H2AX phosphorylation in A549 cells induced by the bulky and stable DNA adducts of benzo[a]pyrene and dibenzo[a,l]pyrene diol epoxides

Chemico-Biological Interactions

Volumn 177, Issue 1, 2009, Pages 40-47

  Mattsson, Åse ^a   Jernström, Bengt ^a   Cotgreave, Ian A ^a,b   Bajak, Edyta ^a,c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

BPDE; DBPDE; Diol epoxide; DNA adducts; H2AX; PAH

Indexed keywords

BENZO[A]PYRENE; DIBENZO[A,L]PYRENE DIOL EPOXIDE DERIVATIVE; DIHYDROXYBENZO[A]PYRENE OXIDE; HISTONE H2AX; HISTONE H2AX GAMMA; HYDROGEN PEROXIDE; POLYCYCLIC AROMATIC HYDROCARBON; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENICITY; COMET ASSAY; CONTROLLED STUDY; DNA ADDUCT; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; BAY-REGION, POLYCYCLIC AROMATIC HYDROCARBON; BENZO(A)PYRENE; BENZOPYRENES; BLOTTING, WESTERN; CELL LINE, TUMOR; COMET ASSAY; DNA ADDUCTS; DNA DAMAGE; DNA FRAGMENTATION; EPOXY COMPOUNDS; HISTONES; HUMANS; IMMUNOHISTOCHEMISTRY; PHOSPHORYLATION; TIME FACTORS;

EID: 57449087440     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2008.09.015     Document Type: Article

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