Ras farnesylation inhibitor FTI-277 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis

Japanese Journal of Cancer Research

Volumn 93, Issue 9, 2002, Pages 1020-1028

  Nam, Jeong Seok ^a   Ino, Yoshinori ^a   Sakamoto, Michiie ^a   Hirohashi, Setsuo ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Catenin; E Cadherin; FTI 277; Metastasis; Ras

Indexed keywords

ACTIN; ALPHA CATENIN; BETA CATENIN; CATENIN; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; PLAKOGLOBIN; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; UVOMORULIN; CADHERIN; CTNNA1 PROTEIN, HUMAN; CTNNB1 PROTEIN, HUMAN; CYTOSKELETON PROTEIN; DESMOPLAKIN; DRUG DERIVATIVE; ENZYME INHIBITOR; MESSENGER RNA; METHIONINE; TRANSACTIVATOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSAY; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER INVASION; CELL ADHESION; CELL AGGREGATION; CELL CONTACT; COLON CANCER; CONTROLLED STUDY; CYTOSKELETON; DOWN REGULATION; EPITHELIUM TUMOR; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; INOCULATION; LIVER CANCER; LIVER METASTASIS; MALE; METASTASIS INHIBITION; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; SCID MOUSE; SPLEEN; SPLEEN TUMOR; TUMOR GROWTH; CELL CULTURE; CELL DIVISION; DRUG EFFECT; GENETICS; METASTASIS; ONCOGENE RAS; PHYSIOLOGY;

ALPHA CATENIN; BETA CATENIN; CADHERINS; CELL AGGREGATION; CELL DIVISION; CYTOSKELETAL PROTEINS; DESMOPLAKINS; ENZYME INHIBITORS; GENES, RAS; HUMANS; METHIONINE; NEOPLASM METASTASIS; RNA, MESSENGER; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

EID: 0036748514     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2002.tb02479.x     Document Type: Article

References (37)

1. Takeichi, M. Cadherins in cancer: implications for invasion and metastasis. Curr. Opin. Cell Biol., 5, 806-811 (1993).
2. Hirohashi, S. Inactivation of the E-cadherin-mediated cell adhesion system in human cancers. Am. J. Pathol., 153, 333-339 (1998).
3. Perl, A. K., Wilgenbus, P., Dahl, U., Semb, H. and Christofori, G. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature, 392, 190-193 (1998).
4. Yamamoto, T., Taya, S. and Kaibuchi, K. Ras-induced transformation and signaling pathway. J. Biochem. (Tokyo), 126, 799-803 (1999).
5. Potempa, S. and Ridley, A. J. Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly. Mol. Biol. Cell, 9, 2185-2200 (1998).
6. Espada, J., Perez-Moreno, M., Braga, V. M., Rodriguez-Viciana, P. and Cano, A. H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of beta-catenin in epidermal keratinocytes. J. Cell Biol., 146, 967-980 (1999).
7. Chen, Y., Lu, Q., Schneeberger, E. E. and Goodenough, D. A. Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells. Mol. Biol. Cell, 11, 849-862 (2000).
8. Hancock, J. F., Magee, A. I., Childs, J. E. and Marshall, C. J. All ras proteins are polyisoprenylated but only some are palmitoylated. Cell, 57, 1167-1177 (1989).
9. Casey, P. J., Solski, P. A., Der, C. J. and Buss, J. E. p21ras is modified by a farnesyl isoprenoid. Proc. Natl. Acad. Sci. USA, 86, 8323-8327 (1989).
10. Stacey, D. W., Feig, L. A. and Gibbs, J. B. Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras. Mol. Cell. Biol., 11, 4053-4064 (1991).
11. Kato, K., Cox, A. D., Hisaka, M. M., Graham, S. M., Buss, J. E. and Der, C. J. Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity. Proc. Natl. Acad. Sci. USA, 89, 6403-6407 (1992).
12. Lantry, L. E., Zhang, Z., Yao, R., Crist, K. A., Wang, Y., Ohkanda, J., Hamilton, A. D., Sebti, S. M., Lubet, R. A. and You, M. Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis, 21, 113-116 (2000).
13. Yamamoto, T., Gotoh, M., Kitajima, M. and Hirohashi, S. Thymosin beta-4 expression is correlated with metastatic capacity of colorectal carcinomas. Biochem. Biophys. Res. Commun., 193, 706-710 (1993).
14. Yano, H., Maruiwa, M., Murakami, T., Fukuda, K., Ito, Y., Sugihara, S. and Kojiro, M. A new human pleomorphic hepatocellular carcinoma cell line, KYN-2. Acta Pathol. Jpn., 38, 953-966 (1988).
15. Osada, T., Sakamoto, M., Ino, Y., Iwamatsu, A., Matsuno, Y., Muto, T. and Hirohashi, S. E-Cadherin is involved in the intrahepatic metastasis of hepatocellular carcinoma. Hepatology, 24, 1460-1467 (1996).
16. Shimoyama, Y., Nagafuchi, A., Fujita, S., Gotoh, M., Takeichi, M., Tsukita, S. and Hirohashi, S. Cadherin dysfunction in a human cancer cell line: possible involvement of loss of alpha-catenin expression in reduced cell-cell adhesiveness. Cancer Res., 52, 5770-5774 (1992).
17. Shimoyama, Y., Hirohashi, S., Hirano, S., Noguchi, M., Shimosato, Y., Takeichi, M. and Abe, O. Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas. Cancer Res., 49, 2128-2133 (1989).
18. Hinck, L., Nathke, I. S., Papkoff, J. and Nelson, W. J. Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly. J. Cell Biol., 125, 1327-1340 (1994).
19. Church, G. M. and Gilbert, W. Genomic sequencing. Proc. Natl. Acad. Sci. USA, 81, 1991-1995 (1984).
20. Yoshiura, K., Kanai, Y., Ochiai, A., Shimoyama, Y., Sugimura, T. and Hirohashi, S. Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. Proc. Natl. Acad. Sci. USA, 92, 7416-7419 (1995).
21. Oda, T., Kanai, Y., Shimoyama, Y., Nagafuchi, A., Tsukita, S. and Hirohashi, S. Cloning of the human alpha-catenin cDNA and its aberrant mRNA in a human cancer cell line. Biochem. Biophys. Res. Commun., 193, 897-904 (1993).
22. Shibata, T., Ochiai, A., Kanai, Y., Akimoto, S., Gotoh, M., Yasui, N., Machinami, R. and Hirohashi, S. Dominant negative inhibition of the association between beta-catenin and c-erbB-2 by N-terminally deleted beta-catenin suppresses the invasion and metastasis of cancer cells. Oncogene, 13, 883-889 (1996).
23. Kanai, Y., Ochiai, A., Shibata, T., Oyama, T., Ushijima, S., Akimoto, S. and Hirohashi, S. c-erbB-2 gene product directly associates with beta-catenin and plakoglobin. Biochem. Biophys. Res. Commun., 208, 1067-1072 (1995).
24. Yasui, N., Sakamoto, M., Ochiai, A., Ino, Y., Akimoto, S., Orikasa, A., Kitajima, M. and Hirohashi, S. Tumor growth and metastasis of human colorectal cancer cell lines in SCID mice resemble clinical metastatic behaviors. Invasion Metastasis, 17, 259-269 (1997).
25. Nam, J.-S., Ino, Y., Sakamoto, M. and Hirohashi, S. Src family kinase inhibitor PP2 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis. Clin. Cancer Res., 8, 2430-2436 (2002).
26. Sebolt-Leopold, J. S., Dudley, D. T., Herrera, R., Van Becelaere, K., Wiland, A., Gowan, R. C., Tecle, H., Barrett, S. D., Bridges, A., Przybranowski, S., Leopold, W. R. and Saltiel, A. R. Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nat. Med., 5, 810-816 (1999).
27. Rodrigo, I., Cato, A. C. and Cano, A. Regulation of E-cadherin gene expression during tumor progression: the role of a new Ets-binding site and the E-pal element. Exp. Cell Res., 248, 358-371 (1999).
28. Menke, A., Philippi, C., Vogelmann, R., Seidel, B., Lutz, M. P., Adler, G. and Wedlich, D. Down-regulation of E-cadherin gene expression by collagen type I and type III in pancreatic cancer cell lines. Cancer Res., 61, 3508-3517 (2001).
29. White, M. A., Nicolette, C., Minden, A., Polverino, A., Van Aelst, L., Karin, M. and Wigler, M. H. Multiple Ras functions can contribute to mammalian cell transformation. Cell, 80, 533-541 (1995).
30. Joneson, T., White, M. A., Wigler, M. H. and Bar-Sagi, D. Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science, 271, 810-812 (1996).
31. Rodriguez-Viciana, P., Warne, P. H., Khwaja, A., Marte, B. M., Pappin, D., Das, P., Waterfield, M. D., Ridley, A. and Downward, J. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell, 89, 457-467 (1997).
32. Sander, E. E., van Delft, S., ten Klooster, J. P., Reid, T., van der Kammen, R. A., Michiels, F. and Collard, J. G. Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase. J. Cell Biol., 143, 1385-1398 (1998).
33. Zhong, C., Kinch, M. S. and Burridge, K. Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells. Mol. Biol. Cell, 8, 2329-2344 (1997).
34. Izawa, I., Amano, M., Chihara, K., Yamamoto, T. and Kaibuchi, K. Possible involvement of the inactivation of the Rho-Rho-kinase pathway in oncogenic Ras-induced transformation. Oncogene, 17, 2863-2871 (1998).
35. End, D. W., Smets, G., Todd, A. V., Applegate, T. L., Fuery, C. J., Angibaud, P., Venet, M., Sanz, G., Poignet, H., Skrzat, S., Devine, A., Wouters, W. and Bowden, C. Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Res., 61, 131-137 (2001).
36. Jansen, B., Schlagbauer-Wadl, H., Kahr, H., Heere-Ress, E., Mayer, B. X., Eichler, H., Pehamberger, H., Gana-Weisz, M., Ben-David, E., Kloog, Y. and Wolff, K. Novel Ras antagonist blocks human melanoma growth. Proc. Natl. Acad. Sci. USA, 96, 14019-14024 (1999).
37. Wong, A. K. and Chin, L. An inducible melanoma model implicates a role for RAS in tumor maintenance and angiogenesis. Cancer Metastasis Rev., 19, 121-129 (2000).