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Volumn 19, Issue 7, 2005, Pages 704-715

More than just strand breaks: The recognition of structural DNA discontinuities by DNA-dependent protein kinase catalytic subunit

Author keywords

DNA synthesis; DNA PK; Double strand break; Eukaryote; Genome

Indexed keywords

DNA DEPENDENT PROTEIN KINASE; NUCLEIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE;

EID: 18144399248     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.04-3041rev     Document Type: Review
Times cited : (38)

References (97)
  • 1
    • 0035289717 scopus 로고    scopus 로고
    • Chromosomal stability and the DNA double-stranded break connection
    • van Gent, D. C., Hoeijmakers, J. H., and Kanaar, R. (2001) Chromosomal stability and the DNA double-stranded break connection. Nat. Rev. Genet. 2, 196-206
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 196-206
    • Van Gent, D.C.1    Hoeijmakers, J.H.2    Kanaar, R.3
  • 2
    • 0037196076 scopus 로고    scopus 로고
    • The nonmutagenic repair of broken replication forks via recombination
    • Cox, M. M. (2002) The nonmutagenic repair of broken replication forks via recombination. Mutat. Res. 510, 107-120
    • (2002) Mutat. Res. , vol.510 , pp. 107-120
    • Cox, M.M.1
  • 3
  • 4
    • 0025224761 scopus 로고
    • Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen
    • Lees-Miller, S. P., Chen, Y. R., and Anderson, C. W. (1990) Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen. Mol. Cell. Biol. 10, 6472-6481
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 6472-6481
    • Lees-Miller, S.P.1    Chen, Y.R.2    Anderson, C.W.3
  • 5
    • 0027048773 scopus 로고
    • Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II
    • Dvir, A., Peterson, S. R., Knuth, M. W., Lu, H., and Dynan, W. S. (1992) Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II. Proc. Natl. Acad. Sci. USA 89, 11920-11924
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 11920-11924
    • Dvir, A.1    Peterson, S.R.2    Knuth, M.W.3    Lu, H.4    Dynan, W.S.5
  • 6
    • 2342565902 scopus 로고    scopus 로고
    • A means to a DNA end: The many roles of Ku
    • Downs, J. A., and Jackson, S. P. (2004) A means to a DNA end: the many roles of Ku. Nat. Rev. Mol. Cell Biol. 5, 367-378
    • (2004) Nat. Rev. Mol. Cell Biol. , vol.5 , pp. 367-378
    • Downs, J.A.1    Jackson, S.P.2
  • 8
    • 0029582791 scopus 로고
    • Equine severe combined immunodeficiency: A defect in V(D)J recombination and DNA-dependent protein kinase activity
    • Wiler, R., Leber, R., Moore, B. B., VanDyk, L. F., Perryman, L. E., and Meek, K. (1995) Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity. Proc. Natl. Acad. Sci. USA 92, 11485-11489
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 11485-11489
    • Wiler, R.1    Leber, R.2    Moore, B.B.3    VanDyk, L.F.4    Perryman, L.E.5    Meek, K.6
  • 10
    • 0025011134 scopus 로고
    • The scid mutation in mice causes a general defect in DNA repair
    • Fulop, G. M., and Phillips, R. A. (1990) The scid mutation in mice causes a general defect in DNA repair. Nature (London) 347, 479-482
    • (1990) Nature (London) , vol.347 , pp. 479-482
    • Fulop, G.M.1    Phillips, R.A.2
  • 11
    • 0032052815 scopus 로고    scopus 로고
    • Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids
    • Dynan, W. S., and Yoo, S. (1999) Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids. Nucleic Acids Res. 26, 1551-1559
    • (1999) Nucleic Acids Res. , vol.26 , pp. 1551-1559
    • Dynan, W.S.1    Yoo, S.2
  • 13
    • 0347510576 scopus 로고    scopus 로고
    • End-joining of blunt DNA double-strand breaks in mammalian fibroblasts is precise and requires DNA-PK and XRCC4
    • van Heemst, D., Brugmans, L., Verkaik, N. S., and van Gent, D. C. (2004) End-joining of blunt DNA double-strand breaks in mammalian fibroblasts is precise and requires DNA-PK and XRCC4. DNA Repair (Amsterdam) 3, 43-50
    • (2004) DNA Repair (Amsterdam) , vol.3 , pp. 43-50
    • Van Heemst, D.1    Brugmans, L.2    Verkaik, N.S.3    Van Gent, D.C.4
  • 14
    • 0028286463 scopus 로고
    • DNA-dependent protein kinase is activated by nicks and larger single-stranded gaps
    • Morozov, V. E., Falzon, M., Anderson, C. W., and Kuff, E. L. (1994) DNA-dependent protein kinase is activated by nicks and larger single-stranded gaps. J. Biol. Chem. 269, 16684-16688
    • (1994) J. Biol. Chem. , vol.269 , pp. 16684-16688
    • Morozov, V.E.1    Falzon, M.2    Anderson, C.W.3    Kuff, E.L.4
  • 15
    • 0032528228 scopus 로고    scopus 로고
    • DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D
    • Yavuzer, U., Smith, G. C., Bliss, T., Werner, D., and Jackson, S. P. (1998) DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D. Genes Dev. 12, 2188-2199
    • (1998) Genes Dev. , vol.12 , pp. 2188-2199
    • Yavuzer, U.1    Smith, G.C.2    Bliss, T.3    Werner, D.4    Jackson, S.P.5
  • 16
    • 0035822641 scopus 로고    scopus 로고
    • Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells
    • d'Adda di Fagagna, F., Hande, M. P., Tong, W. M., Roth, D., Lansdorp, P. M., Wang, Z. Q., and Jackson, S. P. (2001) Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells. Curr. Biol. 11, 1192-1196
    • (2001) Curr. Biol. , vol.11 , pp. 1192-1196
    • D'Adda Di Fagagna, F.1    Hande, M.P.2    Tong, W.M.3    Roth, D.4    Lansdorp, P.M.5    Wang, Z.Q.6    Jackson, S.P.7
  • 17
    • 0037106537 scopus 로고    scopus 로고
    • DNA-PK-dependent binding of DNA ends to plasmids containing nuclear matrix attachment region DNA sequences: Evidence for assembly of a repair complex
    • Mauldin, S. K., Getts, R. C., Liu, W., and Stamato, T. D. (2002) DNA-PK-dependent binding of DNA ends to plasmids containing nuclear matrix attachment region DNA sequences: evidence for assembly of a repair complex. Nucleic Acids Res. 30, 4075-4087
    • (2002) Nucleic Acids Res. , vol.30 , pp. 4075-4087
    • Mauldin, S.K.1    Getts, R.C.2    Liu, W.3    Stamato, T.D.4
  • 18
    • 3142685133 scopus 로고    scopus 로고
    • Binding of the DNA-dependent protein kinase catalytic subunit to Holliday junctions
    • Dip, R., and Naegeli, H. (2004) Binding of the DNA-dependent protein kinase catalytic subunit to Holliday junctions. Biochem. J. 381, 165-174
    • (2004) Biochem. J. , vol.381 , pp. 165-174
    • Dip, R.1    Naegeli, H.2
  • 20
    • 0037155703 scopus 로고    scopus 로고
    • Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
    • Ma, Y., Pannicke, U., Schwarz, K., and Lieber, M. R. (2002) Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell 108, 781-794
    • (2002) Cell , vol.108 , pp. 781-794
    • Ma, Y.1    Pannicke, U.2    Schwarz, K.3    Lieber, M.R.4
  • 21
    • 0037124322 scopus 로고    scopus 로고
    • DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53
    • Woo, R. A., Jack, M. T., Xu, Y., Burma, S., Chen, D. J., and Lee, P. W. (2002) DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53. EMBO J. 21, 3000-3008
    • (2002) EMBO J. , vol.21 , pp. 3000-3008
    • Woo, R.A.1    Jack, M.T.2    Xu, Y.3    Burma, S.4    Chen, D.J.5    Lee, P.W.6
  • 22
    • 1942469377 scopus 로고    scopus 로고
    • Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions
    • Jensen, R., and Glazer, P. M. (2004) Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions. Proc. Natl. Acad. Sci. USA 101, 6134-6139
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 6134-6139
    • Jensen, R.1    Glazer, P.M.2
  • 24
    • 0035023139 scopus 로고    scopus 로고
    • The absence of the DNA-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang
    • Goytisolo, F. A., Samper, E., Edmonson, S., Taccioli, G. E., and Blasco, M. A. (2001) The absence of the DNA-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang. Mol. Cell. Biol. 21, 3642-3651
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3642-3651
    • Goytisolo, F.A.1    Samper, E.2    Edmonson, S.3    Taccioli, G.E.4    Blasco, M.A.5
  • 27
    • 0242526116 scopus 로고    scopus 로고
    • Down-regulation of histone H2B by DNA-dependent protein kinase in response to DNA damage through modulation of octamer transcription factor 1
    • Schild-Poulter, C., Shih, A., Yarymowich, N. C., and Haché, R. J. (2003) Down-regulation of histone H2B by DNA-dependent protein kinase in response to DNA damage through modulation of octamer transcription factor 1. Cancer Res. 63, 7197-7205
    • (2003) Cancer Res. , vol.63 , pp. 7197-7205
    • Schild-Poulter, C.1    Shih, A.2    Yarymowich, N.C.3    Haché, R.J.4
  • 28
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: Safeguarding genome integrity
    • Shiloh, Y. (2003) ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer 3, 155-168
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 30
    • 0346249708 scopus 로고    scopus 로고
    • Identification of DNA-PK in the arthropods. Evidence for the ancient ancestry of vertebrate non-homologous end-joining
    • Dore, A. S., Drake, A. C., Brewerton, S. C., and Blundell, T. L. (2004) Identification of DNA-PK in the arthropods. Evidence for the ancient ancestry of vertebrate non-homologous end-joining. DNA Repair (Amsterdam) 3, 33-41
    • (2004) DNA Repair (Amsterdam) , vol.3 , pp. 33-41
    • Dore, A.S.1    Drake, A.C.2    Brewerton, S.C.3    Blundell, T.L.4
  • 32
    • 0029156599 scopus 로고
    • DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
    • Hartley, K. O., Gell, D., Smith, G. C., Zhang, H., Divecha, N., Connelly, M. A., Admon, A., Lees-Miller, S. P., Anderson, C. W., and Jackson, S. P. (1995) DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 82, 849-856
    • (1995) Cell , vol.82 , pp. 849-856
    • Hartley, K.O.1    Gell, D.2    Smith, G.C.3    Zhang, H.4    Divecha, N.5    Connelly, M.A.6    Admon, A.7    Lees-Miller, S.P.8    Anderson, C.W.9    Jackson, S.P.10
  • 34
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist, C. J., and Kastan, M. B. (2003) DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature (London) 421, 499-506
    • (2003) Nature (London) , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 35
    • 0030771841 scopus 로고    scopus 로고
    • Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit
    • Jin, S., Kharbanda, S., Mayer, B., Kufe, D., and Weaver, D. T. (1997) Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit. J. Biol. Chem. 272, 24763-24766
    • (1997) J. Biol. Chem. , vol.272 , pp. 24763-24766
    • Jin, S.1    Kharbanda, S.2    Mayer, B.3    Kufe, D.4    Weaver, D.T.5
  • 37
    • 0030680162 scopus 로고    scopus 로고
    • Interaction between DNA-dependent protein kinase and a novel protein, KIP
    • Wu, X., and Lieber, M. R. (1997) Interaction between DNA-dependent protein kinase and a novel protein, KIP. Mutat. Res. 385, 13-20
    • (1997) Mutat. Res. , vol.385 , pp. 13-20
    • Wu, X.1    Lieber, M.R.2
  • 38
    • 0031930488 scopus 로고    scopus 로고
    • DNA-dependent protein kinase: DNA binding and activation in the absence of Ku
    • Hammarsten, O., and Chu, G. (1998) DNA-dependent protein kinase: DNA binding and activation in the absence of Ku. Proc. Natl. Acad. Sci. USA 95, 525-530
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 525-530
    • Hammarsten, O.1    Chu, G.2
  • 39
    • 0033560796 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase
    • Smith, G. C., and Jackson, S. P. (1999) The DNA-dependent protein kinase. Genes Dev. 13, 916-934
    • (1999) Genes Dev. , vol.13 , pp. 916-934
    • Smith, G.C.1    Jackson, S.P.2
  • 40
    • 1942538492 scopus 로고    scopus 로고
    • ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation
    • Stiff, T., O'Driscoll, M., Rief, N., Iwabuchi, K., Lobrich, M., and Jeggo, P. A. (2004) ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res. 64, 2390-2396
    • (2004) Cancer Res. , vol.64 , pp. 2390-2396
    • Stiff, T.1    O'Driscoll, M.2    Rief, N.3    Iwabuchi, K.4    Lobrich, M.5    Jeggo, P.A.6
  • 41
    • 1242264341 scopus 로고    scopus 로고
    • DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner
    • Zhang, S., Schlott, B., Gorlach, M., and Grosse, F. (2004) DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner. Nucleic Acids Res. 32, 1-10
    • (2004) Nucleic Acids Res. , vol.32 , pp. 1-10
    • Zhang, S.1    Schlott, B.2    Gorlach, M.3    Grosse, F.4
  • 42
    • 0035374588 scopus 로고    scopus 로고
    • Protein phosphatases regulate DNA-dependent protein kinase activity
    • Douglas, P., Moorhead, G. B., Ye, R., and Lees-Miller, S. P. (2001) Protein phosphatases regulate DNA-dependent protein kinase activity. J. Biol. Chem. 276, 18992-18998
    • (2001) J. Biol. Chem. , vol.276 , pp. 18992-18998
    • Douglas, P.1    Moorhead, G.B.2    Ye, R.3    Lees-Miller, S.P.4
  • 44
    • 0037159220 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation
    • Merkle, D., Douglas, P., Moorhead, G. B., Leonenko, Z., Yu, Y., Cramb, D., Bazett-Jones, D. P., and Lees-Miller, S. P. (2002) The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation. Biochemistry 41, 12706-12714
    • (2002) Biochemistry , vol.41 , pp. 12706-12714
    • Merkle, D.1    Douglas, P.2    Moorhead, G.B.3    Leonenko, Z.4    Yu, Y.5    Cramb, D.6    Bazett-Jones, D.P.7    Lees-Miller, S.P.8
  • 45
    • 4544295689 scopus 로고    scopus 로고
    • Nonhomologous end-joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends
    • In press
    • Reddy, Y. V., Ding, Q., Lees-Miller, S. P., Meek, K., and Ramsden, D. A. (2004) Nonhomologous end-joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends. J. Biol. Chem. In press
    • (2004) J. Biol. Chem.
    • Reddy, Y.V.1    Ding, Q.2    Lees-Miller, S.P.3    Meek, K.4    Ramsden, D.A.5
  • 46
    • 4043073590 scopus 로고    scopus 로고
    • Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase subunit regulates ligation of DNA ends
    • Block, W. D., Yu, Y., Merkle, D., Gifford, J. L., Ding, Q., Meek, K., and Lees-Miller, S. P. (2004) Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase subunit regulates ligation of DNA ends. Nucleic Acids Res. 32, 4351-4357
    • (2004) Nucleic Acids Res. , vol.32 , pp. 4351-4357
    • Block, W.D.1    Yu, Y.2    Merkle, D.3    Gifford, J.L.4    Ding, Q.5    Meek, K.6    Lees-Miller, S.P.7
  • 47
    • 0037106180 scopus 로고    scopus 로고
    • Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks
    • Chan, D. W., Chen, B. P., Prithivirajsingh, S., Kurimasa, A., Story, M. D., Qin, J., and Chen, D. J. (2002) Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev. 16, 2333-2338
    • (2002) Genes Dev. , vol.16 , pp. 2333-2338
    • Chan, D.W.1    Chen, B.P.2    Prithivirajsingh, S.3    Kurimasa, A.4    Story, M.D.5    Qin, J.6    Chen, D.J.7
  • 48
    • 0037444375 scopus 로고    scopus 로고
    • Threonines 2638/2647 in DNA-PK are essential for cellular resistance to ionizing radiation
    • Soubeyrand, S., Pope, L., Pakuts, B., and Haché, R. J. (2003) Threonines 2638/2647 in DNA-PK are essential for cellular resistance to ionizing radiation. Cancer Res. 63, 1198-1201
    • (2003) Cancer Res. , vol.63 , pp. 1198-1201
    • Soubeyrand, S.1    Pope, L.2    Pakuts, B.3    Haché, R.J.4
  • 49
    • 0042839614 scopus 로고    scopus 로고
    • Mechanism and regulation of human non-homologous DNA end-joining
    • Lieber, M. R., Ma, Y., Pannicke, U., and Schwarz, K. (2003) Mechanism and regulation of human non-homologous DNA end-joining. Nat. Rev. Mol. Cell Biol. 4, 712-720
    • (2003) Nat. Rev. Mol. Cell Biol. , vol.4 , pp. 712-720
    • Lieber, M.R.1    Ma, Y.2    Pannicke, U.3    Schwarz, K.4
  • 50
    • 0037133699 scopus 로고    scopus 로고
    • DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination
    • Allen, C., Kurimasa, A., Brenneman, M. A., Chen, D. J., and Nickoloff, J. A. (2002) DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination. Proc. Natl. Acad. Sci. USA 99, 3758-3763
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 3758-3763
    • Allen, C.1    Kurimasa, A.2    Brenneman, M.A.3    Chen, D.J.4    Nickoloff, J.A.5
  • 51
    • 3042733148 scopus 로고    scopus 로고
    • Amplification and overexpression of oncogene Mdm2 and orphan receptor gene Nrlh4 in immortal PRKDC knockout cells
    • Ai, R., Sandoval, A., Chen, D. J., Burma, S., and Labhart, P. (2004) Amplification and overexpression of oncogene Mdm2 and orphan receptor gene Nrlh4 in immortal PRKDC knockout cells. Mol. Biol. Rep. 31, 91-96
    • (2004) Mol. Biol. Rep. , vol.31 , pp. 91-96
    • Ai, R.1    Sandoval, A.2    Chen, D.J.3    Burma, S.4    Labhart, P.5
  • 52
    • 0037124373 scopus 로고    scopus 로고
    • Synapsis of DNA ends by DNA-dependent protein kinase
    • DeFazio, L. G., Stansel, R. M., Griffith, J. D., and Chu, G. (2002) Synapsis of DNA ends by DNA-dependent protein kinase. EMBO J. 21, 3192-3200
    • (2002) EMBO J. , vol.21 , pp. 3192-3200
    • DeFazio, L.G.1    Stansel, R.M.2    Griffith, J.D.3    Chu, G.4
  • 55
    • 0036293744 scopus 로고    scopus 로고
    • Association of DNA polymerase μ (pol μ) with Ku and ligase IV: Role for pol μ in end-joining double-strand break repair
    • Mahajan, K. N., McElhinny, S. A., Mitchell, B. S., and Ramsden, D. A. (2002) Association of DNA polymerase μ (pol μ) with Ku and ligase IV: role for pol μ in end-joining double-strand break repair. Mol. Cell. Biol. 22, 5194-5202
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 5194-5202
    • Mahajan, K.N.1    McElhinny, S.A.2    Mitchell, B.S.3    Ramsden, D.A.4
  • 56
    • 0029788520 scopus 로고    scopus 로고
    • Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse
    • Blunt, T., Gell, D., Fox, M., Taccioli, G. E., Lehmann, A. R., Jackson, S. P., and Jeggo, P. A. (1996) Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse. Proc. Natl. Acad. Sci. USA 93, 10285-10290
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 10285-10290
    • Blunt, T.1    Gell, D.2    Fox, M.3    Taccioli, G.E.4    Lehmann, A.R.5    Jackson, S.P.6    Jeggo, P.A.7
  • 57
    • 0035997348 scopus 로고    scopus 로고
    • V(D)J recombination: RAG proteins, repair factors, and regulation
    • Gellert, M. (2002) V(D)J recombination: RAG proteins, repair factors, and regulation. Annu. Rev. Biochem. 71, 101-132
    • (2002) Annu. Rev. Biochem. , vol.71 , pp. 101-132
    • Gellert, M.1
  • 58
    • 0031741234 scopus 로고    scopus 로고
    • Failure of hairpin-ended and nicked DNA to activate DNA-dependent protein kinase: Implications for V(D)J recombination
    • Smider, V., Rathmell, W. K., Brown, G., Lewis, S., and Chu, G. (1998) Failure of hairpin-ended and nicked DNA to activate DNA-dependent protein kinase: implications for V(D)J recombination. Mol. Cell. Biol. 18, 6853-6858
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 6853-6858
    • Smider, V.1    Rathmell, W.K.2    Brown, G.3    Lewis, S.4    Chu, G.5
  • 59
    • 0027156278 scopus 로고
    • Impairment of V(D)J recombination in double-strand break repair mutants
    • Taccioli, G. E., Rathbun, G., Oltz, E., Stamato, T., Jeggo, P. A., and Alt, F. W. (1993) Impairment of V(D)J recombination in double-strand break repair mutants. Science 260, 207-210
    • (1993) Science , vol.260 , pp. 207-210
    • Taccioli, G.E.1    Rathbun, G.2    Oltz, E.3    Stamato, T.4    Jeggo, P.A.5    Alt, F.W.6
  • 61
    • 0030667702 scopus 로고    scopus 로고
    • DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
    • Shieh, S. Y., Ikeda, M., Taya, Y., and Prives, C. (1997) DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91, 325-334
    • (1997) Cell , vol.91 , pp. 325-334
    • Shieh, S.Y.1    Ikeda, M.2    Taya, Y.3    Prives, C.4
  • 62
    • 0032514485 scopus 로고    scopus 로고
    • DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
    • Woo, R. A., McLure, K. G., Lees-Miller, S. P., Rancourt, D. E., and Lee, P. W. (1998) DNA-dependent protein kinase acts upstream of p53 in response to DNA damage. Nature (London) 394, 700-704
    • (1998) Nature (London) , vol.394 , pp. 700-704
    • Woo, R.A.1    McLure, K.G.2    Lees-Miller, S.P.3    Rancourt, D.E.4    Lee, P.W.5
  • 65
    • 0034025078 scopus 로고    scopus 로고
    • The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase
    • Jhappan, C., Yusufzai, T. M., Anderson, S., Anver, M. R., and Merlino, G. (2000) The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase. Mol. Cell. Biol. 20, 4075-4083
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 4075-4083
    • Jhappan, C.1    Yusufzai, T.M.2    Anderson, S.3    Anver, M.R.4    Merlino, G.5
  • 67
    • 2442527878 scopus 로고    scopus 로고
    • DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage
    • Jack, M. T., Woo, R. A., Motoama, N., Takai, H., and Lee, P. W. (2004) DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage. J. Biol. Chem. 279, 15269-15273
    • (2004) J. Biol. Chem. , vol.279 , pp. 15269-15273
    • Jack, M.T.1    Woo, R.A.2    Motoama, N.3    Takai, H.4    Lee, P.W.5
  • 68
    • 0035893389 scopus 로고    scopus 로고
    • Interaction of p53 and DNA-PK in response to nucleoside analogues: Potential role as a sensor complex for DNA damage
    • Achanta, G., Pelicano, H., Feng, L., Plunkett, W., and Huang, P. (2001) Interaction of p53 and DNA-PK in response to nucleoside analogues: potential role as a sensor complex for DNA damage. Cancer Res. 61, 8723-8729
    • (2001) Cancer Res. , vol.61 , pp. 8723-8729
    • Achanta, G.1    Pelicano, H.2    Feng, L.3    Plunkett, W.4    Huang, P.5
  • 69
    • 1342304040 scopus 로고    scopus 로고
    • ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-κB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage
    • Panta, G. R., Kaur, S., Cavin, L. G., Cortes, M. L., Mercurio, F., Lothstein, L., Sweatman, T. W., Israel, M., and Arsura, M. (2004) ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-κB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage. Mol. Cell. Biol. 24, 1823-1835
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 1823-1835
    • Panta, G.R.1    Kaur, S.2    Cavin, L.G.3    Cortes, M.L.4    Mercurio, F.5    Lothstein, L.6    Sweatman, T.W.7    Israel, M.8    Arsura, M.9
  • 70
    • 0033591244 scopus 로고    scopus 로고
    • DNA-dependent protein kinase protects against heat-induced apoptosis
    • Nueda, A., Hudson, F., Mivechi, N. F., and Dynan, W. S. (1999) DNA-dependent protein kinase protects against heat-induced apoptosis. J. Biol. Chem. 274, 14988-14996
    • (1999) J. Biol. Chem. , vol.274 , pp. 14988-14996
    • Nueda, A.1    Hudson, F.2    Mivechi, N.F.3    Dynan, W.S.4
  • 71
    • 0033104517 scopus 로고    scopus 로고
    • Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes
    • Shao, R. G., Cao, C. X., Zhang, H., Kohn, K. W., Wold, M. S., and Pommier, Y. (1999) Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes. EMBO J. 18, 1397-1406
    • (1999) EMBO J. , vol.18 , pp. 1397-1406
    • Shao, R.G.1    Cao, C.X.2    Zhang, H.3    Kohn, K.W.4    Wold, M.S.5    Pommier, Y.6
  • 72
    • 0028355488 scopus 로고
    • UV light-induced DNA synthesis arrest in HeLa cells is associated with changes in phosphorylation of human single-stranded DNA-binding protein
    • Carry, M. P., Zernik-Kobak, M., McGrath, S., and Dixon, K. (1994) UV light-induced DNA synthesis arrest in HeLa cells is associated with changes in phosphorylation of human single-stranded DNA-binding protein. EMBO J. 13, 2114-2123
    • (1994) EMBO J. , vol.13 , pp. 2114-2123
    • Carry, M.P.1    Zernik-Kobak, M.2    McGrath, S.3    Dixon, K.4
  • 73
    • 0033527543 scopus 로고    scopus 로고
    • Involvement of DNA-dependent protein kinase in UV-induced replication arrest
    • Park, J. S., Park, S. J., Peng, X., Wang, M., Yu, M. A., and Lee, S. H. (1999) Involvement of DNA-dependent protein kinase in UV-induced replication arrest. J. Biol. Chem. 274, 32520-32527
    • (1999) J. Biol. Chem. , vol.274 , pp. 32520-32527
    • Park, J.S.1    Park, S.J.2    Peng, X.3    Wang, M.4    Yu, M.A.5    Lee, S.H.6
  • 74
    • 18144380382 scopus 로고    scopus 로고
    • Glyoblastoma cells deficient in DNA-dependent protein kinase are resistant to cell death
    • In press
    • Chen, G. G., Sin, F. L., Leung, B. C., Ng, H. K., and Poon, W. S. (2004) Glyoblastoma cells deficient in DNA-dependent protein kinase are resistant to cell death. J. Cell. Physiol. In press
    • (2004) J. Cell. Physiol.
    • Chen, G.G.1    Sin, F.L.2    Leung, B.C.3    Ng, H.K.4    Poon, W.S.5
  • 75
    • 0036868349 scopus 로고    scopus 로고
    • Mechanism of inhibition of RNA polymerase I transcription by DNA-dependent protein kinase
    • Micliaelidis, T. M., and Grummt, I. (2002) Mechanism of inhibition of RNA polymerase I transcription by DNA-dependent protein kinase. J. Biol. Chem. 383, 1683-1690
    • (2002) J. Biol. Chem. , vol.383 , pp. 1683-1690
    • Micliaelidis, T.M.1    Grummt, I.2
  • 76
    • 0030801003 scopus 로고    scopus 로고
    • Phosphorylation of human general transcription factors TATA-binding protein and transcription factor IIB by DNA-dependent protein kinase-Synergistic stimulation of RNA polymerase II basal transcription in vitro
    • Chibazakura, T., Watanabe, F., Kitajima, S., Tsukada, K., Yasukochi, Y., and Teraoka, H. (1997) Phosphorylation of human general transcription factors TATA-binding protein and transcription factor IIB by DNA-dependent protein kinase-Synergistic stimulation of RNA polymerase II basal transcription in vitro. Eur. J. Biochem. 247, 1166-1173
    • (1997) Eur. J. Biochem. , vol.247 , pp. 1166-1173
    • Chibazakura, T.1    Watanabe, F.2    Kitajima, S.3    Tsukada, K.4    Yasukochi, Y.5    Teraoka, H.6
  • 77
    • 0034618517 scopus 로고    scopus 로고
    • Transcription by RNA polymerase II in DNA-PK deficient scid mouse cells
    • Sheppard, H. M., and Liu, X. (2000) Transcription by RNA polymerase II in DNA-PK deficient scid mouse cells. Biochim. Biophys. Acta 1493, 41-47
    • (2000) Biochim. Biophys. Acta , vol.1493 , pp. 41-47
    • Sheppard, H.M.1    Liu, X.2
  • 79
    • 0036566036 scopus 로고    scopus 로고
    • Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres
    • Espejel, S., Franco, S., Rodriguez-Perales, S., Bouffler, S. D., Cigudosa, J. C., and Blasco, M. A. (2002) Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres. EMBO J. 21, 2207-2219
    • (2002) EMBO J. , vol.21 , pp. 2207-2219
    • Espejel, S.1    Franco, S.2    Rodriguez-Perales, S.3    Bouffler, S.D.4    Cigudosa, J.C.5    Blasco, M.A.6
  • 82
    • 0034695658 scopus 로고    scopus 로고
    • Activation of DNA-dependent protein kinase by single-stranded DNA ends
    • Hammarsten, O., DeFazio, L. G., and Chu, G. (2000) Activation of DNA-dependent protein kinase by single-stranded DNA ends. J. Biol. Chem. 275, 1541-1550
    • (2000) J. Biol. Chem. , vol.275 , pp. 1541-1550
    • Hammarsten, O.1    DeFazio, L.G.2    Chu, G.3
  • 83
    • 0032509097 scopus 로고    scopus 로고
    • Cryo-EM imaging of the catalytic subunit of the DNA-dependent protein kinase
    • Chiu, C. Y., Cary, R. B., Chen, D. J., Peterson, S. R., and Stewart, P. L. (1998) Cryo-EM imaging of the catalytic subunit of the DNA-dependent protein kinase. J. Mol. Biol. 284, 1075-1081
    • (1998) J. Mol. Biol. , vol.284 , pp. 1075-1081
    • Chiu, C.Y.1    Cary, R.B.2    Chen, D.J.3    Peterson, S.R.4    Stewart, P.L.5
  • 85
    • 0033104498 scopus 로고    scopus 로고
    • Structure of DNA-dependent protein kinase: Implications for its regulation by DNA
    • Leuther, K. K., Hammarsten, O., Kornberg, R. D., and Chu, G. (1999) Structure of DNA-dependent protein kinase: implications for its regulation by DNA. EMBO J. 18, 1114-1123
    • (1999) EMBO J. , vol.18 , pp. 1114-1123
    • Leuther, K.K.1    Hammarsten, O.2    Kornberg, R.D.3    Chu, G.4
  • 86
    • 0027397867 scopus 로고
    • The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen
    • Gottlieb, T. M., and Jackson, S. P. (1993) The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 72, 31-42
    • (1993) Cell , vol.72 , pp. 31-42
    • Gottlieb, T.M.1    Jackson, S.P.2
  • 87
    • 0032868259 scopus 로고    scopus 로고
    • Induction of apoptosis by overexpression of the DNA-binding and DNA-PK-activating protein C1D
    • Rothbarth, K., Spiess, E., Juodka, B., Yavuzer, U., Nehls, P., Stammer, H., and Werner, D. (1999) Induction of apoptosis by overexpression of the DNA-binding and DNA-PK-activating protein C1D. J. Cell Sci. 112, 2223-2232
    • (1999) J. Cell Sci. , vol.112 , pp. 2223-2232
    • Rothbarth, K.1    Spiess, E.2    Juodka, B.3    Yavuzer, U.4    Nehls, P.5    Stammer, H.6    Werner, D.7
  • 88
    • 0036436084 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae C1D is implicated in both non-homologous DNA end joining and homologous recombination
    • Erdemir, T., Bilican, B., Cagatay, T., Coding, C. R., and Yavuzer, U. (2002) Saccharomyces cerevisiae C1D is implicated in both non-homologous DNA end joining and homologous recombination. Mol. Microbiol 46, 947-957
    • (2002) Mol. Microbiol. , vol.46 , pp. 947-957
    • Erdemir, T.1    Bilican, B.2    Cagatay, T.3    Coding, C.R.4    Yavuzer, U.5
  • 89
    • 14544288305 scopus 로고    scopus 로고
    • Colocalization of poly(ADPR)polymerase 1 (PARP-1), poly(ADPR) polymerase 2 (PARP-2) and related proteins in rat testis nuclear matrix defined by chemical cross-linking
    • Tramontano, F., Di Meglio, S., and Quesada, P. (2004) Colocalization of poly(ADPR)polymerase 1 (PARP-1), poly(ADPR) polymerase 2 (PARP-2) and related proteins in rat testis nuclear matrix defined by chemical cross-linking. J. Cell. Biochem. 94, 58-66
    • (2004) J. Cell. Biochem. , vol.94 , pp. 58-66
    • Tramontano, F.1    Di Meglio, S.2    Quesada, P.3
  • 90
    • 0035793429 scopus 로고    scopus 로고
    • Analysis of sequence-dependent curvature in matrix attachment regions
    • Yamamura, J., and Nomura, K. (2001) Analysis of sequence-dependent curvature in matrix attachment regions. FEBS Lett. 489, 166-170
    • (2001) FEBS Lett. , vol.489 , pp. 166-170
    • Yamamura, J.1    Nomura, K.2
  • 91
    • 0031696265 scopus 로고    scopus 로고
    • High mobility group proteins 1 and 2 can function as DNA-binding regulatory components for DNA-dependent protein kinase in vitro
    • Yumoto, Y., Shirakawa, H., Yoshida, M., Suwa, A., Watanabe, F., and Teraoka, H. (1998) High mobility group proteins 1 and 2 can function as DNA-binding regulatory components for DNA-dependent protein kinase in vitro. J. Biochem 124, 519-527
    • (1998) J. Biochem. , vol.124 , pp. 519-527
    • Yumoto, Y.1    Shirakawa, H.2    Yoshida, M.3    Suwa, A.4    Watanabe, F.5    Teraoka, H.6
  • 92
    • 0024843757 scopus 로고
    • Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops
    • Sundquist, W. I., and Klug, A. (1989) Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops. Nature (London) 342, 825-829
    • (1989) Nature (London) , vol.342 , pp. 825-829
    • Sundquist, W.I.1    Klug, A.2
  • 93
    • 0036682122 scopus 로고    scopus 로고
    • An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells
    • Delacote, F., Han, M., Stamato, T. D., Jasin, M., and Lopez, B. S. (2002) An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells. Nucleic Acids Res. 30, 3454-3463
    • (2002) Nucleic Acids Res. , vol.30 , pp. 3454-3463
    • Delacote, F.1    Han, M.2    Stamato, T.D.3    Jasin, M.4    Lopez, B.S.5
  • 94
    • 8744233919 scopus 로고    scopus 로고
    • After double-strand break induction by UV-A, homologous recombination and nonhomologous end joining cooperate at the same DSB if both systems are available
    • Rapp, A., and Greulich, K. O. (2004) After double-strand break induction by UV-A, homologous recombination and nonhomologous end joining cooperate at the same DSB if both systems are available. J. Cell Sci. 117, 4935-4945
    • (2004) J. Cell Sci. , vol.117 , pp. 4935-4945
    • Rapp, A.1    Greulich, K.O.2
  • 95
    • 3242886503 scopus 로고    scopus 로고
    • Role of DNA-PK in the cellular response to double-strand breaks
    • Burma, S., and Chen, D. J. (2004) Role of DNA-PK in the cellular response to double-strand breaks. DNA Repair (Amsterdam) 3, 909-918
    • (2004) DNA Repair (Amsterdam) , vol.3 , pp. 909-918
    • Burma, S.1    Chen, D.J.2
  • 96
    • 0035361714 scopus 로고    scopus 로고
    • Increased gene amplification in immortal rodent cells deficient for the DNA-dependent protein kinase catalytic subunit
    • Mondello, C., Rebuzzini, P., Dolzan, M., Edmonson, S., Taccioli, G. E., and Giulotto, E. (2001) Increased gene amplification in immortal rodent cells deficient for the DNA-dependent protein kinase catalytic subunit. Cancer Res. 61, 4520-4525
    • (2001) Cancer Res. , vol.61 , pp. 4520-4525
    • Mondello, C.1    Rebuzzini, P.2    Dolzan, M.3    Edmonson, S.4    Taccioli, G.E.5    Giulotto, E.6
  • 97
    • 0035833552 scopus 로고    scopus 로고
    • Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
    • Walker, J. R., Corpina, R. A., and Goldberg, J. (2001) Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature (London) 412, 607-614
    • (2001) Nature (London) , vol.412 , pp. 607-614
    • Walker, J.R.1    Corpina, R.A.2    Goldberg, J.3


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