopolysaccharide receptor CD14 and severe sepsis in trauma patients
    • Heesen M, Bloemeke B, Schade U, Obertacke U, Majetschak M (2002) The -260 C→T promoter polymorphism of the lipopolysaccharide receptor CD14 and severe sepsis in trauma patients. Intensive Care Med 28:1161-1163
    • (2002) Intensive Care Med , vol.28 , pp. 1161-1163
    • Heesen, M.1    Bloemeke, B.2    Schade, U.3    Obertacke, U.4    Majetschak, M.5
  • 103
    • 0036255629 scopus 로고    scopus 로고
    • Association between a genomic polymorphism within the CD14 locus and septic shock susceptibility and mortality rate
    • Gibot S, Cariou A, Drouet L, Rossignol M, Ripoll L (2002) Association between a genomic polymorphism within the CD14 locus and septic shock susceptibility and mortality rate. Crit Care Med 30:969-973
    • (2002) Crit Care Med , vol.30 , pp. 969-973
    • Gibot, S.1    Cariou, A.2    Drouet, L.3    Rossignol, M.4    Ripoll, L.5
  • 104
    • 33646792250 scopus 로고    scopus 로고
    • Pre- and postoperative cytokine release after in vitro whole blood lipopolysaccharide stimulation and frequent toll-like receptor 4 polymorphisms
    • Kumpf O, Hamann L, Schlag PM, Schumann RR (2006) Pre- and postoperative cytokine release after in vitro whole blood lipopolysaccharide stimulation and frequent toll-like receptor 4 polymorphisms. Shock 25:123-128
    • (2006) Shock , vol.25 , pp. 123-128
    • Kumpf, O.1    Hamann, L.2    Schlag, P.M.3    Schumann, R.R.4
  • 106
    • 34250848196 scopus 로고    scopus 로고
    • Chronic sepsis mortality characterized by an individualized inflammatory response
    • Osuchowski MF, Welch K, Yang H, Siddiqui J, Remick DG (2007) Chronic sepsis mortality characterized by an individualized inflammatory response. J Immunol 179:623-630
    • (2007) J Immunol , vol.179 , pp. 623-630
    • Osuchowski, M.F.1    Welch, K.2    Yang, H.3    Siddiqui, J.4    Remick, D.G.5
  • 107
    • 0031003777 scopus 로고    scopus 로고
    • Magnitude and duration of the effect of sepsis on survival. Department of Veterans Affairs Systemic Sepsis Cooperative Studies Group
    • Quartin AA, Schein RM, Kett DH, Peduzzi PN (1997) Magnitude and duration of the effect of sepsis on survival. Department of Veterans Affairs Systemic Sepsis Cooperative Studies Group. JAMA 277:1058-1063
    • (1997) JAMA , vol.277 , pp. 1058-1063
    • Quartin, A.A.1    Schein, R.M.2    Kett, D.H.3    Peduzzi, P.N.4
  • 108
    • 16644366184 scopus 로고    scopus 로고
    • Severe sepsis in managed care: Analysis of incidence, one-year mortality, and associated costs of care
    • Braun L, Riedel AA, Cooper LM (2004) Severe sepsis in managed care: analysis of incidence, one-year mortality, and associated costs of care. J Manag Care Pharm 10:521-530
    • (2004) J Manag Care Pharm , vol.10 , pp. 521-530
    • Braun, L.1    Riedel, A.A.2    Cooper, L.M.3
  • 109
    • 23444457479 scopus 로고    scopus 로고
    • Surgical trauma and immunosuppression: Pathophysiology and potential immunomodulatory approaches
    • Angele MK, Chaudry IH (2005) Surgical trauma and immunosuppression: pathophysiology and potential immunomodulatory approaches. Langenbecks Arch Surg 390:333-341
    • (2005) Langenbecks Arch Surg , vol.390 , pp. 333-341
    • Angele, M.K.1    Chaudry, I.H.2
  • 110
    • 0036336711 scopus 로고    scopus 로고
    • Clinical review: Immunodepression in the surgical patient and increased susceptibility to infection
    • Angele MK, Faist E (2002) Clinical review: immunodepression in the surgical patient and increased susceptibility to infection. Crit Care 6:298-305
    • (2002) Crit Care , vol.6 , pp. 298-305
    • Angele, M.K.1    Faist, E.2
  • 111
    • 0035135739 scopus 로고    scopus 로고
    • Normal responses to injury prevent systemic inflammation and can be immunosuppressive
    • Munford RS, Pugin J (2001) Normal responses to injury prevent systemic inflammation and can be immunosuppressive. Am J Respir Crit Care Med 163:316-321
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 316-321
    • Munford, R.S.1    Pugin, J.2
  • 112
    • 0014044981 scopus 로고
    • Endotoxin shock. Hemodynamic and survival effects of methylprednisolone
    • Hinshaw LB, Solomon LA, Freeny PC, Reins DA (1967) Endotoxin shock. Hemodynamic and survival effects of methylprednisolone. Arch Surg 94:61-66
    • (1967) Arch Surg , vol.94 , pp. 61-66
    • Hinshaw, L.B.1    Solomon, L.A.2    Freeny, P.C.3    Reins, D.A.4
  • 113
    • 0023252009 scopus 로고
    • A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock
    • Bone RC, Fisher CJ Jr., Clemmer TP, Slotman GJ, Metz CA, Balk RA (1987) A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med 317:653-658
    • (1987) N Engl J Med , vol.317 , pp. 653-658
    • Bone, R.C.1    Fisher Jr., C.J.2    Clemmer, T.P.3    Slotman, G.J.4    Metz, C.A.5    Balk, R.A.6
  • 114
    • 0023239471 scopus 로고
    • Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. the Veterans Administration Systemic Sepsis Cooperative Study Group
    • Group TVASSCS
    • Group TVASSCS (1987) Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. The Veterans Administration Systemic Sepsis Cooperative Study Group. N Engl J Med 317:659-665
    • (1987) N Engl J Med , vol.317 , pp. 659-665
  • 115
    • 0037151571 scopus 로고    scopus 로고
    • Effect of treatment with low doses of hydrocortisone and fluorocortisone on mortality in patients with septic shock
    • Annane D, Sebille V, Charpentier C et al (2002) Effect of treatment with low doses of hydrocortisone and fluorocortisone on mortality in patients with septic shock. JAMA 288:862-871
    • (2002) JAMA , vol.288 , pp. 862-871
    • Annane, D.1    Sebille, V.2    Charpentier, C.3
  • 116
    • 8544262221 scopus 로고    scopus 로고
    • Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels
    • Panacek EA, Marshall JC, Albertson TE et al (2004) Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels. Crit Care Med 32:2173-2182
    • (2004) Crit Care Med , vol.32 , pp. 2173-2182
    • Panacek, E.A.1    Marshall, J.C.2    Albertson, T.E.3
  • 117
    • 0343775765 scopus 로고    scopus 로고
    • Injury induces deficient interleukin-12 production, but interleukin-12 therapy after injury restores resistance to infection
    • Goebel A, Kavanagh E, Lyons A et al (2000) Injury induces deficient interleukin-12 production, but interleukin-12 therapy after injury restores resistance to infection. Ann Surg 231:253-261
    • (2000) Ann Surg , vol.231 , pp. 253-261
    • Goebel, A.1    Kavanagh, E.2    Lyons, A.3
  • 119
    • 31844434994 scopus 로고    scopus 로고
    • Statins and sepsis in patients with cardiovascular disease: A population-based cohort analysis
    • Hackam DG, Mamdani M, Li P, Redelmeier DA (2006) Statins and sepsis in patients with cardiovascular disease: a population-based cohort analysis. Lancet 367:413-418
    • (2006) Lancet , vol.367 , pp. 413-418
    • Hackam, D.G.1    Mamdani, M.2    Li, P.3    Redelmeier, D.A.4
  • 120
    • 33750958903 scopus 로고    scopus 로고
    • Statins and outcomes in patients admitted to hospital with community acquired pneumonia: Population based prospective cohort study
    • Majumdar SR, McAlister FA, Eurich DT, Padwal RS, Marrie TJ (2006) Statins and outcomes in patients admitted to hospital with community acquired pneumonia: population based prospective cohort study. Br Med J 333:999
    • (2006) Br Med J , vol.333 , pp. 999
    • Majumdar, S.R.1    McAlister, F.A.2    Eurich, D.T.3    Padwal, R.S.4    Marrie, T.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.